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Inflammopharmacology

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03.08.2022 | COVID-19 | Review

Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

verfasst von: Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Walaa A. Negm, Athanasios Alexiou, Gaber El-Saber Batiha

Erschienen in: Inflammopharmacology | Ausgabe 5/2022

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Abstract

SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) has been identified as the source of a world coronavirus pandemic in 2019. Covid-19 is considered a main respiratory disease-causing viral pneumonia and, in severe cases, leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Although, extrapulmonary manifestations of Covid-19 like neurological, cardiovascular, and gastrointestinal have been confirmed. Exaggerated immune response and release of a high amount of pro-inflammatory cytokines may progress, causing a cytokine storm. Consequently, direct and indirect effects of SARS-CoV-2 infection can evolve into systemic complications due to the progression of hyper inflammation, oxidative stress and dysregulation of the renin-angiotensin system (RAS). Therefore, anti-inflammatory and antioxidant agents could be efficient in alleviating these disorders. Ursolic acid has anti-inflammatory, antioxidant, and antiviral effects; it reduces the release of pro-inflammatory cytokines, improves anti-inflammatory cytokines, and inhibits the production of reactive oxygen species (ROS). In virtue of its anti-inflammatory and antioxidant effects, ursolic acid may minimize SARS-CoV-2 infection-induced complications. Also, by regulating RAS and inflammatory signaling pathways, ursolic acid might effectively reduce the development of ALI in ARDS in Covid-19. In this state, this perspective discusses how ursolic acid can mitigate hyper inflammation and oxidative stress in Covid-19.

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Titel: Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective
verfasst von: Hayder M. Al-kuraishy
Ali I. Al-Gareeb
Walaa A. Negm
Athanasios Alexiou
Gaber El-Saber Batiha
Publikationsdatum: 03.08.2022
Verlag: Springer International Publishing
Schlagwort: COVID-19
Erschienen in: Inflammopharmacology / Ausgabe 5/2022
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-022-01038-3

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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