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Inflammopharmacology
Erschienen in:

31.01.2022 | COVID-19 | Original Article Zur Zeit gratis

Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19

verfasst von: Parisa Feizollahi, Somaieh matin, Seyed Askar Roghani, Shayan Mostafaei, Elham Safarzadeh, Mahdi Taghadosi

Erschienen in: Inflammopharmacology | Ausgabe 1/2022

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Abstract

Background

Severe coronavirus disease-2019 (COVID-19) is associated with dysregulated immune response and extreme inflammatory injury. Considering the role of insulin growth factor-1 (IGF-1) in immune-mediated and inflammatory reactions, this study was conducted to investigate the IGF-1 contribution to the pathogenesis of severe form of COVID-19.

Material and methods

Sixty-two patients with severe COVID-19 and 52 healthy subjects were enrolled in this study. The serum levels of IGF-1 were measured using a solid-phase enzyme-linked chemiluminescent immunoassay on an Immulite 2000 system (Siemens Healthcare Diagnostics.

Result

The serum levels of IGF-1 had no significant difference in COVID-19 patients compared to the healthy subjects (p = 0.359). There was a positive correlation between IGF-1 and age in the severe COVID-19 patients, while a negative correlation was observed for the serum levels of IGF-1 and age in the control group (r = 0.364, p = 0.036, r = − 0.536, p = 0.001, respectively). Moreover, IGF-1 was remarkably associated with hypertension, neurogenic disease, shock, and nausea in patients with the severe form of COVID-19 (p = 0.031, p = 0.044, p = 0.01, p = 0.03, respectively).

Conclusion

Our results pointed to the complex role of IGF-1 in the severe form of COVID-19, and its association with clinical parameters, and some risk factors in the severe form of COVID-19.
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Metadaten
Titel
Evaluation serum levels of Insulin Growth Factor-1 (IGF-1) and its association with clinical parameters in severe COVID-19
verfasst von
Parisa Feizollahi
Somaieh matin
Seyed Askar Roghani
Shayan Mostafaei
Elham Safarzadeh
Mahdi Taghadosi
Publikationsdatum
31.01.2022
Verlag
Springer International Publishing
Schlagwörter
COVID-19
Virologie
Erschienen in
Inflammopharmacology / Ausgabe 1/2022
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-021-00908-6

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