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Erschienen in: HSS Journal ® 1/2020

14.09.2020 | COVID-19 | Response to COVID-19/Review Article Zur Zeit gratis

Perioperative Nonsteroidal Anti-Inflammatory Agents in the COVID-19 Orthopedic Patient

verfasst von: Christopher L. Wu, MD, Kethy M. Jules-Elysee, MD, Meghan A. Kirksey, MD, PhD, Gregory A. Liguori, MD

Erschienen in: HSS Journal ® | Sonderheft 1/2020

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Abstract

Background

SARS-CoV-2 infection can cause serious complications beyond lung injury and respiratory failure, including sepsis, cardiovascular injury, renal failure, coagulation abnormalities, and neurologic injury. Widely used medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) have been flagged as having the potential to cause harm in the context of COVID-19. It is unknown if the benefits of NSAID use in the orthopedic population will outweigh the potential risks of increased morbidity in COVID-19 orthopedic patients.

Methods

We conducted a narrative review of the use of NSAIDs in the orthopedic patient with COVID-19, focusing on the effects of NSAIDs on the inflammatory process, the role of NSAIDs in orthopedics, and the associations between NSAID use and complications of pneumonia.

Results

We found that it may be appropriate to consider NSAID use in otherwise healthy orthopedic patients with COVID-19 and significant pain.

Conclusions

In this context, we recommend that NSAIDs be used at the lowest effective dose for the shortest duration possible in orthopedic patients with COVID-19. However, pending further data and based on the concerns outlined in this review, we recommend avoiding NSAIDs in orthopedic patients with significant comorbidities and those who are undergoing major orthopedic surgery.
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Metadaten
Titel
Perioperative Nonsteroidal Anti-Inflammatory Agents in the COVID-19 Orthopedic Patient
verfasst von
Christopher L. Wu, MD
Kethy M. Jules-Elysee, MD
Meghan A. Kirksey, MD, PhD
Gregory A. Liguori, MD
Publikationsdatum
14.09.2020
Verlag
Springer US
Schlagwort
COVID-19
Erschienen in
HSS Journal ® / Ausgabe Sonderheft 1/2020
Print ISSN: 1556-3316
Elektronische ISSN: 1556-3324
DOI
https://doi.org/10.1007/s11420-020-09783-3

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