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Erschienen in:

08.06.2022 | COVID-19 | Original Article

Outcomes of infants with hypoxic-ischemic encephalopathy during COVID-19 pandemic lockdown in Canada: a cohort study

verfasst von: Sujith Kumar Reddy Gurram Venkata, Prakesh S. Shah, Marc Beltempo, Eugene Yoon, Stephen Wood, Matthew Hicks, Thierry Daboval, Jonathan Wong, Pia Wintermark, Khorshid Mohammad, the Canadian Neonatal Network Investigators

Erschienen in: Child's Nervous System | Ausgabe 9/2022

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Abstract

Purpose

To evaluate change in the severity of hypoxic-ischemic encephalopathy (HIE) and associated morbidities between pre- and during COVID-19 pandemic periods in Canada.

Methods

We conducted a retrospective cohort study extracting the data from level-3 NICUs participating in Canadian Neonatal Network (CNN). The primary outcome was a composite of death in the first week after birth and/or stage 3 HIE (Sarnat and Sarnat). Secondary outcomes included rate and severity of HIE among admitted neonates, overall mortality, brain injury on magnetic resonance imaging (MRI), neonates requiring resuscitation, organ dysfunction, and therapeutic hypothermia (TH) usage. We included 1591 neonates with gestational age ≥ 36 weeks with HIE during the specified periods: pandemic cohort from April 1st to December 31st of 2020; pre-pandemic cohort between April 1st and December 31st of 2017, 2018, and 2019. We calculated the odds ratio (OR) and confidence intervals (CI).

Results

We observed no significant difference in the primary outcome (15% vs. 16%; OR 1.08; 95%CI 0.78–1.48), mortality in the first week after birth (6% vs. 6%; OR 1.10, 95%CI 0.69–1.75), neonates requiring resuscitation, organ dysfunction, TH usage, or rate of brain injury. In the ad hoc analysis, per 1000 live births, there was an increase in the rate of infants with HIE and TH use.

Conclusions

Severity of HIE, associated morbidities, and mortality were not significantly different during the pandemic lockdown compared to a pre-pandemic period in Canada. Anticipated risks and difficulties in accessing healthcare have not increased the mortality and morbidities in neonates with HIE in Canada.
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Metadaten
Titel
Outcomes of infants with hypoxic-ischemic encephalopathy during COVID-19 pandemic lockdown in Canada: a cohort study
verfasst von
Sujith Kumar Reddy Gurram Venkata
Prakesh S. Shah
Marc Beltempo
Eugene Yoon
Stephen Wood
Matthew Hicks
Thierry Daboval
Jonathan Wong
Pia Wintermark
Khorshid Mohammad
the Canadian Neonatal Network Investigators
Publikationsdatum
08.06.2022
Verlag
Springer Berlin Heidelberg
Schlagwort
COVID-19
Erschienen in
Child's Nervous System / Ausgabe 9/2022
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-022-05575-8

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