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Digestive Diseases and Sciences

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04.02.2021 | COVID-19 | Case Report Zur Zeit gratis

Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis

verfasst von: Inayat Gill, Aciel Ahmed Shaheen, Ahmed Iqbal Edhi, Mitual Amin, Ketan Rana, Mitchell S. Cappell

Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2021

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Abstract

Collagenous colitis (CC) is associated with non-bloody, watery diarrhea, which is pathophysiologically reasonable because normal colonic absorption (or excretion) of water and electrolytes can be blocked by the abnormally thick collagen layer in CC. However, CC has also been associated with six previous cases of protein-losing enteropathy (PLE), with no pathophysiologic explanation. The colon does not normally absorb (or excrete) amino acids/proteins, which is primarily the function of the small bowel. Collagenous duodenitis (CD) has not been associated with PLE. This work reports a novel case of CD (and CC) associated with PLE; a pathophysiologically reasonable mechanism for CD causing PLE (by the thick collagen layer of CD blocking normal intestinal amino acid absorption); and a novel association of PLE with severe COVID-19 infection (attributed to relative immunosuppression from hypoproteinemia, hypoalbuminemia, hypogammaglobulinemia, and malnutrition from PLE).

CD herein denotes collagenous duodenitis and not Crohn’s disease.

Excludes references with collagenous gastritis without collagenous duodenitis, because the stomach is not physiologically an important site of amino acid absorption, and therefore a thickened gastric collagen layer should not pathophysiologically cause protein-losing enteropathy [20‐22].

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Titel: Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis
verfasst von: Inayat Gill
Aciel Ahmed Shaheen
Ahmed Iqbal Edhi
Mitual Amin
Ketan Rana
Mitchell S. Cappell
Publikationsdatum: 04.02.2021
Verlag: Springer US
Schlagwort: COVID-19
Erschienen in: Digestive Diseases and Sciences / Ausgabe 12/2021
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-020-06804-3

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Novel Case Report: A Previously Reported, but Pathophysiologically Unexplained, Association Between Collagenous Colitis and Protein-Losing Enteropathy May Be Explained by an Undetected Link with Collagenous Duodenitis

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