Skip to main content
Erschienen in: Rheumatology International 9/2022

01.06.2022 | COVID-19 | Observational Research

Herpesvirus infections and post-COVID-19 manifestations: a pilot observational study

verfasst von: Svitlana Zubchenko, Iryna Kril, Olena Nadizhko, Oksana Matsyura, Valentyna Chopyak

Erschienen in: Rheumatology International | Ausgabe 9/2022

Einloggen, um Zugang zu erhalten

Abstract

The global spread of SARS-CoV-2 points to unrivaled mutational variation of the virus, contributing to a variety of post-COVID sequelae in immunocompromised subjects and high mortality. Numerous studies have reported the reactivation of "sluggish" herpes virus infections in COVID-19, which exaggerate the course of the disease and complicate with lasting post-COVID manifestations CMV, EBV, HHV6). This study aimed to describe clinical and laboratory features of post-COVID manifestations accompanied by the reactivation of herpes virus infections (CMV, EBV, HHV6). 88 patients were recruited for this study, including subjects with reactivation of herpes viruses, 68 (72.3%) (main group) and 20 (27.7%) subjects without detectable DNA of herpesviruses (control group): 46 (52.3%) female and 42 (47.7%) male; median age was 41.4 ± 6.7 years. Patients with post-COVID manifestations presented with reactivation of EBV in 42.6%, HHV6 in 25.0%, and EBV plus HHV6 in 32.4%. Compared with controls, patients with herpes virus infections presented with more frequent slight fever temperature, headache, psycho-neurological disorders, pulmonary abnormalities and myalgia (p < 0.01), activation of liver enzymes, elevated CRP and D-dimer, and suppressed cellular immune response (p ≤ 0.05). Preliminary results indicate a likely involvement of reactivated herpes virus infections, primarily EBV infections in severe COVID-19 and the formation of the post-COVID syndrome. Patients with the post-COVID syndrome and reactivation of EBV and HHV6 infections are at high risk of developing various pathologies, including rheumatologic diseases.
Literatur
12.
27.
Zurück zum Zitat Vernon SD, Whistler T, Cameron B et al (2006) Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus. BMC Infect Dis 6:15CrossRef Vernon SD, Whistler T, Cameron B et al (2006) Preliminary evidence of mitochondrial dysfunction associated with post-infective fatigue after acute infection with Epstein Barr virus. BMC Infect Dis 6:15CrossRef
35.
Zurück zum Zitat Gammazza MA, Légaré S, Lo Bosco G et al (2020) Human molecular chaperons share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19. Cell Stress Chaperons 25:737–741. https://doi.org/10.1007/s12192-020-01148-3CrossRef Gammazza MA, Légaré S, Lo Bosco G et al (2020) Human molecular chaperons share with SARS-CoV-2 antigenic epitopes potentially capable of eliciting autoimmunity against endothelial cells: possible role of molecular mimicry in COVID-19. Cell Stress Chaperons 25:737–741. https://​doi.​org/​10.​1007/​s12192-020-01148-3CrossRef
Metadaten
Titel
Herpesvirus infections and post-COVID-19 manifestations: a pilot observational study
verfasst von
Svitlana Zubchenko
Iryna Kril
Olena Nadizhko
Oksana Matsyura
Valentyna Chopyak
Publikationsdatum
01.06.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Rheumatology International / Ausgabe 9/2022
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-022-05146-9

Weitere Artikel der Ausgabe 9/2022

Rheumatology International 9/2022 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.