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Erschienen in: Internal and Emergency Medicine 5/2022

02.03.2022 | COVID-19 | EM - ORIGINAL Zur Zeit gratis

Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection

verfasst von: Fares Darawshy, Ayman Abu Rmeileh, Rottem Kuint, Dan Padawer, Khalil Karim, Zvi Fridlender, Uri Laxer, Polina Goychman Cohen, Neville Berkman

Erschienen in: Internal and Emergency Medicine | Ausgabe 5/2022

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Abstract

Symptoms following acute COVID-19 infection are common, but their relationship to initial COVID-19 severity is unclear. We hypothesize that residual symptoms are related to disease severity, and severe acute COVID-19 infection is more likely to cause residual pulmonary damage. This study aims to evaluate symptoms, lung function, and abnormal imaging within 3 months following COVID-19 infection, and to determine whether they are related to initial disease severity. A cross-sectional study was carried out at a designated post-COVID clinic in Hadassah Medical Center, Jerusalem, Israel. Patients with PCR-confirmed SARS-CoV-2 infection were evaluated within 12 weeks following infection and included both admitted and non-admitted subjects. All study participants underwent assessment of symptoms, quality of life (SGRQ), pulmonary function tests, and imaging. A total of 208 patients (age 49.3 ± 16 years) were included in the study. Initial disease severity was mild in 86, moderate in 49, and severe in 73 patients. At the time of follow-up, there were no differences in frequency of residual symptoms or in SGRQ score between groups. Patients with severe COVID-19 were more likely to have residual dyspnea (p = 0.04), lower oxygen saturation (p < 0.01), lower FVC and TLC (p < 0.001, p = 0.03 respectively), abnormal CXR (p < 0.01), and abnormal CT scan (p < 0.01) compared to other groups.Frequency of symptoms and impairment of quality of life at 12 week follow-up are common and are not related to severity of initial COVID-19 disease. In contrast, reduced lung function and abnormal pulmonary imaging are more common in patients with more severe acute COVID-19 infection.
Literatur
Metadaten
Titel
Residual symptoms, lung function, and imaging findings in patients recovering from SARS-CoV-2 infection
verfasst von
Fares Darawshy
Ayman Abu Rmeileh
Rottem Kuint
Dan Padawer
Khalil Karim
Zvi Fridlender
Uri Laxer
Polina Goychman Cohen
Neville Berkman
Publikationsdatum
02.03.2022
Verlag
Springer International Publishing
Schlagwort
COVID-19
Erschienen in
Internal and Emergency Medicine / Ausgabe 5/2022
Print ISSN: 1828-0447
Elektronische ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-022-02950-w