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Erschienen in: Neurological Sciences 3/2021

11.01.2021 | COVID-19 | COVID-19 Zur Zeit gratis

Neurological manifestations of coronavirus disease 2019: exploring past to understand present

verfasst von: Ishita Desai, Rajat Manchanda, Niraj Kumar, Ashutosh Tiwari, Mritunjai Kumar

Erschienen in: Neurological Sciences | Ausgabe 3/2021

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Abstract

SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term “Neuro-COVID syndrome” for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients.
Literatur
1.
Zurück zum Zitat Galassi G, Marchioni A (2020) Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain–Barré syndrome. Acta Neurol Belg [Internet] 120(5):1067–1075PubMedPubMedCentralCrossRef Galassi G, Marchioni A (2020) Facing acute neuromuscular diseases during COVID-19 pandemic: focus on Guillain–Barré syndrome. Acta Neurol Belg [Internet] 120(5):1067–1075PubMedPubMedCentralCrossRef
2.
Zurück zum Zitat Xie M, Chen Q (2020) Insight into 2019 novel coronavirus — an updated interim review and lessons from SARS-CoV and MERS-CoV. Int J Infect Dis [Internet] 94:119–124PubMedPubMedCentralCrossRef Xie M, Chen Q (2020) Insight into 2019 novel coronavirus — an updated interim review and lessons from SARS-CoV and MERS-CoV. Int J Infect Dis [Internet] 94:119–124PubMedPubMedCentralCrossRef
3.
Zurück zum Zitat Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W et al (2020) Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses [Internet] 12(4):1–17CrossRef Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W et al (2020) Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses [Internet] 12(4):1–17CrossRef
4.
Zurück zum Zitat Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S (2020) Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol 77(8):1018–1027PubMedPubMedCentralCrossRef Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S (2020) Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol 77(8):1018–1027PubMedPubMedCentralCrossRef
6.
Zurück zum Zitat Vonck K, Garrez I, De Herdt V, Hemelsoet D, Laureys G, Raedt R et al (2020) Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2. Eur J Neurol 27(8):1578–1587PubMedCrossRef Vonck K, Garrez I, De Herdt V, Hemelsoet D, Laureys G, Raedt R et al (2020) Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2. Eur J Neurol 27(8):1578–1587PubMedCrossRef
7.
Zurück zum Zitat Coolen T, Lolli V, Sadeghi N, Rovai A, Trotta N, Taccone FS et al (2020) Early postmortem brain MRI findings in COVID-19 non-survivors. Neurology 95(14):e2016–e2027PubMedCrossRef Coolen T, Lolli V, Sadeghi N, Rovai A, Trotta N, Taccone FS et al (2020) Early postmortem brain MRI findings in COVID-19 non-survivors. Neurology 95(14):e2016–e2027PubMedCrossRef
8.
Zurück zum Zitat Karimi-Galougahi M, Yousefi-Koma A, Bakhshayeshkaram M, Raad N, Haseli S (2020) 18FDG PET/CT scan reveals hypoactive orbitofrontal cortex in anosmia of COVID-19. Acad Radiol 27(7):1042–1043PubMedPubMedCentralCrossRef Karimi-Galougahi M, Yousefi-Koma A, Bakhshayeshkaram M, Raad N, Haseli S (2020) 18FDG PET/CT scan reveals hypoactive orbitofrontal cortex in anosmia of COVID-19. Acad Radiol 27(7):1042–1043PubMedPubMedCentralCrossRef
9.
Zurück zum Zitat Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL et al (2020) Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series. BMJ 368(January):1–7 Xu XW, Wu XX, Jiang XG, Xu KJ, Ying LJ, Ma CL et al (2020) Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series. BMJ 368(January):1–7
10.
Zurück zum Zitat Borges do Nascimento IJ, Cacic N, Abdulazeem HM, von Groote TC, Jayarajah U, Weerasekara I et al (2020) Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis. J Clin Med 9(4):941PubMedCentralCrossRef Borges do Nascimento IJ, Cacic N, Abdulazeem HM, von Groote TC, Jayarajah U, Weerasekara I et al (2020) Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis. J Clin Med 9(4):941PubMedCentralCrossRef
11.
Zurück zum Zitat Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol [Internet] 77(6):683PubMedCrossRef Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol [Internet] 77(6):683PubMedCrossRef
12.
Zurück zum Zitat Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG (2019) Diagnosis and treatment of adults with community-acquired pneumonia. Am J Respir Crit Care Med 200(7):E45–E67PubMedPubMedCentralCrossRef Metlay JP, Waterer GW, Long AC, Anzueto A, Brozek J, Crothers K, Cooley LA, Dean NC, Fine MJ, Flanders SA, Griffin MR, Metersky ML, Musher DM, Restrepo MI, Whitney CG (2019) Diagnosis and treatment of adults with community-acquired pneumonia. Am J Respir Crit Care Med 200(7):E45–E67PubMedPubMedCentralCrossRef
13.
Zurück zum Zitat Morfopoulou S, Brown JR, Davies EG, Anderson G, Virasami A, Qasim W, Chong WK, Hubank M, Plagnol V, Desforges M, Jacques TS, Talbot PJ, Breuer J (2016) Human coronavirus OC43 associated with fatal encephalitis. N Engl J Med 375(5):497–498PubMedCrossRef Morfopoulou S, Brown JR, Davies EG, Anderson G, Virasami A, Qasim W, Chong WK, Hubank M, Plagnol V, Desforges M, Jacques TS, Talbot PJ, Breuer J (2016) Human coronavirus OC43 associated with fatal encephalitis. N Engl J Med 375(5):497–498PubMedCrossRef
14.
Zurück zum Zitat Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ (2006) Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology. 349(2):335–346PubMedCrossRef Jacomy H, Fragoso G, Almazan G, Mushynski WE, Talbot PJ (2006) Human coronavirus OC43 infection induces chronic encephalitis leading to disabilities in BALB/C mice. Virology. 349(2):335–346PubMedCrossRef
15.
Zurück zum Zitat Kim JE, Heo JH, Kim HO, Song SH, Park SS, Park TH, Ahn JY, Kim MK, Choi JP (2017) Neurological complications during treatment of middle east respiratory syndrome. J Clin Neurol 13(3):227–233PubMedPubMedCentralCrossRef Kim JE, Heo JH, Kim HO, Song SH, Park SS, Park TH, Ahn JY, Kim MK, Choi JP (2017) Neurological complications during treatment of middle east respiratory syndrome. J Clin Neurol 13(3):227–233PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B (2020) COVID-19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology [Internet] 5(564):201187 Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, Griffith B (2020) COVID-19–associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features. Radiology [Internet] 5(564):201187
17.
Zurück zum Zitat Dixon L, Varley J, Gontsarova A, Mallon D, Tona F, Muir D et al (2020) COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia. Neurol Neuroimmunol Neuroinflamm 7(5):1–8CrossRef Dixon L, Varley J, Gontsarova A, Mallon D, Tona F, Muir D et al (2020) COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia. Neurol Neuroimmunol Neuroinflamm 7(5):1–8CrossRef
18.
Zurück zum Zitat Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al (2020) A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis [Internet] 94:55–58PubMedPubMedCentralCrossRef Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J et al (2020) A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis [Internet] 94:55–58PubMedPubMedCentralCrossRef
19.
Zurück zum Zitat Zhou L, Zhang M, Wang J, Gao J (2020) Sars-Cov-2: Underestimated damage to nervous system. Travel Med Infect Dis [Internet] 36(January):101642 Zhou L, Zhang M, Wang J, Gao J (2020) Sars-Cov-2: Underestimated damage to nervous system. Travel Med Infect Dis [Internet] 36(January):101642
20.
Zurück zum Zitat Etemadifar M, Salari M, Murgai AA, Hajiahmadi S (2020) Fulminant encephalitis as a sole manifestation of COVID-19. Neurol Sci [Internet] 41(11):3027–3029PubMedCrossRef Etemadifar M, Salari M, Murgai AA, Hajiahmadi S (2020) Fulminant encephalitis as a sole manifestation of COVID-19. Neurol Sci [Internet] 41(11):3027–3029PubMedCrossRef
21.
Zurück zum Zitat Duong L, Xu P, Liu A (2020) Meningoencephalitis without respiratory failure in a young female patient with COVID-19 infection in Downtown Los Angeles, early April 2020. Brain Behav Immun 87:33PubMedPubMedCentralCrossRef Duong L, Xu P, Liu A (2020) Meningoencephalitis without respiratory failure in a young female patient with COVID-19 infection in Downtown Los Angeles, early April 2020. Brain Behav Immun 87:33PubMedPubMedCentralCrossRef
22.
Zurück zum Zitat Wong PF, Craik S, Newman P, Makan A, Srinivasan K, Crawford E, Dev D, Moudgil H, Ahmad N (2020) Lessons of the month 1: A case of rhombencephalitis as a rare complication of acute COVID-19 infection. Clin Med 20(3):293–294CrossRef Wong PF, Craik S, Newman P, Makan A, Srinivasan K, Crawford E, Dev D, Moudgil H, Ahmad N (2020) Lessons of the month 1: A case of rhombencephalitis as a rare complication of acute COVID-19 infection. Clin Med 20(3):293–294CrossRef
23.
Zurück zum Zitat Umapathi T, Kor AC, Venketasubramanian N, Lim CCT, Pang BC, Yeo TT, Lee CC, Lim PL, Ponnudurai K, Chuah KL, Tan PH, Tai DYH, Ang SPB (2004) Large artery ischaemic stroke in severe acute respiratory syndrome (SARS). J Neurol 251(10):1227–1231PubMedPubMedCentralCrossRef Umapathi T, Kor AC, Venketasubramanian N, Lim CCT, Pang BC, Yeo TT, Lee CC, Lim PL, Ponnudurai K, Chuah KL, Tan PH, Tai DYH, Ang SPB (2004) Large artery ischaemic stroke in severe acute respiratory syndrome (SARS). J Neurol 251(10):1227–1231PubMedPubMedCentralCrossRef
24.
Zurück zum Zitat Fatima N, Saqqur M, Qamar F, Shaukat S, Shuaib A (2020) Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic. Neurol Sci 41(10):2675–2679PubMedCrossRef Fatima N, Saqqur M, Qamar F, Shaukat S, Shuaib A (2020) Impact of COVID-19 on neurological manifestations: an overview of stroke presentation in pandemic. Neurol Sci 41(10):2675–2679PubMedCrossRef
25.
Zurück zum Zitat Sharifi-Razavi A, Karimi N, Rouhani N (2020) COVID-19 and intracerebral haemorrhage: causative or coincidental? New Microbes New Infect 35:100669PubMedPubMedCentralCrossRef Sharifi-Razavi A, Karimi N, Rouhani N (2020) COVID-19 and intracerebral haemorrhage: causative or coincidental? New Microbes New Infect 35:100669PubMedPubMedCentralCrossRef
26.
Zurück zum Zitat Al Saiegh F, Ghosh R, Leibold A, Avery MB, Schmidt RF, Theofanis T et al (2020) Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke. J Neurol Neurosurg Psychiatry 91(8):846–848PubMedCrossRef Al Saiegh F, Ghosh R, Leibold A, Avery MB, Schmidt RF, Theofanis T et al (2020) Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke. J Neurol Neurosurg Psychiatry 91(8):846–848PubMedCrossRef
27.
Zurück zum Zitat Hughes C, Nichols T, Pike M, Subbe C, Elghenzai S (2020) Cerebral venous sinus thrombosis as a presentation of COVID-19. Eur J Case Rep Intern Med 7(5):1691 Hughes C, Nichols T, Pike M, Subbe C, Elghenzai S (2020) Cerebral venous sinus thrombosis as a presentation of COVID-19. Eur J Case Rep Intern Med 7(5):1691
28.
Zurück zum Zitat Klein DE, Libman R, Kirsch C, Arora R (2020) Cerebral venous thrombosis: atypical presentation of COVID-19 in the young. J Stroke Cerebrovasc Dis [Internet] 29(8):104989PubMedPubMedCentralCrossRef Klein DE, Libman R, Kirsch C, Arora R (2020) Cerebral venous thrombosis: atypical presentation of COVID-19 in the young. J Stroke Cerebrovasc Dis [Internet] 29(8):104989PubMedPubMedCentralCrossRef
29.
Zurück zum Zitat Dakay K, Cooper J, Bloomfield J, Overby P, Mayer SA, Nuoman R et al (2020) Cerebral venous sinus thrombosis in COVID-19 infection: a case series and review of the literature. J Stroke Cerebrovasc Dis 30(1):105434PubMedPubMedCentralCrossRef Dakay K, Cooper J, Bloomfield J, Overby P, Mayer SA, Nuoman R et al (2020) Cerebral venous sinus thrombosis in COVID-19 infection: a case series and review of the literature. J Stroke Cerebrovasc Dis 30(1):105434PubMedPubMedCentralCrossRef
30.
Zurück zum Zitat Gómez-Enjuto S, Hernando-Requejo V, Lapeña-Motilva J, Ogando-Durán G, Fouz-Ruiz D, Domingo-García J, Rodríguez-García E, Cemillán-Fernández CA (2020) Verapamil as treatment for refractory status epilepticus secondary to PRES syndrome on a SARS-Cov-2 infected patient. Seizure [Internet] 80(January):157–8 Gómez-Enjuto S, Hernando-Requejo V, Lapeña-Motilva J, Ogando-Durán G, Fouz-Ruiz D, Domingo-García J, Rodríguez-García E, Cemillán-Fernández CA (2020) Verapamil as treatment for refractory status epilepticus secondary to PRES syndrome on a SARS-Cov-2 infected patient. Seizure [Internet] 80(January):157–8
31.
Zurück zum Zitat Kishfy L, Casasola M, Banankhah P, Parvez A, Jan YJ, Shenoy AM et al (2020) Posterior reversible encephalopathy syndrome (PRES) as a neurological association in severe Covid-19. J Neurol Sci [Internet] 414(January):116943 Kishfy L, Casasola M, Banankhah P, Parvez A, Jan YJ, Shenoy AM et al (2020) Posterior reversible encephalopathy syndrome (PRES) as a neurological association in severe Covid-19. J Neurol Sci [Internet] 414(January):116943
32.
Zurück zum Zitat Parauda SC, Gao V, Gewirtz AN, Parikh NS, Merkler AE, Lantos J et al (2020) Posterior reversible encephalopathy syndrome in patients with COVID-19. J Neurol Sci [Internet] 416:117019PubMedPubMedCentralCrossRef Parauda SC, Gao V, Gewirtz AN, Parikh NS, Merkler AE, Lantos J et al (2020) Posterior reversible encephalopathy syndrome in patients with COVID-19. J Neurol Sci [Internet] 416:117019PubMedPubMedCentralCrossRef
33.
Zurück zum Zitat Kaya Y, Kara S, Akinci C, Kocaman AS (2020) Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: case report. J Neurol Sci [Internet] 413(January):116858 Kaya Y, Kara S, Akinci C, Kocaman AS (2020) Transient cortical blindness in COVID-19 pneumonia; a PRES-like syndrome: case report. J Neurol Sci [Internet] 413(January):116858
34.
Zurück zum Zitat Saitta L, Molin A, Villani F, Insorsi A, Roccatagliata L, Inglese M et al (2020) Brain microvascular occlusive disorder in COVID-19: a case report. Neurol Sci 41:3401–3404PubMedPubMedCentralCrossRef Saitta L, Molin A, Villani F, Insorsi A, Roccatagliata L, Inglese M et al (2020) Brain microvascular occlusive disorder in COVID-19: a case report. Neurol Sci 41:3401–3404PubMedPubMedCentralCrossRef
35.
Zurück zum Zitat Boucher A, Desforges M, Duquette P, Talbot PJ (2007) Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients. Clin Immunol 123(3):258–267PubMedPubMedCentralCrossRef Boucher A, Desforges M, Duquette P, Talbot PJ (2007) Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients. Clin Immunol 123(3):258–267PubMedPubMedCentralCrossRef
36.
37.
Zurück zum Zitat Stewart JN, Mounir S, Talbot PJ (1992) Human coronavirus gene expression in the brains of multiple sclerosis patients. Virology. 191(1):502–505PubMedCrossRef Stewart JN, Mounir S, Talbot PJ (1992) Human coronavirus gene expression in the brains of multiple sclerosis patients. Virology. 191(1):502–505PubMedCrossRef
38.
Zurück zum Zitat Pilotto A, Odolini S, Stefano Masciocchi S, Comelli A, Volonghi I, Gazzina S et al (2020) Steroid-responsive encephalitis in Covid-19 disease. Ann Neurol 2:1–5 Pilotto A, Odolini S, Stefano Masciocchi S, Comelli A, Volonghi I, Gazzina S et al (2020) Steroid-responsive encephalitis in Covid-19 disease. Ann Neurol 2:1–5
39.
Zurück zum Zitat Zanin L, Saraceno G, Panciani PP, Renisi G, Signorini L, Migliorati K et al (2020) SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochir 162(7):1491–1494PubMedCrossRef Zanin L, Saraceno G, Panciani PP, Renisi G, Signorini L, Migliorati K et al (2020) SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochir 162(7):1491–1494PubMedCrossRef
40.
Zurück zum Zitat AlKetbi R, AlNuaimi D, AlMulla M, AlTalai N, Samir M, Kumar N (2020) Acute myelitis as a neurological complication of Covid-19: a case report and MRI findings. Radiol Case Rep 15(9):1591–1595PubMedPubMedCentralCrossRef AlKetbi R, AlNuaimi D, AlMulla M, AlTalai N, Samir M, Kumar N (2020) Acute myelitis as a neurological complication of Covid-19: a case report and MRI findings. Radiol Case Rep 15(9):1591–1595PubMedPubMedCentralCrossRef
42.
Zurück zum Zitat Munz M, Wessendorf S, Koretsis G, Tewald F, Baegi R, Krämer S et al (2020) Acute transverse myelitis after COVID-19 pneumonia. J Neurol 267(8):2196–2197PubMedPubMedCentralCrossRef Munz M, Wessendorf S, Koretsis G, Tewald F, Baegi R, Krämer S et al (2020) Acute transverse myelitis after COVID-19 pneumonia. J Neurol 267(8):2196–2197PubMedPubMedCentralCrossRef
43.
Zurück zum Zitat Sarma D, Bilello LA (2020) A case report of acute transverse myelitis following novel coronavirus infection. Clin Pract Cases Emerg Med 4(3):321–323PubMedPubMedCentralCrossRef Sarma D, Bilello LA (2020) A case report of acute transverse myelitis following novel coronavirus infection. Clin Pract Cases Emerg Med 4(3):321–323PubMedPubMedCentralCrossRef
44.
Zurück zum Zitat Panariello A, Bassetti R, Radice A, Rossotti R, Puoti M, Corradin M et al (2020) Anti-NMDA receptor encephalitis in a psychiatric Covid-19 patient: a case report. Brain Behav Immun 87:179–181PubMedPubMedCentralCrossRef Panariello A, Bassetti R, Radice A, Rossotti R, Puoti M, Corradin M et al (2020) Anti-NMDA receptor encephalitis in a psychiatric Covid-19 patient: a case report. Brain Behav Immun 87:179–181PubMedPubMedCentralCrossRef
45.
Zurück zum Zitat Rábano-Suárez P, Bermejo-Guerrero L, Méndez-Guerrero A, Parra-Serrano J, Toledo-Alfocea D, Sánchez-Tejerina D et al (2020) Generalized myoclonus in COVID-19. Neurology 95(6):e767–e772PubMedPubMedCentralCrossRef Rábano-Suárez P, Bermejo-Guerrero L, Méndez-Guerrero A, Parra-Serrano J, Toledo-Alfocea D, Sánchez-Tejerina D et al (2020) Generalized myoclonus in COVID-19. Neurology 95(6):e767–e772PubMedPubMedCentralCrossRef
46.
Zurück zum Zitat Borroni B, Gazzina S, Dono F, Mazzoleni V, Liberini P, Carrarini C, Russo M, Pontolillo M, Vecchiet J, Onofrj M, Bonanni L (2020) Diaphragmatic myoclonus due to SARS-CoV-2 infection. Neurol Sci [Internet] 41(12):3471–3474PubMedPubMedCentralCrossRef Borroni B, Gazzina S, Dono F, Mazzoleni V, Liberini P, Carrarini C, Russo M, Pontolillo M, Vecchiet J, Onofrj M, Bonanni L (2020) Diaphragmatic myoclonus due to SARS-CoV-2 infection. Neurol Sci [Internet] 41(12):3471–3474PubMedPubMedCentralCrossRef
47.
Zurück zum Zitat Wright D, Rowley R, Halks-Wellstead P, Anderson T, Wu TY (2020) Abnormal saccadic oscillations associated with severe acute respiratory syndrome coronavirus 2 encephalopathy and ataxia. Mov Disord Clin Pract 7(8):980–982PubMedPubMedCentralCrossRef Wright D, Rowley R, Halks-Wellstead P, Anderson T, Wu TY (2020) Abnormal saccadic oscillations associated with severe acute respiratory syndrome coronavirus 2 encephalopathy and ataxia. Mov Disord Clin Pract 7(8):980–982PubMedPubMedCentralCrossRef
50.
Zurück zum Zitat Cohen ME, Eichel R, Steiner-Birmanns B, Janah A, Ioshpa M, Bar-Shalom R, Paul JJ, Gaber H, Skrahina V, Bornstein NM, Yahalom G (2020) A case of probable Parkinson’s disease after SARS-CoV-2 infection. Lancet Neurol [Internet] 19(10):804–805PubMedPubMedCentralCrossRef Cohen ME, Eichel R, Steiner-Birmanns B, Janah A, Ioshpa M, Bar-Shalom R, Paul JJ, Gaber H, Skrahina V, Bornstein NM, Yahalom G (2020) A case of probable Parkinson’s disease after SARS-CoV-2 infection. Lancet Neurol [Internet] 19(10):804–805PubMedPubMedCentralCrossRef
51.
Zurück zum Zitat Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J', Yu T, Zhang X, Zhang L (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet [Internet] 395(10223):507–513PubMedPubMedCentralCrossRef Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J', Yu T, Zhang X, Zhang L (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet [Internet] 395(10223):507–513PubMedPubMedCentralCrossRef
52.
Zurück zum Zitat Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer PY, Lepiller Q, Gendrin V et al (2020) Features of anosmia in COVID-19. Med Mal Infect 50(5):436–439PubMedPubMedCentralCrossRef Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer PY, Lepiller Q, Gendrin V et al (2020) Features of anosmia in COVID-19. Med Mal Infect 50(5):436–439PubMedPubMedCentralCrossRef
53.
Zurück zum Zitat Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C et al (2020) Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 382(23):2268–2270PubMedCrossRef Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C et al (2020) Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 382(23):2268–2270PubMedCrossRef
54.
Zurück zum Zitat Dono F, Carrarini C, Russo M, De Angelis MV, Anzellotti F, Onofrj M et al (2020) New-onset refractory status epilepticus (NORSE) in post SARS-CoV-2 autoimmune encephalitis: a case report. Neurol Sci 3:1–4 Dono F, Carrarini C, Russo M, De Angelis MV, Anzellotti F, Onofrj M et al (2020) New-onset refractory status epilepticus (NORSE) in post SARS-CoV-2 autoimmune encephalitis: a case report. Neurol Sci 3:1–4
55.
Zurück zum Zitat Vaira LA, Salzano G, Deiana G, De Riu G (2020) Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 130(7):1787PubMedCrossRef Vaira LA, Salzano G, Deiana G, De Riu G (2020) Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope 130(7):1787PubMedCrossRef
56.
Zurück zum Zitat Bagheri SHR, Asghari AM, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK et al (2020) Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran. Med J Islam Repub Iran 34:62PubMedPubMedCentral Bagheri SHR, Asghari AM, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK et al (2020) Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran. Med J Islam Repub Iran 34:62PubMedPubMedCentral
57.
Zurück zum Zitat Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A et al (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261PubMedPubMedCentralCrossRef Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A et al (2020) Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 277(8):2251–2261PubMedPubMedCentralCrossRef
59.
Zurück zum Zitat Cabañes-Martínez L, Villadóniga M, González-Rodríguez L, Araque L, Díaz-Cid A, Ruz-Caracuel I, Pian H, Sánchez-Alonso S, Fanjul S, del Álamo M, Regidor I (2020) Neuromuscular involvement in COVID-19 critically ill patients. Clin Neurophysiol [Internet] 131(12):2809–2816PubMedPubMedCentralCrossRef Cabañes-Martínez L, Villadóniga M, González-Rodríguez L, Araque L, Díaz-Cid A, Ruz-Caracuel I, Pian H, Sánchez-Alonso S, Fanjul S, del Álamo M, Regidor I (2020) Neuromuscular involvement in COVID-19 critically ill patients. Clin Neurophysiol [Internet] 131(12):2809–2816PubMedPubMedCentralCrossRef
60.
Zurück zum Zitat Huber M, Rogozinski S, Puppe W, Framme C, Höglinger G, Hufendiek K et al (2020) Postinfectious onset of myasthenia gravis in a COVID-19 patient. Front Neurol 11(October):1–5 Huber M, Rogozinski S, Puppe W, Framme C, Höglinger G, Hufendiek K et al (2020) Postinfectious onset of myasthenia gravis in a COVID-19 patient. Front Neurol 11(October):1–5
61.
Zurück zum Zitat Belvis R (2020) Headaches during COVID-19: my clinical case and review of the literature. Headache 60(7):1422–1426PubMedCrossRef Belvis R (2020) Headaches during COVID-19: my clinical case and review of the literature. Headache 60(7):1422–1426PubMedCrossRef
62.
Zurück zum Zitat Benameur K, Agarwal A, Auld SC, Butters MP, Webster AS, Ozturk T, Howell JC, Bassit LC, Velasquez A, Schinazi RF, Mullins ME, Hu WT (2020) Encephalopathy and encephalitis associated with cerebrospinal fluid cytokine alterations and coronavirus disease, Atlanta, Georgia, USA, 2020. Emerg Infect Dis [Internet] 26(9):2016–2021PubMedPubMedCentralCrossRef Benameur K, Agarwal A, Auld SC, Butters MP, Webster AS, Ozturk T, Howell JC, Bassit LC, Velasquez A, Schinazi RF, Mullins ME, Hu WT (2020) Encephalopathy and encephalitis associated with cerebrospinal fluid cytokine alterations and coronavirus disease, Atlanta, Georgia, USA, 2020. Emerg Infect Dis [Internet] 26(9):2016–2021PubMedPubMedCentralCrossRef
63.
Zurück zum Zitat Trigo López J, García-Azorín D, Planchuelo-Gómez Á, García-Iglesias C, Dueñas-Gutiérrez C, Guerrero ÁL (2020) Phenotypic characterization of acute headache attributed to SARS-CoV-2: an ICHD-3 validation study on 106 hospitalized patients. Cephalalgia [Internet] 40(13):1432–1442CrossRef Trigo López J, García-Azorín D, Planchuelo-Gómez Á, García-Iglesias C, Dueñas-Gutiérrez C, Guerrero ÁL (2020) Phenotypic characterization of acute headache attributed to SARS-CoV-2: an ICHD-3 validation study on 106 hospitalized patients. Cephalalgia [Internet] 40(13):1432–1442CrossRef
64.
Zurück zum Zitat Caronna E, Ballvé A, Llauradó A, Gallardo VJ, María Ariton D, Lallana S et al (2020) Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution. Cephalalgia. 40(13):1410–1421PubMedPubMedCentralCrossRef Caronna E, Ballvé A, Llauradó A, Gallardo VJ, María Ariton D, Lallana S et al (2020) Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution. Cephalalgia. 40(13):1410–1421PubMedPubMedCentralCrossRef
65.
Zurück zum Zitat Ferrando SJ, Klepacz L, Lynch S, Tavakkoli M, Dornbush R, Baharani R et al (2020) COVID-19 Psychosis: A potential new neuropsychiatric condition triggered by novel coronavirus infection and the inflammatory response? Psychosomatics 61(5):551–555PubMedPubMedCentralCrossRef Ferrando SJ, Klepacz L, Lynch S, Tavakkoli M, Dornbush R, Baharani R et al (2020) COVID-19 Psychosis: A potential new neuropsychiatric condition triggered by novel coronavirus infection and the inflammatory response? Psychosomatics 61(5):551–555PubMedPubMedCentralCrossRef
67.
Zurück zum Zitat Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY et al (2020) Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry 0(0):8–11 Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY et al (2020) Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry 0(0):8–11
69.
Zurück zum Zitat Grau AJ, Buggle F, Becher H, Zimmermann E, Spiel M, Fent T, Maiwald M, Werle E, Zorn M, Hengel H, Hacke W (1998) Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia. Clinical and biochemical studies. Neurology. 50(1):196–203PubMedCrossRef Grau AJ, Buggle F, Becher H, Zimmermann E, Spiel M, Fent T, Maiwald M, Werle E, Zorn M, Hengel H, Hacke W (1998) Recent bacterial and viral infection is a risk factor for cerebrovascular ischemia. Clinical and biochemical studies. Neurology. 50(1):196–203PubMedCrossRef
70.
Zurück zum Zitat Tang N, Li D, Wang X, Sun Z (2020) Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 18(4):844–847PubMedPubMedCentralCrossRef Tang N, Li D, Wang X, Sun Z (2020) Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost 18(4):844–847PubMedPubMedCentralCrossRef
71.
Zurück zum Zitat Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T (2020) Neurological associations of COVID-19. Lancet Neurol [Internet] 19(9):767–783PubMedPubMedCentralCrossRef Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S, Sejvar J, Solomon T (2020) Neurological associations of COVID-19. Lancet Neurol [Internet] 19(9):767–783PubMedPubMedCentralCrossRef
72.
Zurück zum Zitat Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W et al (2020) Coagulopathy and antiphospholipid antibodies in patients with Covid-19. N Engl J Med [Internet] 382(17):e38PubMedCrossRef Zhang Y, Xiao M, Zhang S, Xia P, Cao W, Jiang W et al (2020) Coagulopathy and antiphospholipid antibodies in patients with Covid-19. N Engl J Med [Internet] 382(17):e38PubMedCrossRef
73.
Zurück zum Zitat Doo FX, Kassim G, Lefton DR, Patterson S, Pham H, Belani P (2021) Rare presentations of COVID-19: PRES-like leukoencephalopathy and carotid thrombosis. Clin Imaging [Internet] 69(January):94–101 Doo FX, Kassim G, Lefton DR, Patterson S, Pham H, Belani P (2021) Rare presentations of COVID-19: PRES-like leukoencephalopathy and carotid thrombosis. Clin Imaging [Internet] 69(January):94–101
74.
Zurück zum Zitat Filatov A, Sharma P, Hindi F, Espinosa PS (2020) Neurological complications of coronavirus disease (COVID-19): encephalopathy. Cureus 2(3):e7352 Filatov A, Sharma P, Hindi F, Espinosa PS (2020) Neurological complications of coronavirus disease (COVID-19): encephalopathy. Cureus 2(3):e7352
75.
Zurück zum Zitat Vollono C, Rollo E, Romozzi M, Frisullo G, Servidei S, Borghetti A, Calabresi P (2020) Focal status epilepticus as unique clinical feature of COVID-19: a case report. Seizure [Internet] 78:109–112PubMedPubMedCentralCrossRef Vollono C, Rollo E, Romozzi M, Frisullo G, Servidei S, Borghetti A, Calabresi P (2020) Focal status epilepticus as unique clinical feature of COVID-19: a case report. Seizure [Internet] 78:109–112PubMedPubMedCentralCrossRef
76.
Zurück zum Zitat Nemoto W, Yamagata R, Nakagawasai O, Nakagawa K, Hung WY, Fujita M et al (2020) Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice. Eur J Pharmacol [Internet] 872(July 2019):172950 Nemoto W, Yamagata R, Nakagawasai O, Nakagawa K, Hung WY, Fujita M et al (2020) Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice. Eur J Pharmacol [Internet] 872(July 2019):172950
77.
Zurück zum Zitat Diezma-Martín AM, Morales-Casado MI, García-Alvarado N, Vadillo Bermejo A, López-Ariztegui N, Sepúlveda Berrocal MA (2020) Temblor y ataxia en COVID-19. Neurología [Internet] 35(6):409–410PubMedPubMedCentralCrossRef Diezma-Martín AM, Morales-Casado MI, García-Alvarado N, Vadillo Bermejo A, López-Ariztegui N, Sepúlveda Berrocal MA (2020) Temblor y ataxia en COVID-19. Neurología [Internet] 35(6):409–410PubMedPubMedCentralCrossRef
78.
Zurück zum Zitat Schellekens MMI, Bleeker-Rovers CP, Keurlings PAJ, Mummery CJ, Bloem BR (2020) Reversible myoclonus-ataxia as a postinfectious manifestation of COVID-19. Mov Disord Clin Pract 7(8):977–979PubMedPubMedCentralCrossRef Schellekens MMI, Bleeker-Rovers CP, Keurlings PAJ, Mummery CJ, Bloem BR (2020) Reversible myoclonus-ataxia as a postinfectious manifestation of COVID-19. Mov Disord Clin Pract 7(8):977–979PubMedPubMedCentralCrossRef
79.
Zurück zum Zitat Steardo L, Steardo L, Zorec R, Verkhratsky A (2020) Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19. Acta Physiol (Oxf) 229(3):e13473CrossRef Steardo L, Steardo L, Zorec R, Verkhratsky A (2020) Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19. Acta Physiol (Oxf) 229(3):e13473CrossRef
80.
Zurück zum Zitat Wei H, Yin H, Huang M, Guo Z (2020) The 2019 novel cornoavirus pneumonia with onset of oculomotor nerve palsy: a case study. J Neurol [Internet] 267(5):1550–1553PubMedCrossRef Wei H, Yin H, Huang M, Guo Z (2020) The 2019 novel cornoavirus pneumonia with onset of oculomotor nerve palsy: a case study. J Neurol [Internet] 267(5):1550–1553PubMedCrossRef
81.
Zurück zum Zitat Zito A, Alfonsi E, Franciotta D, Todisco M, Gastaldi M, Cotta Ramusino M et al (2020) COVID-19 and Guillain–Barré syndrome: a case report and review of literature. Front Neurol [Internet] 11(August):1–7 Zito A, Alfonsi E, Franciotta D, Todisco M, Gastaldi M, Cotta Ramusino M et al (2020) COVID-19 and Guillain–Barré syndrome: a case report and review of literature. Front Neurol [Internet] 11(August):1–7
82.
Zurück zum Zitat Suwanwongse K, Shabarek N (2020) Rhabdomyolysis as a presentation of 2019 novel coronavirus disease. Cureus [Internet] 12(4):10–13 Suwanwongse K, Shabarek N (2020) Rhabdomyolysis as a presentation of 2019 novel coronavirus disease. Cureus [Internet] 12(4):10–13
83.
84.
85.
Zurück zum Zitat Medicherla CB, Pauley RA, de Havenon A, Yaghi S, Ishida K, Torres JL (2020) Cerebral venous sinus thrombosis in the coronavirus disease 2019 pandemic. J Neuroophthalmol Publish Ah:457–462CrossRef Medicherla CB, Pauley RA, de Havenon A, Yaghi S, Ishida K, Torres JL (2020) Cerebral venous sinus thrombosis in the coronavirus disease 2019 pandemic. J Neuroophthalmol Publish Ah:457–462CrossRef
86.
Zurück zum Zitat Gigli GL, Vogrig A, Nilo A, Fabris M, Biasotto A, Curcio F, Miotti V, Tascini C, Valente M (2020) HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome. Neurol Sci 41(12):3391–3394PubMedPubMedCentralCrossRef Gigli GL, Vogrig A, Nilo A, Fabris M, Biasotto A, Curcio F, Miotti V, Tascini C, Valente M (2020) HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome. Neurol Sci 41(12):3391–3394PubMedPubMedCentralCrossRef
87.
Zurück zum Zitat Pilato MS, Urban A, Alkawadri R, Barot N V., Castellano JF, Rajasekaran V et al (2020) EEG findings in coronavirus disease. J Clin Neurophysiol [Internet] Publish Ah(00):1–7 Pilato MS, Urban A, Alkawadri R, Barot N V., Castellano JF, Rajasekaran V et al (2020) EEG findings in coronavirus disease. J Clin Neurophysiol [Internet] Publish Ah(00):1–7
88.
Zurück zum Zitat Kassardjian CD, Desai U, Narayanaswami P (2020) Practical guidance for managing EMG requests and testing during the COVID-19 pandemic. Muscle Nerve 62:30–33PubMedCrossRef Kassardjian CD, Desai U, Narayanaswami P (2020) Practical guidance for managing EMG requests and testing during the COVID-19 pandemic. Muscle Nerve 62:30–33PubMedCrossRef
89.
Zurück zum Zitat Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB (2020) Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA 323(18):1824–1836PubMed Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB (2020) Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA 323(18):1824–1836PubMed
90.
Zurück zum Zitat Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M et al (2020) ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 8(5):1023–1026CrossRef Thachil J, Tang N, Gando S, Falanga A, Cattaneo M, Levi M et al (2020) ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost 8(5):1023–1026CrossRef
91.
Zurück zum Zitat Manji H, Carr AS, Brownlee WJ, Lunn MP (2020) Neurology in the time of COVID-19. J Neurol Neurosurg Psychiatry [Internet] 91(6):568–570PubMedCrossRef Manji H, Carr AS, Brownlee WJ, Lunn MP (2020) Neurology in the time of COVID-19. J Neurol Neurosurg Psychiatry [Internet] 91(6):568–570PubMedCrossRef
Metadaten
Titel
Neurological manifestations of coronavirus disease 2019: exploring past to understand present
verfasst von
Ishita Desai
Rajat Manchanda
Niraj Kumar
Ashutosh Tiwari
Mritunjai Kumar
Publikationsdatum
11.01.2021
Verlag
Springer International Publishing
Schlagwort
COVID-19
Erschienen in
Neurological Sciences / Ausgabe 3/2021
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-020-04964-8

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