Postmortem CT pulmonary findings in SARS-CoV-2-positive cases: correlation with lung histopathological findings and autopsy results
- Zur Zeit gratis
- 14.02.2022
- COVID-19
- Original Article
Erschienen in:
- Verfasst von
- Laura Filograna
- Simone Grassi
- Guglielmo Manenti
- Carlo Di Donna
- Doriana Tatulli
- Francesco Nardoni
- Valentina Masini
- Francesco Ausania
- Vincenzo Maria Grassi
- Roberto Floris
- Cesare Colosimo
- Vincenzo Arena
- Vincenzo Lorenzo Pascali
- Antonio Oliva
- Erschienen in
- International Journal of Legal Medicine | Ausgabe 5/2022
Abstract
Introduction/purpose
Postmortem computed tomography (PMCT) is a valuable tool for analyzing the death of patients with SARS-CoV-2 infection. The purpose of this study was to investigate the correlation between PMCT lung findings in autopsy cadavers positive for SARS-CoV-2 infection and the severity of COVID-19 lung disease by histopathological analysis.
Materials and methods
We reviewed chest PMCT findings, paying particular attention to the lung parenchyma, in 8 autopsy cases positive for SARS-CoV-2. Correlations between chest PMCT and histopathological findings were assessed. Clinical conditions and comorbidities were also recorded and discussed. The primary cause of death was finally considered.
Results
In 6/8 cases, pulmonary PMCT findings were massive consolidation (4/8) and bilateral diffuse mixed densities with a crazy-paving pattern (2/8). These cases showed severe pulmonary signs of COVID-19 at histopathological analysis. In the remaining 2/8 cases, pulmonary PMCT findings were scant antideclive ground-glass opacities in prevalent gradient densities attributed to hypostasis. In 4/8 cases with massive consolidations, important comorbidities were noted. In 6/8 cases with severe pulmonary histopathological signs of lung COVID-19, autopsy found that the cause of death was cardiorespiratory failure. In the remaining 2/8 cases, histopathological analysis revealed lung alterations due to edema and some signs of SARS-CoV-2 infection; the cause of death was not attributed to SARS-CoV-2 infection (Table 1).
Discussion and conclusion
Chest PMCT findings correlate with the severity of COVID-19 lung disease at histopathology examination. According to our results, there may also be a relationship between cause of death and PMCT findings in COVID-19, which must be critically analyzed considering clinical antemortem data.
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- Titel
- Postmortem CT pulmonary findings in SARS-CoV-2-positive cases: correlation with lung histopathological findings and autopsy results
- Verfasst von
-
Laura Filograna
Simone Grassi
Guglielmo Manenti
Carlo Di Donna
Doriana Tatulli
Francesco Nardoni
Valentina Masini
Francesco Ausania
Vincenzo Maria Grassi
Roberto Floris
Cesare Colosimo
Vincenzo Arena
Vincenzo Lorenzo Pascali
Antonio Oliva
- Publikationsdatum
- 14.02.2022
- Verlag
- Springer Berlin Heidelberg
- Schlagwort
- COVID-19
- Erschienen in
-
International Journal of Legal Medicine / Ausgabe 5/2022
Print ISSN: 0937-9827
Elektronische ISSN: 1437-1596 - DOI
- https://doi.org/10.1007/s00414-022-02793-2
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