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22.01.2022 | COVID-19 | COVID-19 Zur Zeit gratis

In-hospital and out-of-hospital stroke in patients with COVID-19: two different diseases?

verfasst von: Ludovico Ciolli, Veronica Righi, Gabriele Vandelli, Laura Giacobazzi, Niccolò Biagioli, Donato Marzullo, Laura Vandelli, Francesca Rosafio, Giulia Vinceti, Stefania Maffei, Livio Picchetto, Maria Luisa Dell’Acqua, Giuseppe Maria Borzì, Riccardo Ricceri, Guido Bigliardi, Stefano Meletti

Erschienen in: Neurological Sciences | Ausgabe 4/2022

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Abstract

Background

Ischemic stroke is a known complication of COVID-19. It may have a different pathogenesis and worse outcome compared to stroke in patients without COVID-19. Furthermore, patients with COVID-19 and out-of-hospital stroke onset might have different characteristics compared to patients with COVID-19 and in-hospital stroke onset. The aim of our study was to analyze the characteristics of patients with stroke with and without COVID-19 and of patients with COVID-19 with in-hospital and out-of-hospital stroke.

Methods

We performed a retrospective study of all consecutive patients admitted to our hospital with ischemic stroke between October 2020 and February 2021. We compared functional outcome, lab test, demographic, and clinical characteristics between patients with or without COVID-19. We performed a sub-analysis comparing patients with COVID-19 and in-hospital and out-of-hospital stroke onset.

Results

We included in the final analysis 137 patients of whom 26 with COVID-19. Half (13) had out-of-hospital stroke and half in-hospital stroke onset. Overall, patients with COVID-19 had higher mortality compared to the control group (27% vs 9%, p: 0.02), and non-significantly lower rate of good functional outcome (50% vs 63%, p: 0.22). Patients with COVID-19 and out-of-hospital stroke had higher rate of good functional outcome (69% vs 39%, p: 0.05), higher lymphocyte count, and lower D-dimer compared with patients with in-hospital stroke onset.

Conclusions

Patients with stroke and COVID-19 had higher mortality compared to patients without COVID-19. Among patients with COVID-19 those with out-of-hospital stroke had better outcome and fewer blood test abnormalities compared to patients with in-hospital stroke.
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Metadaten
Titel
In-hospital and out-of-hospital stroke in patients with COVID-19: two different diseases?
verfasst von
Ludovico Ciolli
Veronica Righi
Gabriele Vandelli
Laura Giacobazzi
Niccolò Biagioli
Donato Marzullo
Laura Vandelli
Francesca Rosafio
Giulia Vinceti
Stefania Maffei
Livio Picchetto
Maria Luisa Dell’Acqua
Giuseppe Maria Borzì
Riccardo Ricceri
Guido Bigliardi
Stefano Meletti
Publikationsdatum
22.01.2022
Verlag
Springer International Publishing
Schlagwort
COVID-19
Erschienen in
Neurological Sciences / Ausgabe 4/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-021-05807-w

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