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Erschienen in: Journal of Thrombosis and Thrombolysis 1/2021

26.04.2021 | COVID-19 Zur Zeit gratis

Highlights from the American society of hematology conference 2020

verfasst von: Punita Grover, Shuchi Gulati

Erschienen in: Journal of Thrombosis and Thrombolysis | Ausgabe 1/2021

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Abstract

American Society of Hematology conducts an annual meeting, where investigators from around the globe presented ground-breaking research in the fields of malignant and non-malignant hematology. We provide a summary of non-malignant hematology abstracts from the 2020 meeting. Topics included range from those related to thrombosis, including thrombotic complications of COVID-19, bleeding and novel therapies such as gene therapies. Readers are encouraged to access meeting materials for a more detailed coverage of the event.
Literatur
1.
Zurück zum Zitat Davenport A (2011) What are the anticoagulation options for intermittent hemodialysis? Nat Rev Nephrol 7(9):499–508CrossRefPubMed Davenport A (2011) What are the anticoagulation options for intermittent hemodialysis? Nat Rev Nephrol 7(9):499–508CrossRefPubMed
2.
Zurück zum Zitat Lorentz CU, Verbout NG, Shatzel JJ et al (2020) Safety and efficacy of the contact activation inhibitor AB023 in patients with end-stage renal disease on chronic hemodialysis: A phase 2, double-blind, randomized placebo-controlled trial. Blood 136(Supplement 1):23–24CrossRef Lorentz CU, Verbout NG, Shatzel JJ et al (2020) Safety and efficacy of the contact activation inhibitor AB023 in patients with end-stage renal disease on chronic hemodialysis: A phase 2, double-blind, randomized placebo-controlled trial. Blood 136(Supplement 1):23–24CrossRef
3.
Zurück zum Zitat Khorana AA, Kuderer NM, Culakova E et al (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111(10):4902–4907CrossRefPubMedPubMedCentral Khorana AA, Kuderer NM, Culakova E et al (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111(10):4902–4907CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Iorio A, Kearon C, Filippucci E et al (2010) Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med 170(19):1710–1716CrossRefPubMed Iorio A, Kearon C, Filippucci E et al (2010) Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med 170(19):1710–1716CrossRefPubMed
5.
Zurück zum Zitat Kapoor S, Opneja A, Gollamudi J et al (2020) Prior history of venous thromboembolism is a significant risk factor for recurrence of thrombosis after cancer diagnosis. Blood 136(Supplement 1):32–33CrossRef Kapoor S, Opneja A, Gollamudi J et al (2020) Prior history of venous thromboembolism is a significant risk factor for recurrence of thrombosis after cancer diagnosis. Blood 136(Supplement 1):32–33CrossRef
6.
Zurück zum Zitat Eichinger S, Hron G, Bialonczyk C et al (2008) Overweight, obesity, and the risk of recurrent venous thromboembolism. Arch Intern Med 168(15):1678–1683CrossRefPubMed Eichinger S, Hron G, Bialonczyk C et al (2008) Overweight, obesity, and the risk of recurrent venous thromboembolism. Arch Intern Med 168(15):1678–1683CrossRefPubMed
7.
Zurück zum Zitat McCaughan GJ, Crowther HJ, Chen V et al (2020) Australian and New Zealand registry of anticoagulation in the obese: prescribing patterns, drug levels and patient outcomes. Blood 136(Supplement 1):21–21CrossRef McCaughan GJ, Crowther HJ, Chen V et al (2020) Australian and New Zealand registry of anticoagulation in the obese: prescribing patterns, drug levels and patient outcomes. Blood 136(Supplement 1):21–21CrossRef
8.
Zurück zum Zitat Hart RG, Diener HC, Yang S et al (2012) Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke 43(6):1511–1517CrossRefPubMed Hart RG, Diener HC, Yang S et al (2012) Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial. Stroke 43(6):1511–1517CrossRefPubMed
9.
Zurück zum Zitat Hankey GJ, Stevens SR, Piccini JP et al (2014) Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation. Stroke 45(5):1304–1312CrossRefPubMed Hankey GJ, Stevens SR, Piccini JP et al (2014) Intracranial hemorrhage among patients with atrial fibrillation anticoagulated with warfarin or rivaroxaban: the rivaroxaban once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism trial in atrial fibrillation. Stroke 45(5):1304–1312CrossRefPubMed
10.
Zurück zum Zitat Srinathan S, Cipkar C, Chiang P et al (2020) Mortality rate and functional outcomes among patients presenting with anticoagulation- associated intracranial hemorrhage. Blood 136(Supplement 1):24–25CrossRef Srinathan S, Cipkar C, Chiang P et al (2020) Mortality rate and functional outcomes among patients presenting with anticoagulation- associated intracranial hemorrhage. Blood 136(Supplement 1):24–25CrossRef
11.
Zurück zum Zitat Inohara T, Xian Y, Liang L et al (2018) Association of intracerebral hemorrhage among patients taking non-vitamin K antagonist vs vitamin K antagonist oral anticoagulants with in-hospital mortality. JAMA 319(5):463–473CrossRefPubMedPubMedCentral Inohara T, Xian Y, Liang L et al (2018) Association of intracerebral hemorrhage among patients taking non-vitamin K antagonist vs vitamin K antagonist oral anticoagulants with in-hospital mortality. JAMA 319(5):463–473CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Tsivgoulis G, Katsanos AH, Seiffge DJ et al (2020) Fatal intracranial haemorrhage occurring after oral anticoagulant treatment initiation for secondary stroke prevention in patients with atrial fibrillation. Eur J Neurol 27(8):1612–1617CrossRefPubMed Tsivgoulis G, Katsanos AH, Seiffge DJ et al (2020) Fatal intracranial haemorrhage occurring after oral anticoagulant treatment initiation for secondary stroke prevention in patients with atrial fibrillation. Eur J Neurol 27(8):1612–1617CrossRefPubMed
13.
Zurück zum Zitat Ansell J, Laulicht B, Bakhru S et al (2020) Reversal of anticoagulation by ciraparantag: time to onset and duration of effect. Blood 136(Supplement 1):24–24CrossRef Ansell J, Laulicht B, Bakhru S et al (2020) Reversal of anticoagulation by ciraparantag: time to onset and duration of effect. Blood 136(Supplement 1):24–24CrossRef
14.
Zurück zum Zitat Loo J, Spittle DA, Newnham M (2021) COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax 76(4):412–420CrossRefPubMed Loo J, Spittle DA, Newnham M (2021) COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms. Thorax 76(4):412–420CrossRefPubMed
15.
Zurück zum Zitat Poissy J, Goutay J, Caplan M et al (2020) Pulmonary embolism in patients with COVID-19. Circulation 142(2):184–186CrossRefPubMed Poissy J, Goutay J, Caplan M et al (2020) Pulmonary embolism in patients with COVID-19. Circulation 142(2):184–186CrossRefPubMed
17.
Zurück zum Zitat Nopp S, Moik F, Jilma B et al (2020) Risk of venous thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Res Pract Thromb Haemost 4(7):1178–1191CrossRefPubMedCentral Nopp S, Moik F, Jilma B et al (2020) Risk of venous thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Res Pract Thromb Haemost 4(7):1178–1191CrossRefPubMedCentral
18.
Zurück zum Zitat Goshua G, Liu Y, Meizlish ML et al (2020) Admission Rothman index, aspirin, and intermediate dose anticoagulation effects on outcomes in COVID-19: a multi-site propensity matched analysis. Blood 136(Supplement 1):23–24CrossRef Goshua G, Liu Y, Meizlish ML et al (2020) Admission Rothman index, aspirin, and intermediate dose anticoagulation effects on outcomes in COVID-19: a multi-site propensity matched analysis. Blood 136(Supplement 1):23–24CrossRef
19.
Zurück zum Zitat Al-Samkari H, Gupta S, Karp Leaf R et al (2020). Thrombosis, bleeding, and the effect of anticoagulation on survival in critically ill patients with COVID-19 in the United States [abstract]. American Society of Hematology Annual Meeting Al-Samkari H, Gupta S, Karp Leaf R et al (2020). Thrombosis, bleeding, and the effect of anticoagulation on survival in critically ill patients with COVID-19 in the United States [abstract]. American Society of Hematology Annual Meeting
20.
Zurück zum Zitat Patell R, Bogue T, Koshy A et al (2020) Postdischarge thrombosis and hemorrhage in patients with COVID-19. Blood 136(11):1342–1346CrossRefPubMed Patell R, Bogue T, Koshy A et al (2020) Postdischarge thrombosis and hemorrhage in patients with COVID-19. Blood 136(11):1342–1346CrossRefPubMed
21.
Zurück zum Zitat Roberts LN, Whyte MB, Georgiou L et al (2020) Postdischarge venous thromboembolism following hospital admission with COVID-19. Blood 136(11):1347–1350CrossRefPubMed Roberts LN, Whyte MB, Georgiou L et al (2020) Postdischarge venous thromboembolism following hospital admission with COVID-19. Blood 136(11):1347–1350CrossRefPubMed
22.
Zurück zum Zitat Giannis D, Allen SL, Davidson A et al (2020) Thromboembolic outcomes of hospitalized COVID-19 patients in the 90-day post-discharge period: early data from the northwell CORE-19 registry. Blood 136(Supplement 1):33–34CrossRef Giannis D, Allen SL, Davidson A et al (2020) Thromboembolic outcomes of hospitalized COVID-19 patients in the 90-day post-discharge period: early data from the northwell CORE-19 registry. Blood 136(Supplement 1):33–34CrossRef
23.
Zurück zum Zitat Bhalla V, Lamping OF, Abdel-Latif A et al (2020) Contemporary meta-analysis of extended direct-acting oral anticoagulant thromboprophylaxis to prevent venous thromboembolis. Am J Med 133(9):1074-1081.e1078CrossRefPubMed Bhalla V, Lamping OF, Abdel-Latif A et al (2020) Contemporary meta-analysis of extended direct-acting oral anticoagulant thromboprophylaxis to prevent venous thromboembolis. Am J Med 133(9):1074-1081.e1078CrossRefPubMed
24.
Zurück zum Zitat Eswaran H, Jarmul J, Shaheen A et al (2020) Incidence of vascular thromboembolic events in outpatients with mild COVID-19. Blood 136(Supplement 1):31–32CrossRef Eswaran H, Jarmul J, Shaheen A et al (2020) Incidence of vascular thromboembolic events in outpatients with mild COVID-19. Blood 136(Supplement 1):31–32CrossRef
25.
Zurück zum Zitat Li A, Kuderer NM, Warner JL et al (2020) Incidence of and risk factors for venous thromboembolism among hospitalized patients with cancer and COVID-19: report from the COVID-19 and cancer consortium (CCC19) registry. Blood 136(Supplement 1):56–58CrossRef Li A, Kuderer NM, Warner JL et al (2020) Incidence of and risk factors for venous thromboembolism among hospitalized patients with cancer and COVID-19: report from the COVID-19 and cancer consortium (CCC19) registry. Blood 136(Supplement 1):56–58CrossRef
26.
Zurück zum Zitat Gernsheimer TB, Brown SP, Triulzi DJ et al (2020) Effects of tranexamic acid prophylaxis on bleeding outcomes in hematologic malignancy: the a-TREAT trial. Blood 136(Supplement 1):1–2CrossRef Gernsheimer TB, Brown SP, Triulzi DJ et al (2020) Effects of tranexamic acid prophylaxis on bleeding outcomes in hematologic malignancy: the a-TREAT trial. Blood 136(Supplement 1):1–2CrossRef
27.
Zurück zum Zitat Neunert C, Noroozi N, Norman G et al (2015) Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review. J Thromb Haemost 13(3):457–464CrossRefPubMedPubMedCentral Neunert C, Noroozi N, Norman G et al (2015) Severe bleeding events in adults and children with primary immune thrombocytopenia: a systematic review. J Thromb Haemost 13(3):457–464CrossRefPubMedPubMedCentral
28.
Zurück zum Zitat Bradbury CA, Greenwood R, Pell J et al (2020) A multicentre randomised trial of first line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The flight trial. Blood 136(Supplement 2):LBA-2CrossRef Bradbury CA, Greenwood R, Pell J et al (2020) A multicentre randomised trial of first line treatment pathways for newly diagnosed immune thrombocytopenia: standard steroid treatment versus combined steroid and mycophenolate. The flight trial. Blood 136(Supplement 2):LBA-2CrossRef
29.
Zurück zum Zitat Kuter DJ, Efraim M, Mayer J et al (2020) Oral rilzabrutinib, a bruton tyrosine kinase inhibitor, showed clinically active and durable platelet responses and was well-tolerated in patients with heavily pretreated immune thrombocytopenia. Blood 136(Supplement 1):13–14 Kuter DJ, Efraim M, Mayer J et al (2020) Oral rilzabrutinib, a bruton tyrosine kinase inhibitor, showed clinically active and durable platelet responses and was well-tolerated in patients with heavily pretreated immune thrombocytopenia. Blood 136(Supplement 1):13–14
30.
Zurück zum Zitat Frangoul H, Altshuler D, Cappellini MD et al (2020) CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia. N Engl J Med 384(3):252–260CrossRefPubMed Frangoul H, Altshuler D, Cappellini MD et al (2020) CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia. N Engl J Med 384(3):252–260CrossRefPubMed
31.
Zurück zum Zitat Frangoul H, Bobruff Y, Cappellini MD et al (2020) Safety and efficacy of CTX001 in patients with transfusion-dependent β-thalassemia and sickle cell disease: early results from the climb THAL-111 and climb SCD-121 studies of autologous CRISPR-CAS9-modified CD34+ hematopoietic stem and progenitor cells. Blood 136(Supplement 1):3–4CrossRef Frangoul H, Bobruff Y, Cappellini MD et al (2020) Safety and efficacy of CTX001 in patients with transfusion-dependent β-thalassemia and sickle cell disease: early results from the climb THAL-111 and climb SCD-121 studies of autologous CRISPR-CAS9-modified CD34+ hematopoietic stem and progenitor cells. Blood 136(Supplement 1):3–4CrossRef
32.
Zurück zum Zitat Pipe SW, Recht M, Key NS et al (2020) First data from the phase 3 HOPE-B gene therapy trial: efficacy and safety of etranacogene dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in adults with severe or moderate-severe hemophilia B treated irrespective of pre-existing anti-capsid neutralizing antibodies. Blood 136(Supplement 2):LBA-6CrossRef Pipe SW, Recht M, Key NS et al (2020) First data from the phase 3 HOPE-B gene therapy trial: efficacy and safety of etranacogene dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in adults with severe or moderate-severe hemophilia B treated irrespective of pre-existing anti-capsid neutralizing antibodies. Blood 136(Supplement 2):LBA-6CrossRef
Metadaten
Titel
Highlights from the American society of hematology conference 2020
verfasst von
Punita Grover
Shuchi Gulati
Publikationsdatum
26.04.2021
Verlag
Springer US
Schlagwort
COVID-19
Erschienen in
Journal of Thrombosis and Thrombolysis / Ausgabe 1/2021
Print ISSN: 0929-5305
Elektronische ISSN: 1573-742X
DOI
https://doi.org/10.1007/s11239-021-02449-9

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