COVID Abdomen: SARS-CoV-2 Infection Presenting as ‘Acute Abdomen’ in a Child

Excerpt

To the Editor: Despite lesser incidence and disease severity of COVID-19 in children, growing evidence suggests huge heterogeneity in clinical presentation [1]. We describe an 11-y-old boy, who presented with fever, pain abdomen for five days, vomiting, loose stool for three days, transient non-itchy, maculopapular rashes on both feet. At admission, he had diffuse abdominal tenderness with guarding. He was kept nil by mouth and started on intravenous maintenance fluid and ceftriaxone. Initial blood investigations showed Hemoglobin 11.6 g/dl; total leukocyte count (TLC) – 11,500 cells/mm³ with 90% neutrophils (N) and 9% lymphocytes (L), Platelets – 3.0 Lakhs/mm³, CRP – 107 mg/L, hypoalbuminemia (2.6 g/dl), INR 1.46, Ferritin 666 ng/ml, LDH 233 U/L with preserved renal function, lactate and transaminases. CT abdomen revealed normal appendix, diffuse mural wall thickening in the terminal ileum and ascending colon with adjacent significant mesenteric lymphadenopathy. COVID-19 RT-PCR from the nasopharyngeal and oropharyngeal samples were negative. On day 3 of hospitalization child developed features of shock, required 40 ml/kg crystalloid fluid resuscitation. On extended evaluation, 2D ECHO was normal, CRP increased to 142 mg/L, D-dimer was high (2.16 mg/L) with negative pro-BNP and Troponin T. Due to worsening clinical condition, and negative yield in all other infective (dengue, leptospirosis, typhoid, scrub typhus) workup, we repeated COVID RT-PCR and it turned out to be positive on 10th day of illness. He was treated with 2 g/kg of IVIG in view of ‘acute inflammation associated with COVID’. Clinical and blood parameters improved and the child recovered over next two days. …