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Erschienen in: Lung 5/2020

11.09.2020 | COVID-19 | COVID-19 AND SARCOIDOSIS Zur Zeit gratis

Moderate or Severe Impairment in Pulmonary Function is Associated with Mortality in Sarcoidosis Patients Infected with SARS‑CoV‑2

verfasst von: Adam S. Morgenthau, Matthew A. Levin, Robert Freeman, David L. Reich, Eyal Klang

Erschienen in: Lung | Ausgabe 5/2020

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Abstract

Purpose

To investigate whether sarcoidosis patients infected with SARS-CoV-2 are at risk for adverse disease outcomes.

Study Design and Methods

This retrospective study was conducted in five hospitals within the Mount Sinai Health System during March 1, 2020 to July 29, 2020. All patients diagnosed with COVID-19 were included in the study. We identified sarcoidosis patients who met diagnostic criteria for sarcoidosis according to accepted guidelines. An adverse disease outcome was defined as the presence of intubation and mechanical ventilation or in-hospital mortality. In sarcoidosis patients, we reported (when available) the results of pulmonary function testing measured within 3 years prior to the time of SARS‑CoV‑2 infection. A multivariable logistic regression model was used to generate an adjusted odds ratio (aOR) to evaluate sarcoidosis as a risk factor for an adverse outcome. The same model was used to analyze sarcoidosis patients with moderate and/or severe impairment in pulmonary function.

Results

The study included 7337 patients, 37 of whom (0.5%) had sarcoidosis. The crude rate of developing an adverse outcome was significantly higher in patients with moderately and/or severely impaired pulmonary function (9/14 vs. 3/23, p = 0.003). While the diagnosis of sarcoidosis was not independently associated with risk of an adverse event, (aOR 1.8, 95% CI 0.9–3.6), the diagnosis of sarcoidosis in patients with moderately and/or severely impaired pulmonary function was associated with an adverse outcome (aOR 7.8, 95% CI 2.4–25.8).

Conclusion

Moderate or severe impairment in pulmonary function is associated with mortality in sarcoidosis patients infected with SARS‑CoV‑2.
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Metadaten
Titel
Moderate or Severe Impairment in Pulmonary Function is Associated with Mortality in Sarcoidosis Patients Infected with SARS‑CoV‑2
verfasst von
Adam S. Morgenthau
Matthew A. Levin
Robert Freeman
David L. Reich
Eyal Klang
Publikationsdatum
11.09.2020
Verlag
Springer US
Schlagwort
COVID-19
Erschienen in
Lung / Ausgabe 5/2020
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-020-00392-9

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