Highlights
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The administration of heparin was associated with lower mortality in patients admitted with Covid-19.
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Our findings support that there is a thrombotic component in the development of respiratory distress for these patients.
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The positive effect of heparin seems consistent and its use, when indicated, could be considered in clinical settings.
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Randomized controlled trials are necessary to complement observational studies, and assess the causal associations between heparin, in different therapeutic regimes, and clinical outcomes.
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Heparin is easy to administer, its use in ambulatory patients, to prevent admissions, or reduce their duration, could also be considered by clinicians and future researchers.
Introduction
Methods
Results
N | Age M(SD) | Female n(%) | Death n(%) | ||
---|---|---|---|---|---|
Total cohort | 2075 | 67.57 (15.52) | 819 (39.47%) | 301 (14.51%) | |
Oxygen saturation < 90% | Yes | 70 | 73.18 (13.7) | 20 (28.57) | 28 (53.85) |
No | 221 | 67.00 (16.14) | 95 (42.99) | 24 (46.15) | |
Temperature > 37° C | Yes | 159 | 61.20 (17.27) | 47 (29.56) | 24 (10.86) |
No | 1422 | 68.53 (15.65) | 577 (40.58) | 197 (89.14) | |
Heparin | Yes | 1734 | 68.77 (15.09) | 686 (39.56) | 242 (13.96) |
No | 285 | 61.76 (17.67) | 96 (33.68) | 44 (15.44) | |
Hydroxychloroquine | Yes | 1857 | 67.11 (15.51) | 705 (37.96) | 237 (12.76) |
No | 162 | 73.47 (16.22) | 77 (47.53) | 49 (30.25) | |
Azithromycin | Yes | 1223 | 68.33 (15.03) | 456 (37.29) | 146 (11.94) |
No | 796 | 66.54 (16.51) | 326 (40.95) | 140 (17.59) | |
Steroids | Yes | 960 | 69.88 (16.76) | 330 (34.38) | 200 (20.83) |
No | 1059 | 65.58 (16.76) | 452 (42.68) | 86 (8.12) | |
Tocilizumab | Yes | 421 | 66.1 (13.11) | 117 (27.79) | 89 (21.14) |
No | 1598 | 68.00 (16.24) | 665 (41.61) | 197 (12.33) | |
Lopinavir + Ritonavir | Yes | 1230 | 63.94 (14.28) | 421 (34.23) | 160 (13.01) |
No | 789 | 73.37 (15.99) | 361 (45.75) | 126 (15.97) | |
Oseltamivir | Yes | 132 | 67.78 (13.79) | 51 (38.64) | 26 (19.70) |
No | 1887 | 67.61 (15.78) | 731 (38.74) | 260 (13.78) |