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18.05.2020 | COVID-19 | Review | Ausgabe 7/2020 Zur Zeit gratis

European Journal of Pediatrics 7/2020

SARS-COV-2 infection in children and newborns: a systematic review

European Journal of Pediatrics > Ausgabe 7/2020
Ilaria Liguoro, Chiara Pilotto, Margherita Bonanni, Maria Elena Ferrari, Anna Pusiol, Agostino Nocerino, Enrico Vidal, Paola Cogo
Wichtige Hinweise
Communicated by Nicole Ritz

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1007/​s00431-020-03684-7) contains supplementary material, which is available to authorized users.

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A recent outbreak of a novel Coronavirus responsible for a Severe Acute Respiratory Syndrome (SARS-CoV-2) is spreading globally. The aim of this study was to systematically review main clinical characteristics and outcomes of SARS-CoV-2 infections in pediatric age. An electronic search was conducted in PubMed database. Papers published between 1 January and 1 May 2020 including children aged 0–18 years were selected. Sixty-two studies and three reviews were included, with a total sample size of 7480 children (2428/4660 males, 52.1%; weighted mean age 7.6 years). Patients showed mainly mild (608/1432, 42.5%) and moderate (567/1432, 39.6%) signs of the infection. About 2% of children were admitted to the pediatric intensive care unit. The most commonly described symptoms were fever (51.6%) and cough (47.3%). Laboratory findings were often unremarkable. Children underwent a chest CT scan in 73.9% of all cases, and 32.7% resulted normal. Overall, the estimated mortality was 0.08%. A higher proportion of newborns was severely ill (12%) and dyspnea was the most common reported sign (40%).
Conclusion: SARS-CoV-2 affects children less severely than adults. Laboratory and radiology findings are mainly nonspecific. Larger epidemiological and clinical cohort studies are needed to better understand possible implications of COVID-19 infection in children.
What is Known:
• A novel Coronavirus has been recently identified as responsible for a new Severe Acute Respiratory Syndrome (SARS-CoV-2) spreading globally.
• There is limited evidence on SARS-CoV2 infection in children.
What is New:
• Systematically reviewed available evidence showed that children with SARS-CoV-2 infection may have a less severe pattern of disease in comparison to adults.
• Blood tests and radiology findings are mainly nonspecific in children but may help to identify those who are severely ill.

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