WHO Ordinal Scale and Inflammation Risk Categories in COVID-19. Comparative Study of the Severity Scales
- Zur Zeit gratis
- 08.04.2022
- COVID-19
- Original Research
Erschienen in:
- Verfasst von
- Manuel Rubio-Rivas, MD PhD
- José María Mora-Luján, MD PhD
- Francesc Formiga, MD PhD
- Coral Arévalo-Cañas, MD
- Juan Manuel Lebrón Ramos, MD PhD
- María Victoria Villalba García, MD
- Eva Mª Fonseca Aizpuru, MD
- Jesús Díez-Manglano, MD
- Francisco Arnalich Fernández, MD PhD
- Juan Luis Romero Cabrera, MD
- Gema María García García, MD PhD
- Paula M. Pesqueira Fontan, MD
- Juan Antonio Vargas Núñez, MD PhD
- Santiago Jesús Freire Castro, MD
- José Loureiro Amigo, MD
- Maria de los Reyes Pascual Pérez, MD
- José N. Alcalá Pedrajas, MD PhD
- Daniel Encinas-Sánchez, MD
- Carmen Mella Pérez, MD
- Javier Ena, MD
- Anyuli Gracia Gutiérrez, MD PhD
- María José Esteban Giner, MD PhD
- José F. Varona, MD PhD
- Jesús Millán Núñez-Cortés, MD PhD
- José-Manuel Casas-Rojo, MD PhD
- on behalf of the SEMI-COVID-19 Network
- Erschienen in
- Journal of General Internal Medicine | Ausgabe 8/2022
Abstract
Background
The WHO ordinal severity scale has been used to predict mortality and guide trials in COVID-19. However, it has its limitations.
Objective
The present study aims to compare three classificatory and predictive models: the WHO ordinal severity scale, the model based on inflammation grades, and the hybrid model.
Design
Retrospective cohort study with patient data collected and followed up from March 1, 2020, to May 1, 2021, from the nationwide SEMI-COVID-19 Registry. The primary study outcome was in-hospital mortality. As this was a hospital-based study, the patients included corresponded to categories 3 to 7 of the WHO ordinal scale. Categories 6 and 7 were grouped in the same category.
Key Results
A total of 17,225 patients were included in the study. Patients classified as high risk in each of the WHO categories according to the degree of inflammation were as follows: 63.8% vs. 79.9% vs. 90.2% vs. 95.1% (p<0.001). In-hospital mortality for WHO ordinal scale categories 3 to 6/7 was as follows: 0.8% vs. 24.3% vs. 45.3% vs. 34% (p<0.001). In-hospital mortality for the combined categories of ordinal scale 3a to 5b was as follows: 0.4% vs. 1.1% vs. 11.2% vs. 27.5% vs. 35.5% vs. 41.1% (p<0.001). The predictive regression model for in-hospital mortality with our proposed combined ordinal scale reached an AUC=0.871, superior to the two models separately.
Conclusions
The present study proposes a new severity grading scale for COVID-19 hospitalized patients. In our opinion, it is the most informative, representative, and predictive scale in COVID-19 patients to date.
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- Titel
- WHO Ordinal Scale and Inflammation Risk Categories in COVID-19. Comparative Study of the Severity Scales
- Verfasst von
-
Manuel Rubio-Rivas, MD PhD
José María Mora-Luján, MD PhD
Francesc Formiga, MD PhD
Coral Arévalo-Cañas, MD
Juan Manuel Lebrón Ramos, MD PhD
María Victoria Villalba García, MD
Eva Mª Fonseca Aizpuru, MD
Jesús Díez-Manglano, MD
Francisco Arnalich Fernández, MD PhD
Juan Luis Romero Cabrera, MD
Gema María García García, MD PhD
Paula M. Pesqueira Fontan, MD
Juan Antonio Vargas Núñez, MD PhD
Santiago Jesús Freire Castro, MD
José Loureiro Amigo, MD
Maria de los Reyes Pascual Pérez, MD
José N. Alcalá Pedrajas, MD PhD
Daniel Encinas-Sánchez, MD
Carmen Mella Pérez, MD
Javier Ena, MD
Anyuli Gracia Gutiérrez, MD PhD
María José Esteban Giner, MD PhD
José F. Varona, MD PhD
Jesús Millán Núñez-Cortés, MD PhD
José-Manuel Casas-Rojo, MD PhD
on behalf of the SEMI-COVID-19 Network
- Publikationsdatum
- 08.04.2022
- Verlag
- Springer International Publishing
- Schlagwort
- COVID-19
- Erschienen in
-
Journal of General Internal Medicine / Ausgabe 8/2022
Print ISSN: 0884-8734
Elektronische ISSN: 1525-1497 - DOI
- https://doi.org/10.1007/s11606-022-07511-7
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