Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration
- 08.07.2023
- Verfasst von
- Piera Smeriglio
- Antoine Zalc
- Erschienen in
- Current Osteoporosis Reports | Ausgabe 5/2023
Abstract
Purpose of Review
This review aims to summarize (i) the latest evidence on cranial neural crest cells (CNCC) contribution to craniofacial development and ossification; (ii) the recent discoveries on the mechanisms responsible for their plasticity; and (iii) the newest procedures to ameliorate maxillofacial tissue repair.
Recent Findings
CNCC display a remarkable differentiation potential that exceeds the capacity of their germ layer of origin. The mechanisms by which they expand their plasticity was recently described. Their ability to participate to craniofacial bone development and regeneration open new perspectives for treatments of traumatic craniofacial injuries or congenital syndromes.
Summary
These conditions can be life-threatening, require invasive maxillofacial surgery and can leave deep sequels on our health or quality of life. With accumulating evidence showing how CNCC-derived stem cells potential can ameliorate craniofacial reconstruction and tissue repair, we believe a deeper understanding of the mechanisms regulating CNCC plasticity is essential to ameliorate endogenous regeneration and improve tissue repair therapies.
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- Titel
- Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration
- Verfasst von
-
Piera Smeriglio
Antoine Zalc
- Publikationsdatum
- 08.07.2023
- Verlag
- Springer US
- Erschienen in
-
Current Osteoporosis Reports / Ausgabe 5/2023
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241 - DOI
- https://doi.org/10.1007/s11914-023-00804-8
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