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Erschienen in: Irish Journal of Medical Science (1971 -) 3/2022

11.07.2021 | COVID-19 | Brief Report Zur Zeit gratis

Herpes simplex and herpes zoster viruses in COVID-19 patients

verfasst von: Joseph Katz, Sijia Yue, Wei Xue

Erschienen in: Irish Journal of Medical Science (1971 -) | Ausgabe 3/2022

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Abstract

Background

Reactivation of herpes family viruses in immunocompromised patients may result in detrimental outcomes for the hosts; therefore, herpes simplex virus-1 and varicella zoster virus infections in the context of COVID-19 may have clinical and prognostic implications.
Several reports associated this human herpes virus with COVID-19 infection and have claimed that it can be an indicator for latent COVID-19 infection. However, since most of these were case reports, it is impossible to assess the prevalence of these associations.

Methods

The University of Florida patient registry i2b2 with ICD-10 diagnosis codes was used for retrieval of patients with diagnosis of COVID-19 and each of the other viruses over the period of October 2015–June 2020.

Results

The prevalence of the herpes simplex-1 occurrence in the COVID-19 group was 2.81% compared to 0.77% in the hospital population odds ratio of 5.27. When adjusted for gender, race, and age, the odds were 5.18, 4.48, and 4.61, respectively. After adjustment for respiratory disease, endocrine disease, obesity, diabetes, circulatory disease, and smoking, the odds were 1.94, 3.18, 1.37, 3.54, 3.7, and 5.1, respectively. The prevalence of the varicella zoster virus in COVID-19 patients was 1.8% compared to 0.43% in the hospital population, odds ratio of 5.26 before adjustment, and 5.2, 5.47, and 4.76 after adjusting for gender, age, and race, respectively. When adjusted for respiratory disease, endocrine disease, obesity, diabetes, and circulatory and neurological diseases, the odds were 1.3, 2.2, 1.48, 2.33, 2.85, and 2.6, respectively.

Conclusion

Herpes simplex-1 and varicella zoster viruses are strongly associated with COVID-19 infection.
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Metadaten
Titel
Herpes simplex and herpes zoster viruses in COVID-19 patients
verfasst von
Joseph Katz
Sijia Yue
Wei Xue
Publikationsdatum
11.07.2021

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