Introduction
Methods
Search Strategy
Inclusion and Exclusion Criteria
Statistical Analysis
Publication Bias
Study Quality
Results
Authors | Source | Description of study | Outcomes | ACEi/ARB | Total patients | Characteristics of total patients | Subgroup | ACEi/ARB in subgroup | Characteristics of subgroup patients |
---|---|---|---|---|---|---|---|---|---|
Abajo | PubMed | Case-population study in Madrid, Spain | Prevalence of ACEi/ARB | ACEi: 240 ARB: 244 | 1139 | Female: 39.0% HTN: 54.2% DM: 27.2% HF: 7.0% Stroke/TIA: 6.4% Cardiovascular disease: 27.4% | - | - | - |
Andrea | PubMed | Retrospective, observational single-centre case series in Milan, Italy | Survival data. Median follow-up 28 days | 69 | 191 | Female: 31.4% Age (mean): 63.4 ± 14.9 CHD:14.7% DM: 14.7% HTN: 50.2% HF: 4.7% | HTN: 96 | 68 | CHD: 28.1% DM: 22.9% HTN: 100% HF: 8.3% |
Bean | Medxiv | Multi-centre cohort study of COVID-19 inpatients in London, UK | Survival and critical care admission. Follow-up 21 days | 399 | 1200 | Female: 42.8% Age (mean): 68.0 ± 17.07 Stroke/TIA: 19.6 IHD: 13.3% DM: 34.8% HTN: 53.8% HF: 8.9% | - | - | - |
Chen | PubMed | Retrospective study of COVID-19 inpatients in central hospital of Wuhan, China | Length of hospital stay, clinical outcome: discharge or death in hospital. | NR | 341 | Female: 46.3% Age (median): 58 (42.0–62.0) DM: 14.4% HTN: 36.7% Cardiovascular: 14.7% | HTN+ DM: 71 | 32 | Age (median): 67.0 (61.0–76.0) DM: 100% HTN: 100% |
Chocdik | PubMed | Observational study of 1 COVID-19 inpatients identified using Maccabi Health Services database Israel | Prevalence of ACEi/ARB | ACEi: 55 ARB: 76 | 1317 | Female: 40.2% Age (mean): 40.6 ± 19.1 DM: 8.7% HTN: 14.0% HF: 0.2% | - | - | - |
Dauchet | Medxiv | Mono-centric study of in-patients and outpatients of Lille, France | Critical care admission | ACEi: 31 ARB: 31 | 187 | NR | - | - | - |
Feng | PubMed | Multi-centre retrospective, observational study of COVID-19 inpatients in China Wuhan, Shanghai and Anhui | Survival, severity of disease based on CCDC* | NR | 476 | Female: 46.1% Age (median): 53(40–64) CVD: 3.6% DM: 10.3% HTN: 23.7% Cardiovascular: 7.9% | HTN: 113 | 33 | NR |
Guo | PubMed | Retrospective single-centre case series of COVID-19 inpatients in Wuhan City, China | Prevalence of ACEi/ARB | 19 | 187 | Female: 51.3% Age (mean): 58.5 ± 14.7 CHD: 11.2% DM: 15.0% HTN: 32.6% | - | - | - |
Huang | PubMed | Observational, single-centre study of COVID-19 inpatients with HTN in Wuhan, China | Non-invasive (+ high flow oxygen), invasive ventilation, death, ECMO, severity based on CCDC* | - | - | - | HTN: 50 | 20 | Female: 46.0% HTN: 100% |
Ip | Medxiv | Retrospective, multi-centre study with convenience sampling of COVID-19 inpatients in USA | Survival data | NR | 3017 | NR | HTN: 1129 | 460 | NR |
Li | PubMed | Single-centre, observational, case series of COVID-19 inpatients with HTN in Wuhan, China | Mortality ARDS Length of hospital stay Severity based on CCDC* | NR | 1178 | Female: 53.7% CVD: 8.1% CHD: 8.7% DM: 17.2% HTN: 30.1% HF: 1.8% | HTN: 362 | 115 | Female: 47.8% Age (median): 66 (59–73) CVD: 18.8% CHD: 17.1% DM: 35.2% HTN: 100% HF: 2.8% |
Mancia | PubMed | Population-based, case-control study in the Lombardy, Italy | Critical/fatal infection who had assisted ventilation or died | ACEi: 1502 ARB: 1394 | 6272 | Female: 36.7% Age (mean): 68 ± 13 CHD:7.5% HF: 5.1% Cardiovascular: 30.1% | - | - | - |
Mehra | PubMed | Multi-centre observational study in 169 hospitals in Asia, Europe and North America | Survival data | ACEi: 770 ARB: 556 | 8910 | Female: 40.0% Age (mean): 49 ± 16 CHD:11.3% HTN: 26.3% HF: 2.1% Cardiovascular: 30.1% | - | - | - |
Mehta | PubMed | Retrospective, cohort study of all patients tested for COVID-19 at the Cleveland Clinic Health System in Ohio and Florida | Intensive care admission, ventilation, hospital admission | ACEi: 116 ARB: 98 | 1735 | NR | - | - | - |
Meng | PubMed | Retrospective, single-centre review of COVID-19 inpatients admitted to the Shenzhen Third People’s Hospital in China | Mortality Severity based on CCDC* | NR | 417 | NR | HTN 42 | 17 | Female: 42.9% Age (median): 64.5 (55.8–69) CHD: 19.0% DM: 14.2% HTN: 100% |
Reynolds | PubMed | Observational study of people who were tested for COVID-19 using New York University (NYU) Langone Health record | Likelihood of positive test and severe outcomes | NR | 5894 | NR | HTN 2573 | NR | NR |
Richardson | PubMed | Multi-centre case series of patients with COVID-19 inpatients in New York, USA | Death | 456 | 2411 | NR | HTN 1366 | ACEi: 189 ARB: 267 | Female: 39.7% Age (median): 63(52–75) CHD:11.1% DM: 33.8% HTN: 56.6% HF: 6.9% |
Yan | Medxiv | Multi-centre, case-control study of COVID-19 inpatients Zhejiang province, China | Clinical outcomes; severity based on CCDC* | ACEi: 5 ARB: 53 | 610 | Female: 48.9% Age (mean): 48.8 ± 14.2 Cardio or cerebro disease: 2.62% DM: 9.8% HTN: 22.5% | - | - | - |
Yang | PubMed | Retrospective, single-centre, case-control study of COVID-19 inpatients with HTN in Wuhan, China | Death, severity based on CCDC and length of hospital stay | NR | 462 | NR | HTN 126 | 43 | Female: 50.8% Age (median): 66(61–73) DM: 30.2% HTN: 100% |
Zhang | PubMed | Observational, retrospective, multi-centre cohort study in Hubei, China, of HTN patients with COVID-19 | Death, clinical outcomes: ARDS, DIC, AKI, acute heart injury septic shock NIV, IV, ECMO Follow-up 28 days | NR | 3430 | NR | HTN: 1128 | 188 | Female: 46.5% Age (median): 64- CVD: 3.6% CHD: 11.6% DM: 21.2% HTN: 100% |