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03.08.2022 | COVID-19 | Review

Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

verfasst von: Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Walaa A. Negm, Athanasios Alexiou, Gaber El-Saber Batiha

Erschienen in: Inflammopharmacology

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Abstract

SARS-CoV-2 (severe acute respiratory syndrome coronavirus type 2) has been identified as the source of a world coronavirus pandemic in 2019. Covid-19 is considered a main respiratory disease-causing viral pneumonia and, in severe cases, leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Although, extrapulmonary manifestations of Covid-19 like neurological, cardiovascular, and gastrointestinal have been confirmed. Exaggerated immune response and release of a high amount of pro-inflammatory cytokines may progress, causing a cytokine storm. Consequently, direct and indirect effects of SARS-CoV-2 infection can evolve into systemic complications due to the progression of hyper inflammation, oxidative stress and dysregulation of the renin-angiotensin system (RAS). Therefore, anti-inflammatory and antioxidant agents could be efficient in alleviating these disorders. Ursolic acid has anti-inflammatory, antioxidant, and antiviral effects; it reduces the release of pro-inflammatory cytokines, improves anti-inflammatory cytokines, and inhibits the production of reactive oxygen species (ROS). In virtue of its anti-inflammatory and antioxidant effects, ursolic acid may minimize SARS-CoV-2 infection-induced complications. Also, by regulating RAS and inflammatory signaling pathways, ursolic acid might effectively reduce the development of ALI in ARDS in Covid-19. In this state, this perspective discusses how ursolic acid can mitigate hyper inflammation and oxidative stress in Covid-19.
Literatur
Zurück zum Zitat Al-Kuraishy HM, Hussien NR, Al-Naimi MS, Al-Buhadily AK, Al-Gareeb AI, Lungnier C (2020) Renin–angiotensin system and fibrinolytic pathway in COVID-19: one-way skepticism. Biomed Biotechnol Res J (BBRJ) 4(5):33 Al-Kuraishy HM, Hussien NR, Al-Naimi MS, Al-Buhadily AK, Al-Gareeb AI, Lungnier C (2020) Renin–angiotensin system and fibrinolytic pathway in COVID-19: one-way skepticism. Biomed Biotechnol Res J (BBRJ) 4(5):33
Zurück zum Zitat Al-Kuraishy HM, Al-Gareeb AI, Abdullah SM, Cruz-Martins N, Batiha GE-S (2021a) Case report: hyperbilirubinemia in gilbert syndrome attenuates Covid-19-induced metabolic disturbances. Front Cardiovasc Med 8:642181 PubMedPubMedCentralCrossRef Al-Kuraishy HM, Al-Gareeb AI, Abdullah SM, Cruz-Martins N, Batiha GE-S (2021a) Case report: hyperbilirubinemia in gilbert syndrome attenuates Covid-19-induced metabolic disturbances. Front Cardiovasc Med 8:642181 PubMedPubMedCentralCrossRef
Zurück zum Zitat Al-Kuraishy HM, Al-Gareeb AI, Almulaiky YQ, Cruz-Martins N, Batiha GE-S (2021b) Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: the enigmatic entity. Eur J Pharmacol 904:174196 PubMedPubMedCentralCrossRef Al-Kuraishy HM, Al-Gareeb AI, Almulaiky YQ, Cruz-Martins N, Batiha GE-S (2021b) Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: the enigmatic entity. Eur J Pharmacol 904:174196 PubMedPubMedCentralCrossRef
Zurück zum Zitat Al-Kuraishy HM, Al-Gareeb AI, Alqarni M, Cruz-Martins N, El-Saber Batiha G (2021c) Pleiotropic effects of tetracyclines in the management of COVID-19: emerging perspectives. Front Pharmacol 12:642822 PubMedPubMedCentralCrossRef Al-Kuraishy HM, Al-Gareeb AI, Alqarni M, Cruz-Martins N, El-Saber Batiha G (2021c) Pleiotropic effects of tetracyclines in the management of COVID-19: emerging perspectives. Front Pharmacol 12:642822 PubMedPubMedCentralCrossRef
Zurück zum Zitat Al-Kuraishy HM, Al-Gareeb AI, Alzahrani KJ, Alexiou A, Batiha GE-S (2021d) Niclosamide for Covid-19: bridging the gap. Mol Biol Rep 48(12):8195–8202 PubMedPubMedCentralCrossRef Al-Kuraishy HM, Al-Gareeb AI, Alzahrani KJ, Alexiou A, Batiha GE-S (2021d) Niclosamide for Covid-19: bridging the gap. Mol Biol Rep 48(12):8195–8202 PubMedPubMedCentralCrossRef
Zurück zum Zitat Al-Kuraishy HM, Al-Gareeb AI, Alzahrani KJ, Cruz-Martins N, Batiha GE-S (2021e) The potential role of neopterin in Covid-19: a new perspective. Mol Cell Biochem 476(11):4161–4166 PubMedPubMedCentralCrossRef Al-Kuraishy HM, Al-Gareeb AI, Alzahrani KJ, Cruz-Martins N, Batiha GE-S (2021e) The potential role of neopterin in Covid-19: a new perspective. Mol Cell Biochem 476(11):4161–4166 PubMedPubMedCentralCrossRef
Zurück zum Zitat Al-Kuraishy HM, Al-Gareeb AI, Al-Niemi MS, Aljowaie RM, Almutairi SM, Alexiou A, Batiha GE-S (2022) The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19. Inflammation 45:1651–1667 PubMedCrossRef Al-Kuraishy HM, Al-Gareeb AI, Al-Niemi MS, Aljowaie RM, Almutairi SM, Alexiou A, Batiha GE-S (2022) The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19. Inflammation 45:1651–1667 PubMedCrossRef
Zurück zum Zitat Appelberg S, Gupta S, SvenssonAkusjärvi S, Ambikan AT, Mikaeloff F, Saccon E, Végvári Á, Benfeitas R, Sperk M, Ståhlberg M (2020) Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerg Microbes Infect 9(1):1748–1760 PubMedPubMedCentralCrossRef Appelberg S, Gupta S, SvenssonAkusjärvi S, Ambikan AT, Mikaeloff F, Saccon E, Végvári Á, Benfeitas R, Sperk M, Ståhlberg M (2020) Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerg Microbes Infect 9(1):1748–1760 PubMedPubMedCentralCrossRef
Zurück zum Zitat Attallah NG, El-Kadem AH, Negm WA, Elekhnawy E, El-Masry TA, Elmongy EI, Altwaijry N, Alanazi AS, Al-Hamoud GA, Ragab AE (2021) Promising antiviral activity of agrimonia pilosa phytochemicals against severe acute respiratory syndrome coronavirus 2 supported with in vivo mice study. Pharmaceuticals 14(12):1313 PubMedPubMedCentralCrossRef Attallah NG, El-Kadem AH, Negm WA, Elekhnawy E, El-Masry TA, Elmongy EI, Altwaijry N, Alanazi AS, Al-Hamoud GA, Ragab AE (2021) Promising antiviral activity of agrimonia pilosa phytochemicals against severe acute respiratory syndrome coronavirus 2 supported with in vivo mice study. Pharmaceuticals 14(12):1313 PubMedPubMedCentralCrossRef
Zurück zum Zitat Bag P, Chattopadhyay D, Mukherjee H, Ojha D, Mandal N, Sarkar MC, Chatterjee T, Das G, Chakraborti S (2012) Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman islands. Virol J 9(1):1–12 CrossRef Bag P, Chattopadhyay D, Mukherjee H, Ojha D, Mandal N, Sarkar MC, Chatterjee T, Das G, Chakraborti S (2012) Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman islands. Virol J 9(1):1–12 CrossRef
Zurück zum Zitat Bakhtiari N, Hosseinkhani S, Soleimani M, Hemmati R, Noori-Zadeh A, Javan M, Tashakor A (2016) Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation. Biomed Pharmacother 78:185–196 PubMedCrossRef Bakhtiari N, Hosseinkhani S, Soleimani M, Hemmati R, Noori-Zadeh A, Javan M, Tashakor A (2016) Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancing of SIRT1 expression and satellite cells proliferation. Biomed Pharmacother 78:185–196 PubMedCrossRef
Zurück zum Zitat Bello-Perez M, Sola I, Novoa B, Klionsky DJ, Falco A (2020) Canonical and noncanonical autophagy as potential targets for COVID-19. Cells 9(7):1619 PubMedCentralCrossRef Bello-Perez M, Sola I, Novoa B, Klionsky DJ, Falco A (2020) Canonical and noncanonical autophagy as potential targets for COVID-19. Cells 9(7):1619 PubMedCentralCrossRef
Zurück zum Zitat Cargnin ST, Gnoatto SB (2017) Ursolic acid from apple pomace and traditional plants: a valuable triterpenoid with functional properties. Food Chem 220:477–489 PubMedCrossRef Cargnin ST, Gnoatto SB (2017) Ursolic acid from apple pomace and traditional plants: a valuable triterpenoid with functional properties. Food Chem 220:477–489 PubMedCrossRef
Zurück zum Zitat Chen X, Wan Y, Zhou T, Li J, Wei Y (2013) Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model. Immunotherapy 5(1):39–47 PubMedCrossRef Chen X, Wan Y, Zhou T, Li J, Wei Y (2013) Ursolic acid attenuates lipopolysaccharide-induced acute lung injury in a mouse model. Immunotherapy 5(1):39–47 PubMedCrossRef
Zurück zum Zitat Chen H, Gao Y, Wang A, Zhou X, Zheng Y, Zhou J (2015) Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. Eur J Med Chem 92:648–655 PubMedPubMedCentralCrossRef Chen H, Gao Y, Wang A, Zhou X, Zheng Y, Zhou J (2015) Evolution in medicinal chemistry of ursolic acid derivatives as anticancer agents. Eur J Med Chem 92:648–655 PubMedPubMedCentralCrossRef
Zurück zum Zitat Chen R, Huang Y, Quan J, Liu J, Wang H, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D (2020a) HMGB1 as a potential biomarker and therapeutic target for severe COVID-19. Heliyon 6(12):e05672 PubMedPubMedCentralCrossRef Chen R, Huang Y, Quan J, Liu J, Wang H, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D (2020a) HMGB1 as a potential biomarker and therapeutic target for severe COVID-19. Heliyon 6(12):e05672 PubMedPubMedCentralCrossRef
Zurück zum Zitat Chen Z, Liu Q, Zhu Z, Xiang F, Zhang M, Wu R, Kang X (2020b) Ursolic acid protects against proliferation and inflammatory response in LPS-treated gastric tumour model and cells by inhibiting NLRP3 inflammasome activation. Cancer Manag Res 12:8413 PubMedPubMedCentralCrossRef Chen Z, Liu Q, Zhu Z, Xiang F, Zhang M, Wu R, Kang X (2020b) Ursolic acid protects against proliferation and inflammatory response in LPS-treated gastric tumour model and cells by inhibiting NLRP3 inflammasome activation. Cancer Manag Res 12:8413 PubMedPubMedCentralCrossRef
Zurück zum Zitat Chiappalupi S, Salvadori L, Vukasinovic A, Donato R, Sorci G, Riuzzi F (2021) Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: hypotheses and perspectives. Life Sci 272:119251 PubMedPubMedCentralCrossRef Chiappalupi S, Salvadori L, Vukasinovic A, Donato R, Sorci G, Riuzzi F (2021) Targeting RAGE to prevent SARS-CoV-2-mediated multiple organ failure: hypotheses and perspectives. Life Sci 272:119251 PubMedPubMedCentralCrossRef
Zurück zum Zitat Dai S, Meng X, Cai X, Yuan C, Zhao Z, Zhong L, Shi Y, Yin F (2021) Therapeutic effect of ursolic acid on fetal development in pregnant rats with gestational diabetes mellitus via AGEs-RAGE signaling pathway. J Food Biochem 45(4):e13651 PubMedCrossRef Dai S, Meng X, Cai X, Yuan C, Zhao Z, Zhong L, Shi Y, Yin F (2021) Therapeutic effect of ursolic acid on fetal development in pregnant rats with gestational diabetes mellitus via AGEs-RAGE signaling pathway. J Food Biochem 45(4):e13651 PubMedCrossRef
Zurück zum Zitat Dhall A, Patiyal S, Sharma N, Devi NL, Raghava GP (2021) Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm. Comput Biol Med 137:104780 PubMedPubMedCentralCrossRef Dhall A, Patiyal S, Sharma N, Devi NL, Raghava GP (2021) Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm. Comput Biol Med 137:104780 PubMedPubMedCentralCrossRef
Zurück zum Zitat Di Maro M, Cataldi M, Santillo M, Chiurazzi M, Damiano S, De Conno B, Colantuoni A, Guida B (2021) The cholinergic and ACE-2-dependent anti-inflammatory systems in the lung: new scenarios emerging from COVID-19. Front Physiol 12:653985 PubMedPubMedCentralCrossRef Di Maro M, Cataldi M, Santillo M, Chiurazzi M, Damiano S, De Conno B, Colantuoni A, Guida B (2021) The cholinergic and ACE-2-dependent anti-inflammatory systems in the lung: new scenarios emerging from COVID-19. Front Physiol 12:653985 PubMedPubMedCentralCrossRef
Zurück zum Zitat Elekhnawy E, Negm WA (2022) The potential application of probiotics for the prevention and treatment of COVID-19. Egypt J Med Hum Gene 23(1):1–9 CrossRef Elekhnawy E, Negm WA (2022) The potential application of probiotics for the prevention and treatment of COVID-19. Egypt J Med Hum Gene 23(1):1–9 CrossRef
Zurück zum Zitat Gan D, Zhang W, Huang C, Chen J, He W, Wang A, Li B, Zhu X (2018) Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway. J Cell Physiol 233(10):6799–6813 PubMedPubMedCentralCrossRef Gan D, Zhang W, Huang C, Chen J, He W, Wang A, Li B, Zhu X (2018) Ursolic acid ameliorates CCl4-induced liver fibrosis through the NOXs/ROS pathway. J Cell Physiol 233(10):6799–6813 PubMedPubMedCentralCrossRef
Zurück zum Zitat Gayathri R, Priya D, Gunassekaran G, Sakthisekaran D (2009) Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. Asian Pac J Cancer Prev 10(5):933–938 PubMed Gayathri R, Priya D, Gunassekaran G, Sakthisekaran D (2009) Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats. Asian Pac J Cancer Prev 10(5):933–938 PubMed
Zurück zum Zitat Guzmán-Ávila R, Flores-Morales V, Paoli P, Camici G, Ramírez-Espinosa JJ, Cerón-Romero L, Navarrete-Vázquez G, Hidalgo-Figueroa S, Yolanda Rios M, Villalobos-Molina R (2018) Ursolic acid derivatives as potential antidiabetic agents: in vitro, in vivo, and in silico studies. Drug Dev Res 79(2):70–80 PubMedCrossRef Guzmán-Ávila R, Flores-Morales V, Paoli P, Camici G, Ramírez-Espinosa JJ, Cerón-Romero L, Navarrete-Vázquez G, Hidalgo-Figueroa S, Yolanda Rios M, Villalobos-Molina R (2018) Ursolic acid derivatives as potential antidiabetic agents: in vitro, in vivo, and in silico studies. Drug Dev Res 79(2):70–80 PubMedCrossRef
Zurück zum Zitat Hojyo S, Uchida M, Tanaka K, Hasebe R, Tanaka Y, Murakami M, Hirano T (2020) How COVID-19 induces cytokine storm with high mortality. Inflamm Regen 40(1):1–7 CrossRef Hojyo S, Uchida M, Tanaka K, Hasebe R, Tanaka Y, Murakami M, Hirano T (2020) How COVID-19 induces cytokine storm with high mortality. Inflamm Regen 40(1):1–7 CrossRef
Zurück zum Zitat Hua WJ, Hua WX, Nan FY, Jiang WA, Yan C (2014) The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1* 1a and* 5. Eur J Drug Metab Pharmacokinet 39(3):221–230 PubMedPubMedCentralCrossRef Hua WJ, Hua WX, Nan FY, Jiang WA, Yan C (2014) The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1* 1a and* 5. Eur J Drug Metab Pharmacokinet 39(3):221–230 PubMedPubMedCentralCrossRef
Zurück zum Zitat Hussain H, Green IR, Ali I, Khan IA, Ali Z, Al-Sadi AM, Ahmed I (2017) Ursolic acid derivatives for pharmaceutical use: a patent review (2012–2016). Expert Opin Ther Pat 27(9):1061–1072 PubMedCrossRef Hussain H, Green IR, Ali I, Khan IA, Ali Z, Al-Sadi AM, Ahmed I (2017) Ursolic acid derivatives for pharmaceutical use: a patent review (2012–2016). Expert Opin Ther Pat 27(9):1061–1072 PubMedCrossRef
Zurück zum Zitat Jang S-E, Jeong J-J, Hyam SR, Han MJ, Kim D-H (2014) Ursolic acid isolated from the seed of cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 on macrophages. J Agric Food Chem 62(40):9711–9721 PubMedCrossRef Jang S-E, Jeong J-J, Hyam SR, Han MJ, Kim D-H (2014) Ursolic acid isolated from the seed of cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 on macrophages. J Agric Food Chem 62(40):9711–9721 PubMedCrossRef
Zurück zum Zitat Jinhua W (2019) Ursolic acid: pharmacokinetics process in vitro and in vivo, a mini review. Arch Pharm 352(3):1800222 CrossRef Jinhua W (2019) Ursolic acid: pharmacokinetics process in vitro and in vivo, a mini review. Arch Pharm 352(3):1800222 CrossRef
Zurück zum Zitat Kazakova OB, Gul’nara VG, Yamansarov EY, Tolstikov GA (2010) Betulin and ursolic acid synthetic derivatives as inhibitors of papilloma virus. Bioorg Med Chem Lett 20(14):4088–4090 PubMedCrossRef Kazakova OB, Gul’nara VG, Yamansarov EY, Tolstikov GA (2010) Betulin and ursolic acid synthetic derivatives as inhibitors of papilloma virus. Bioorg Med Chem Lett 20(14):4088–4090 PubMedCrossRef
Zurück zum Zitat Koepke L, Hirschenberger M, Hayn M, Kirchhoff F, Sparrer KM (2021) Manipulation of autophagy by SARS-CoV-2 proteins. Autophagy 17(9):2659–2661 PubMedPubMedCentralCrossRef Koepke L, Hirschenberger M, Hayn M, Kirchhoff F, Sparrer KM (2021) Manipulation of autophagy by SARS-CoV-2 proteins. Autophagy 17(9):2659–2661 PubMedPubMedCentralCrossRef
Zurück zum Zitat Kong L, Li S, Liao Q, Zhang Y, Sun R, Zhu X, Zhang Q, Wang J, Wu X, Fang X (2013) Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. Antiviral Res 98(1):44–53 PubMedCrossRef Kong L, Li S, Liao Q, Zhang Y, Sun R, Zhu X, Zhang Q, Wang J, Wu X, Fang X (2013) Oleanolic acid and ursolic acid: novel hepatitis C virus antivirals that inhibit NS5B activity. Antiviral Res 98(1):44–53 PubMedCrossRef
Zurück zum Zitat Kunkel SD, Elmore CJ, Bongers KS, Ebert SM, Fox DK, Dyle MC, Bullard SA, Adams CM (2012) Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS ONE 7(6):e39332 PubMedPubMedCentralCrossRef Kunkel SD, Elmore CJ, Bongers KS, Ebert SM, Fox DK, Dyle MC, Bullard SA, Adams CM (2012) Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease. PLoS ONE 7(6):e39332 PubMedPubMedCentralCrossRef
Zurück zum Zitat Lee K-C, Chen Y-L, Lin P-Y, Chuang W-L (2018) Ursolic acid-induced apoptosis via regulation of the PI3K/Akt and MAPK signaling pathways in Huh-7 cells. Molecules 23(8):2016 PubMedCentralCrossRef Lee K-C, Chen Y-L, Lin P-Y, Chuang W-L (2018) Ursolic acid-induced apoptosis via regulation of the PI3K/Akt and MAPK signaling pathways in Huh-7 cells. Molecules 23(8):2016 PubMedCentralCrossRef
Zurück zum Zitat Leng S, Hao Y, Du D, Xie S, Hong L, Gu H, Zhu X, Zhang J, Fan D, H. f. Kung, (2013) Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. Int J Cancer 133(12):2781–2790 PubMed Leng S, Hao Y, Du D, Xie S, Hong L, Gu H, Zhu X, Zhang J, Fan D, H. f. Kung, (2013) Ursolic acid promotes cancer cell death by inducing Atg5-dependent autophagy. Int J Cancer 133(12):2781–2790 PubMed
Zurück zum Zitat Li S, Meng F, Liao X, Wang Y, Sun Z, Guo F, Li X, Meng M, Li Y, Sun C (2014) Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. PLoS ONE 9(1):e86724 PubMedPubMedCentralCrossRef Li S, Meng F, Liao X, Wang Y, Sun Z, Guo F, Li X, Meng M, Li Y, Sun C (2014) Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. PLoS ONE 9(1):e86724 PubMedPubMedCentralCrossRef
Zurück zum Zitat Li Q, Zhao W, Zeng X, Hao Z (2018) Ursolic acid attenuates atherosclerosis in ApoE−/− mice: role of LOX-1 mediated by ROS/NF-κB pathway. Molecules 23(5):1101 PubMedCentralCrossRef Li Q, Zhao W, Zeng X, Hao Z (2018) Ursolic acid attenuates atherosclerosis in ApoE−/− mice: role of LOX-1 mediated by ROS/NF-κB pathway. Molecules 23(5):1101 PubMedCentralCrossRef
Zurück zum Zitat Liaudet L, Szabo C (2020) Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease. Crit Care 24(1):1–2 CrossRef Liaudet L, Szabo C (2020) Blocking mineralocorticoid receptor with spironolactone may have a wide range of therapeutic actions in severe COVID-19 disease. Crit Care 24(1):1–2 CrossRef
Zurück zum Zitat Lin Y-N, Wang CC, Chang H-Y, Chu F-Y, Hsu Y-A, Cheng W-K, Ma W-C, Chen C-J, Wan L, Lim Y-P (2018) Ursolic acid, a novel liver X receptor α (LXRα) antagonist inhibiting ligand-induced nonalcoholic fatty liver and drug-induced lipogenesis. J Agric Food Chem 66(44):11647–11662 PubMedCrossRef Lin Y-N, Wang CC, Chang H-Y, Chu F-Y, Hsu Y-A, Cheng W-K, Ma W-C, Chen C-J, Wan L, Lim Y-P (2018) Ursolic acid, a novel liver X receptor α (LXRα) antagonist inhibiting ligand-induced nonalcoholic fatty liver and drug-induced lipogenesis. J Agric Food Chem 66(44):11647–11662 PubMedCrossRef
Zurück zum Zitat Lin X, Fu B, Yin S, Li Z, Liu H, Zhang H, Xing N, Wang Y, Xue W, Xiong Y (2021) ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. Iscience 24(4):102293 PubMedPubMedCentralCrossRef Lin X, Fu B, Yin S, Li Z, Liu H, Zhang H, Xing N, Wang Y, Xue W, Xiong Y (2021) ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. Iscience 24(4):102293 PubMedPubMedCentralCrossRef
Zurück zum Zitat Liu T, Ma H, Shi W, Duan J, Wang Y, Zhang C, Li C, Lin J, Li S, Lv J (2017) Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma. Int J Oncol 51(2):555–562 PubMedCrossRef Liu T, Ma H, Shi W, Duan J, Wang Y, Zhang C, Li C, Lin J, Li S, Lv J (2017) Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma. Int J Oncol 51(2):555–562 PubMedCrossRef
Zurück zum Zitat López-Hortas L, Pérez-Larrán P, González-Muñoz MJ, Falqué E, Domínguez H (2018) Recent developments on the extraction and application of ursolic acid. a review. Food Res Int 103:130–149 PubMedCrossRef López-Hortas L, Pérez-Larrán P, González-Muñoz MJ, Falqué E, Domínguez H (2018) Recent developments on the extraction and application of ursolic acid. a review. Food Res Int 103:130–149 PubMedCrossRef
Zurück zum Zitat Lu J, Wu D-M, Zheng Y-L, Hu B, Zhang Z-F, Ye Q, Liu C-M, Shan Q, Wang Y-J (2010) Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. Cereb Cortex 20(11):2540–2548 PubMedCrossRef Lu J, Wu D-M, Zheng Y-L, Hu B, Zhang Z-F, Ye Q, Liu C-M, Shan Q, Wang Y-J (2010) Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation. Cereb Cortex 20(11):2540–2548 PubMedCrossRef
Zurück zum Zitat Lu X, Fan Q, Xu L, Li L, Yue Y, Xu Y, Su Y, Zhang D, Wang L (2015) Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. PLoS ONE 10(2):e0117400 PubMedPubMedCentralCrossRef Lu X, Fan Q, Xu L, Li L, Yue Y, Xu Y, Su Y, Zhang D, Wang L (2015) Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. PLoS ONE 10(2):e0117400 PubMedPubMedCentralCrossRef
Zurück zum Zitat Luo J, Hu YL, Wang H (2017) Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro. Exp Ther Med 14(4):3623–3631 PubMedPubMedCentralCrossRef Luo J, Hu YL, Wang H (2017) Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro. Exp Ther Med 14(4):3623–3631 PubMedPubMedCentralCrossRef
Zurück zum Zitat Lv Y-Y, Jin Y, Han G-Z, Liu Y-X, Wu T, Liu P, Zhou Q, Liu K-X, Sun H-J (2012) Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. Eur J Pharm Sci 45(1–2):190–194 PubMedCrossRef Lv Y-Y, Jin Y, Han G-Z, Liu Y-X, Wu T, Liu P, Zhou Q, Liu K-X, Sun H-J (2012) Ursolic acid suppresses IL-6 induced C-reactive protein expression in HepG2 and protects HUVECs from injury induced by CRP. Eur J Pharm Sci 45(1–2):190–194 PubMedCrossRef
Zurück zum Zitat Ma C, Nakamura N, Miyashiro H, Hattori M, Shimotohno K (1998) Inhibitory effects of ursolic acid derivatives from Cynomorium songaricum, and related triterpenes on human immunodeficiency viral protease. Phytother Res: Int J Devoted Pharmacol Toxicol Eval Natural Product Deriv 12(S1):S138–S142 CrossRef Ma C, Nakamura N, Miyashiro H, Hattori M, Shimotohno K (1998) Inhibitory effects of ursolic acid derivatives from Cynomorium songaricum, and related triterpenes on human immunodeficiency viral protease. Phytother Res: Int J Devoted Pharmacol Toxicol Eval Natural Product Deriv 12(S1):S138–S142 CrossRef
Zurück zum Zitat Ma J-Q, Ding J, Zhang L, Liu C-M (2014) Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway. Environ Toxicol Pharmacol 37(3):975–983 PubMedCrossRef Ma J-Q, Ding J, Zhang L, Liu C-M (2014) Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway. Environ Toxicol Pharmacol 37(3):975–983 PubMedCrossRef
Zurück zum Zitat Ma T-K, Xu L, Lu L-X, Cao X, Li X, Li L-L, Wang X, Fan Q-L (2019) Ursolic acid treatment alleviates diabetic kidney injury by regulating the ARAP1/AT1R signaling pathway. Diabetes, Metab Syndr Obes: Targets Ther 12:2597 CrossRef Ma T-K, Xu L, Lu L-X, Cao X, Li X, Li L-L, Wang X, Fan Q-L (2019) Ursolic acid treatment alleviates diabetic kidney injury by regulating the ARAP1/AT1R signaling pathway. Diabetes, Metab Syndr Obes: Targets Ther 12:2597 CrossRef
Zurück zum Zitat McGonagle D, Bridgewood C, Ramanan AV, Meaney JF, Watad A (2021) COVID-19: angiotensin II in development of lung immunothrombosis and vasculitis mimics–Author’s reply. Lancet Rheumatol 3(5):e326 PubMedPubMedCentralCrossRef McGonagle D, Bridgewood C, Ramanan AV, Meaney JF, Watad A (2021) COVID-19: angiotensin II in development of lung immunothrombosis and vasculitis mimics–Author’s reply. Lancet Rheumatol 3(5):e326 PubMedPubMedCentralCrossRef
Zurück zum Zitat Mehta OP, Bhandari P, Raut A, Kacimi SEO, Huy NT (2021) Coronavirus disease (COVID-19): comprehensive review of clinical presentation. Front Public Health 8:582932 PubMedPubMedCentralCrossRef Mehta OP, Bhandari P, Raut A, Kacimi SEO, Huy NT (2021) Coronavirus disease (COVID-19): comprehensive review of clinical presentation. Front Public Health 8:582932 PubMedPubMedCentralCrossRef
Zurück zum Zitat Messner B, Zeller I, Ploner C, Frotschnig S, Ringer T, Steinacher-Nigisch A, Ritsch A, Laufer G, Huck C, Bernhard D (2011) Ursolic acid causes DNA-damage, p53-mediated, mitochondria-and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. Atherosclerosis 219(2):402–408 PubMedCrossRef Messner B, Zeller I, Ploner C, Frotschnig S, Ringer T, Steinacher-Nigisch A, Ritsch A, Laufer G, Huck C, Bernhard D (2011) Ursolic acid causes DNA-damage, p53-mediated, mitochondria-and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo. Atherosclerosis 219(2):402–408 PubMedCrossRef
Zurück zum Zitat Mishra V, Soren AD, Yadav AK (2021) Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in north-east India. Future J Pharm Sci 7(1):1–13 CrossRef Mishra V, Soren AD, Yadav AK (2021) Toxicological evaluations of betulinic acid and ursolic acid; common constituents of Houttuynia cordata used as an anthelmintic by the Naga tribes in north-east India. Future J Pharm Sci 7(1):1–13 CrossRef
Zurück zum Zitat Onohuean H, Al-Kuraishy HM, Al-Gareeb AI, Qusti S, Alshammari EM, Batiha GE-S (2021) Covid-19 and development of heart failure: mystery and truth. Naunyn Schmiedebergs Arch Pharmacol 394(10):2013–2021 PubMedPubMedCentralCrossRef Onohuean H, Al-Kuraishy HM, Al-Gareeb AI, Qusti S, Alshammari EM, Batiha GE-S (2021) Covid-19 and development of heart failure: mystery and truth. Naunyn Schmiedebergs Arch Pharmacol 394(10):2013–2021 PubMedPubMedCentralCrossRef
Zurück zum Zitat Parasher A (2021) COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J 97(1147):312–320 PubMedCrossRef Parasher A (2021) COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J 97(1147):312–320 PubMedCrossRef
Zurück zum Zitat Peshattiwar V, Muke S, Kaikini A, Bagle S, Dighe V, Sathaye S (2020) Mechanistic evaluation of ursolic acid against rotenone induced Parkinson’s disease–emphasizing the role of mitochondrial biogenesis. Brain Res Bull 160:150–161 PubMedCrossRef Peshattiwar V, Muke S, Kaikini A, Bagle S, Dighe V, Sathaye S (2020) Mechanistic evaluation of ursolic acid against rotenone induced Parkinson’s disease–emphasizing the role of mitochondrial biogenesis. Brain Res Bull 160:150–161 PubMedCrossRef
Zurück zum Zitat Poor HD (2021) Pulmonary thrombosis and thromboembolism in COVID-19. Chest 160(4):1471–1480 PubMedCrossRef Poor HD (2021) Pulmonary thrombosis and thromboembolism in COVID-19. Chest 160(4):1471–1480 PubMedCrossRef
Zurück zum Zitat Radhiga T, Senthil S, Sundaresan A, Pugalendi K (2019) Ursolic acid modulates MMPs, collagen-I, α-SMA, and TGF-β expression in isoproterenol-induced myocardial infarction in rats. Hum Exp Toxicol 38(7):785–793 PubMedCrossRef Radhiga T, Senthil S, Sundaresan A, Pugalendi K (2019) Ursolic acid modulates MMPs, collagen-I, α-SMA, and TGF-β expression in isoproterenol-induced myocardial infarction in rats. Hum Exp Toxicol 38(7):785–793 PubMedCrossRef
Zurück zum Zitat Ramasamy R, Shekhtman A, Schmidt AM (2016) The multiple faces of RAGE–opportunities for therapeutic intervention in aging and chronic disease. Expert Opin Ther Targets 20(4):431–446 PubMedCrossRef Ramasamy R, Shekhtman A, Schmidt AM (2016) The multiple faces of RAGE–opportunities for therapeutic intervention in aging and chronic disease. Expert Opin Ther Targets 20(4):431–446 PubMedCrossRef
Zurück zum Zitat Ramirez-Rodriguez AM, González-Ortiz M, Martínez-Abundis E, Acuña Ortega N (2017) Effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation. J Med Food 20(9):882–886 PubMedCrossRef Ramirez-Rodriguez AM, González-Ortiz M, Martínez-Abundis E, Acuña Ortega N (2017) Effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation. J Med Food 20(9):882–886 PubMedCrossRef
Zurück zum Zitat Roy D, Ramasamy R, Schmidt AM (2021) Journey to a receptor for advanced glycation end products connection in severe acute respiratory syndrome coronavirus 2 infection: with stops along the way in the lung, heart, blood vessels, and adipose tissue. Arterioscler Thromb Vasc Biol 41(2):614–627 PubMedCrossRef Roy D, Ramasamy R, Schmidt AM (2021) Journey to a receptor for advanced glycation end products connection in severe acute respiratory syndrome coronavirus 2 infection: with stops along the way in the lung, heart, blood vessels, and adipose tissue. Arterioscler Thromb Vasc Biol 41(2):614–627 PubMedCrossRef
Zurück zum Zitat Sakuma K, Yamaguchi A (2012) Novel intriguing strategies attenuating to sarcopenia. J Aging Res 2012:1–11 CrossRef Sakuma K, Yamaguchi A (2012) Novel intriguing strategies attenuating to sarcopenia. J Aging Res 2012:1–11 CrossRef
Zurück zum Zitat Saravanakumar K, Park S, Sathiyaseelan A, Kim K-N, Cho S-H, Mariadoss AVA, Wang M-H (2021) Metabolite profiling of methanolic extract of Gardenia jaminoides by LC-MS/MS and GC-MS and its anti-diabetic, and anti-oxidant activities. Pharmaceuticals 14(2):102 PubMedPubMedCentralCrossRef Saravanakumar K, Park S, Sathiyaseelan A, Kim K-N, Cho S-H, Mariadoss AVA, Wang M-H (2021) Metabolite profiling of methanolic extract of Gardenia jaminoides by LC-MS/MS and GC-MS and its anti-diabetic, and anti-oxidant activities. Pharmaceuticals 14(2):102 PubMedPubMedCentralCrossRef
Zurück zum Zitat Schönfeld D, Arias S, Bossio JC, Fernández H, Gozal D, Pérez-Chada D (2021) Clinical presentation and outcomes of the first patients with COVID-19 in argentina: results of 207079 cases from a national database. PLoS ONE 16(2):e0246793 PubMedPubMedCentralCrossRef Schönfeld D, Arias S, Bossio JC, Fernández H, Gozal D, Pérez-Chada D (2021) Clinical presentation and outcomes of the first patients with COVID-19 in argentina: results of 207079 cases from a national database. PLoS ONE 16(2):e0246793 PubMedPubMedCentralCrossRef
Zurück zum Zitat Senthil S, Chandramohan G, Pugalendi K (2007) Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. Int J Cardiol 119(1):131–133 PubMedCrossRef Senthil S, Chandramohan G, Pugalendi K (2007) Isomers (oleanolic and ursolic acids) differ in their protective effect against isoproterenol-induced myocardial ischemia in rats. Int J Cardiol 119(1):131–133 PubMedCrossRef
Zurück zum Zitat Seo DY, Lee SR, Heo J-W, No M-H, Rhee BD, Ko KS, Kwak H-B, Han J (2018) Ursolic acid in health and disease. Korean J Physiol Pharmacol 22(3):235 PubMedPubMedCentralCrossRef Seo DY, Lee SR, Heo J-W, No M-H, Rhee BD, Ko KS, Kwak H-B, Han J (2018) Ursolic acid in health and disease. Korean J Physiol Pharmacol 22(3):235 PubMedPubMedCentralCrossRef
Zurück zum Zitat Shimada A, Inagaki M (2014) Angiotensin I-Converting enzyme (ACE) inhibitory activity of ursolic acid isolated from Thymus vulgaris, L. Food Sci Technol Res 20(3):711–714 CrossRef Shimada A, Inagaki M (2014) Angiotensin I-Converting enzyme (ACE) inhibitory activity of ursolic acid isolated from Thymus vulgaris, L. Food Sci Technol Res 20(3):711–714 CrossRef
Zurück zum Zitat Shree P, Mishra P, Selvaraj C, Singh SK, Chaube R, Garg N, Tripathi YB (2022) Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants– Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)–a molecular docking study. J Biomol Struct Dyn 40(1):190–203 PubMedCrossRef Shree P, Mishra P, Selvaraj C, Singh SK, Chaube R, Garg N, Tripathi YB (2022) Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants– Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi)–a molecular docking study. J Biomol Struct Dyn 40(1):190–203 PubMedCrossRef
Zurück zum Zitat Sivakorn C, Dechsanga J, Jamjumrus L, Boonnak K, Schultz MJ, Dondorp AM, Phumratanaprapin W, Ratanarat R, Naorungroj T, Wattanawinitchai P (2021) High mobility group box 1 and interleukin 6 at intensive care unit admission as biomarkers in critically ill COVID-19 patients. Am J Trop Med Hyg 105(1):73 PubMedPubMedCentralCrossRef Sivakorn C, Dechsanga J, Jamjumrus L, Boonnak K, Schultz MJ, Dondorp AM, Phumratanaprapin W, Ratanarat R, Naorungroj T, Wattanawinitchai P (2021) High mobility group box 1 and interleukin 6 at intensive care unit admission as biomarkers in critically ill COVID-19 patients. Am J Trop Med Hyg 105(1):73 PubMedPubMedCentralCrossRef
Zurück zum Zitat Subbaiyan A, Ravichandran K, Singh SV, Sankar M, Thomas P, Dhama K, Malik YS, Singh RK, Chaudhuri P (2020) In silico molecular docking analysis targeting SARS-CoV-2 spike protein and selected herbal constituents. J Pure Appl Microbiol 14:989–998 CrossRef Subbaiyan A, Ravichandran K, Singh SV, Sankar M, Thomas P, Dhama K, Malik YS, Singh RK, Chaudhuri P (2020) In silico molecular docking analysis targeting SARS-CoV-2 spike protein and selected herbal constituents. J Pure Appl Microbiol 14:989–998 CrossRef
Zurück zum Zitat Sun Q, He M, Zhang M, Zeng S, Chen L, Zhou L, Xu H (2020) Ursolic acid: a systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model. Fitoterapia 147:104735 PubMedCrossRef Sun Q, He M, Zhang M, Zeng S, Chen L, Zhou L, Xu H (2020) Ursolic acid: a systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model. Fitoterapia 147:104735 PubMedCrossRef
Zurück zum Zitat Tiwari Pandey A, Pandey I, Zamboni P, Gemmati D, Kanase A, Singh AV, Singh MP (2020) Traditional herbal remedies with a multifunctional therapeutic approach as an implication in COVID-19 associated co-infections. Coatings 10(8):761 CrossRef Tiwari Pandey A, Pandey I, Zamboni P, Gemmati D, Kanase A, Singh AV, Singh MP (2020) Traditional herbal remedies with a multifunctional therapeutic approach as an implication in COVID-19 associated co-infections. Coatings 10(8):761 CrossRef
Zurück zum Zitat Tohmé M, Giménez MC, Peralta A, Colombo M, Delgui LR (2019) Ursolic acid: a novel antiviral compound inhibiting rotavirus infection in vitro. Int J Antimicrob Agents 54(5):601–609 PubMedCrossRef Tohmé M, Giménez MC, Peralta A, Colombo M, Delgui LR (2019) Ursolic acid: a novel antiviral compound inhibiting rotavirus infection in vitro. Int J Antimicrob Agents 54(5):601–609 PubMedCrossRef
Zurück zum Zitat Wang X-H, Zhou S-Y, Qian Z-Z, Zhang H-L, Qiu L-H, Song Z, Zhao J, Wang P, Hao X-S, Wang H-Q (2013) Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. Expert Opin Drug Metab Toxicol 9(2):117–125 PubMedCrossRef Wang X-H, Zhou S-Y, Qian Z-Z, Zhang H-L, Qiu L-H, Song Z, Zhao J, Wang P, Hao X-S, Wang H-Q (2013) Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors. Expert Opin Drug Metab Toxicol 9(2):117–125 PubMedCrossRef
Zurück zum Zitat Wang Q, Liang M, Dong Y, Yun W, Qiu F, Zhao L, Guo Y (2015) Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy. Drug Metab Pharmacokinet 30(3):209–213 PubMedCrossRef Wang Q, Liang M, Dong Y, Yun W, Qiu F, Zhao L, Guo Y (2015) Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy. Drug Metab Pharmacokinet 30(3):209–213 PubMedCrossRef
Zurück zum Zitat Wang Y, Li L, Deng S, Liu F, He Z (2018) Ursolic acid ameliorates inflammation in cerebral ischemia and reperfusion injury possibly via high mobility group box 1/Toll-like receptor 4/NFκB pathway. Front Neurol 9:253 PubMedPubMedCentralCrossRef Wang Y, Li L, Deng S, Liu F, He Z (2018) Ursolic acid ameliorates inflammation in cerebral ischemia and reperfusion injury possibly via high mobility group box 1/Toll-like receptor 4/NFκB pathway. Front Neurol 9:253 PubMedPubMedCentralCrossRef
Zurück zum Zitat Wang C, Gao Y, Zhang Z, Chen C, Chi Q, Xu K, Yang L (2020) Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-κB/NLRP3 inflammasome pathway and ameliorates osteoarthritis. Biomed Pharmacother 130:110568 PubMedCrossRef Wang C, Gao Y, Zhang Z, Chen C, Chi Q, Xu K, Yang L (2020) Ursolic acid protects chondrocytes, exhibits anti-inflammatory properties via regulation of the NF-κB/NLRP3 inflammasome pathway and ameliorates osteoarthritis. Biomed Pharmacother 130:110568 PubMedCrossRef
Zurück zum Zitat Woodby B, Arnold MM, Valacchi G (2021) SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: what is the connection? Ann N Y Acad Sci 1486(1):15–38 PubMedCrossRef Woodby B, Arnold MM, Valacchi G (2021) SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: what is the connection? Ann N Y Acad Sci 1486(1):15–38 PubMedCrossRef
Zurück zum Zitat Xie, Q., S. Tang and Y. Li (2021). "The divergent protective effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on clinical outcomes of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis." Annals of Palliative Medicine. Xie, Q., S. Tang and Y. Li (2021). "The divergent protective effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on clinical outcomes of coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis." Annals of Palliative Medicine.
Zurück zum Zitat Yang Y, Li C, Liu N, Wang M, Zhou X, Kim IH, Wu Z (2021) Ursolic acid alleviates heat stress-induced lung injury by regulating endoplasmic reticulum stress signaling in mice. J Nutr Biochem 89:108557 PubMedCrossRef Yang Y, Li C, Liu N, Wang M, Zhou X, Kim IH, Wu Z (2021) Ursolic acid alleviates heat stress-induced lung injury by regulating endoplasmic reticulum stress signaling in mice. J Nutr Biochem 89:108557 PubMedCrossRef
Zurück zum Zitat Yim E-K, Lee M-J, Lee K-H, Um S-J, Park J-S (2006) Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. Int J Gynecol Cancer 16(6):2023–2031 PubMedCrossRef Yim E-K, Lee M-J, Lee K-H, Um S-J, Park J-S (2006) Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines. Int J Gynecol Cancer 16(6):2023–2031 PubMedCrossRef
Zurück zum Zitat Zhai M, Guo J, Ma H, Shi W, Jou D, Yan D, Liu T, Tao J, Duan J, Wang Y (2018) Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice. Atherosclerosis 271:128–135 PubMedCrossRef Zhai M, Guo J, Ma H, Shi W, Jou D, Yan D, Liu T, Tao J, Duan J, Wang Y (2018) Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice. Atherosclerosis 271:128–135 PubMedCrossRef
Zurück zum Zitat Zhang, T.-Y., C.-S. Li, P. Li, X.-Q. Bai, S.-Y. Guo, Y. Jin and S.-J. Piao (2020). "Synthesis and evaluation of ursolic acid-based 1, 2, 4-triazolo [1, 5-a] pyrimidines derivatives as anti-inflammatory agents." Molecular Diversity: 1–12. Zhang, T.-Y., C.-S. Li, P. Li, X.-Q. Bai, S.-Y. Guo, Y. Jin and S.-J. Piao (2020). "Synthesis and evaluation of ursolic acid-based 1, 2, 4-triazolo [1, 5-a] pyrimidines derivatives as anti-inflammatory agents." Molecular Diversity: 1–12.
Metadaten
Titel
Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective
verfasst von
Hayder M. Al-kuraishy
Ali I. Al-Gareeb
Walaa A. Negm
Athanasios Alexiou
Gaber El-Saber Batiha
Publikationsdatum
03.08.2022
Verlag
Springer International Publishing
Schlagwort
COVID-19
Erschienen in
Inflammopharmacology
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-022-01038-3

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