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Critical Care

Ausgabe 1/2020

Inhalt (697 Artikel)

Open Access Research

0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial

Vijai Williams, Muralidharan Jayashree, Karthi Nallasamy, Devi Dayal, Amit Rawat

Open Access Research

Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis

Torgeir Folkestad, Kjetil Gundro Brurberg, Kine Marie Nordhuus, Christine Kooy Tveiten, Anne Berit Guttormsen, Ingrid Os, Sigrid Beitland

Open Access Correction

Correction to: The association between premorbid beta blocker exposure and mortality in sepsis—a systematic review

Kaiquan Tan, Martin Harazim, Benjamin Tang, Anthony Mclean, Marek Nalos

Open Access Review

Brainstem dysfunction in critically ill patients

Sarah Benghanem, Aurélien Mazeraud, Eric Azabou, Vibol Chhor, Cassia Righy Shinotsuka, Jan Claassen, Benjamin Rohaut, Tarek Sharshar

Open Access Viewpoint

High Quality Targeted Temperature Management (TTM) After Cardiac Arrest

Fabio Silvio Taccone, Edoardo Picetti, Jean-Louis Vincent

Open Access Editorial

ECPR for out-of-hospital cardiac arrest: more evidence is needed

Graeme MacLaren, Amirali Masoumi, Daniel Brodie

Open Access Research

A novel urinary biomarker predicts 1-year mortality after discharge from intensive care

Esther Nkuipou-Kenfack, Agnieszka Latosinska, Wen-Yi Yang, Marie-Céline Fournier, Alice Blet, Blerim Mujaj, Lutgarde Thijs, Elodie Feliot, Etienne Gayat, Harald Mischak, Jan A. Staessen, Alexandre Mebazaa, Zhen-Yu Zhang, N. Deye, C. Fauvaux, A. Mebazaa, C. Damoisel, D. Payen, E. Azoulay, A. S. Moreau, L. Jacob, O. Marie, M. Wolf, R. Sonneville, R. Bronchard, I. Rennuit, C. Paugam, J. P. Mira, A. Cariou, A. Tesnières, N. Dufour, N. Anguel, L. Guérin, J. Duranteau, C. Ract, M. Leone, B. Pastène, T. Sharshar, A. Fayssoyl, J. L. Baudel, B. Guidet, Q. Lu, W. Jie Gu, N. Brechot, A. Combes, S. Jaber, A. Pradel, Y. Coisel, M. Conseil, A. Vieillard-Baron, L. Bodson, J. Y. Lefrant, L. Elotmani, A. Ayral, S. Lloret, S. Pily-Flouri, J. B. Pretalli, P. F. Laterre, V. Montiel, M. F. Dujardin, C. Berghe

Open Access Letter

Optimizing ceftolozane-tazobactam dosage during continuous renal replacement therapy: some nuances

Gerardo Aguilar, Rafael Ferriols, Sara Martínez-Castro, Carlos Ezquer, Ernesto Pastor, Jose A. Carbonell, Manuel Alós, David Navarro

Open Access Research

Impact of acyclovir use on survival of patients with ventilator-associated pneumonia and high load herpes simplex virus replication

Lukas Schuierer, Michael Gebhard, Hans-Georg Ruf, Ulrich Jaschinski, Thomas M. Berghaus, Michael Wittmann, Georg Braun, Dirk H. Busch, Reinhard Hoffmann

Open Access Research

Should the ultrasound probe replace your stethoscope? A SICS-I sub-study comparing lung ultrasound and pulmonary auscultation in the critically ill

Eline G. M. Cox, Geert Koster, Aidan Baron, Thomas Kaufmann, Ruben J. Eck, T. Corien Veenstra, Bart Hiemstra, Adrian Wong, Thomas C. Kwee, Jaap E. Tulleken, Frederik Keus, Renske Wiersema, Iwan C. C. van der Horst, Geert Koster, Frederik Keus, Iwan C. C. van der Horst, Willem Dieperink, Roos Bleijendaal, Yasmin F. Cawale, Ramon P. Clement, Devon Dijkhuizen, Ruben J. Eck, Bart Hiemstra, Anja Haker, Casper D. H. Hilbink, Thomas Kaufmann, Martiene Klasen, Manon Klaver, Laura J. Schokking, Victor W. Sikkens, Madelon Vos, Justin Woerlee, Renske Wiersema

Open Access Research

New-onset atrial fibrillation and associated outcomes and resource use among critically ill adults—a multicenter retrospective cohort study

Shannon M. Fernando, Rebecca Mathew, Benjamin Hibbert, Bram Rochwerg, Laveena Munshi, Allan J. Walkey, Morten Hylander Møller, Trevor Simard, Pietro Di Santo, F. Daniel Ramirez, Peter Tanuseputro, Kwadwo Kyeremanteng

Open Access Research

Sublingual microcirculation does not reflect red blood cell transfusion thresholds in the intensive care unit—a prospective observational study in the intensive care unit

Jonas Scheuzger, Anna Zehnder, Vera Meier, Desirée Yeginsoy, Julian Flükiger, Martin Siegemund

Open Access Review

Clinical controversies in anticoagulation monitoring and antithrombin supplementation for ECMO

Meghan M. Chlebowski, Sirine Baltagi, Mel Carlson, Jerrold H. Levy, Philip C. Spinella

Open Access Letter

Biomarkers to delineate bacteremia from candidemia remain a challenging issue

Patrick M. Honore, Christina David, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

Open Access Letter

Mechanical ventilation and neurocritical patients: is there a role for anti-neuroinflammatory therapies?

Giovanni Giordano, Francesco Pugliese, Federico Bilotta

Open Access Research

Systematic assessment of fluid responsiveness during early septic shock resuscitation: secondary analysis of the ANDROMEDA-SHOCK trial

Eduardo Kattan, Gustavo A. Ospina-Tascón, Jean-Louis Teboul, Ricardo Castro, Maurizio Cecconi, Giorgio Ferri, Jan Bakker, Glenn Hernández, Glenn Hernandez, Gustavo Ospina-Tascón, Lucas Petri Damiani, Elisa Estenssoro, Arnaldo Dubin, Javier Hurtado, Gilberto Friedman, Ricardo Castro, Leyla Alegría, Jean-Louis Teboul, Maurizio Cecconi, Giorgio Ferri, Manuel Jibaja, Ronald Pairumani, Paula Fernández, Diego Barahona, Alexandre Biasi Cavalcanti, Jan Bakker, Glenn Hernandez, Leyla Alegría, Giorgio Ferri, Nicolás Rodriguez, Patricia Holger, Natalia Soto, Mario Pozo, Jan Bakker, Deborah Cook, Jean-Louis Vincent, Bryan P. Kavanagh, Phil Dellinger, Wim Rietdijk

Open Access Research

Variability in usual care fluid resuscitation and risk-adjusted outcomes for mechanically ventilated patients in shock

Jason N. Mansoori, Walter Linde-Zwirble, Peter C. Hou, Edward P. Havranek, Ivor S. Douglas

Open Access Research

Effects of endovascular and surface cooling on resuscitation in patients with cardiac arrest and a comparison of effectiveness, stability, and safety: a systematic review and meta-analysis

Xueli Liao, Ziyu Zhou, Manhong Zhou, Hui Tang, Menglong Feng, Bujin Kou, Ni Zhu, Futuan Liao, Liaozhang Wu

Open Access Research

Time to appropriate antibiotic therapy is a predictor of outcome in patients with bloodstream infection caused by KPC-producing Klebsiella pneumoniae

Marco Falcone, Matteo Bassetti, Giusy Tiseo, Cesira Giordano, Elia Nencini, Alessandro Russo, Elena Graziano, Enrico Tagliaferri, Alessandro Leonildi, Simona Barnini, Alessio Farcomeni, Francesco Menichetti

Open Access Letter

Mechanical ventilation and long-term neurocognitive impairment after acute respiratory distress syndrome

Giovanni Giordano, Francesco Pugliese, Federico Bilotta

Open Access Research

The impact of high frequency oscillatory ventilation on mortality in paediatric acute respiratory distress syndrome

Judith Ju-Ming Wong, Siqi Liu, Hongxing Dang, Nattachai Anantasit, Phuc Huu Phan, Suwannee Phumeetham, Suyun Qian, Jacqueline Soo May Ong, Chin Seng Gan, Yek Kee Chor, Rujipat Samransamruajkit, Tsee Foong Loh, Mengling Feng, Jan Hau Lee

Open Access Research

The effect of cisatracurium infusion on the energy expenditure of critically ill patients: an observational cohort study

W. A. C. Koekkoek, Y. A. Menger, F. J. L. van Zanten, D. van Dijk, A. R. H. van Zanten

Open Access Research

Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study

Nicola Latronico, Simone Piva, Nazzareno Fagoni, Lorenzo Pinelli, Michele Frigerio, Davide Tintori, Maurizio Berardino, Andrea Bottazzi, Livio Carnevale, Tiziana Casalicchio, Carlo Alberto Castioni, Simona Cavallo, Davide Cerasti, Giuseppe Citerio, Marco Fontanella, Serena Galiberti, Alan Girardini, Paolo Gritti, Ornella Manara, Paolo Maremmani, Roberta Mazzani, Giuseppe Natalini, Mirko Patassini, Maria Elena Perna, Ilaria Pesaresi, Danila Katia Radolovich, Maurizio Saini, Roberto Stefini, Cosetta Minelli, Roberto Gasparotti, Francesco A. Rasulo

Open Access Research

Real-time shear wave ultrasound elastography: a new tool for the evaluation of diaphragm and limb muscle stiffness in critically ill patients

Aurelien Flatres, Yassir Aarab, Stephanie Nougaret, Fanny Garnier, Romaric Larcher, Mathieu Amalric, Kada Klouche, Pascal Etienne, Gilles Subra, Samir Jaber, Nicolas Molinari, Stefan Matecki, Boris Jung

Open Access Review

Nutrition therapy in critical illness: a review of the literature for clinicians

Kate J. Lambell, Oana A. Tatucu-Babet, Lee-anne Chapple, Dashiell Gantner, Emma J. Ridley

Open Access Review

Vasoplegic syndrome following cardiothoracic surgery—review of pathophysiology and update of treatment options

Laurence W. Busse, Nicholas Barker, Christopher Petersen

Open Access Correction

Correction to: Screening for posttraumatic stress disorder in ARDS survivors: validation of the impact of event Scale-6 (IES-6)

Megan M. Hosey, Jeannie-Marie S. Leoutsakos, Ximin Li, Victor D. Dinglas, O. Joseph Bienvenu, Ann M. Parker, Ramona O. Hopkins, Dale M. Needham, Karin J. Neufeld

Open Access Letter

How I use transcranial Doppler in the ICU

Chidinma L. Onweni, Diane C. McLaughlin, William D. Freeman

Open Access Editorial

Which component of mechanical power is most important in causing VILI?

John J. Marini, Patricia R. M. Rocco

Open Access Correction

Correction to: Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study

Peter M. C. Klein Klouwenberg, Cristian Spitoni, Tom van der Poll, Marc J. Bonten, Olaf L. Cremer, Marcus J. Schultz, Janneke Horn, Brendon Scicluna, Maryse A. Wiewel, Jos F. Frencken, Kirsten van de Groep, Marlies E. Koster-Brouwer, David S.Y. Ong, Diana Verboom, Friso M. de Beer, Lieuwe D. J. Bos, Gerie J. Glas, Roosmarijn T. M. van Hooijdonk, Laura R. A. Schouten, Marleen Straat, Esther Witteveen, Luuk Wieske, Arie J. Hoogendijk, Mischa A. Huson, Lonneke A. van Vught

Open Access Research

Machine learning algorithm to predict mortality in patients undergoing continuous renal replacement therapy

Min Woo Kang, Jayoun Kim, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Yon Su Kim, Seung Seok Han

Open Access Research

Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock

Rinaldo Bellomo, Richard G. Wunderink, Harold Szerlip, Shane W. English, Laurence W. Busse, Adam M. Deane, Ashish K. Khanna, Michael T. McCurdy, Marlies Ostermann, Paul J. Young, Damian R. Handisides, Lakhmir S. Chawla, George F. Tidmarsh, Timothy E. Albertson

Open Access Review

Surgery for spontaneous intracerebral hemorrhage

Airton Leonardo de Oliveira Manoel

Open Access Research

Lactate kinetics in ICU patients using a bolus of 13C-labeled lactate

Jonathan Grip, Tobias Falkenström, Panuwat Promsin, Jan Wernerman, Åke Norberg, Olav Rooyackers

Open Access Research

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis

Jeffery Ho, Hung Chan, Yonghao Liang, Xiaodong Liu, Lin Zhang, Qing Li, Yuchen Zhang, Judeng Zeng, Felix N. Ugwu, Idy H. T. Ho, Wei Hu, Johnny C. W. Yau, Sunny H. Wong, Wai Tat Wong, Lowell Ling, Chi H. Cho, Richard L. Gallo, Tony Gin, Gary Tse, Jun Yu, Matthew T. V. Chan, Czarina C. H. Leung, William K. K. Wu

Open Access Letter

New alternative to antidotes for novel oral anticoagulants and ticagrelor in the case of severe bleeding

Patrick M. Honore, Christina David, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

Open Access Research

Determining the optimal time for liberation from renal replacement therapy in critically ill patients: a systematic review and meta-analysis (DOnE RRT)

Riley Jeremy Katulka, Abdalrhman Al Saadon, Meghan Sebastianski, Robin Featherstone, Ben Vandermeer, Samuel A. Silver, R. T. Noel Gibney, Sean M. Bagshaw, Oleksa G. Rewa

Open Access Research

Effects of very early start of norepinephrine in patients with septic shock: a propensity score-based analysis

Gustavo A. Ospina-Tascón, Glenn Hernandez, Ingrid Alvarez, Luis E. Calderón-Tapia, Ramiro Manzano-Nunez, Alvaro I. Sánchez-Ortiz, Egardo Quiñones, Juan E. Ruiz-Yucuma, José L. Aldana, Jean-Louis Teboul, Alexandre Biasi Cavalcanti, Daniel De Backer, Jan Bakker

Open Access Viewpoint

Nutritional support in sepsis: when less may be more

Gustav van Niekerk, Charné Meaker, Anna-Mart Engelbrecht

Open Access Research

Validation of neuromuscular blocking agent use in acute respiratory distress syndrome: a meta-analysis of randomized trials

Wei Chang, Qin Sun, Fei Peng, Jianfeng Xie, Haibo Qiu, Yi Yang

Open Access Research

Intrapulmonary concentrations of meropenem administered by continuous infusion in critically ill patients with nosocomial pneumonia: a randomized pharmacokinetic trial

Adela Benítez-Cano, Sonia Luque, Luisa Sorlí, Jesús Carazo, Isabel Ramos, Nuria Campillo, Víctor Curull, Albert Sánchez-Font, Carles Vilaplana, Juan P. Horcajada, Ramón Adalia, Silvia Bermejo, Enric Samsó, William Hope, Santiago Grau

Open Access Research

Defining persistent critical illness based on growth trajectories in patients with sepsis

Zhongheng Zhang, Kwok M. Ho, Hongqiu Gu, Yucai Hong, Yunsong Yu

Open Access Letter

Immune biomarker-based enrichment in sepsis trials

Thibaud Spinetti, Christian Meisel, Stephan von Gunten, Joerg C. Schefold

Open Access Letter

No dose adjustment of tigecycline is necessary during continuous renal replacement therapy: we are not sure

Patrick M. Honore, Cristina David, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Prognostic value of venous blood analysis at the start of CPR in non-traumatic out-of-hospital cardiac arrest: association with ROSC and the neurological outcome

Ervigio Corral Torres, Alberto Hernández-Tejedor, Rosa Suárez Bustamante, Ramón de Elías Hernández, Isabel Casado Flórez, Antonio San Juan Linares

Open Access Research

The global survival rate among adult out-of-hospital cardiac arrest patients who received cardiopulmonary resuscitation: a systematic review and meta-analysis

Shijiao Yan, Yong Gan, Nan Jiang, Rixing Wang, Yunqiang Chen, Zhiqian Luo, Qiao Zong, Song Chen, Chuanzhu Lv

Open Access Research

Fluid-limiting treatment strategies among sepsis patients in the ICU: a retrospective causal analysis

Zach Shahn, Nathan I. Shapiro, Patrick D. Tyler, Daniel Talmor, Li-wei H. Lehman

Open Access Letter

In severe liver disease, citrate can be used safely: the question remains—by which mechanism

Patrick M. Honore, Aurore Mugisha, Cristina David, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

Open Access Letter

Thrombolytic therapy during resuscitation for pulmonary embolism-related out-of-hospital cardiac arrest: perhaps not the ideal solution for everyone

Patrick M. Honore, Cristina David, Aude Mugisha, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

Open Access Research

International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)

Yogen Singh, Cecile Tissot, María V. Fraga, Nadya Yousef, Rafael Gonzalez Cortes, Jorge Lopez, Joan Sanchez-de-Toledo, Joe Brierley, Juan Mayordomo Colunga, Dusan Raffaj, Eduardo Da Cruz, Philippe Durand, Peter Kenderessy, Hans-Joerg Lang, Akira Nishisaki, Martin C. Kneyber, Pierre Tissieres, Thomas W. Conlon, Daniele De Luca

Open Access Research

Neuromonitoring of delirium with quantitative pupillometry in sedated mechanically ventilated critically ill patients

Eva Favre, Adriano Bernini, Paola Morelli, Jerôme Pasquier, John-Paul Miroz, Samia Abed-Maillard, Nawfel Ben-Hamouda, Mauro Oddo

Open Access Research

Pneumococcal purpura fulminans in asplenic or hyposplenic patients: a French multicenter exposed-unexposed retrospective cohort study

Damien Contou, Rémi Coudroy, Gwenhaël Colin, Jean-Marc Tadié, Martin Cour, Romain Sonneville, Armand Mekontso Dessap, Nicolas de Prost, Laurent Argaud, François Barbier, Amélie Bazire, Gaëtan Béduneau, Frédéric Bellec, Pascal Beuret, Pascal Blanc, Cédric Bruel, Christian Brun-Buisson, Gwenhaël Colin, Delphine Colling, Alexandre Conia, Rémi Coudroy, Martin Cour, Damien Contou, Fabrice Daviaud, Vincent Das, Jean Dellamonica, Nadège Demars, Stephan Ehrmann, Arnaud Galbois, Elodie Gelisse, Julien Grouille, Laurent Guérin, Emmanuel Guérot, Samir Jaber, Caroline Jannière, Sébastien Jochmans, Mathieu Jozwiak, Pierre Kalfon, Antoine Kimmoun, Alexandre Lautrette, Jérémie Lemarié, Charlène Le Moal, Christophe Lenclud, Nicolas Lerolle, Olivier Leroy, Antoine Marchalot, Bruno Mégarbane, Armand Mekontso Dessap, Etienne de Montmollin, Frédéric Pène, Claire Pichereau, Gaëtan Plantefève, Sébastien Préau, Gabriel Preda, Nicolas de Prost, Jean-Pierre Quenot, Sylvie Ricome, Damien Roux, Bertrand Sauneuf, Matthieu Schmidt, Guillaume Schnell, Romain Sonneville, Jean-Marc Tadié, Yacine Tandjaoui, Martial Tchir, Nicolas Terzi, Xavier Valette, Lara Zafrani, Benjamin Zuber

Open Access Research Letter

Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU

Alice Blet, Charles de Roquetaillade, Oliver Hartmann, Joachim Struck, Alexandre Mebazaa, Benjamin Glenn Chousterman, Pierre-François Laterre, Caroline Berghe, Marie-France Dujardin, Suzanne Renard, Xavier Wittebole, Christine Collienne, Diego Castanares Zapatero, Thierry Dugernier, Marco Vinetti, Nicolas de Schryver, Anne Thirifays, Jacques Mairesse, Vincent Huberlant, Hélène Petre, Isabelle Buelens, Pierre Henin, Hugues Trine, Yves Laurent, Loix Sébastien, Paul Geukens, Laurent Kehl, Bruno François, Philippe Vignon, Nicolas Pichon, Emmanuelle Begot, Anne-Laure Fedou, Catherine Chapellas, Antoine Galy, Nicolas Rodier, Ludmilla Baudrillart, Michelle Nouaille, Séverine Laleu, Claire Mancia, Thomas Daix, Paul Bourzeix, Isabelle Herafa, Anne-Aurore Duchambon, Jean Baptiste Lascarrou, Maud Fiancette, Gwenhael Colin, Matthieu Henry-Lagarrigue, Jean-Claude Lacherade, Christine Lebert, Laurent Martin-Levfèvre, Isabelle Vinatier, Aihem Yehia, Konstantinos Bachoumas, Aurélie Joret, Jean Reignier, Cécille Rousseau, Natacha Maquigneau, Yolaine Alcourt, Vanessa Erragne Zinzonni, Angélique Deschamps, Angelina Robert, Emmanuelle Mercier, Véronique Simeon-Vieules, Aurélie Aubrey, Christine Mabilat, Denis Garot, Stephan Ehrmann, Annick Legras, Youenn Jouan, Pierre François Dequin, Antoine Guillon, Laetitia Bodet-Contentin, Emmannuelle Rouve, Charlotte Salmon, Lysiane Brick, Stéphanie Massat, Arnaud Desachy, Marie Anne Fally, Laurence Robin, Christophe Cracco, Charles Lafon, Sylvie Calvat, Stéphane Rouleau, David Schnell, Sigismond Lasocki, Philippe Fesard, Damien Leblanc, Guillaume Bouhours, Claire Chassier, Mathieu Conte, Thomas Gaillard, Floriane Denou, Mathieu Kerymel, Marion Guyon, Anthéa Loiez, Stéphanie Lebreton, Ferhat Meziani, Hayat Allam, Samir Chenaf, Hassène Rahmani, Sarah Heenen, Christine Kummerlen, Xavier Delabranche, Alexandra Boivin, Raphaël Clere-Jehl, Yannick Rabouël, Julien Pottecher, Sophie Bayer, Catherine Metzger, Stéphane Hecketsweiler, Pierre Olivier Ludes, Hortense Besancenot, Nadia Dhif, Guy Freys, Jean-Marc Lessinger, Anne Launoy, Aude Ruimy, Alain Meyer, M. Szozot, Alexandre Mebazaa, Nicolas Deye, Etienne Gayat, Marie-Céline Fournier, Sarra Abroug, Badr Louadah, Elodie Feliot, Sebastian Voicu, Isabelle Malissin, Bruno Megarbane, Philippe Manivet, Gardianot Victori, Da Silva Kelly, Béatrice La Foucher, Valérie Pierre, Lamia Kerdjana, Thomas Beeken, Antoine Goury, Pierre Garcon, Samuel Gaugain, Benjamin Glenn Chousterman, Benjamin Huot, Romain Barthelemy, Benjamin Soyer, Laurent Jacob, Matthieu Legrand, Marie-Céline Fournier, Francine Bonnet, Chloé Legall, Haikel Oueslati, Alexandru Cupaciu, Philippe Manivet, Badr Louadah, Romain Sonneville, Sophie Letrou, Lila Bouadma, Bruno Mourvillier, Véronique Deiler, Eric Magalhaes, Mathilde Neuville, Jean-François Timsit, Aguila Radjou, Stéphane Gaudry, Emeline Dubief, Jonathan Messika, Béatrice La Combe, Damien Roux, Guillaume Berquier, Mohamed Laissi, Jean-Damien Ricard, Jean-Michel Constantin, Sebastien Perbet, Julie Delmas, Julien Pascal, Sophie Cayot, Renaud Guerin, Matthieu Jabaudon, Laurence Roszyk, Christine Rolhion, Justine Bourdier, Mathilde Lematte, Charlène Gouhier, Camille Verlhac, Thomas Godet, Sophiano Radji, Elodie Caumon, Sandrine Thibault, Nikolaus Marx, Tobias Schuerholz, Jessica Pezechk, Florian Feld, Christian Brülls, Thorben Beeker, Tim-Philipp Simon, Robert Deisz, Achim Schindler, Bianca Meier, Thorsten Janisch, Andreas Hohn, Dirk Schedler, Wolfgang Wetsch, Daniel Schröder, Andreas Meier-Hellmann, Alexander Lucht, Robert Henker, Magdalena Römmer, Torsten Meinig, Kai D. Zacharowski, Patrick Meybohm, Simone Lindau, Haitham Mutlak, Stefan Kluge, Grit Ringeis, Birgit Füllekrug, Brigitte Singer, Axel Nierhaus, Katrin Bangert, Geraldine de Heer, Daniel Frings, Valentin Fuhrmann, Jakob Müller, Jörg Schreiber, Barbara Sensen, Stephanie Siedler, Annekatrin Siewecke, Gerold Söffker, Dominic Wichmann, Mélanie Kerinn, Ulrich Jaschinski, Ilse Kreuser, Marlene Zanquila, Andreas Kortgen, Frank Bloos, Falk Gonnert, Daniel Thomas-Rüddel, Anja Haucke, Steffi Kolanos, Karina Knuhr Kohlberg, Petra Bloos, Katrin Schwope, Salvatore Di Somma, Marino Rossella, Veronica Russo, Santarelli Simona, Christopher Bartoli, Sylvia Navarin, Cristina Bongiovanni, Michela Orru, Daniela Quatrocchi, Giada Zoccoli, Antonella Varchetta, Massimo Antonelli, Gennaro de Pascale, Maria Sole Vallecoccia, Salvatore Lucio Cutuli, Valentina Digravio, Daniela Quattrochi, Sonia D’Arrigo, Filippo Elvino Leone, Bert Beishuizen, Martin Rinket, Natalie Border, Mariska Bos-Burgmeijer, Astrid Braad, S. Papendorp, Alexander Cornet, J. Vermeijden, Ronald J. Trof, Peter Pickkers, Marieke van de A, Helen Van Wezel, Leo Heunks, Natalie Border, Chantal Luijten-Arts, Astrid Hoedemaekers, Hans van der Hoeven, Noortje Roovers, Pleun Hemelaar

Open Access Research

Impact of protocolized diuresis for de-resuscitation in the intensive care unit

Brittany D. Bissell, Melanie E. Laine, Melissa L. Thompson Bastin, Alexander H. Flannery, Andrew Kelly, Jeremy Riser, Javier A. Neyra, Jordan Potter, Peter E. Morris

Open Access Research

Effect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock

Klaus Stahl, Julius J. Schmidt, Benjamin Seeliger, Bernhard M. W. Schmidt, Tobias Welte, Hermann Haller, Marius M. Hoeper, Ulrich Budde, Christian Bode, Sascha David

Open Access Letter

Treatment of influenza virus-related critical illness during continuous renal replacement therapy: take caution with dosing

Patrick M. Honore, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Effects of a national quality improvement program on ICUs in China: a controlled pre-post cohort study in 586 hospitals

Huaiwu He, Xudong Ma, Longxiang Su, Lu Wang, Yanhong Guo, Guangliang Shan, Hui Jing He, Xiang Zhou, Dawei Liu, Yun Long, Yupei Zhao, Shuyang Zhang

Open Access Research

Efficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients—a randomized clinical trial

Christopher Adlbrecht, Raphael Wurm, Pieter Depuydt, Herbert Spapen, Jose A. Lorente, Thomas Staudinger, Jacques Creteur, Christian Zauner, Andreas Meier-Hellmann, Philipp Eller, Margot Vander Laenen, Zsolt Molnár, István Várkonyi, Bernhard Schaaf, Mária Héjja, Vladimír Šrámek, Hauke Schneider, Niranjan Kanesa-thasan, Susanne Eder-Lingelbach, Anton Klingler, Katrin Dubischar, Nina Wressnigg, Jordi Rello

Open Access Research

Association between furosemide administration and outcomes in critically ill patients with acute kidney injury

Guang-ju Zhao, Chang Xu, Jian-chao Ying, Wen-biao Lü, Guang-liang Hong, Meng-fang Li, Bing Wu, Yong-ming Yao, Zhong-qiu Lu

Open Access Research

Brain BOLD MRI O2 and CO2 stress testing: implications for perioperative neurocognitive disorder following surgery

W. Alan C. Mutch, Renée El-Gabalawy, Lawrence Ryner, Josep Puig, Marco Essig, Kayla Kilborn, Kelsi Fidler, M. Ruth Graham

Open Access Research

Quality indicators for patients with traumatic brain injury in European intensive care units: a CENTER-TBI study

Jilske A. Huijben, Eveline J. A. Wiegers, Ari Ercole, Nicolette F. de Keizer, Andrew I. R. Maas, Ewout W. Steyerberg, Giuseppe Citerio, Lindsay Wilson, Suzanne Polinder, Daan Nieboer, David Menon, Hester F. Lingsma, Mathieu van der Jagt, Cecilia Åkerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Gérard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana M. Castaño-León, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Véronique De Keyser, Vincent Degos, Francesco Della Corte, Hugo den Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Dulière, Erzsébet Ezer, Martin Fabricius, Kelly Foks, Shirin Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro A. Gomez, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund Helbok, Eirik Helseth, Peter J. Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos G. Kolias, Daniel Kondziella, Evgenios Koraropoulos, Lars-Owe Koskinen, Noémi Kovács, Ana Kowark, Alfonso Lagares, Steven Laureys, Fiona Lecky, Didier Ledoux, Aurelie Lejeune, Roger Lightfoot, Alex Manara, Costanza Martino, Hugues Maréchal, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, József Nyirádi, Fabrizio Ortolano, Jean-François Payen, Vincent Perlbarg, Paolo Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi P. Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey V. Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oddrun Sandrød, Oliver Sakowitz, Renan Sanchez-Porras, Kari Schirmer-Mikalsen, Rico Frederik Schou, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Nino Stocchetti, Nina Sundström, Riikka Takala, Viktória Tamás, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Peter Vajkoczy, Shirley Vallance, Egils Valeinis, Zoltán Vámos, Gregory Van der Steen, Jeroen T. J. M. van Dijck, Thomas A. van Essen, Roel P. J. van Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Daphne Voormolen, Petar Vulekovic, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick A. Zeiler, Agate Ziverte, Tommaso Zoerle, Hans Clusmann

Open Access Correction

Correction to: Real-time shear wave ultrasound elastography: a new tool for the evaluation of diaphragm and limb muscle stiffness in critically ill patients

Aurelien Flatres, Yassir Aarab, Stephanie Nougaret, Fanny Garnier, Romaric Larcher, Mathieu Amalric, Kada Klouche, Pascal Etienne, Gilles Subra, Samir Jaber, Nicolas Molinari, Stefan Matecki, Boris Jung

Open Access Research

Effect of an ICU diary on psychiatric disorders, quality of life, and sleep quality among adult cardiac surgical ICU survivors: a randomized controlled trial

Shuo Wang, Hui-Ning Xin, Chiang Chung Lim Vico, Jin-Hua Liao, Sai-Lan Li, Na-Mei Xie, Rong-Fang Hu

Open Access Research

Effect of postextubation high-flow nasal cannula therapy on lung recruitment and overdistension in high-risk patient

Rui Zhang, Huaiwu He, Long Yun, Xiang Zhou, Xu Wang, Yi Chi, Siyi Yuan, Zhanqi Zhao

Open Access COVID-19 Letter

Preparing for COVID-19: early experience from an intensive care unit in Singapore

Mei Fong Liew, Wen Ting Siow, Graeme MacLaren, Kay Choong See

Open Access Research Letter

International survey on influenza-associated pulmonary aspergillosis (IAPA) in intensive care units: responses suggest low awareness and potential underdiagnosis outside Europe

Karin Thevissen, Cato Jacobs, Michelle Holtappels, Mitsuru Toda, Paul Verweij, Joost Wauters

Open Access Research

Assisted mechanical ventilation promotes recovery of diaphragmatic thickness in critically ill patients: a prospective observational study

Alice Grassi, Daniela Ferlicca, Ermes Lupieri, Serena Calcinati, Silvia Francesconi, Vittoria Sala, Valentina Ormas, Elena Chiodaroli, Chiara Abbruzzese, Francesco Curto, Andrea Sanna, Massimo Zambon, Roberto Fumagalli, Giuseppe Foti, Giacomo Bellani

Open Access Research

Role of ICU-acquired weakness on extubation outcome among patients at high risk of reintubation

Arnaud W. Thille, Florence Boissier, Michel Muller, Albrice Levrat, Gaël Bourdin, Sylvène Rosselli, Jean-Pierre Frat, Rémi Coudroy, Emmanuel Vivier

Open Access Letter

ECMO in paediatric septic shock: an urgent need for prospective trial

Xavier Beretta-Piccoli, Dominique Biarent, David De Bels, Patrick M. Honore, Sébastien Redant

Open Access Editorial

Use a “GHOST-CAP” in acute brain injury

Fabio Silvio Taccone, Airton Leonardo De Oliveira Manoel, Chiara Robba, Jean-Louis Vincent

Open Access Editorial

Coronavirus: just imagine…

Jean-Louis Vincent, Arthur S. Slutsky

Open Access COVID-19 Editorial

Treatment of COVID-19: old tricks for new challenges

Anne Catherine Cunningham, Hui Poh Goh, David Koh

Open Access Letter

Endostatin shows a useful value for predicting failure to recover from acute kidney injury: some confounders to consider

Patrick M. Honore, Christina David, Aude Mugisha, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

Open Access Letter

N-terminal pro-brain natriuretic peptide levels during the acute phase of sepsis may be a useful indicator of higher risk of long-term impairments: some confounders to consider

Patrick M. Honore, Cristina David, Aude Mugisha, Rachid Attou, Sebastien Redant, Andrea Gallerani, David De Bels

Open Access COVID-19 Letter

Safe patient transport for COVID-19

Mei Fong Liew, Wen Ting Siow, Ying Wei Yau, Kay Choong See

Open Access Research

Impact of concomitant vasoactive treatment and mechanical left ventricular unloading in a porcine model of profound cardiogenic shock

Nanna L. J. Udesen, Ole K. L. Helgestad, Ann B. S. Banke, Peter H. Frederiksen, Jakob Josiassen, Lisette O. Jensen, Henrik Schmidt, Elazer R. Edelman, Brian Y. Chang, Hanne B. Ravn, Jacob E. Møller

Open Access Research

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

Marine Mommert, Olivier Tabone, Audrey Guichard, Guy Oriol, Elisabeth Cerrato, Mélanie Denizot, Valérie Cheynet, Alexandre Pachot, Alain Lepape, Guillaume Monneret, Fabienne Venet, Karen Brengel-Pesce, Julien Textoris, François Mallet, Christine Alberti-Segui, Bernard Allaouchiche, Laurent Argaud, Frédéric Aubrun, Véronique Barbalat, Thomas Baudry, Julien Bohé, Marie-Angélique Cazalis, Elisabeth Cerrato, Martin Cour, Sylvie De La Salle, Benjamin Delwarde, Bernard Floccard, Arnaud Friggeri, Emmanuelle Gallet-Gorius, Christian Guillaume, Romain Hernu, Audrey Larue-Triolet, Alain Lepape, Guillaume Marcotte, Delphine Maucort-Boulch, Boris Meunier, Guillaume Monneret, Stéphane Morisset, Julie Mouillaux, Alexandre Pachot, Mathieu Page, Nathalie Panel, Estelle Peronnet, Vincent Piriou, Anne Portier, Marion Provent, Thomas Rimmelé, Marie Simon, Julien Textoris, Fabrice Thiolliere, Hélène Vallin, Fabienne Venet, André Boibieux, Julien Davidson, Laure Fayolle-PivoT, Julie Gatel, Charline Genin, Arnaud Gregoire, Alain Lepape, Anne-Claire Lukaszewicz, Guillaume Marcotte, Marie Matray, Delphine Maucort-Boulch, Guillaume Monneret, Nathalie Panel, Thomas Rimmele, Hélène Vallin, Fabienne Venet, Sophie Blein, Karen Brengel-Pesce, Elisabeth Cerrato, Valérie Cheynet, Emmanuelle Gallet-Gorius, Audrey Guichard, Camille Jourdan, Natacha Koenig, François Mallet, Boris Meunier, Virginie Moucadel, Marine Mommert, Guy Oriol, Alexandre Pachot, Claire Schrevel, Olivier Tabone, Julien Textoris, Javier Yugueros Marcos, Jérémie Becker, Frédéric Bequet, Yacine Bounab, Florian Brajon, Bertrand Canard, Muriel Collus, Nathalie Garcon, Irène Gorse, Cyril Guyard, Fabien Lavocat, Philippe Leissner, Karen Louis, Maxime Mistretta, Jeanne Moriniere, Yoann MouscaZ, Laura Noailles, Magali Perret, Frédéric Reynier, Cindy Riffaud, Mary-Luz Rol, Nicolas Sapay, Trang Tran, Christophe Vedrine, Christophe Carre, Pierre Cortez, Aymeric De Monfort, Karine Florin, Laurent Fraisse, Isabelle Fugier, Maïna L’Azou, Sandrine Payrard, Annick PELERAUX, Laurence Quemeneur, Andrew Griffiths, Stephanie Toetsch, Teri Ashton, Peter J. Gough, Scott B. Berger, David Gardiner, Iain Gillespie, Aidan Macnamara, Aparna Raychaudhuri, Rob Smylie, Lionel Tan, Craig Tipple

Open Access Review

Burnout and Joy in the Profession of Critical Care Medicine

Meeta Prasad Kerlin, Joanne McPeake, Mark E. Mikkelsen

Open Access Review

Heterogeneity of Cardiovascular Response to Standardized Sepsis Resuscitation

Fabio Guarracino, Pietro Bertini, Michael R. Pinsky

Open Access Review

Essential Noninvasive Multimodality Neuromonitoring for the Critically Ill Patient

Frank A. Rasulo, Tommaso Togni, Stefano Romagnoli

Open Access Review

Artificial Intelligence in the Intensive Care Unit

Guillermo Gutierrez

Open Access Review

ARDS Subphenotypes: Understanding a Heterogeneous Syndrome

Jennifer G. Wilson, Carolyn S. Calfee

Open Access Review

Respiratory Muscle Rehabilitation in Patients with Prolonged Mechanical Ventilation: A Targeted Approach

Bernie Bissett, Rik Gosselink, Frank M. P. van Haren

Open Access Review

Physiology of the Respiratory Drive in ICU Patients: Implications for Diagnosis and Treatment

Annemijn H. Jonkman, Heder J. de Vries, Leo M. A. Heunks

Open Access Review

Therapeutic Potential of the Gut Microbiota in the Management of Sepsis

Matteo Bassetti, Alessandra Bandera, Andrea Gori

Open Access COVID-19 Research Letter

Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan

Yu Shi, Xia Yu, Hong Zhao, Hao Wang, Ruihong Zhao, Jifang Sheng

Open Access Research

Risk factors for candidemia: a prospective matched case-control study

Julien Poissy, Lauro Damonti, Anne Bignon, Nina Khanna, Matthias Von Kietzell, Katia Boggian, Dionysios Neofytos, Fanny Vuotto, Valérie Coiteux, Florent Artru, Stephan Zimmerli, Jean-Luc Pagani, Thierry Calandra, Boualem Sendid, Daniel Poulain, Christian van Delden, Frédéric Lamoth, Oscar Marchetti, Pierre-Yves Bochud, J. D. Aubert, Ch. Berger, P.-Y. Bochud, K. Boggian, T. Calandra, A. Christe, A. Conen, C. Corti-Fragoso, P. Dutkowski, Ph. Eggimann, C. Garzoni, D. Goldenberger, N. Khanna, F. Lamoth, O. Marchetti, E. Marques Maggio, K. Mühlethaler, D. Neofytos, D. Sanglard, P. W. Schreiber, U. Schanz, C. van Delden, M. Von Kietzell, R. Zbinden, S. Zimmerli, F. Artru, A. Bignon, V. Coiteux, D. Deblauw, A. El Kalioubie, K. Faure, N. François, T. Galpérine, B. Guéry, E. Jaillette, E. Kipnis, D. Mathieu, C. Nilès, E. Parmentier-Decrucq, J. Poissy, D. Poulain, S. Préau, L. Rahmania, L. Robriquet, A. Rouzé, B. Sendid, E. Vega, B. Voisin, P. Weyrich

Open Access Research

Monocytic HLA-DR expression kinetics in septic shock patients with different pathogens, sites of infection and adverse outcomes

Guus P. Leijte, Thomas Rimmelé, Matthijs Kox, Niklas Bruse, Céline Monard, Morgane Gossez, Guillaume Monneret, Peter Pickkers, Fabienne Venet

Open Access Research

Changes in shunt, ventilation/perfusion mismatch, and lung aeration with PEEP in patients with ARDS: a prospective single-arm interventional study

Dan Stieper Karbing, Mauro Panigada, Nicola Bottino, Elena Spinelli, Alessandro Protti, Stephen Edward Rees, Luciano Gattinoni

Open Access Research Letter

Early sepsis identification following cytoreductive surgery for peritoneal malignancy

Darius Cameron Wilson, Danylo Yershov, Chandrakumaran Kandiah, Nicholas Cortes, Kirsty Gordon, Kordo Saeed

Open Access Letter

Prophylactic use of levosimendan in pediatric patients undergoing cardiac surgery: the jury is still out

Xavier Beretta-Piccoli, Dominique Biarent, David De Bels, Patrick M. Honore, Sébastien Redant

Open Access Letter

Prone positioning combined with high-flow nasal cannula in severe noninfectious ARDS

Orlando R. Pérez-Nieto, Manuel A. Guerrero-Gutiérrez, Ernesto Deloya-Tomas, Silvio A. Ñamendys-Silva

Open Access Research

Renal replacement therapy is independently associated with a lower risk of death in patients with severe acute kidney injury treated with targeted temperature management after out-of-hospital cardiac arrest

Yoon Hee Choi, Dong Hoon Lee, Je Hyeok Oh, Jung Hee Wee, Tae Chang Jang, Seung Pill Choi, Kyu Nam Park, Seung Pill Choi, Kyu Nam Park, Minjung Kathy Chae, Won Young Kim, Byung Kook Lee, Dong Hoon Lee, Tae Chang Jang, Jae Hoon Lee, Yoon Hee Choi, Je Sung You, Young Hwan Lee, In Soo Cho, Su Jin Kim, Jong-Seok Lee, Yong Hwan Kim, Min Seob Sim, Jonghwan Shin, Yoo Seok Park, Hyung Jun Moon, Won Jung Jeong, Joo Suk Oh, Kyoung-Chul Cha

Open Access Letter

Impact of HFOV in pARDS outcomes: questions remain

Hari Krishnan Kanthimathinathan, Martin C. J. Kneyber

Open Access Research

Factors associated with the development of septic shock in patients with candidemia: a post hoc analysis from two prospective cohorts

Matteo Bassetti, Antonio Vena, Marco Meroi, Celia Cardozo, Guillermo Cuervo, Daniele Roberto Giacobbe, Miguel Salavert, Paloma Merino, Francesca Gioia, Mario Fernández-Ruiz, Luis Eduardo López-Cortés, Benito Almirante, Laura Escolà-Vergé, Miguel Montejo, Manuela Aguilar-Guisado, Pedro Puerta-Alcalde, Mariona Tasias, Alba Ruiz-Gaitán, Fernando González, Mireia Puig-Asensio, Francesc Marco, Javier Pemán, Jesus Fortún, Jose Maria Aguado, Alejandro Soriano, Jordi Carratalá, Carolina Garcia-Vidal, Maricela Valerio, Assunta Sartor, Emilio Bouza, Patricia Muñoz

Open Access Letter

High-frequency oscillatory ventilation for PARDS: awaiting PROSPect

Martin C. J. Kneyber, Ira M. Cheifetz, Martha A. Q. Curley

Open Access COVID-19 Research Letter

Familial cluster of COVID-19 infection from an asymptomatic

Jinjun Zhang, Sijia Tian, Jing Lou, Yuguo Chen

Open Access COVID-19 Editorial

Special attention to nurses’ protection during the COVID-19 epidemic

Lishan Huang, Guanwen Lin, Li Tang, Lingna Yu, Zhilai Zhou

Open Access Review

The dawn of physiological closed-loop ventilation—a review

Philip von Platen, Anake Pomprapa, Burkhard Lachmann, Steffen Leonhardt

Open Access Research Letter

High-flow nasal cannula for body rewarming in hypothermia

Emanuele Gilardi, Martina Petrucci, Luca Sabia, Kidane Wolde Sellasie, Domenico Luca Grieco, Mariano Alberto Pennisi

Open Access Research Letter

Evaluation of the E-PRE-DELIRIC prediction model for ICU delirium: a retrospective validation in a UK general ICU

Sarah L. Cowan, Jacobus Preller, Robert J. B. Goudie

Open Access COVID-19 Editorial

Covid-19 in China: ten critical issues for intensive care medicine

Li Li, Shijin Gong, Jing Yan

Open Access Research

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study

Fabiana Madotto, Emanuele Rezoagli, Tài Pham, Marcello Schmidt, Bairbre McNicholas, Alessandro Protti, Rakshit Panwar, Giacomo Bellani, Eddy Fan, Frank van Haren, Laurent Brochard, John G. Laffey, Antonio Pesenti, John G. Laffey, Laurent Brochard, Andres Esteban, Luciano Gattinoni, Frank van Haren, Anders Larsson, Daniel F. McAuley, Marco Ranieri, Gordon Rubenfeld, B. Taylor Thompson, Hermann Wrigge, Arthur S. Slutsky, Fernando Rios, T. Sottiaux, P. Depuydt, Fredy S. Lora, Luciano Cesar Azevedo, Eddy Fan, Guillermo Bugedo, Haibo Qiu, Marcos Gonzalez, Juan Silesky, Vladimir Cerny, Jonas Nielsen, Manuel Jibaja, Tài Pham, Dimitrios Matamis, Jorge Luis Ranero, Pravin Amin, S. M. Hashemian, Kevin Clarkson, Giacomo Bellani, Kiyoyasu Kurahashi, Asisclo Villagomez, Amine Ali Zeggwagh, Leo M. Heunks, Jon Henrik Laake, Jose Emmanuel Palo, Antero do Vale Fernandes, Dorel Sandesc, Yaasen Arabi, Vesna Bumbasierevic, Nicolas Nin, Jose A. Lorente, Lise Piquilloud, Fekri Abroug, Daniel F. McAuley, Lia McNamee, Javier Hurtado, Ed Bajwa, Gabriel Démpaire, Uhc Mother Theresa, Hektor Sula, Lordian Nunci, Alma Cani, Villa Maria, Alan Zazu, Christian Dellera, Carolina S. Insaurralde, Risso V. Alejandro, Julio Daldin, Mauricio Vinzio, Ruben O. Fernandez, Luis P. Cardonnet, Lisandro R. Bettini, Mariano Carboni Bisso, Emilio M. Osman, Mariano G. Setten, Pablo Lovazzano, Javier Alvarez, Veronica Villar, Norberto C. Pozo, Nicolas Grubissich, Gustavo A. Plotnikow, Daniela N. Vasquez, Santiago Ilutovich, Norberto Tiribelli, Ariel Chena, Carlos A. Pellegrini, María G. Saenz, Elisa Estenssoro, Matias Brizuela, Hernan Gianinetto, Pablo E. Gomez, Valeria I. Cerrato, Marco G. Bezzi, Silvina A. Borello, Flavia A. Loiacono, Adriana M. Fernandez, Serena Knowles, Claire Reynolds, Deborah M. Inskip, Jennene J. Miller, Jing Kong, Christina Whitehead, Shailesh Bihari, Aylin Seven, Amanda Krstevski, Helen J. Rodgers, Rebecca T. Millar, Toni E. Mckenna, Irene M. Bailey, Gabrielle C. Hanlon, Anders Aneman, Joan M. Lynch, Raman Azad, John Neal, Paul W. Woods, Brigit L. Roberts, Mark R. Kol, Helen S. Wong, Katharina C. Riss, Thomas Staudinger, Xavier Wittebole, Caroline Berghe, Pierre A. Bulpa, Alain M. Dive, Rik Verstraete, Herve Lebbinck, Pieter Depuydt, Joris Vermassen, Philippe Meersseman, Helga Ceunen, Jonas I. Rosa, Daniel O. Beraldo, Claudio Piras, Adenilton M. Rampinelli, Antonio P. Nassar Jr, Sergio Mataloun, Marcelo Moock, Marlus M. Thompson, Claudio H. Gonçalves, Ana Carolina P. Antônio, Aline Ascoli, Rodrigo S. Biondi, Danielle C. Fontenele, Danielle Nobrega, Vanessa M. Sales, Suresh Shindhe, Dk Maizatul Aiman B. Pg Hj Ismail, John Laffey, Francois Beloncle, Kyle G. Davies, Rob Cirone, Venika Manoharan, Mehvish Ismail, Ewan C. Goligher, Mandeep Jassal, Erin Nishikawa, Areej Javeed, Gerard Curley, Nuttapol Rittayamai, Matteo Parotto, Niall D. Ferguson, Sangeeta Mehta, Jenny Knoll, Antoine Pronovost, Sergio Canestrini, Alejandro R. Bruhn, Patricio H. Garcia, Felipe A. Aliaga, Pamela A. Farías, Jacob S. Yumha, Claudia A. Ortiz, Javier E. Salas, Alejandro A. Saez, Luis D. Vega, Eduardo F. Labarca, Felipe T. Martinez, Nicolás G. Carreño, Pilar Lora, Haitao Liu, Ling Liu, Rui Tang, Xiaoming Luo, Youzhong An, Huiying Zhao, Yan Gao, Zhe Zhai, Zheng L. Ye, Wei Wang, Wenwen Li, Qingdong Li, Ruiqiang Zheng, Wenkui Yu, Juanhong Shen, Xinyu Li, Tao Yu, Weihua Lu, Ya Q. Wu, Xiao B. Huang, Zhenyang He, Yuanhua Lu, Hui Han, Fan Zhang, Renhua Sun, Hua X. Wang, Shu H. Qin, Bao H. Zhu, Jun Zhao, Jian Liu, Bin Li, Jing L. Liu, Fa C. Zhou, Qiong J. Li, Xing Y. Zhang, Zhou Li-Xin, Qiang Xin-Hua, Liangyan Jiang, Yuan N. Gao, Xian Y. Zhao, Yuan Y. Li, Xiao L. Li, Chunting Wang, Qingchun Yao, Rongguo Yu, Kai Chen, Huanzhang Shao, Bingyu Qin, Qing Q. Huang, Wei H. Zhu, Ai Y. Hang, Ma X. Hua, Yimin Li, Yonghao Xu, Yu D. Di, Long L. Ling, Tie H. Qin, Shou H. Wang, Junping Qin, Yi Han, Suming Zhou, Monica P. Vargas, Juan I. Silesky Jimenez, Manuel A. González Rojas, Jaime E. Solis-Quesada, Christian M. Ramirez-Alfaro, Jan Máca, Peter Sklienka, Jakob Gjedsted, Aage Christiansen, Boris G. Villamagua, Miguel Llano, Philippe Burtin, Gautier Buzancais, Pascal Beuret, Nicolas Pelletier, Satar Mortaza, Alain Mercat, Jonathan Chelly, Sébastien Jochmans, Nicolas Terzi, Cédric Daubin, Guillaume Carteaux, Nicolas de Prost, Jean-Daniel Chiche, Fabrice Daviaud, Tai Pham, Muriel Fartoukh, Guillaume Barberet, Jerome Biehler, Jean Dellamonica, Denis Doyen, Jean-Michel Arnal, Anais Briquet, Sami Hraiech, Laurent Papazian, Arnaud Follin, Damien Roux, Jonathan Messika, Evangelos Kalaitzis, Laurence Dangers, Alain Combes, Siu-Ming Au, Gaetan Béduneau, Dorothée Carpentier, Elie H. Zogheib, Herve Dupont, Sylvie Ricome, Francesco L. Santoli, Sebastien L. Besset, Philippe Michel, Bruno Gelée, Pierre-Eric Danin, Bernard Goubaux, Philippe J. Crova, Nga T. Phan, Frantz Berkelmans, Julio C. Badie, Romain Tapponnier, Josette Gally, Samy Khebbeb, Jean-Etienne Herbrecht, Francis Schneider, Pierre-Louis M. Declercq, Jean-Philippe Rigaud, Jacques Duranteau, Anatole Harrois, Russell Chabanne, Julien Marin, Charlene Bigot, Sandrine Thibault, Mohammed Ghazi, Messabi Boukhazna, Salem Ould Zein, Jack R. Richecoeur, Daniele M. Combaux, Fabien Grelon, Charlene Le Moal, Elise P. Sauvadet, Adrien Robine, Virginie Lemiale, Danielle Reuter, Martin Dres, Alexandre Demoule, Dany Goldgran-Toledano, Loredana Baboi, Claude Guérin, Ralph Lohner, Jens Kraßler, Susanne Schäfer, Kai D. Zacharowski, Patrick Meybohm, Andreas W. Reske, Philipp Simon, Hans-Bernd F. Hopf, Michael Schuetz, Thomas Baltus, Metaxia N. Papanikolaou, Theonymfi G. Papavasilopoulou, Giannis A. Zacharas, Vasilis Ourailogloy, Eleni K. Mouloudi, Eleni V. Massa, Eva O. Nagy, Electra E. Stamou, Ellada V. Kiourtzieva, Marina A. Oikonomou, Luis E. Avila, Cesar A. Cortez, Johanna E. Citalán, Sameer A. Jog, Safal D. Sable, Bhagyesh Shah, Mohan Gurjar, Arvind K. Baronia, Mohammedfaruk Memon, Radhakrishnan Muthuchellappan, Venkatapura J. Ramesh, Anitha Shenoy, Ramesh Unnikrishnan, Subhal B. Dixit, Rachana V. Rhayakar, Nagarajan Ramakrishnan, Vallish K. Bhardwaj, Heera L. Mahto, Sudha V. Sagar, Vijayanand Palaniswamy, Deeban Ganesan, Seyed Mohammadreza Hashemian, Hamidreza Jamaati, Farshad Heidari, Edel A. Meaney, Alistair Nichol, Karl M. Knapman, Donall O’Croinin, Eimhin S. Dunne, Dorothy M. Breen, Kevin P. Clarkson, Rola F. Jaafar, Rory Dwyer, Fahd Amir, Olaitan O. Ajetunmobi, Aogan C. O’Muircheartaigh, Colin S. Black, Nuala Treanor, Daniel V. Collins, Wahid Altaf, Gianluca Zani, Maurizio Fusari, Savino Spadaro, Carlo A. 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Open Access COVID-19 Editorial

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Philip Keith, Matthew Day, Linda Perkins, Lou Moyer, Kristi Hewitt, Adam Wells

Open Access Letter

Assessment of noise levels in the intensive care unit using Apple Watch

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Open Access Research

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Shannon M. Fernando, Danial Qureshi, Peter Tanuseputro, Sonny Dhanani, Anne-Marie Guerguerian, Sam D. Shemie, Robert Talarico, Eddy Fan, Laveena Munshi, Bram Rochwerg, Damon C. Scales, Daniel Brodie, Kednapa Thavorn, Kwadwo Kyeremanteng

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Louis Waeckel, Fabienne Venet, Morgane Gossez, Céline Monard, Thomas Rimmelé, Guillaume Monneret

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Open Access Letter

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Shou-Tao Yuan, Wen-Hao Zhang, Lei Zou, Jia-Kui Sun, Ying Liu, Qian-Kun Shi

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Open Access Letter

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Open Access Editorial

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Open Access Research

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Open Access COVID-19 Research Letter

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Open Access COVID-19 Research Letter

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Open Access COVID-19 Editorial

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Open Access Commentary

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Open Access Letter

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Open Access Research Letter

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Open Access Review

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Open Access COVID-19 Editorial

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Open Access Research Letter

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Open Access COVID-19 Editorial

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Open Access Research

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Open Access COVID-19 Research Letter

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Open Access Research

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Open Access Review

How to measure blood pressure using an arterial catheter: a systematic 5-step approach

Bernd Saugel, Karim Kouz, Agnes S. Meidert, Leonie Schulte-Uentrop, Stefano Romagnoli

Open Access Letter

Naloxone should remain the appropriate antidote to treat opioid overdose

Bruno Mégarbane, Lucie Chevillard, Dominique Vodovar

Open Access COVID-19 Research Letter

Lung ultrasound findings in patients with COVID-19 pneumonia

Changyang Xing, Qiaoying Li, Hong Du, Wenzhen Kang, Jianqi Lian, Lijun Yuan

Open Access COVID-19 Research Letter

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Giulia Lorenzoni, Corrado Lanera, Danila Azzolina, Paola Berchialla, Dario Gregori, Dario Gregori, Corrado Lanera, Paola Berchialla, Dolores Catelan, Danila Azzolina, Ilaria Prosepe, Annibale Biggeri, Cristina Canova, Elisa Gallo, Francesco Garzotto, Giulia Lorenzoni, Nicolas Destro

Open Access COVID-19 Review

COVID-19: ICU delirium management during SARS-CoV-2 pandemic

Katarzyna Kotfis, Shawniqua Williams Roberson, Jo Ellen Wilson, Wojciech Dabrowski, Brenda T. Pun, E. Wesley Ely

Open Access Research Letter

Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study

Hidehiko Nakano, Tsunehiro Matsubara, Kazuma Yamakawa, Kensuke Nakamura

Open Access COVID-19 Letter

Clinical determinants for fatality of 44,672 patients with COVID-19

Guangtong Deng, Mingzhu Yin, Xiang Chen, Furong Zeng

Open Access Letter

Who may benefit most from future vitamin D intervention trials: do not forget patients on continuous renal replacement therapy

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Vital-sign circadian rhythms in patients prior to discharge from an ICU: a retrospective observational analysis of routinely recorded physiological data

Shaun Davidson, Mauricio Villarroel, Mirae Harford, Eoin Finnegan, Joao Jorge, Duncan Young, Peter Watkinson, Lionel Tarassenko

Open Access COVID-19 Commentary

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Nicholas E. Ingraham, David Boulware, Matthew A. Sparks, Timothy Schacker, Bradley Benson, Jeffrey A. Sparks, Thomas Murray, John Connett, Jeffrey G. Chipman, Anthony Charles, Christopher J. Tignanelli

Open Access Letter

Association between metformin use prior to admission and lower mortality in septic adult patients with diabetes mellitus: beware of potential confounders

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Copeptin as a marker of outcome after cardiac arrest: a sub-study of the TTM trial

Joachim Düring, Martin Annborn, Tobias Cronberg, Josef Dankiewicz, Yvan Devaux, Christian Hassager, Janneke Horn, Jesper Kjaergaard, Michael Kuiper, Homa Rafi Nikoukhah, Pascal Stammet, Johan Undén, Michael Jaeger Wanscher, Matt Wise, Hans Friberg, Niklas Nielsen

Open Access COVID-19 Research Letter

Soluble urokinase plasminogen activator receptor (suPAR) as an early predictor of severe respiratory failure in patients with COVID-19 pneumonia

Nikoletta Rovina, Karolina Akinosoglou, Jesper Eugen-Olsen, Salim Hayek, Jochen Reiser, Evangelos J. Giamarellos-Bourboulis

Open Access Research

Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China

Dawei Wang, Yimei Yin, Chang Hu, Xing Liu, Xingguo Zhang, Shuliang Zhou, Mingzhi Jian, Haibo Xu, John Prowle, Bo Hu, Yirong Li, Zhiyong Peng

Open Access COVID-19 Research Letter

Liver injury in critically ill patients with COVID-19: a case series

Filipe S. Cardoso, Rui Pereira, Nuno Germano

Open Access Research

Plasma volume expansion and capillary leakage of 20% albumin in burned patients and volunteers

Markus Zdolsek, Robert G. Hahn, Folke Sjöberg, Joachim H. Zdolsek

Open Access Letter

Meropenem: continuous or extended infusion?

Frédéric Frippiat, Christelle Vercheval, Nathalie Layios

Open Access COVID-19 Research Letter

Can computed tomography be a primary tool for COVID-19 detection? Evidence appraisal through meta-analysis

Edward Pei-Chuan Huang, Chih-Wei Sung, Chi-Hsin Chen, Cheng-Yi Fan, Pei-Chun Lai, Yen-Ta Huang

Open Access Review

Heating, ventilation and air conditioning (HVAC) in intensive care unit

Sai Saran, Mohan Gurjar, Arvind Baronia, Vijayalakshmi Sivapurapu, Pralay S. Ghosh, Gautham M. Raju, Indubala Maurya

Open Access Review

Revisited: Therapeutic and toxic blood concentrations of more than 1100 drugs and other xenobiotics

Martin Schulz, Achim Schmoldt, Hilke Andresen-Streichert, Stefanie Iwersen-Bergmann

Open Access COVID-19 Editorial

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Xin Shen, Xiaoyue Zou, Xiaofeng Zhong, Jing Yan, Li Li

Open Access COVID-19 Editorial

Ethics guidelines on COVID-19 triage—an emerging international consensus

Susanne Joebges, Nikola Biller-Andorno

Open Access Research

Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study

Julie A. Stortz, Michael C. Cox, Russell B. Hawkins, Gabriela L. Ghita, Babette A. Brumback, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron, Scott C. Brakenridge, Frederick A. Moore

Open Access COVID-19 Review

COVID-19 and ECMO: the interplay between coagulation and inflammation—a narrative review

Mariusz Kowalewski, Dario Fina, Artur Słomka, Giuseppe Maria Raffa, Gennaro Martucci, Valeria Lo Coco, Maria Elena De Piero, Marco Ranucci, Piotr Suwalski, Roberto Lorusso

Open Access COVID-19 Editorial

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Jiarong Ye, Liqi Yang, Xiaotu Xi, Xinghua Lin, Deping He, Weiliang Wang

Open Access COVID-19 Editorial

Our recommendations for acute management of COVID-19

Francesco Mojoli, Silvia Mongodi, Anita Orlando, Eric Arisi, Marco Pozzi, Luca Civardi, Guido Tavazzi, Fausto Baldanti, Raffaele Bruno, Giorgio Antonio Iotti, Carlo Marena, Monica Calvi, Giuseppina Grugnetti, Marco Maurelli, Alba Muzzi, Bruno Raffaele, Paolo Lago, Gianluigi Marseglia, Stefano Perlini, Alessandra Palo, Fausto Baldanti, Luigi Oltrona Visconti, Angelo Guido Corsico, Antonio Di Sabatino, Francesco Mojoli, Giorgio Iotti, Marco Benazzo, Nicora Carlo, Triarico Antonio, Petronella Vincenzo

Open Access COVID-19 Letter

COVID-19 pandemic, healthcare providers’ contamination and death: an international view

Hossein Hassanian-Moghaddam, Nasim Zamani, Ali-Asghar Kolahi

Open Access COVID-19 Research Letter

Use of triiodothyronine to treat critically ill COVID-19 patients: a new clinical trial

Constantinos Pantos, Ioulia Tseti, Iordanis Mourouzis

Open Access COVID-19 Editorial

Chloroquine for COVID-19: rationale, facts, hopes

Andrea Cortegiani, Mariachiara Ippolito, Giulia Ingoglia, Sharon Einav

Open Access COVID-19 Letter

Students Supporting Critical Care – A contention plan to prevent the decompensation of ICUs in the COVID-19 pandemic:Translating Bjorn Ibsens’ polio-lessons to modern times

Pedro David Wendel Garcia, Paola Massarotto, Katja Auinger, Reto Andreas Schuepbach, Stephanie Klinzing

Open Access Review

Pulmonary complications associated with veno-arterial extra-corporeal membrane oxygenation: a comprehensive review

Aurélien Roumy, Lucas Liaudet, Marco Rusca, Carlo Marcucci, Matthias Kirsch

Open Access Research

Brain natriuretic peptide to predict successful liberation from mechanical ventilation in critically ill patients: a systematic review and meta-analysis

Jean Deschamps, Sarah K. Andersen, Jordan Webber, Robin Featherstone, Meghan Sebastianski, Ben Vandermeer, Janek Senaratne, Sean M. Bagshaw

Open Access COVID-19 Research Letter

Simultaneous ventilation of two simulated ARDS patients in COVID-19 pandemic

Danny Epstein, Yoav Hoffman, George Dahoud, Aeyal Raz, Asaf Miller

Open Access COVID-19 Review

Preparing your intensive care unit for the COVID-19 pandemic: practical considerations and strategies

Ken Junyang Goh, Jolin Wong, Jong-Chie Claudia Tien, Shin Yi Ng, Sewa Duu Wen, Ghee Chee Phua, Carrie Kah-Lai Leong

Open Access Research Letter

A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury

Raphaël Cinotti, Thierry Le Tourneau, Kalyane Bach-Ngohou, Maxime Le Courtois du Manoir, Bertrand Rozec, Karim Asehnoune

Open Access Letter

The use of a neuromuscular blocking agent could significantly decrease mortality in moderate-to-severe ARDS patients: is moderate ARDS the best indication for neuromuscular blocking agents

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Microcirculatory perfusion disturbances following cardiopulmonary bypass: a systematic review

Matthijs M. den Os, Charissa E. van den Brom, Anoek L. I. van Leeuwen, Nicole A. M. Dekker

Open Access COVID-19 Research

Patients with COVID-19 in 19 ICUs in Wuhan, China: a cross-sectional study

Yuan Yu, Dan Xu, Shouzhi Fu, Jun Zhang, Xiaobo Yang, Liang Xu, Jiqian Xu, Yongran Wu, Chaolin Huang, Yaqi Ouyang, Luyu Yang, Minghao Fang, Hongwen Xiao, Jing Ma, Wei Zhu, Song Hu, Quan Hu, Daoyin Ding, Ming Hu, Guochao Zhu, Weijiang Xu, Jun Guo, Jinglong Xu, Haitao Yuan, Bin Zhang, Zhui Yu, Dechang Chen, Shiying Yuan, You Shang

Open Access Research

Neurally adjusted ventilatory assist versus pressure support ventilation: a randomized controlled feasibility trial performed in patients at risk of prolonged mechanical ventilation

Daniel J. Hadfield, Louise Rose, Fiona Reid, Victoria Cornelius, Nicholas Hart, Clare Finney, Bethany Penhaligon, Jasmine Molai, Clair Harris, Sian Saha, Harriet Noble, Emma Clarey, Leah Thompson, John Smith, Lucy Johnson, Phillip A. Hopkins, Gerrard F. Rafferty

Open Access COVID-19 Research Letter

Age and sex differences in soluble ACE2 may give insights for COVID-19

Per Swärd, Andreas Edsfeldt, Anton Reepalu, Lars Jehpsson, Björn E. Rosengren, Magnus K. Karlsson

Open Access Research Letter

Safe doubling of ventilator capacity: a last resort proposal for last resorts

J. Geoffrey Chase, Yeong Shiong Chiew, Bernard Lambermont, Philippe Morimont, Geoffrey M. Shaw, Thomas Desaive

Open Access Research

Trauma complications and in-hospital mortality: failure-to-rescue

Toshikazu Abe, Akira Komori, Atsushi Shiraishi, Takehiro Sugiyama, Hiroki Iriyama, Takako Kainoh, Daizoh Saitoh

Open Access Research

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

Annika Reintam Blaser, Jean-Charles Preiser, Sonja Fruhwald, Alexander Wilmer, Jan Wernerman, Carina Benstoem, Michael P. Casaer, Joel Starkopf, Arthur van Zanten, Olav Rooyackers, Stephan M. Jakob, Cecilia I. Loudet, Danielle E. Bear, Gunnar Elke, Matthias Kott, Ingmar Lautenschläger, Jörn Schäper, Jan Gunst, Christian Stoppe, Leda Nobile, Valentin Fuhrmann, Mette M. Berger, Heleen M. Oudemans-van Straaten, Yaseen M. Arabi, Adam M. Deane, Annika Reintam Blaser, Jean-Charles Preiser, Sonja Fruhwald, Alexander Wilmer, Jan Wernerman, Carina Benstoem, Michael P. Casaer, Joel Starkopf, Arthur van Zanten, Olav Rooyackers, Stephan M. Jakob, Cecilia I. Loudet, Danielle E. Bear, Gunnar Elke, Matthias Kott, Ingmar Lautenschläger, Jörn Schäper, Jan Gunst, Christian Stoppe, Leda Nobile, Valentin Fuhrmann, Mette M. Berger, Heleen M. Oudemans-van Straaten, Yaseen M. Arabi, Adam M. Dean, Karin Amrein, Guillaume Besch, Brenno Belazi Nery de Souza Campos, Elisabeth De Waele, Vincent Fraipont, Teodoro Grau, Kursat Gundogan, Claudia Heidegger, Michael Hiesmayr, Carole Ichai, Mar Juan-Díaz, Kurt Kobke-Jacobsen, Vasiliki Koutsoukou, Marcus Laube, Juan Carlos Montejo González, Zudin Puthucheary, Anne-Francoise Rousseau, Pierre Singer, Sandra N. Stapel, Hakan Tekguc, Carlos Torruco-Sotelo

Open Access Research Letter

Prolonged prone position ventilation for SARS-CoV-2 patients is feasible and effective

Andrea Carsetti, Agnese Damia Paciarini, Benedetto Marini, Simona Pantanetti, Erica Adrario, Abele Donati

Open Access COVID-19 Letter

Therapeutic plasma exchange as a routine therapy in septic shock and as an experimental treatment for COVID-19: we are not sure

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series

Alberto Zangrillo, Giovanni Landoni, Luigi Beretta, Federica Morselli, Ary Serpa Neto, Rinaldo Bellomo, Anna Mara Scandroglio, Sergio Colombo, Antonio Dell’Acqua, Paolo Silvani, Evgeny Fominskiy, Giacomo Monti, Maria Luisa Azzolini, Antonio Bellantoni, Cristina Barberio, Gabriele Valsecchi, Omar Saleh, Gaetano Lombardi, Moreno Tresoldi, Paolo Scarpellini, Lorenzo Dagna, Fabio Ciceri, Yanase Fumitaka

Open Access COVID-19 Letter

COVID-19 mortality and ICU admission: the Italian experience

Paolo Immovilli, Nicola Morelli, Elio Antonucci, Guido Radaelli, Mario Barbera, Donata Guidetti

Open Access COVID-19 Letter

COVID-19: room for treating T cell exhaustion?

Giovanni Riva, Vincenzo Nasillo, Enrico Tagliafico, Tommaso Trenti, Mario Luppi

Open Access COVID-19 Research Letter

Advanced respiratory monitoring in COVID-19 patients: use less PEEP!

Lisanne Roesthuis, Maarten van den Berg, Hans van der Hoeven

Open Access Research

Severe diffuse alveolar hemorrhage related to autoimmune disease: a multicenter study

Adrien Mirouse, Antoine Parrot, Vincent Audigier, Alexandre Demoule, Julien Mayaux, Guillaume Géri, Eric Mariotte, Nicolas Bréchot, Nicolas de Prost, Mathieu Vautier, Mathilde Neuville, Naïke Bigé, Etienne de Montmollin, Patrice Cacoub, Matthieu Resche-Rigon, Jacques Cadranel, David Saadoun

Open Access COVID-19 Editorial

Unconventional approaches to mechanical ventilation—step-by-step through the COVID-19 crisis

Christopher Lotz, Quirin Notz, Peter Kranke, Markus Kredel, Patrick Meybohm

Open Access Letter

With the current COVID pandemic: should we use single-use flexible bronchoscopes instead of conventional bronchoscopes?

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research Letter

Bedside ultrasound measurement of optic nerve sheath diameter in patients with sepsis: a prospective observational study

Ziyue Yang, Cuihong Qin, Shuguang Zhang, Shaohua Liu, Tongwen Sun

Open Access COVID-19 Research Letter

Cardiovascular phenotypes in ventilated patients with COVID-19 acute respiratory distress syndrome

Bruno Evrard, Marine Goudelin, Noelie Montmagnon, Anne-Laure Fedou, Thomas Lafon, Philippe Vignon

Open Access COVID-19 Research Letter

Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients

Maria Vargas, Giuseppe De Marco, Stefania De Simone, Giuseppe Servillo

Open Access Research

Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019— results from a systematic review and meta-analysis

Michael Bauer, Herwig Gerlach, Tobias Vogelmann, Franziska Preissing, Julia Stiefel, Daniel Adam

Open Access Editorial

Interpreting trials on renal replacement therapy initiation: beware of methodologic issues

Stéphane Gaudry, Paul M. Palevsky, Didier Dreyfuss

Open Access COVID-19 Research Letter

Adjuvant corticosteroid therapy for critically ill patients with COVID-19

Xiaofan Lu, Taige Chen, Yang Wang, Jun Wang, Fangrong Yan

Open Access Research

A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality

Philip van der Zee, Wim Rietdijk, Peter Somhorst, Henrik Endeman, Diederik Gommers

Open Access Research

Hemophagocytic lymphohistiocytosis in critically ill patients: diagnostic reliability of HLH-2004 criteria and HScore

Cornelia Knaak, Peter Nyvlt, Friederike S. Schuster, Claudia Spies, Patrick Heeren, Thomas Schenk, Felix Balzer, Paul La Rosée, Gritta Janka, Frank M. Brunkhorst, Didier Keh, Gunnar Lachmann

Open Access COVID-19 Research Letter

Duration of SARS-CoV-2 viral RNA in asymptomatic carriers

Xiquan Yan, Xiaotong Han, Yong Fan, Zhixiong Fang, Da Long, Yimin Zhu

Open Access Research

Effect of mechanical power on intensive care mortality in ARDS patients

Silvia Coppola, Alessio Caccioppola, Sara Froio, Paolo Formenti, Valentina De Giorgis, Valentina Galanti, Dario Consonni, Davide Chiumello

Open Access COVID-19 Research Letter

Effect of flow and cannula size on generated pressure during nasal high flow

Maximilian Pinkham, Stanislav Tatkov

Open Access Research

Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study

Lisa Van Dyck, Ilse Vanhorebeek, Alexander Wilmer, An Schrijvers, Inge Derese, Liese Mebis, Pieter J. Wouters, Greet Van den Berghe, Jan Gunst, Michaël P. Casaer

Open Access COVID-19 Research Letter

Early awake prone position combined with high-flow nasal oxygen therapy in severe COVID-19: a case series

Qiancheng Xu, Tao Wang, Xuemei Qin, Yanli Jie, Lei Zha, Weihua Lu

Open Access Research Letter

Transfer of skills for difficult intubation after videolaryngoscopy training: a randomized simulation study

Adrian Kee, Reyor Ko, Rolando Capistrano, Melvin Dajac, Juvel Taculod, Kay Choong See

Open Access Letter

Nutritional therapy in patients with sepsis: is less really more?

Marie-Sophie Louise Yvonne de Koning, Florianne Johanna Louise van Zanten, Arthur Raymond Hubert van Zanten

Open Access COVID-19 Research Letter

The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis

Muhammad Aziz, Rawish Fatima, Wade Lee-Smith, Ragheb Assaly

Open Access COVID-19 Research Letter

Prone positioning combined with high-flow nasal or conventional oxygen therapy in severe Covid-19 patients

Cyrielle Despres, Yannick Brunin, Francis Berthier, Sebastien Pili-Floury, Guillaume Besch

Open Access COVID-19 Research Letter

Clinical analysis of sinus bradycardia in patients with severe COVID-19 pneumonia

Lijuan Hu, Linjing Gong, Zhilong Jiang, Qibing Wang, Yunzeng Zou, Lei Zhu

Open Access COVID-19 Letter

Prone ventilation of critically ill adults with COVID-19: how to perform CPR in cardiac arrest?

Wioletta Mędrzycka-Dąbrowska, Katarzyna Lewandowska, Daniel Ślęzak, Sebastian Dąbrowski

Open Access COVID-19 Research Letter

Two consecutive myocardial tissue insults for inpatients with COVID-19

Minghua Su, Jieru Peng, Mengjun Wu, Wuquan Deng, Yousheng Yang, Yong G. Peng

Open Access COVID-19 Letter

The importance of a “socially responsible” approach during COVID-19: the invisible heroes of science in Italy

Filippo Sanfilippo, Elena Bignami, Ferdinando Luca Lorini, Marinella Astuto

Open Access COVID-19 Letter

Essential ICU drug shortages for COVID-19: what can frontline clinicians do?

Wen Ting Siow, Simeon H. Tang, Rohit Vijay Agrawal, Addy Y. H. Tan, Kay Choong See

Open Access Letter

Acyclovir for ventilator-associated pneumonia refractory to antibiotics and with high viral herpes simplex load: we are not sure

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

Matthijs Kox, Tim Frenzel, Jeroen Schouten, Frank L. van de Veerdonk, Hans J. P. M. Koenen, Peter Pickkers, Pleun Hemelaar, Remi Beunders, Johannes van der Hoeven, Sjef van der Velde, Hetty van der Eng, Noortje Rovers, Margreet Klop-Riehl, Jelle Gerretsen, Emma Kooistra, Nicole Waalders, Wout Claassen, Hidde Heesakkers, Tirsa van Schaik, Mihai Netea, Leo Joosten, Nico Janssen, Inge Grondman, Aline de Nooijer, Quirijn de Mast, Martin Jaeger, Ilse Kouijzer, Helga Dijkstra, Heidi Lemmers, Reinout van Crevel, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esther Taks, Priya Debisarun, Heiman Wertheim, Joost Hopman, Janette Rahamat-Langendoen, Chantal Bleeker-Rovers, Esther Fasse, Esther van Rijssen, Manon Kolkman, Bram van Cranenbroek, Ruben Smeets, Irma Joosten

Open Access COVID-19 Letter

Universal mobile protection system for aerosol-generating medical interventions in COVID-19 patients

Florian Straube, Clemens Wendtner, Ellen Hoffmann, S. Volz, U. Dorwarth, M. Engel, N. Schneider, J. Lärmer, B. Nagel, P. Friederich, R. Fisch, A. Riess, J. Benedikter, F. J. Meyer, B. Lewerenz, W. Schepp, M. Schmid, C. Dodt, W. Schmidt, K. Weidenbach, S. Rogowski, H. Kossmann, M. Berger, C. Gatos, B. Wuerstl, M. Deichstetter

Open Access Editorial

How machine learning could be used in clinical practice during an epidemic

Charles Verdonk, Franck Verdonk, Gérard Dreyfus

Open Access Research

Low-resolution pressure reactivity index and its derived optimal cerebral perfusion pressure in adult traumatic brain injury: a CENTER-TBI study

Lennart Riemann, Erta Beqiri, Peter Smielewski, Marek Czosnyka, Nino Stocchetti, Oliver Sakowitz, Klaus Zweckberger, Andreas Unterberg, Alexander Younsi, Audny Anke, Ronny Beer, Bo-Michael Bellander, Andras Buki, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Endre Czeiter, Bart Depreitere, George Eapen, Shirin Frisvold, Raimund Helbok, Stefan Jankowski, Daniel Kondziella, Lars-Owe Koskinen, Geert Meyfroidt, Kirsten Moeller, David Nelson, Anna Piippo-Karjalainen, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Saulius Rocka, Rolf Rossaint, Juan Sahuquillo, Ana Stevanovic, Nina Sundström, Riikka Takala, Tomas Tamosuitis, Olli Tenovuo, Peter Vajkoczy, Alessia Vargiolu, Rimantas Vilcinis, Stefan Wolf

Open Access Research

Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis

Mengmeng Li, Congya Li, Xianan Wu, Tangtian Chen, Lei Ren, Banglao Xu, Ju Cao

Open Access Commentary

Recommendations for the use of vascular access in the COVID-19 patients: an Italian perspective

Mauro Pittiruti, Fulvio Pinelli, Mauro Pittiruti, Fulvio Pinelli, Maria Giuseppina Annetta, Sergio Bertoglio, Daniele G. Biasucci, Roberto Biffi, Simona Biondi, Fabrizio Brescia, Massimo Buononato, Giuseppe Capozzoli, Paolo Cotogni, Elisa Deganello, Laura Dolcetti, Daniele Elisei, Stefano Elli, Davide Giustivi, Emanuele Iacobone, Antonio La Greca, Massimo Lamperti, Giada Maspero, Giancarlo Scoppettuolo, Davide Vailati, Daniele Vezzali

Open Access Letter

Physiologic approach to diuresis in de-resuscitation phase in intensive care

Amos Lal, Juan Pablo Domecq Garces

Open Access Letter

The causal link between hyperchloremia and acute kidney injury is yet to be conclusively established: we are not sure

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Letter

COVID-19 pneumonia: phenotype assessment requires bedside tools

Zhanqi Zhao, Wan-Hsuan Kung, Hou-Tai Chang, Yeong-Long Hsu, Inéz Frerichs

Open Access COVID-19 Letter

Timely rehabilitation for critical patients with COVID-19: another issue should not be ignored

Zhen Wang, Zhongjing Wang, Ruixiang Sun, Xiaoye Wang, Shaofei Gu, Xiancui Zhang, Houbao Huang

Open Access COVID-19 Research Letter

Severe pulmonary embolism in COVID-19 patients: a call for increased awareness

Guillaume Hékimian, Guillaume Lebreton, Nicolas Bréchot, Charles-Edouard Luyt, Matthieu Schmidt, Alain Combes

Open Access COVID-19 Research Letter

Thrombotic and hemorrhagic events in critically ill COVID-19 patients: a French monocenter retrospective study

Megan Fraissé, Elsa Logre, Olivier Pajot, Hervé Mentec, Gaëtan Plantefève, Damien Contou

Open Access Letter

Endovascular cooling is superior to surface cooling in terms of effectiveness by improving the neurological prognosis, but what about the safety?

Patrick M. Honore, Aude Mugisha, Luc Kugener, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Fluid removal associates with better outcomes in critically ill patients receiving continuous renal replacement therapy: a cohort study

Anna Hall, Siobhan Crichton, Alison Dixon, Ilia Skorniakov, John A. Kellum, Marlies Ostermann

Open Access Research

Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study

Dimitri Titeca-Beauport, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Sami Alaya, Karim Chaoui, Maud Andrieu, Isabelle Rouquette-Vincenti, Frederic Godde, Michel Pascal, Momar Diouf, Christophe Vinsonneau, Kada Klouche, Julien Maizel

Open Access Review

The gut microbiome’s role in the development, maintenance, and outcomes of sepsis

Max W. Adelman, Michael H. Woodworth, Charles Langelier, Lindsay M. Busch, Jordan A. Kempker, Colleen S. Kraft, Greg S. Martin

Open Access Research

Duration of antibiotic therapy in critically ill patients: a randomized controlled trial of a clinical and C-reactive protein-based protocol versus an evidence-based best practice strategy without biomarkers

Isabela Borges, Rafael Carneiro, Rafael Bergo, Larissa Martins, Enrico Colosimo, Carolina Oliveira, Saulo Saturnino, Marcus Vinícius Andrade, Cecilia Ravetti, Vandack Nobre, Isabela N. Borges, Rafael M. Carneiro, Rafael Bergo, Larissa N. Martins, Enrico A. Colosimo, Carolina F. Oliveira, Saulo F. Saturnino, Marcus Vinícius M. Andrade, Cecilia G. Ravetti, Vandack Nobre

Open Access COVID-19 Editorial

Precision medicine for COVID-19: a call for better clinical trials

Gentle Sunder Shrestha, Hem Raj Paneru, Jean-Louis Vincent

Open Access Research Letter

Visualisation of limb movements by accelerometers in sedated patients

Erlend Flinstad Harbo, Silje S. Fuglerud, Nils Kristian Skjærvold

Open Access Research

Elastic power but not driving power is the key promoter of ventilator-induced lung injury in experimental acute respiratory distress syndrome

Patricia R. M. Rocco, Pedro L. Silva, Cynthia S. Samary, Muhammad K. Hayat Syed, John J. Marini

Open Access Research

Recommendations for fluid management of adults with sepsis in sub-Saharan Africa: a systematic review of guidelines

Benjamin Silberberg, Stephen Aston, Selda Boztepe, Shevin Jacob, Jamie Rylance

Open Access Research

Biomarkers of sepsis: time for a reappraisal

Charalampos Pierrakos, Dimitrios Velissaris, Max Bisdorff, John C. Marshall, Jean-Louis Vincent

Open Access COVID-19 Research Letter

Neutrophil-to-lymphocyte ratio as a predictive biomarker for moderate-severe ARDS in severe COVID-19 patients

Aijia Ma, Jiangli Cheng, Jing Yang, Meiling Dong, Xuelian Liao, Yan Kang

Open Access COVID-19 Editorial

The challenge of ventilator-associated pneumonia diagnosis in COVID-19 patients

Bruno François, Pierre-François Laterre, Charles-Edouard Luyt, Jean Chastre

Open Access COVID-19 Research Letter

Elevation of plasma angiotensin II level is a potential pathogenesis for the critically ill COVID-19 patients

Zhiyong Wu, Rui Hu, Cuizhen Zhang, Wei Ren, Anfeng Yu, Xiaoyang Zhou

Open Access Research

Procedural volume and outcomes in patients undergoing VA-ECMO support

Peter Moritz Becher, Alina Goßling, Benedikt Schrage, Raphael Twerenbold, Nina Fluschnik, Moritz Seiffert, Alexander M. Bernhardt, Hermann Reichenspurner, Stefan Blankenberg, Dirk Westermann

Open Access COVID-19 Review

In-hospital airway management of COVID-19 patients

Elise H. Sullivan, Lauren E. Gibson, Lorenzo Berra, Marvin G. Chang, Edward A. Bittner

Open Access COVID-19 Viewpoint

Admission decisions to intensive care units in the context of the major COVID-19 outbreak: local guidance from the COVID-19 Paris-region area

Élie Azoulay, Sadek Beloucif, Bertrand Guidet, Dominique Pateron, Benoît Vivien, Matthieu Le Dorze

Open Access Letter

Detecting influenza-associated pulmonary aspergillosis by determination of galactomannan in broncho-alveolar lavage fluid and in serum: should we add (1,3)-beta-D-glucan to improve efficacy

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Editorial

How COVID-19 pandemic changed our communication with families: losing nonverbal cues

Annachiara Marra, Pasquale Buonanno, Maria Vargas, Carmine Iacovazzo, Eugene Wesley Ely, Giuseppe Servillo

Open Access COVID-19 Research Letter

Body temperature correlates with mortality in COVID-19 patients

Serena Tharakan, Koichi Nomoto, Satoshi Miyashita, Kiyotake Ishikawa

Open Access COVID-19 Research Letter

Clinical characteristics of invasive pulmonary aspergillosis in patients with COVID-19 in Zhejiang, China: a retrospective case series

Jie Wang, Qing Yang, Piaopiao Zhang, Jifang Sheng, Jianying Zhou, Tingting Qu

Open Access COVID-19 Research Letter

Lung ventilation function characteristics of survivors from severe COVID-19: a prospective study

Xianyong Li, Changsong Wang, Shengjie Kou, Peiyao Luo, Mingyan Zhao, Kaijiang Yu

Open Access COVID-19 Review

ECMO use in COVID-19: lessons from past respiratory virus outbreaks—a narrative review

Hwa Jin Cho, Silver Heinsar, In Seok Jeong, Kiran Shekar, Gianluigi Li Bassi, Jae Seung Jung, Jacky Y. Suen, John F. Fraser

Open Access Research

Morbidity and mortality in critically ill patients with invasive group A streptococcus infection: an observational study

Viveka Björck, Lisa I. Påhlman, Mikael Bodelsson, Ann-Cathrine Petersson, Thomas Kander

Open Access COVID-19 Research Letter

PEEP levels in COVID-19 pneumonia

Vasiliki Tsolaki, Ilias Siempos, Eleni Magira, Stelios Kokkoris, George E. Zakynthinos, Spyros Zakynthinos

Open Access Research

Maximum emergency department overcrowding is correlated with occurrence of unexpected cardiac arrest

June-sung Kim, Hyun-Jin Bae, Chang Hwan Sohn, Sung-Eun Cho, Jeongeun Hwang, Won Young Kim, Namkug Kim, Dong-Woo Seo

Open Access Editorial

How I approach weaning from venoarterial ECMO

Justin A. Fried, Amirali Masoumi, Koji Takeda, Daniel Brodie

Open Access Commentary

Health-related quality of life after critical care—the emperor’s new clothes

Folke Sjöberg, Lotti Orwelius, Sören Berg

Open Access COVID-19 Research Letter

Peritoneal dialysis for COVID-19-associated acute kidney injury

Mika Nagatomo, Hiroyuki Yamada, Ken Shinozuka, Manabu Shimoto, Tomoyuki Yunoki, Shigeru Ohtsuru

Open Access Editorial

Neutrophil Elastase Inhibitors: A potential prophylactic treatment option for SARS-CoV-2-induced respiratory complications?

Mahmoud M. A. Mohamed, Ismail Amr El-Shimy, Muhammad Abdul Hadi

Open Access Research

Serum and fecal profiles of aromatic microbial metabolites reflect gut microbiota disruption in critically ill patients: a prospective observational pilot study

Ekaterina Chernevskaya, Natalia Beloborodova, Natalia Klimenko, Alisa Pautova, Dmitrii Shilkin, Vitaliy Gusarov, Alexander Tyakht

Open Access COVID-19 Research Letter

Non-febrile COVID-19 patients were common and often became critically ill: a retrospective multicenter cohort study

Yichen Li, Na Jiao, Lixin Zhu, Sijing Cheng, Ruixin Zhu, Ping Lan

Open Access COVID-19 Research Letter

Prehospital pulse oximetry: a red flag for early detection of silent hypoxemia in COVID-19 patients

Romain Jouffroy, Daniel Jost, Bertrand Prunet

Open Access COVID-19 Research Letter

Three-step checklist for tracheostomy in critically ill COVID-19 patients

Maria Vargas, Giuseppe Servillo

Open Access COVID-19 Research Letter

Extracorporeal membrane oxygenation programs for COVID-19 in China

Chenglong Li, Xiaotong Hou, Zhaohui Tong, Haibo Qiu, Yimin Li, Ang Li

Open Access COVID-19 Research Letter

A simple custom appliance against droplet and aerosol transmission of COVID-19 during advanced airway management

Meng Chi, Changming Lou, Xiuli Zhao, Xin Sui, Fei Han

Open Access COVID-19 Research Letter

Systemic hypoferremia and severity of hypoxemic respiratory failure in COVID-19

Akshay Shah, Joe N. Frost, Louise Aaron, Killian Donovan, Hal Drakesmith, Stuart R. McKechnie, Simon J. Stanworth

Open Access COVID-19 Commentary

Should we deny ICU admission to the elderly? Ethical considerations in times of COVID-19

Lenneke E. M. Haas, Dylan W. de Lange, Diederik van Dijk, Johannes J. M. van Delden

Open Access Letter

Early latency evoked potentials can no longer be considered an infallible predictor of neurologic outcome

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Letter

COVID-19: desperate times call for desperate measures

Stephan von Düring, Steve Primmaz, Karim Bendjelid

Open Access COVID-19 Letter

Potential benefit of angiotensin II in COVID-19 patients: beyond reasonable doubt?

António Tralhão, Luís Ferreira Moita, Pedro Póvoa

Open Access COVID-19 Research Letter

Low molecular weight heparins in COVID-19 patients: beware of augmented renal clearance!

Teresa Maria Tomasa-Irriguible, Sergi Martínez-Vega, Ester Mor-Marco, Alba Herraiz-Ruiz, Laura Raguer-Pardo, Carlos Cubells-Larrosa

Open Access COVID-19 Letter

Severe Covid-19 disease: rather AVDS than ARDS?

Yazine Mahjoub, Daniel Oscar Rodenstein, Vincent Jounieaux

Open Access COVID-19 Letter

Ventilator management in the age of COVID-19: response to “Logistic and organizational aspects of a dedicated intensive care unit for COVID-19 patients”

Alastair E. Moody, Bryce D. Beutler, Daniel Antwi-Amoabeng, Eric X. Lu, Charles E. Willyard, Irtqa Ilyas, Nageshwara Gullapalli

Open Access Research

The performance of acute versus antecedent patient characteristics for 1-year mortality prediction during intensive care unit admission: a national cohort study

Monika C. Kerckhoffs, Sylvia Brinkman, Nicolet de Keizer, Ivo W. Soliman, Dylan W. de Lange, Johannes J. M. van Delden, Diederik van Dijk

Open Access COVID-19 Viewpoint

Exploring pharmacological approaches for managing cytokine storm associated with pneumonia and acute respiratory distress syndrome in COVID-19 patients

Irma Convertino, Marco Tuccori, Sara Ferraro, Giulia Valdiserra, Emiliano Cappello, Daniele Focosi, Corrado Blandizzi

Open Access COVID-19 Letter

COVID-19: opening a new paradigm in thromboprophylaxis for critically ill patients?

Raquel Ferrandis, Juan V. Llau, Manuel Quintana, Pilar Sierra, Francisco Hidalgo, Concepción Cassinello, Aurelio Gómez-Luque

Open Access COVID-19 Research Letter

A valuable and affordable handheld ultrasound in combating COVID-19

Feng Qian, Xueqin Zhou, Jianqiao Zhou, Zhenhua Liu, Qian Nie

Open Access Research

The interaction between arterial oxygenation and carbon dioxide and hospital mortality following out of hospital cardiac arrest: a cohort study

Peter J. McGuigan, Manu Shankar-Hari, David A. Harrison, John G. Laffey, Danny F. McAuley

Open Access COVID-19 Commentary

Interferon beta-1a for COVID-19: critical importance of the administration route

Juho Jalkanen, Maija Hollmén, Sirpa Jalkanen

Open Access COVID-19 Research Letter

A plea for avoiding systematic intubation in severely hypoxemic patients with COVID-19-associated respiratory failure

Eduardo Villarreal-Fernandez, Ravi Patel, Reshma Golamari, Muhammad Khalid, Ami DeWaters, Philippe Haouzi

Open Access COVID-19 Research Letter

COVID-19 targets the right lung

Jingwen Li, Xiaxia Yu, Shaoping Hu, Zhicheng Lin, Nian Xiong, Yi Gao

Open Access COVID-19 Research Letter

Clinical features and outcomes of COVID-19 patients with gastrointestinal symptoms

Chao Cao, Meiping Chen, Li He, Jiao Xie, Xiaomin Chen

Open Access Research Letter

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study

Irene T. Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu, Dylan W. de Lange

Open Access COVID-19 Letter

Early rehabilitation with dedicated use of belt-type electrical muscle stimulation for severe COVID-19 patients

Kensuke Nakamura, Hidehiko Nakano, Hiromu Naraba, Masaki Mochizuki, Hideki Hashimoto

Open Access Letter

Optic nerve sheath diameter in critically ill patients: nuances and interpretation

Amos Lal, Kamal Kant Sahu, Ajay Kumar Mishra, Jamal Akhtar

Open Access Letter

Success and complications by team composition for prehospital pediatric intubation: children also need physicians!

Romain Jouffroy, Stéphanie Fogel, Peter Jones, Benoît Vivien

Open Access COVID-19 Letter

Response to “COVID-19: room for treating T cell exhaustion?”

Anne M. Drewry, Richard Hotchkiss, Erik Kulstad

Open Access COVID-19 Research Letter

Incidence of acute kidney injury in COVID-19 infection: a systematic review and meta-analysis

Yih-Ting Chen, Shih-Chieh Shao, Cheng-Kai Hsu, I-Wen Wu, Ming-Jui Hung, Yung-Chang Chen

Open Access Research

Health-related quality of life of children and their parents 2 years after critical illness: pre-planned follow-up of the PEPaNIC international, randomized, controlled trial

José Hordijk, Sascha Verbruggen, Ilse Vanhorebeek, Fabian Güiza, Pieter Wouters, Greet Van den Berghe, Koen Joosten, Karolijn Dulfer

Open Access COVID-19 Research Letter

Invasive mechanical ventilation in COVID-19 patient management: the experience with 469 patients in Wuhan

Jing Hua, Chenchen Qian, Zhibing Luo, Qiang Li, Feilong Wang

Open Access COVID-19 Letter

Paediatric and adult critical care medicine: joining forces against Covid-19

Martin C. J. Kneyber, Bernadette Engels, Peter H. J. van der Voort

Open Access COVID-19 Letter

The ARDSnet protocol may be detrimental in COVID-19

Vasiliki Tsolaki, George E. Zakynthinos, Dimosthenis Makris

Open Access COVID-19 Letter

Liver injury without liver failure in COVID-19 patients: how to explain, in some cases, elevated ammonia without hepatic decompensation

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Review

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

Stéphanie Pons, Sofiane Fodil, Elie Azoulay, Lara Zafrani

Open Access Research

Hypertonic sodium lactate improves microcirculation, cardiac function, and inflammation in a rat model of sepsis

Emmanuel Besnier, David Coquerel, Geoffrey Kouadri, Thomas Clavier, Raphael Favory, Thibault Duburcq, Olivier Lesur, Soumeya Bekri, Vincent Richard, Paul Mulder, Fabienne Tamion

Open Access COVID-19 Research

Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis

Xianghong Yang, Yiyang Jin, Ranran Li, Zhongheng Zhang, Renhua Sun, Dechang Chen

Open Access COVID-19 Research Letter

Single ventilator for multiple patients during COVID19 surge: matching and balancing patients

Lonnie G. Petersen, James Friend, Sidney Merritt

Open Access COVID-19 Letter

Compassionate use of others’ immunity — understanding gut microbiome in Covid-19

Prashanth Thalanayar Muthukrishnan, Robert Faillace

Open Access Research Letter

Can augmented renal clearance be detected using estimators of glomerular filtration rate?

Matthias Gijsen, Alexander Wilmer, Geert Meyfroidt, Joost Wauters, Isabel Spriet

Open Access COVID-19 Review

The unique characteristics of COVID-19 coagulopathy

Toshiaki Iba, Jerrold H. Levy, Jean Marie Connors, Theodore E. Warkentin, Jecko Thachil, Marcel Levi

Open Access COVID-19 Research Letter

Bedside rapid placement of nasointestinal feeding tube via ultrasound-guided stylet positioning in critical COVID-19 patients

Chuan-xi Chen, Zheng-deng Wei, Yong-jun Liu, Shou-zhen Cheng, Xiang-dong Guan

Open Access Letter

High doses of ketamine to improve neuronal edema in subarachnoid hemorrhage: we should consider other undesirable organ targets

Patrick M. Honore, Aude Mugisha, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Review

Prevention of thrombotic risk in hospitalized patients with COVID-19 and hemostasis monitoring

Sophie Susen, Charles Ambroise Tacquard, Alexandre Godon, Alexandre Mansour, Delphine Garrigue, Philippe Nguyen, Anne Godier, Sophie Testa, Jerrold H. Levy, Pierre Albaladejo, Yves Gruel, P. Albaladejo, N. Blais, F. Bonhomme, A. Borel-Derlon, A. Cohen, J.-P. Collet, E. de Maistre, P. Fontana, D. Garrigue Huet, A. Godier, Y. Gruel, A. Godon, B. Ickx, S. Laporte, D. Lasne, J. Llau, G. Le Gal, T. Lecompte, S. Lessire, J. H. Levy, D. Longrois, S. Madi-Jebara, A. Mansour, M. Mazighi, P. Mismetti, P. E. Morange, S. Motte, F. Mullier, N. Nathan, P. Nguyen, G. Pernod, N. Rosencher, S. Roullet, P. M. Roy, S. Schlumberger, P. Sié, A. Steib, S. Susen, C. A. Tacquard, S. Testa, A. Vincentelli, P. Zufferey, A. Borel-Derlon, E. Boissier, B. Dumont, E. de Maistre, Y. Gruel, C. James, D. Lasne, T. Lecompte, P. E. Morange, P. Nguyen, V. Siguret, S. Susen

Open Access COVID-19 Viewpoint

“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients

Gabriele Guglielmetti, Marco Quaglia, Pier Paolo Sainaghi, Luigi Mario Castello, Rosanna Vaschetto, Mario Pirisi, Francesco Della Corte, Gian Carlo Avanzi, Piero Stratta, Vincenzo Cantaluppi

Open Access Research

Performance and impact of a multiplex PCR in ICU patients with ventilator-associated pneumonia or ventilated hospital-acquired pneumonia

Nathan Peiffer-Smadja, Lila Bouadma, Vincent Mathy, Kahina Allouche, Juliette Patrier, Martin Reboul, Philippe Montravers, Jean-François Timsit, Laurence Armand-Lefevre

Open Access Research

Mobilization practices in critically ill children: a European point prevalence study (EU PARK-PICU)

Erwin Ista, Barnaby R. Scholefield, Joseph C. Manning, Irene Harth, Orsola Gawronski, Alicja Bartkowska-Śniatkowska, Anne-Sylvie Ramelet, Sapna R. Kudchadkar, Paul C. Ritson, Filippia Nikolaou, Marjorie de Neef, Martin Kneyber, Kate Penny-Thomas, Christina Linton, Reinis Balmaks, Matthias Richter, Fabrizio Chiusolo, Corrado Cecchetti, Marco Roberti, Michela Di Furia, Chantal Grandjean, Bettina Nygaard, Yolanda Lopez, Tolga Koroglu, Tolga Besci, Roberta Da Rin Della Mora, Rachel S. Agbeko, Emma Borrows, Nathalie Bochaton, Janet Mattsson, Anne Ksellmann, Barbara Hero, Jowita Rosada-Kurasinska, Magdalena Świder, Amabile Bonaldi, Cristina Giugni, Siva Oruganti, Simon Gates, Hazel Smith, Annelies van Zwol, Jenna Hills, Johanna Conroy, Mark Bebbington, Felix Neunhoeffer, Els Duval

Open Access Letter

Using indirect calorimetry in place of fixed energy prescription was feasible and energy targets were more closely met: do not forget an important limitation

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Letter

Learning from cubism to understand the reality of hemodynamics

Jason Stankiewicz, Maniraj Jeyaraju, Michael T. McCurdy

Open Access COVID-19 Research Letter

VEGF-D: a novel biomarker for detection of COVID-19 progression

Yaxian Kong, Junyan Han, Xueying Wu, Hui Zeng, Jingyuan Liu, Henghui Zhang

Open Access Correction

Correction to: How to measure blood pressure using an arterial catheter: a systematic 5-step approach

Bernd Saugel, Karim Kouz, Agnes S. Meidert, Leonie Schulte-Uentrop, Stefano Romagnoli

Open Access Research

Usefulness of point-of-care multiplex PCR to rapidly identify pathogens responsible for ventilator-associated pneumonia and their resistance to antibiotics: an observational study

Charles-Edouard Luyt, Guillaume Hékimian, Isabelle Bonnet, Nicolas Bréchot, Matthieu Schmidt, Jérôme Robert, Alain Combes, Alexandra Aubry

Open Access Research

Multimodal non-invasive assessment of intracranial hypertension: an observational study

Chiara Robba, Selene Pozzebon, Bedrana Moro, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone

Open Access Research

Platelet-derived exosomes promote neutrophil extracellular trap formation during septic shock

Yang Jiao, Weiwei Li, Wei Wang, Xingyu Tong, Ran Xia, Jie Fan, Jianer Du, Chengmi Zhang, Xueyin Shi

Open Access COVID-19 Letter

Italian pulmonologist units and COVID-19 outbreak: “mind the gap”!

Raffaele Scala, Teresa Renda, Antonio Corrado, Adriano Vaghi

Open Access Research

Biofilm formation on three different endotracheal tubes: a prospective clinical trial

Hulda R. Thorarinsdottir, Thomas Kander, Anna Holmberg, Sarunas Petronis, Bengt Klarin

Open Access Review

Update of the treatment of nosocomial pneumonia in the ICU

Rafael Zaragoza, Pablo Vidal-Cortés, Gerardo Aguilar, Marcio Borges, Emili Diaz, Ricard Ferrer, Emilio Maseda, Mercedes Nieto, Francisco Xavier Nuvials, Paula Ramirez, Alejandro Rodriguez, Cruz Soriano, Javier Veganzones, Ignacio Martín-Loeches

Open Access Research

Long-term survival of elderly patients after intensive care unit admission for acute respiratory infection: a population-based, propensity score-matched cohort study

Antoine Guillon, Coralie Hermetet, Kimberly A. Barker, Youenn Jouan, Christophe Gaborit, Stephan Ehrmann, Yannick Le Manach, Pierre-François Dequin, Leslie Grammatico-Guillon

Open Access Research

Brain tight junction protein expression in sepsis in an autopsy series

Kristo Erikson, Hannu Tuominen, Merja Vakkala, Janne Henrik Liisanantti, Tuomo Karttunen, Hannu Syrjälä, Tero Ilmari Ala-Kokko

Open Access Viewpoint

Hospital preparedness for mass critical care during SARS-CoV-2 pandemic

Thomas Wurmb, Katja Scholtes, Felix Kolibay, Nora Schorscher, Georg Ertl, Ralf-Ingo Ernestus, Ulrich Vogel, Axel Franke, Barbara Kowalzik

Open Access Research

Significance of body temperature in elderly patients with sepsis

Takashi Shimazui, Taka-aki Nakada, Keith R. Walley, Taku Oshima, Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Akiyoshi Hagiwara, Kazuma Yamakawa, Tomohiko Masuno, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Masashi Ueyama, Satoshi Fujimi, Satoshi Gando, Takashi Shimazui, Taka-aki Nakada, Keith R. Walley, Taku Oshima, Toshikazu Abe, Hiroshi Ogura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Toshihiko Mayumi, Yasukazu Shiino, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Kohji Okamoto, Yutaka Umemura, Joji Kotani, Yuichiro Sakamoto, Junichi Sasaki, Shin-ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Akiyoshi Hagiwara, Kazuma Yamakawa, Tomohiko Masuno, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Masashi Ueyama, Satoshi Fujimi, Satoshi Gando, Osamu Tasaki, Yasumitsu Mizobata, Hiraku Funakoshi, Toshiro Okuyama, Iwao Yamashita, Toshio Kanai, Yasuo Yamada, Mayuki Aibiki, Keiji Sato, Susumu Yamashita, Kenichi Yoshida, Shunji Kasaoka, Akihide Kon, Hiroshi Rinka, Hiroshi Kato, Hiroshi Okudera, Eichi Narimatsu, Toshifumi Fujiwara, Manabu Sugita, Yasuo Shichinohe, Hajime Nakae, Ryouji Iiduka, Mitsunobu Nakamura, Yuji Murata, Yoshitake Sato, Hiroyasu Ishikura, Yasuhiro Myojo, Yasuyuki Tsujita, Kosaku Kinoshita, Hiroyuki Yamaguchi, Toshihiro Sakurai, Satoru Miyatake, Takao Saotome, Susumu Yasuda, Toshikazu Abe, Hiroshi Ogura, Yutaka Umemura, Atsushi Shiraishi, Shigeki Kushimoto, Daizoh Saitoh, Seitaro Fujishima, Junichi Sasaki, Toshihiko Mayumi, Yasukazu Shiino, Taka-aki Nakada, Takehiko Tarui, Toru Hifumi, Yasuhiro Otomo, Joji Kotani, Yuichiro Sakamoto, Shin-ichiro Shiraishi, Kiyotsugu Takuma, Ryosuke Tsuruta, Akiyoshi Hagiwara, Kazuma Yamakawa, Naoshi Takeyama, Norio Yamashita, Hiroto Ikeda, Yasuaki Mizushima, Satoshi Gando

Open Access COVID-19 Research

Acute complications and mortality in hospitalized patients with coronavirus disease 2019: a systematic review and meta-analysis

Nicola Potere, Emanuele Valeriani, Matteo Candeloro, Marco Tana, Ettore Porreca, Antonio Abbate, Silvia Spoto, Anne W. S. Rutjes, Marcello Di Nisio

Open Access Letter

Virtual reality device training for extracorporeal membrane oxygenation

Georg Wolff, Raphael R. Bruno, Martina Reiter, Boris Kantzow, Malte Kelm, Christian Jung

Open Access Research

Causes and characteristics of death in patients with acute hypoxemic respiratory failure and acute respiratory distress syndrome: a retrospective cohort study

Scott W. Ketcham, Yub Raj Sedhai, H. Catherine Miller, Thomas C. Bolig, Amy Ludwig, Ivan Co, Dru Claar, Jakob I. McSparron, Hallie C. Prescott, Michael W. Sjoding

Open Access COVID-19 Research Letter

Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series

Kent Doi, Mahoko Ikeda, Naoki Hayase, Kyoji Moriya, Naoto Morimura, Hiromu Maehara, Shunsuke Tagami, Kazutaka Fukushima, Naho Misawa, Yutaro Inoue, Hitomi Nakamura, Daisuke Takai, Mio Kurimoto, Kurato Tokunaga, Miyuki Yamamoto, Ichiro Hirayama, Ryohei Horie, Yuri Endo, Kengo Hiwatashi, Mio Shikama, Daisuke Jubishi, Yoshiaki Kanno, Koh Okamoto, Sohei Harada, Shu Okugawa, Kohei Miyazono, Yasuyuki Seto, Jun-ichiro Inoue

Open Access Review

Recommendations for core critical care ultrasound competencies as a part of specialist training in multidisciplinary intensive care: a framework proposed by the European Society of Intensive Care Medicine (ESICM)

Adrian Wong, Laura Galarza, Lui Forni, Daniel De Backer, Michael Slama, Bernard Cholley, Paul Mayo, Anthony McLean, Antoine Vieillard-Baron, Daniel Lichtenstein, Giovanni Volpicelli, Robert Arntfield, Ignacio Martin-Loeches, Gizella Melania Istrate, František Duška, Adrian Wong, Laura Galarza, Lui Forni, Daniel De Backer, Michael Slama, Bernard Cholley, Paul Mayo, Anthony McLean, Antoine Vieillard-Baron, Daniel Lichtenstein, Giovanni Volpicelli, Robert Arntfield, Ignacio Martin-Loeches, Gizella Melania Istrate, František Duška

Open Access COVID-19 Research

Clinical course and predictors of 60-day mortality in 239 critically ill patients with COVID-19: a multicenter retrospective study from Wuhan, China

Jiqian Xu, Xiaobo Yang, Luyu Yang, Xiaojing Zou, Yaxin Wang, Yongran Wu, Ting Zhou, Yin Yuan, Hong Qi, Shouzhi Fu, Hong Liu, Jia’an Xia, Zhengqin Xu, Yuan Yu, Ruiting Li, Yaqi Ouyang, Rui Wang, Lehao Ren, Yingying Hu, Dan Xu, Xin Zhao, Shiying Yuan, Dingyu Zhang, You Shang

Open Access COVID-19 Editorial

COVID-19: a hypothesis regarding the ventilation-perfusion mismatch

Mario G. Santamarina, Dominique Boisier, Roberto Contreras, Martiniano Baque, Mariano Volpacchio, Ignacio Beddings

Open Access Research

Prone positioning in severe ARDS requiring extracorporeal membrane oxygenation

Jonathan Rilinger, Viviane Zotzmann, Xavier Bemtgen, Carin Schumacher, Paul M. Biever, Daniel Duerschmied, Klaus Kaier, Peter Stachon, Constantin von zur Mühlen, Manfred Zehender, Christoph Bode, Dawid L. Staudacher, Tobias Wengenmayer

Open Access Research

Identification, collection, and reporting of harms among non-industry-sponsored randomized clinical trials of pharmacologic interventions in the critically ill population: a systematic review

Ari Moskowitz, Lars W. Andersen, Mathias J. Holmberg, Anne V. Grossestreuer, Katherine M. Berg, Asger Granfeldt

Open Access COVID-19 Research Letter

Classification of COVID-19 in intensive care patients

Xiaofan Lu, Yang Wang, Taige Chen, Jun Wang, Fangrong Yan

Open Access Research Letter

Visualisation of epidemiological map using an Internet of Things infectious disease surveillance platform

Guanghao Sun, Nguyen Vu Trung, Le Thi Hoi, Pham Thanh Hiep, Koichiro Ishibashi, Takemi Matsui

Open Access Research Letter

Is delirium a specific complication of viral acute respiratory distress syndrome?

Markus Jäckel, Xavier Bemtgen, Tobias Wengenmayer, Christoph Bode, Paul Marc Biever, Dawid Leander Staudacher

Open Access COVID-19 Research Letter

Double trouble: methanol outbreak in the wake of the COVID-19 pandemic in Iran—a cross-sectional assessment

Hossein Hassanian-Moghaddam, Nasim Zamani, Ali-Asghar Kolahi, Rebecca McDonald, Knut Erik Hovda

Open Access Research

The effect of short-course antibiotics on the resistance profile of colonizing gut bacteria in the ICU: a prospective cohort study

Christian Munck, Ravi U. Sheth, Edward Cuaresma, Jessica Weidler, Stephania L. Stump, Philip Zachariah, David H. Chong, Anne-Catrin Uhlemann, Julian A. Abrams, Harris H. Wang, Daniel E. Freedberg

Open Access COVID-19 Viewpoint

Molecular mechanisms of sex bias differences in COVID-19 mortality

Yuchong Li, Mirjana Jerkic, Arthur S. Slutsky, Haibo Zhang

Open Access COVID-19 Research Letter

Unrecognized diabetes in critically ill COVID-19 patients

Sebastian J. Klein, Dietmar Fries, Susanne Kaser, Simon Mathis, Claudius Thomé, Michael Joannidis

Open Access Research Letter

Transpulmonary pressure in SARS-CoV-2-associated acute respiratory distress syndrome: a single-center observational study

Severin Ramin, Jonathan Charbit, Geoffrey Dagod, Mehdi Girard, Samir Jaber, Xavier Capdevila

Open Access COVID-19 Research Letter

Angiotensin II treatment in COVID-19 patients: more risk than benefit? A single-center experience

Ulrike Heinicke, Elisabeth Adam, Michael Sonntagbauer, Andreas von Knethen, Kai Zacharowski, Holger Neb

Open Access COVID-19 Research Letter

Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis

Alexia Verroken, Anaïs Scohy, Ludovic Gérard, Xavier Wittebole, Christine Collienne, Pierre-François Laterre

Open Access COVID-19 Letter

Adrenomedullin in COVID-19 induced endotheliitis

Darius Cameron Wilson, Joerg C. Schefold, Jaume Baldirà, Thibaud Spinetti, Kordo Saeed, Gunnar Elke

Open Access COVID-19 Research Letter

Impact of initial respiratory compliance in ventilated patients with acute respiratory distress syndrome related to COVID-19

Florent Laverdure, Amélie Delaporte, Astrid Bouteau, Thibaut Genty, François Decailliot, François Stéphan

Open Access COVID-19 Research Letter

Effect of favipiravir and an anti-inflammatory strategy for COVID-19

Hitoshi Yamamura, Hiroshi Matsuura, Junichiro Nakagawa, Hiroshi Fukuoka, Hisaya Domi, Satoru Chujoh

Open Access COVID-19 Letter

Letter to the Editor in response to “COVID-19: desperate times call for desperate measures”

J. Geoffrey Chase, Yeong-Shiong Chiew, Bernard Lambermont, Philippe Morimont, Geoffrey M. Shaw, Thomas Desaive

Open Access Research

Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy

Carolyn M. Hendrickson, Yuenting D. Kwong, Annika G. Belzer, Michael G. Shlipak, Michael A. Matthay, Kathleen D. Liu

Open Access Research

Bedside calculation of mechanical power during volume- and pressure-controlled mechanical ventilation

Davide Chiumello, Miriam Gotti, Mariateresa Guanziroli, Paolo Formenti, Michele Umbrello, Iacopo Pasticci, Giovanni Mistraletti, Mattia Busana

Open Access Research

Comparison of hydroxychloroquine, lopinavir/ritonavir, and standard of care in critically ill patients with SARS-CoV-2 pneumonia: an opportunistic retrospective analysis

Marie Lecronier, Alexandra Beurton, Sonia Burrel, Luc Haudebourg, Robin Deleris, Julien Le Marec, Sara Virolle, Safaa Nemlaghi, Côme Bureau, Pierre Mora, Martin De Sarcus, Olivier Clovet, Baptiste Duceau, Paul Henri Grisot, Marie Hélène Pari, Jérémy Arzoine, Ulrich Clarac, David Boutolleau, Mathieu Raux, Julie Delemazure, Morgane Faure, Maxens Decavele, Elise Morawiec, Julien Mayaux, Alexandre Demoule, Martin Dres

Open Access COVID-19 Research Letter

COVID-19-associated acute cerebral venous thrombosis: clinical, CT, MRI and EEG features

Fabian Roy-Gash, Marine De Mesmay, Jean-Michel Devys, Hervé Vespignani, Raphaël Blanc, Nicolas Engrand

Open Access COVID-19 Research Letter

Administration of umbilical cord mesenchymal stem cells in patients with severe COVID-19 pneumonia

Zhinian Guo, Yunlong Chen, Xiaoyu Luo, Xiaolong He, Yong Zhang, Jiang Wang

Open Access COVID-19 Research

Neurological manifestations of COVID-19: a systematic review

Gaurav Nepal, Jessica Holly Rehrig, Gentle Sunder Shrestha, Yow Ka Shing, Jayant Kumar Yadav, Rajeev Ojha, Gaurab Pokhrel, Zhi Lan Tu, Dong Ya Huang

Open Access COVID-19 Review

Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19

Wentao Ni, Xiuwen Yang, Deqing Yang, Jing Bao, Ran Li, Yongjiu Xiao, Chang Hou, Haibin Wang, Jie Liu, Donghong Yang, Yu Xu, Zhaolong Cao, Zhancheng Gao

Open Access Research

The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis

Hina N. Khan, Xanthe Brands, Simona Aufiero, Arie J. Hoogendijk, Augustijn M. Klarenbeek, Tjitske S. R. van Engelen, Bastiaan W. Haak, Lonneke A. van Vught, Janneke Horn, Marcus J. Schultz, Aeilko H. Zwinderman, Tom van der Poll, Brendon P. Scicluna

Open Access COVID-19 Letter

Walkie talkies to aid health care workers’ compliance with personal protective equipment in the fight against COVID-19

Dominic Fenn, Jonny Coppel, Jessica Kearney, Lucy Everson, Simon Braithwaite, Rahul Chodhari

Open Access Research

Risk factors and intestinal microbiota: Clostridioides difficile infection in patients receiving enteral nutrition at Intensive Care Units

Daosheng Wang, Danfeng Dong, Chen Wang, Yingchao Cui, Cen Jiang, Qi Ni, Tongxuan Su, Guanzheng Wang, Enqiang Mao, Yibing Peng

Open Access Letter

Use of multiple laboratory tests including anti-factor Xa to optimally manage anticoagulation during ECMO

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

Prone positioning under VV-ECMO in SARS-CoV-2-induced acute respiratory distress syndrome

Bruno Garcia, Nicolas Cousin, Claire Bourel, Mercé Jourdain, Julien Poissy, Thibault Duburcq, Pauline Boddaert, Arthur Durand, Ahmed El Kalioubie, Patrick Girardie, Marion Houard, Geoffrey Ledoux, Anne Sophie Moreau, Christopher Niles, Saad Nseir, Thierry Onimus, Aurelia Toussaint, Sebastien Préau, Laurent Robriquet, Anahita Rouze, Arthur Simonnet, Sophie Six, Morgan Caplan, Julien Goutay, Emmanuelle Jaillette, Erika Parmentier-Decrucq, Raphael Favory, Daniel Mathieu, Guillaume Degouy, Mouhamed Moussa

Open Access COVID-19 Research Letter

Atorvastatin associated with decreased hazard for death in COVID-19 patients admitted to an ICU: a retrospective cohort study

Guillermo Rodriguez-Nava, Daniela Patricia Trelles-Garcia, Maria Adriana Yanez-Bello, Chul Won Chung, Valeria Patricia Trelles-Garcia, Harvey J. Friedman

Open Access COVID-19 Letter

Nurse-performed ultrasound: a new weapon against COVID-19

Jianhua Sun, Qi Li, Xinjuan Wu, Xiaoting Wang, Dawei Liu

Open Access Research

Hemodynamic response during endotracheal suctioning predicts awakening and functional outcome in subarachnoid hemorrhage patients

Verena Rass, Bogdan-Andrei Ianosi, Anna Lindner, Mario Kofler, Alois J. Schiefecker, Bettina Pfausler, Ronny Beer, Erich Schmutzhard, Raimund Helbok

Open Access Research

Central venous pressure measurement is associated with improved outcomes in septic patients: an analysis of the MIMIC-III database

Hui Chen, Zhu Zhu, Chenyan Zhao, Yanxia Guo, Dongyu Chen, Yao Wei, Jun Jin

Open Access Research

Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia

Céline Monard, Jonathan Pehlivan, Gabriel Auger, Sophie Alviset, Alexy Tran Dinh, Paul Duquaire, Nabil Gastli, Camille d’Humières, Adel Maamar, André Boibieux, Marion Baldeyrou, Julien Loubinoux, Olivier Dauwalder, Vincent Cattoir, Laurence Armand-Lefèvre, Solen Kernéis, Agathe Becker, Julien Charpentier, Julien Textoris, Claude-Alexandre Gustave, Grégory Destras, François Vandenesch, Bruno Lina, Jean Sebastien Casalegno, Manon Lejeune, Philippe Montravers, Claire Poyart, Hugo Tête, Jean-François Timsit, Thomas Uberti

Open Access COVID-19 Research Letter

Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation

Marina Rieder, Tobias Wengenmayer, Dawid Staudacher, Daniel Duerschmied, Alexander Supady

Open Access COVID-19 Research

Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study

Shuai Zhang, Mengfei Guo, Limin Duan, Feng Wu, Guorong Hu, Zhihui Wang, Qi Huang, Tingting Liao, Juanjuan Xu, Yanling Ma, Zhilei Lv, Wenjing Xiao, Zilin Zhao, Xueyun Tan, Daquan Meng, Shujing Zhang, E Zhou, Zhengrong Yin, Wei Geng, Xuan Wang, Jianchu Zhang, Jianguo Chen, Yu Zhang, Yang Jin

Open Access COVID-19 Research Letter

Mortality rate of acute kidney injury in SARS, MERS, and COVID-19 infection: a systematic review and meta-analysis

Yih-Ting Chen, Shih-Chieh Shao, Edward Chia-Cheng Lai, Ming-Jui Hung, Yung-Chang Chen

Open Access Research Letter

Chest physiotherapy improves regional lung volume in ventilated children

Bronagh McAlinden, Suzanne Kuys, Andreas Schibler, Judith L. Hough

Open Access Research

The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial

Luca Cioccari, Nora Luethi, Michael Bailey, Yahya Shehabi, Belinda Howe, Anna S. Messmer, Helena K. Proimos, Leah Peck, Helen Young, Glenn M. Eastwood, Tobias M. Merz, Jukka Takala, Stephan M. Jakob, Rinaldo Bellomo, Yahya Shehabi, Yaseen Arabi, Frances Bass, Rinaldo Bellomo, Simon Erickson, Belinda Howe, Suhaini Kadiman, Colin McArthur, Lynnette Murray, Michael Reade, Ian Seppelt, Jukka Takala, Steve A. Webb, Matthew P. Wise, Yahya Shehabi, Belinda Howe, Rinaldo Bellomo, Yaseen M. Arabi, Michael J. Bailey, Frances Bass, Suhaini Kadiman, Colin McArthur, Lynnette Murray, Michael Reade, Ian Seppelt, Jukka Takala, Steve A. Webb, Matthew P. Wise, Michael J. Bailey, Belinda D. Howe, Lynette Murray, Vanessa Singh

Open Access Research

Can levosimendan reduce ECMO weaning failure in cardiogenic shock?: a cohort study with propensity score analysis

Enrique Guilherme, Matthias Jacquet-Lagrèze, Matteo Pozzi, Felix Achana, Xavier Armoiry, Jean-Luc Fellahi

Open Access COVID-19 Editorial

The application of 6S and PDCA management strategies in the nursing of COVID-19 patients

Wenju Wei, Sicong Wang, Hongliang Wang, Hongjia Quan

Open Access COVID-19 Research Letter

Infliximab against severe COVID-19-induced cytokine storm syndrome with organ failure—a cautionary case series

Andreas Stallmach, Andreas Kortgen, Falk Gonnert, Sina M. Coldewey, Philipp Reuken, Michael Bauer

Open Access COVID-19 Review

Blocking IL-1 to prevent respiratory failure in COVID-19

Frank L. van de Veerdonk, Mihai G. Netea

Open Access COVID-19 Research Letter

Neuromuscular blocking agents (NMBA) for COVID-19 acute respiratory distress syndrome: a multicenter observational study

Romain Courcelle, Stéphane Gaudry, Nicolas Serck, Gauthier Blonz, Jean-Baptiste Lascarrou, David Grimaldi, Nadia Aissaoui, Giuseppe Carbutti, Alain D’hondt, Julien Higny, Geoffrey Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Michael Piagnerelli, Bertrand Sauneuf, Thibaud Soumagne, Piotr Szychowiak, Julien Textoris, Benoit Vandenbunder, Christophe Vinsonneau

Nutrition of the COVID-19 patient in the intensive care unit (ICU): a practical guidance

Ronan Thibault, Philippe Seguin, Fabienne Tamion, Claude Pichard, Pierre Singer

Open Access COVID-19 Research Letter

Detection of IgG antibody during the follow-up in patients with COVID-19 infection

Jiao Liu, Jun Guo, Qianghong Xu, Guolong Cai, Dechang Chen, Yanfei Shen

Open Access COVID-19 Editorial

Convalescent plasma to treat critically ill patients with COVID-19: framing the need for randomised clinical trials

Manu Shankar-Hari, Lise Estcourt, Heli Harvala, David Roberts, David K. Menon, Manu Shankar-Hari, Lise Estcourt, Heli Harvala, David Roberts, David K. Menon

Open Access Letter

Risk of harlequin syndrome during bi-femoral peripheral VA-ECMO: should we pay more attention to the watershed or try to change the venous cannulation site?

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research Letter

Chinese herbal experience for the 2019 novel coronavirus

Ronglin Jiang, Kungen Wang, Wei Mao, Wei Zhu, Weihang Hu, Liquan Huang

Open Access COVID-19 Research Letter

Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19

Sergey A. Kornilov, Isabelle Lucas, Kathleen Jade, Chengzhen L. Dai, Jennifer C. Lovejoy, Andrew T. Magis

Open Access Research

Automated vs. conventional ventilation in the ICU: a randomized controlled crossover trial comparing blood oxygen saturation during daily nursing procedures (I-NURSING)

Jonathan Chelly, Sandie Mazerand, Sebastien Jochmans, Claire-Marie Weyer, Franck Pourcine, Olivier Ellrodt, Nathalie Thieulot-Rolin, Jean Serbource-Goguel, Oumar Sy, Ly Van Phach Vong, Mehran Monchi

Open Access COVID-19 Review

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence

Frank M. P. van Haren, Clive Page, John G. Laffey, Antonio Artigas, Marta Camprubi-Rimblas, Quentin Nunes, Roger Smith, Janis Shute, Mary Carroll, Julia Tree, Miles Carroll, Dave Singh, Tom Wilkinson, Barry Dixon

Open Access Letter

The role of occludin in vascular barrier function in vivo: do we need to re-examine?

Ruyuan Zhang, Yiyun Liu, Dechang Chen, Yaoqing Tang

Open Access Research Letter

Willingness to attend cardiopulmonary resuscitation training and the associated factors among adults in China

Shijiao Yan, Yong Gan, Rixing Wang, Xingyue Song, Ning Zhou, Chuanzhu Lv

Open Access Research

Chlorhexidine-impregnated sponge versus chlorhexidine gel dressing for short-term intravascular catheters: which one is better?

Niccolò Buetti, Stéphane Ruckly, Carole Schwebel, Olivier Mimoz, Bertrand Souweine, Jean-Christophe Lucet, Jean-François Timsit

Open Access COVID-19 Research Letter

Lactate dehydrogenase elevations is associated with severity of COVID-19: a meta-analysis

Xiao-Yun Chen, Ming-Yao Huang, Zheng-wei Xiao, Sheng Yang, Xiang-Qi Chen

Open Access COVID-19 Letter

Response to “Body temperature correlates with mortality in COVID-19 patients”

Anne M. Drewry, Richard Hotchkiss, Erik Kulstad

Open Access Research

Plasma lipid profiling for the prognosis of 90-day mortality, in-hospital mortality, ICU admission, and severity in bacterial community-acquired pneumonia (CAP)

Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Sachin Yende, Derek C. Angus, Brent W. Winston

Open Access COVID-19 Viewpoint

Provision of ECPR during COVID-19: evidence, equity, and ethical dilemmas

Elliott Worku, Denzil Gill, Daniel Brodie, Roberto Lorusso, Alain Combes, Kiran Shekar

Open Access COVID-19 Letter

Inhibiting IL-6 in COVID-19: we are not sure

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

Incidence and mortality of pulmonary embolism in COVID-19: a systematic review and meta-analysis

Shu-Chen Liao, Shih-Chieh Shao, Yih-Ting Chen, Yung-Chang Chen, Ming-Jui Hung

Open Access Research Letter

Age, sex, and comorbidities predict ICU admission or mortality in cases with SARS-CoV2 infection: a population-based cohort study

Filipe S. Cardoso, Ana L. Papoila, Rita Sá Machado, Pedro Fidalgo

Open Access Research Letter

Pooled prevalence of deep vein thrombosis among coronavirus disease 2019 patients

Ying Wang, Li Shi, Haiyan Yang, Guangcai Duan, Yadong Wang

Open Access Research

Airway pressure morphology and respiratory muscle activity during end-inspiratory occlusions in pressure support ventilation

Stella Soundoulounaki, Evangelia Akoumianaki, Eumorfia Kondili, Emmanouil Pediaditis, Georgios Prinianakis, Katerina Vaporidi, Dimitris Georgopoulos

Open Access COVID-19 Research

Cardiac injury associated with severe disease or ICU admission and death in hospitalized patients with COVID-19: a meta-analysis and systematic review

Xinye Li, Xiandu Pan, Yanda Li, Na An, Yanfen Xing, Fan Yang, Li Tian, Jiahao Sun, Yonghong Gao, Hongcai Shang, Yanwei Xing

Open Access Research

Efficacy of convalescent plasma for the treatment of severe influenza

Zhiheng Xu, Jianmeng Zhou, Yongbo Huang, Xuesong Liu, Yonghao Xu, Sibei Chen, Dongdong Liu, Zhimin Lin, Xiaoqing Liu, Yimin Li

Open Access Research

Early administration of glucocorticoid for thyroid storm: analysis of a national administrative database

Atsushi Senda, Akira Endo, Hisateru Tachimori, Kiyohide Fushimi, Yasuhiro Otomo

Open Access Research Letter

Identification of focal ARDS using PF ratio: a cross-sectional study

Kay Choong See, Juliet Sahagun, Juvel Taculod

Open Access Research Letter

Allocation of the ICU wards according to the patient’s infection condition: a measure to improve antibiotic resistance

Yefei Zhan, Peifu Chen, Jieqiong Chen, Hua Wang, Zhaojun Xu, Yu Chen

Open Access Letter

Patients with emm1/T1 serotype invasive group A streptococci infections demonstrated more renal failure than patients with other serotypes: perhaps we should consider some confounders

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Artificial neural networks improve early outcome prediction and risk classification in out-of-hospital cardiac arrest patients admitted to intensive care

Jesper Johnsson, Ola Björnsson, Peder Andersson, Andreas Jakobsson, Tobias Cronberg, Gisela Lilja, Hans Friberg, Christian Hassager, Jesper Kjaergard, Matt Wise, Niklas Nielsen, Attila Frigyesi

Open Access COVID-19 Research Letter

ACEI/ARB therapy in COVID-19: the double-edged sword of ACE2 and SARS-CoV-2 viral docking

Chidinma L. Onweni, Yu Shrike Zhang, Thomas Caulfield, Christopher E. Hopkins, De Lisa Fairweather, William D. Freeman

Open Access Research

Association between delirium in the intensive care unit and subsequent neuropsychiatric disorders

Kyla N. Brown, Andrea Soo, Peter Faris, Scott B. Patten, Kirsten M. Fiest, Henry T. Stelfox

Open Access COVID-19 Research Letter

Development of a work of breathing scale and monitoring need of intubation in COVID-19 pneumonia

Mylene Apigo, Jeffrey Schechtman, Nyembezi Dhliwayo, Mohammed Al Tameemi, Raúl J. Gazmuri

Open Access Research

Prediction of the development of acute kidney injury following cardiac surgery by machine learning

Po-Yu Tseng, Yi-Ting Chen, Chuen-Heng Wang, Kuan-Ming Chiu, Yu-Sen Peng, Shih-Ping Hsu, Kang-Lung Chen, Chih-Yu Yang, Oscar Kuang-Sheng Lee

Open Access Research

Chest physiotherapy improves lung aeration in hypersecretive critically ill patients: a pilot randomized physiological study

Federico Longhini, Andrea Bruni, Eugenio Garofalo, Chiara Ronco, Andrea Gusmano, Gianmaria Cammarota, Laura Pasin, Pamela Frigerio, Davide Chiumello, Paolo Navalesi

Open Access Correction

Correction to: Maximum emergency department overcrowding is correlated with occurrence of unexpected cardiac arrest

June-sung Kim, Hyun-Jin Bae, Chang Hwan Sohn, Sung-Eun Cho, Jeongeun Hwang, Won Young Kim, Namkug Kim, Dong-Woo Seo

Open Access COVID-19 Research Letter

Plasma exchange in critically ill COVID-19 patients

Christian Morath, Markus A. Weigand, Martin Zeier, Claudius Speer, Shilpa Tiwari-Heckler, Uta Merle

Open Access Letter

Compared to NIPPV, HFNC is more dangerous regarding aerosol dispersion and contamination of healthcare personnel: we are not sure

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Correction

Correction to: Urine cell cycle arrest biomarkers distinguish poorly between transient and persistent AKI in early septic shock: a prospective, multicenter study

Dimitri Titeca-Beauport, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Sami Alaya, Karim Chaoui, Maud Andrieu, Isabelle Rouquette-Vincenti, Frederic Godde, Michel Pascal, Momar Diouf, Christophe Vinsonneau, Kada Klouche, Julien Maizel

Open Access COVID-19 Research Letter

Serum levels of receptor-interacting protein kinase-3 in patients with COVID-19

Hideta Nakamura, Takeshi Kinjo, Wakako Arakaki, Kazuya Miyagi, Masao Tateyama, Jiro Fujita

Open Access Research

The obesity paradox in critically ill patients: a causal learning approach to a casual finding

Alexander Decruyenaere, Johan Steen, Kirsten Colpaert, Dominique D. Benoit, Johan Decruyenaere, Stijn Vansteelandt

Open Access SARS-CoV-2 Research

International variation in the management of severe COVID-19 patients

Elie Azoulay, Jan de Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar-Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu, Maurizio Cecconi

Open Access Correction

Correction to: Can levosimendan reduce ECMO weaning failure in cardiogenic shock?: a cohort study with propensity score analysis

Enrique Guilherme, Matthias Jacquet-Lagrèze, Matteo Pozzi, Felix Achana, Xavier Armoiry, Jean-Luc Fellahi

Open Access Research

High-flow nasal cannula oxygen therapy versus non-invasive ventilation for chronic obstructive pulmonary disease patients after extubation: a multicenter, randomized controlled trial

Dingyu Tan, Joseph Harold Walline, Bingyu Ling, Yan Xu, Jiayan Sun, Bingxia Wang, Xueqin Shan, Yunyun Wang, Peng Cao, Qingcheng Zhu, Ping Geng, Jun Xu

Open Access Research

ECCO2R therapy in the ICU: consensus of a European round table meeting

Alain Combes, Georg Auzinger, Gilles Capellier, Damien du Cheyron, Ian Clement, Guglielmo Consales, Wojciech Dabrowski, David De Bels, Francisco Javier González de Molina Ortiz, Antje Gottschalk, Matthias P. Hilty, David Pestaña, Eduardo Sousa, Redmond Tully, Jacques Goldstein, Kai Harenski

Open Access COVID-19 Research

Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients

Julie Helms, Stéphane Kremer, Hamid Merdji, Malika Schenck, François Severac, Raphaël Clere-Jehl, Antoine Studer, Mirjana Radosavljevic, Christine Kummerlen, Alexandra Monnier, Clotilde Boulay, Samira Fafi-Kremer, Vincent Castelain, Mickaël Ohana, Mathieu Anheim, Francis Schneider, Ferhat Meziani

Open Access COVID-19 Research Letter

Therapeutic plasma exchange in patients with COVID-19 pneumonia in intensive care unit: a retrospective study

Bulent Gucyetmez, Hakan Korkut Atalan, Ibrahim Sertdemir, Ulkem Cakir, Lutfi Telci, Aylin Ogan, Aylin Cimet Ayyildiz, Berrin Yalcin, Behiye Oren, Fadıl Havas, Sevda Dizi, Birsen Kose, Umran Yakici, Cenk Sahan, Elif Ozkilitci, Ugur Tunali, Deniz Gunes, Ozlem Dincer, Reyhan Sahin, Duran Ozdemir, Mehtap Selcuk, Ceyhun Solakoglu, Unsal Arif Turan, Erkan Kaya, Mustafa Emre Kavlak, Pelin Katar, Hande Aygun, Kerim Cikim, Ozkan Uysal, Nur Ozturk Kaskir, Aysun Soylu

Open Access COVID-19 Review

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Pablo Cruces, Jaime Retamal, Daniel E. Hurtado, Benjamín Erranz, Pablo Iturrieta, Carlos González, Franco Díaz

Open Access COVID-19 Research

Unspecific post-mortem findings despite multiorgan viral spread in COVID-19 patients

Myriam Remmelink, Ricardo De Mendonça, Nicky D’Haene, Sarah De Clercq, Camille Verocq, Laetitia Lebrun, Philomène Lavis, Marie-Lucie Racu, Anne-Laure Trépant, Calliope Maris, Sandrine Rorive, Jean-Christophe Goffard, Olivier De Witte, Lorenzo Peluso, Jean-Louis Vincent, Christine Decaestecker, Fabio Silvio Taccone, Isabelle Salmon

Open Access COVID-19 Research Letter

Blood type A associates with critical COVID-19 and death in a Swedish cohort

Michael Hultström, Barbro Persson, Oskar Eriksson, Miklos Lipcsey, Robert Frithiof, Bo Nilsson

Open Access COVID-19 Letter

Adverse events associated with nafamostat mesylate and favipiravir treatment in COVID-19 patients

Toru Hifumi, Shutaro Isokawa, Norio Otani, Shinichi Ishimatsu

Open Access Research Letter

Severity of illness influences the microcirculatory response to red blood cell transfusion in the critically ill: an observational cohort study

Lisa van Manen, Jessica M. Deurvorst, Maike E. van Hezel, Margit Boshuizen, Robin van Bruggen, Nicole P. Juffermans

Open Access Review

Biomarkers in critical care nutrition

Christian Stoppe, Sebastian Wendt, Nilesh M. Mehta, Charlene Compher, Jean-Charles Preiser, Daren K. Heyland, Arnold S. Kristof

Open Access Letter

High-dose intravenous vitamin C may help in cytokine storm in severe SARS-CoV-2 infection

Adriana Françozo de Melo, Mauricio Homem-de-Mello

Open Access COVID-19 Research

Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial

Joseph Miller, Charles Bruen, Michael Schnaus, Jeffrey Zhang, Sadia Ali, April Lind, Zachary Stoecker, Kenneth Stauderman, Sudarshan Hebbar

Open Access COVID-19 Letter

Is previous influenza-like illness a potential Trojan horse for COVID-19?

Giancarlo Ceccarelli, Gabriele d’Ettorre, Giuseppe Pietro Innocenti, Claudio M. Mastroianni, Massimo Ciccozzi, Gabriella d’Ettorre

Open Access Research Letter

Helmet interface increases lung volumes at equivalent ventilator pressures compared to the face mask interface during non-invasive ventilation

Kate C. Tatham, Matthew Ko, Lisa Palozzi, Stephen E. Lapinsky, Laurent J. Brochard, Ewan C. Goligher

Open Access Research

Neurological outcome after extracorporeal cardiopulmonary resuscitation for in-hospital cardiac arrest: a systematic review and meta-analysis

Benjamin Yaël Gravesteijn, Marc Schluep, Maksud Disli, Prakriti Garkhail, Dinis Dos Reis Miranda, Robert-Jan Stolker, Henrik Endeman, Sanne Elisabeth Hoeks

Open Access Review

A narrative review on trans-nasal pulmonary aerosol delivery

Jie Li, James B. Fink, Ronan MacLoughlin, Rajiv Dhand

Open Access COVID-19 Editorial

ECMO during the COVID-19 pandemic: when is it unjustified?

Darryl Abrams, Roberto Lorusso, Jean-Louis Vincent, Daniel Brodie

Open Access COVID-19 Research Letter

Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia

Guido Tavazzi, Marco Pozzi, Silvia Mongodi, Valentino Dammassa, Giovanni Romito, Francesco Mojoli

Open Access COVID-19 Research Letter

Usefulness and safety of a dedicated team to prone patients with severe ARDS due to COVID-19

Antoine Kimmoun, Bruno Levy, Bruno Chenuel, S. Barde, A. Didelot, B. Chenuel, P. Zieminski, M. Lorcin, C. Schweitzer, R. Karunna, V. Moulin, M. Huet, F. Lacour, P. Rodriguez, D. Grandmougin, Y. Liu, P. A. Metzdorf, M. Costa, T. Fouquet, A. Germain, H. Chanty, J. Levy, A. Didier, J. Lawton, C. Parietti-Winkler, A. Manuguerra, C. Mazeaud, C. Gaulier, C. Rumeau, L. Bourson, M. Cholley-Roulleau, A. Ionescu, A. Gatin, M. Perez, A. Schwanké, G. Lauria, L. Freysz, T. Cuinet, J. Chauvelot, C. Mottola, T. Toussaint, L. Dechambenoit, F. Lagrange, C. Mathieu, C. Clément, H. Benamron, L. Dubouis, H. Kremer, L. Cabanel, M. Falcetta, V. Gorzkowski, P. Campoli, J. Cavailhes, J. Zavoli, C. Nominé-Criqui, J. Felloni, V. Cloché-Fouquet, F. G. Midon, G. Vaz, D. Valentin, V. Perkovic, A. Courandon, Y. Briot, A. Epin, K. Dreller, L. Florion, C. Larose, M. Barron, C. Sadoul, M. Gimbert, M. Fernandez, T. Thomas, P. Bichet, N. Petkunaite, S. Brahami, D. Nguyen, G. Vaz, A. Schaefer, C. Fabbri, C. Ferri, A. Gegout, A. Poncy, R. Delaplace, M. Ammisaid, J. Rebois, B. Vendeville, C. Dubroux, R. Raynaud, S. Moog, C. Cottez, L. Woirhaye, J. Menet, A. C. Madkaud, L. Naisseline, C. Mathieu, T. Raze, F. Violon, M. Meiers, D. Albanesi, O. Durand, L. Textoris, T. Dubost

Open Access COVID-19 Letter

Above and beyond: biofilm and the ongoing search for strategies to reduce ventilator-associated pneumonia (VAP)

Takashi Sakano, Edward A. Bittner, Marvin G. Chang, Lorenzo Berra

Open Access Letter

A limitation of Chase’s proposal for safe doubling of ventilator capacity

Ross Freebairn, Michael Park

Open Access Research

Association between mean arterial pressure during the first 24 hours and hospital mortality in patients with cardiogenic shock

Barry Burstein, Meir Tabi, Gregory W. Barsness, Malcolm R. Bell, Kianoush Kashani, Jacob C. Jentzer

Open Access COVID-19 Letter

Extracorporeal cytokine adsorption as an alternative to pharmacological inhibition of IL-6 in COVID-19

Alexander Supady, Daniel Duerschmied, Christoph Bode, Marina Rieder, Achim Lother

Open Access Research

Incidence and outcomes of acute respiratory distress syndrome in intensive care units of mainland China: a multicentre prospective longitudinal study

Xu Huang, Ruoyang Zhang, Guohui Fan, Dawei Wu, Haining Lu, Daoxin Wang, Wang Deng, Tongwen Sun, Lihua Xing, Shaohua Liu, Shilei Wang, Ying Cai, Ye Tian, Yi Zhang, Jingen Xia, Qingyuan Zhan, Lixin Xie, Ying Wang, Li Weng, Guangfa Zhu, Yan Liu, Man Song, Yanming Zhao, Jing Chen, Hongwen Zhao, Haijia Hou, Jingping Yang, Rina Wu, Xiyuan Xu, Xixin Yan, Haibo Xu, Dawei Wu, Haining Lu, Gengyun Sun, Dan Zhang, Beilei Zhao, Binhai Pan, Jialin Liu, Ruoming Tan, Pinhua Pan, Rongli Lu, Hong Luo, Han Zhang, Daoxin Wang, Wang Deng, Yusheng Chen, Fengfeng Lu, Sicheng Xu, Xia Luo, Hong Teng, Lijuan Chen, Lihua Xing, Shilei Wang, Tongwen Sun, Shaohua Liu, Bing Han, Yunlu Li

Open Access COVID-19 Research letter

Incidence of ARDS and outcomes in hospitalized patients with COVID-19: a global literature survey

Susan J. Tzotzos, Bernhard Fischer, Hendrik Fischer, Markus Zeitlinger

Open Access Research Letter

Hyperoxia provokes gut dysbiosis in rats

Zhouxiong Xing, Yunhang Li, Guoyue Liu, Ying He, Yuanfa Tao, Miao Chen

Open Access Research

The therapeutic efficacy of adjunct therapeutic plasma exchange for septic shock with multiple organ failure: a single-center experience

Philip D. Keith, Adam H. Wells, Jeremy Hodges, Stephen H. Fast, Amber Adams, L. Keith Scott

Open Access COVID-19 Editorial

COVID-19 and ethics in the ICU

Sarah E. Nelson

Open Access Research

Assessing physicians’ and nurses’ experience of dying and death in the ICU: development of the CAESAR-P and the CAESAR-N instruments

Florence Boissier, Valérie Seegers, Amélie Seguin, Stéphane Legriel, Alain Cariou, Samir Jaber, Jean-Yves Lefrant, Thomas Rimmelé, Anne Renault, Isabelle Vinatier, Armelle Mathonnet, Danielle Reuter, Olivier Guisset, Christophe Cracco, Jacques Durand-Gasselin, Béatrice Éon, Marina Thirion, Jean-Philippe Rigaud, Bénédicte Philippon-Jouve, Laurent Argaud, Renaud Chouquer, Laurent Papazian, Céline Dedrie, Hugues Georges, Eddy Lebas, Nathalie Rolin, Pierre-Edouard Bollaert, Lucien Lecuyer, Gérald Viquesnel, Marc Leone, Ludivine Chalumeau-Lemoine, Maité Garrouste-Orgeas, Elie Azoulay, Nancy Kentish-Barnes

Open Access Research Letter

Vitamin C levels in patients with SARS-CoV-2-associated acute respiratory distress syndrome

Luis Chiscano-Camón, Juan Carlos Ruiz-Rodriguez, Adolf Ruiz-Sanmartin, Oriol Roca, Ricard Ferrer

Open Access Research Letter

Successful ventilation of two animals with a single ventilator: individualized shared ventilator setup in an in vivo model

Michiel Stiers, Tom Bleeser, Matthias Mergeay, Hannah Pinson, Luc Janssen, Tom Schepens

Open Access COVID-19 Research Letter

Efficacy of tocilizumab treatment in severely ill COVID-19 patients

Jie Zhao, Wei Cui, Bao-ping Tian

Open Access COVID-19 Research

Longitudinal changes of inflammatory parameters and their correlation with disease severity and outcomes in patients with COVID-19 from Wuhan, China

Zhilin Zeng, Haijing Yu, Huilong Chen, Weipeng Qi, Liang Chen, Guang Chen, Weiming Yan, Tao Chen, Qin Ning, Meifang Han, Di Wu

Open Access COVID-19 Research Letter

RNA-expression of adrenomedullin is increased in patients with severe COVID-19

Julian Hupf, Julian Mustroph, Frank Hanses, Katja Evert, Lars S. Maier, Carsten G. Jungbauer

Open Access COVID-19 Correction

Correction to: COVID-19-associated acute cerebral venous thrombosis: clinical, CT, MRI and EEG features

Fabian Roy-Gash, Marine De Mesmay, Jean-Michel Devys, Hervé Vespignani, Raphaël Blanc, Nicolas Engrand

Open Access COVID-19 Research

Respiratory physiology of COVID-19-induced respiratory failure compared to ARDS of other etiologies

Domenico Luca Grieco, Filippo Bongiovanni, Lu Chen, Luca S. Menga, Salvatore Lucio Cutuli, Gabriele Pintaudi, Simone Carelli, Teresa Michi, Flava Torrini, Gianmarco Lombardi, Gian Marco Anzellotti, Gennaro De Pascale, Andrea Urbani, Maria Grazia Bocci, Eloisa S. Tanzarella, Giuseppe Bello, Antonio M. Dell’Anna, Salvatore M. Maggiore, Laurent Brochard, Massimo Antonelli

Open Access COVID-19 Research Letter

Herpes simplex virus and cytomegalovirus reactivations among severe COVID-19 patients

Pierre Le Balc’h, Kieran Pinceaux, Charlotte Pronier, Philippe Seguin, Jean-Marc Tadié, Florian Reizine

Open Access Research

Body-mass index and long-term risk of sepsis-related mortality: a population-based cohort study of 0.5 million Chinese adults

Li Weng, Junning Fan, Canqing Yu, Yu Guo, Zheng Bian, Yuxia Wei, Ling Yang, Yiping Chen, Huaidong Du, Liang Chang, Weiwei Gong, Junshi Chen, Zhengming Chen, Bin Du, Jun Lv, Liming Li

Open Access Research Letter

Substrate utilization and energy expenditure pattern in sepsis by indirect calorimetry

Andrew Li, Amartya Mukhopadhyay

Open Access Research

Effect of withholding early parenteral nutrition in PICU on ketogenesis as potential mediator of its outcome benefit

Astrid De Bruyn, Jan Gunst, Chloë Goossens, Sarah Vander Perre, Gonzalo G. Guerra, Sascha Verbruggen, Koen Joosten, Lies Langouche, Greet Van den Berghe

Open Access Review

The importance of airway and lung microbiome in the critically ill

Ignacio Martin-Loeches, Robert Dickson, Antoni Torres, Håkan Hanberger, Jeffrey Lipman, Massimo Antonelli, Gennaro de Pascale, Fernando Bozza, Jean Louis Vincent, Srinivas Murthy, Michael Bauer, John Marshall, Catia Cilloniz, Lieuwe D. Bos

Open Access COVID-19 Research Letter

Impact of negative air pressure in ICU rooms on the risk of pulmonary aspergillosis in COVID-19 patients

Philippe Ichai, Faouzi Saliba, Patricia Baune, Asma Daoud, Audrey Coilly, Didier Samuel

Open Access COVID-19 Research Letter

Nasopharyngeal viral load predicts hypoxemia and disease outcome in admitted COVID-19 patients

Amir Shlomai, Haim Ben-Zvi, Ahinoam Glusman Bendersky, Noa Shafran, Elad Goldberg, Ella H. Sklan

Open Access COVID-19 Research Letter

Positive end-expiratory pressure titration in COVID-19 acute respiratory failure: electrical impedance tomography vs. PEEP/FiO2 tables

Nicolò Sella, Francesco Zarantonello, Giulio Andreatta, Veronica Gagliardi, Annalisa Boscolo, Paolo Navalesi

Open Access COVID-19 Letter

The application of 6S in the care of COVID-19 patients: a Japanese perspective

Mitsuhito Soh, Toru Hifumi, Shutaro Isokawa, Norio Otani, Shinichi Ishimatsu

Open Access Letter

Hyperthermia is a predictor of high mortality in patients with sepsis

Yanfei Shen, Yangfang Lou, Shiping Zhu

Open Access Research

Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis

Katherine E. Bline, Melissa Moore-Clingenpeel, Josey Hensley, Lisa Steele, Kristin Greathouse, Larissa Anglim, Lisa Hanson-Huber, Jyotsna Nateri, Jennifer A. Muszynski, Octavio Ramilo, Mark W. Hall

Open Access COVID-19 Letter

Treatment with angiotensin II in COVID-19 patients may not be beneficial

Susanne Rysz, Francesca Campoccia Jalde, Anders Oldner, Lars I. Eriksson, Johan Lundberg, Malin Jonsson Fagerlund

Open Access Research

A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort

Björn Ahlström, Ing-Marie Larsson, Gunnar Strandberg, Miklos Lipcsey

Open Access COVID-19 Commentary

COVID-19: more than a cytokine storm

Giovanni Riva, Vincenzo Nasillo, Enrico Tagliafico, Tommaso Trenti, Patrizia Comoli, Mario Luppi

Open Access Research

(1,3)-β-d-Glucan-based empirical antifungal interruption in suspected invasive candidiasis: a randomized trial

Gennaro De Pascale, Brunella Posteraro, Sonia D’Arrigo, Giorgia Spinazzola, Rita Gaspari, Giuseppe Bello, Luca Maria Montini, Salvatore Lucio Cutuli, Domenico Luca Grieco, Valentina Di Gravio, Giulia De Angelis, Riccardo Torelli, Elena De Carolis, Mario Tumbarello, Maurizio Sanguinetti, Massimo Antonelli

Open Access COVID-19 Letter

Plasma exchange in critically ill COVID-19 patients improved inflammation, microcirculatory clot formation, and hypotension, thereby improving clinical outcomes: fact or fiction?

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Letter

Assessment of pulmonary surfactant in COVID-19 patients

Peter Schousboe, Lothar Wiese, Christian Heiring, Henrik Verder, Porntiva Poorisrisak, Povl Verder, Henning Bay Nielsen

Open Access Research

Cross-sectional study for the clinical application of extracorporeal membrane oxygenation in Mainland China, 2018

Wei Cheng, Xu-Dong Ma, Long-Xiang Su, Huai-Wu He, Lu Wang, Bo Tang, Wei Du, Yuan-kai Zhou, Hao Wang, Na Cui, Yun Long, Da-Wei Liu, Yan-Hong Guo, Ye Wang, Guang-Liang Shan, Xiang Zhou, Shu-Yang Zhang, Yu-Pei Zhao

Open Access Research

The clinical potential of GDF15 as a “ready-to-feed indicator” for critically ill adults

Lisa Van Dyck, Jan Gunst, Michaël P. Casaer, Bram Peeters, Inge Derese, Pieter J. Wouters, Francis de Zegher, Ilse Vanhorebeek, Greet Van den Berghe

Open Access Research

Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT)

Alan Abdulla, Annemieke Dijkstra, Nicole G. M. Hunfeld, Henrik Endeman, Soma Bahmany, Tim M. J. Ewoldt, Anouk E. Muller, Teun van Gelder, Diederik Gommers, Birgit C. P. Koch

Open Access COVID-19 Review

Comparison of published guidelines for management of coagulopathy and thrombosis in critically ill patients with COVID 19: implications for clinical practice and future investigations

Adam Flaczyk, Rachel P. Rosovsky, Clay T. Reed, Brittany K. Bankhead-Kendall, Edward A. Bittner, Marvin G. Chang

Open Access Research

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Amy Brenner, Antonio Belli, Rizwana Chaudhri, Timothy Coats, Lauren Frimley, Sabariah Faizah Jamaluddin, Rashid Jooma, Raoul Mansukhani, Peter Sandercock, Haleema Shakur-Still, Temitayo Shokunbi, Ian Roberts, Ian Roberts, Haleema Shakur-Still, Amy Aeron-Thomas, Antonio Belli, Amy Brenner, Muhammad Anwar Chaudary, Rizwana Chaudhri, Sabariah Faizah Bt Jamaluddin, Lauren Frimley, Kiran Javaid, Rashid Jooma, Aasia Kayani, Caroline Leech, Khalid Mahmood, Raoul Mansukhani, Julina Md Noor, Jorge Mejia-Mantilla, Phil Moss, Jason Pott, Peter Sandercock, Temitayo Shokunbi, Liliana Vallecilla, Henry Benjamin Hartzenberg, Manjul Joshipura, Pablo Perel, Michael J. Clarke, Samuel C. Ohaegbulam, Anthony Rodgers, Tony Brady, Yashbir Dewan, Phil Edwards, Edward O. Komolafe, Monica Arribas, Emma Austin, Eni Balogun, Lin Barneston, Collette Barrow, Danielle Beaumont, Myriam Benyahia, Imogen Brooks, Madeleine Cargill, Laura Carrington, Lisa Cook, Beatrice Cornu-Hewitt, Amber Geer, Daniel Gilbert, Catherine Gilliam, Julio Gil-Onandia, Daniel Hetherington, Courtenay Howe, Carolyn Hughes, David I’anson, Rob Jackson, Miland Joshi, Sneha Kansagra, Taemi Kawahara, Katharine Ker, Sergey Kostrov, Abda Mahmood, Hakim Miah, Bernard Ndungu, Kelly Needham, Cecilia Okusi, Aroudra Outtandy, Raul Pardinaz-Solis, Daniel Pearson, Tracey Pepple, Claude Pisani, David Prieto-Merino, Danielle Prowse, Nigel Quashi, Anna Quinn, Maria Ramos, Mia Reid, Chris Roukas, Giulia Scrapa, Chelci Squires, Jemma Tanner, Andrew Thayne, Lesley Vidaurre, Elizabeth Woods, Bukola Fawole, Olusade Adetayo, Olujide Okunade, Tamar Gogichaishvili, Maria de los Angeles Munoz-Sanchez, Fatos Olldashi, Satish Krishnan, Vincent Djientcheu, Jorge Loria Castellanos, Frank Rasulo, Qadamkhear Hama, Yakub Mulla, Ioan Stefan Florian, Juan Tobar, Hussein Khamis, Conor Deasy, Bobby Wellsh, Jean Williams-Johnson, Susilo Chandra, Vincent Mutiso, Rizwan Butt, Muhammad Hammad Nasir, Salman Ahmad, Farwah Aslam, Khurram Ishaque, Faheem Usmani, Shahrukh Rizvi, Farhad Ali, Omair Sajjad, Ali Zunair, Lal Rehman, Raza Rizvi, Farrukh Javeed, Shakeel Ahmed, Asad Abbas, Ali Afzal, Ali Mikdad, Asif Bashir, Anwar Chaudary, Tariq Salahuddin, Bashir Ahemed, Amir Aziz, Naveed Ashraf, Shahzad Hussain, Usman Ahmad, Muhammad Asif, Muhammad Adil, Adeel Rauf, Rizwan Khan, Bilal Ahmad, Umair Afzal, Hassan Raza, Quratul Ain, Sajjad Yaqoob, Qaiser Waseem, Muffasser Nishat, Suneel Semvel, Javed Iqbal, Samra Majeed, Sana Zulfiqar, Madeeha Iqbal, Nazia Majeed, Manzoor Ahmed, Nadeem Akhtar, Mohammad Malik, Yasir Shehzad, Muhammad Yousaf, Abdul Wahid, Abdul Samad, Saifullah Shah, Mumtaz Ali, Jehan Zeb, Abdus Salam Khan, Adeela Irfan, Salman Sharif, Riaz Memon, Ben Bloom, Tim Harris, Imogen Skene, Geoffrey Bellhouse, Olivia Boulton, Geraldine Ward, Catherine Jarvis, Carly Swann, Sathananathan Ratnam, Ronald Carrera, Kamal Yakoub, David Davies, Emma Fellows, Heather Jarman, Sarah Rounding, Elizabeth Johnson, Catherine Loughran, Fiona Lecky, Kate Clayton, Angiy Michael, Angela Coumbarides, Jason Kendall, Beverley Faulkner, Ruth Worner, Emma Gendall, Philip Hopkins, Paul Riozzi, Hannah Cotton, Raine Astin-Chamberlain, Mark Wilson, Jan Bodnar, Rachel Williams, Alberto Rigoni, Abdo Sattout, John Fletcher, Calum Edge, Nina Maryanji, Adrian Boyle, Susie Hardwick, Ellen Nichols, Catherine Hayhurst, Frank Coffey, Chris Gough, Philip Miller, Lucy Ryan, Melanie Darwent, Alexis Espinosa, Sally Beer, Julie Norton, Holly Maguire, Kay Finney, Anthony Kehoe, Rosalyn Squire, Alison Jeffery, Christiane Vorwerk, Denise Foord, Eliot Wilkinson, Avril Kuhrt, Shammi Ramlakhan, Stuart Reid, Andy Curran, Sean McMullan, Tajek Hassan, Stuart Nuttall, Stephen Haig, Saif Al-Nahhas, Diederik Bulters, Ardalan Zolnourian, Tamsin Ribbons, Ian Mew, Tanya de Weymarn, Victoria Hughes, Jane McVicar, Cieran McKiernan, Liza Keating, Henrik Reschreiter, Judith Wright, Louisa Chan, Himanshu Kataria, Alastair Ireland, Richard Body, Alasdair Corfield, Shindo Francis, William Townend, Timothy Coats, James Gagg, Sarah Wilson, Rowley Cottingham, Simon Tucker, Frank Sutherland, Louisa Mitchell, Lucy Parker, Ola Afolabi, Fiona Hunter, Mark Jadav, Kayode Adeboye, Mandy Grocutt, Gabrielle May, David Watson, Andrea Wootten, Sarah Robertshaw, Susan Dorrian, Rob Perry, Hyun Choi, Claire McGroarty, Paul Shone, David Maritz, Sabariah Jamaluddin, Julina Noor, Norizan Rosli, Leonard Leong Sang Xian, Yong De Jun, Fatahul Mohamed, Cheng Hee Song, Arman Hawari, Leong Yuen Chin, Hardawani Mohd Hussein, Mohd Lotfi, Hafiq Hamid, Nujaimin Udin, Peck Lian, See Choo, Kwanhathai Wong, Fathiyah Gani, Mardhiah Jusoh, Darrsini Rajakumar, Chia Boon Yang, Nur Shahidah Binti Dzulkiflee, Wong Chok Ky, Muhaimin Azwan Bin Mohd Azman, Adi Bin Osman, Azma Haryaty Ahmad, Ramzuzaman Ismail, Si Qi Lai, Mohd Amin Bin Mohidin, Norwani Binti Deraman, Salliza Binti Selamat, Ida Abidin, Nurkhairulnizam Halim, Zuraini Bakar, Zainalabidin Mohamed Ismail, Badrul Hisham, Ruhaida Kamal, Zainal Effendy, Mashitah Ismail, Noor Azleen, Liu Yeo Seng, Kamarul Aryffin Baharuddin, Regunath Kandasamy, Azlan Kamalludin, Shamsul Asmee, Mohd Fadzil, Ahmad Basitz, Norhaya Abdullah, Giorgi Ingorokva, Shota Ingorokva, Iamze Agdgomelashvili, Kote Mumladze, Ioseb Maisuradze, Iulia Kugusheva, Buba Shalamberidze, Gia Tomadze, Juan Fernandez-Ortega, Raimundo Seara-Valero, Guillermo Ibañez-Botella, Victoria Garcia-Martinez, Melida Garcia Martul, Santiago Freita Ramos, Guillermo Lago Preciado, Claudio Garcia-Alfaro, Angeles Munoz-Sanchez, Rafael Bellido-Alba, Carmen Corcobado, Ana Bueno, Alfonso Ambros, Juan Tihista Jimenez, Jose Roldan Ramirez, José Martín, Laura Inés Rodríguez, Jaime Fontanals, José Manuel Jiménez-Moragas, Joaquín Paya Berbegal, Olaomi Oluwole, Raji Mahmud, Nancy Ukwu, Femi Bankole, Abidemi Oseni, Bamidele Adebayo, Adefolarin Malomo, Liadi Tiamiyu, Adefisayo Adekanmbi, Lateef Thanni, Ayodeji Olubodun, Fidelis Ojeblenu, Michael Uwaezuoke, Edward Komolafe, Oluwafemi Owagbemi, Fatai Ishola, Adewumi Durodola, Ukpong Udoffa, Adeniran James, Azeez Tella, Andrew Dongo, Uchechi Ekpemiro, Stanley Anyanwu, Nafiu Aigoro, Wilfred Mezue, Danaan Shilong, Abiodun Azeez, Olakunle Babalola, Mohammed Ibrahim, Joseph Obande, Alfredo Constain Franco, Edwin Vasquez Salazar, Sebastian Betancur Londoño, Viviana Medina Cardona, Carlos Morales, Santiago Naranjo, July Agudelo, Sandra Carvajal, Yidhira Fajardo-Gaviria, Yam Roka, Ushma Ghising, Narayani Roka, Manzil Shrestha, Upendra Devkota, Bivek Vaidya, Pankaj Nepal, Amit Thapa, Bidur KC, Ajit Shrestha, Rajiv Jha, Prabin Shrestha, Irgen Hodaj, Erion Spaho, Asllan Selaj, Nirian Bendo, Tomohisa Shoko, Hideki Endo, Atsushi Senda, Yasushi Hagihara, Takashi Fuse, Naohisa Masunaga, Yasuhiro Otomo, Ryuichiro Egashira, Takahiro Ohnuki, Alya AlMazmi, Subrata Saha, Alexander Suvarov, Than Latt Aung, Kaung Myat Tun, Tint Tint Khaing, Thinzar Maw, Orlane Ndome, Mireille Moumi, André Mbida, Joseph Fondop, Mba Sebastien, Abdul Azim, Jan Adil, Zabiullah Amiry, Jorge Loría-Castellanos, Nancy Guevara Rubio, Patricia Ortega Leon, Francisco Estrada, Erandy Montes de Oca-García, Hafid Sanchez, Angélica Soria, Paola Bonucci, Federico Franchi, Alan Girardini, Himdad Hameed, Muhammad Basim, Simon Stock, Eap Hourt, Ali Ilunga, Jonathan Mulenga, Horia Ples, Adam Danil, Mircea Gorgan, Ioan Florian, Dusan Vlahovic, James French, Jeffrey East, Antonius Kurniawan, Julius Kiboi

Open Access COVID-19 Research

Thrombotic and haemorrhagic complications in critically ill patients with COVID-19: a multicentre observational study

Akshay Shah, Killian Donovan, Anna McHugh, Manish Pandey, Louise Aaron, Charlotte A. Bradbury, Simon J. Stanworth, Raza Alikhan, Stephen Von Kier, Keith Maher, Nicola Curry, Susan Shapiro, Matthew J. Rowland, Matt Thomas, Richard Mason, Matthew Holland, Tom Holmes, Michael Ware, Stefan Gurney, Stuart R. McKechnie

Open Access Letter

Chlorhexidine still has skin in the game

Alexandra Lackey, Brandon Kalivoda, Amay Parikh

Open Access Research Letter

Endobronchial ultrasound is feasible and safe to diagnose pulmonary embolism in non-transportable SARS-CoV-2 ARDS patients requiring extracorporeal lung support

Maxens Decavele, Valery Trosini-Désert, Samia Boussouar, Baptiste Duceau, Martin Dres, Alexandre Demoule

Open Access COVID-19 Research Letter

Glucocorticoid therapy does not delay viral clearance in COVID-19 patients

Jingjing Ji, Jinxia Zhang, Ziyun Shao, Qifeng Xie, Li Zhong, Zhifeng Liu

Open Access Research

ICU admission body composition: skeletal muscle, bone, and fat effects on mortality and disability at hospital discharge—a prospective, cohort study

Ariel Jaitovich, Camille L. Dumas, Ria Itty, Hau C. Chieng, Malik M. H. S. Khan, Ali Naqvi, John Fantauzzi, Jesse B. Hall, Paul J. Feustel, Marc A. Judson

Open Access Research Letter

Aminoglycosides for the treatment of septic shock: a propensity-based study

Jean-François Llitjos, Simon Meslin, Swann Bredin, Matthieu Jamme, Frédéric Pène

Open Access COVID-19 Research Letter

Rapid positioning of nasogastric tube by ultrasound in COVID-19 patients

Anyu Qian, Shanxiang Xu, Xiao Lu, Luping Tang, Mao Zhang, Xiao Chen

Open Access Research

Pulse pressure and end-tidal carbon dioxide for monitoring low native cardiac output during veno-arterial ECLS: a prospective observational study

Marc Mourad, Jacob Eliet, Norddine Zeroual, Marine Saour, Pierre Sentenac, Federico Manna, Nicolas Molinari, Thomas Gandet, Pascal H. Colson, Philippe Gaudard

Open Access Letter

Hepcidin is described as the master regulator of iron: could its removal by CRRT lead to iron dysmetabolism in the critically ill?

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Review

Practical strategies to reduce nosocomial transmission to healthcare professionals providing respiratory care to patients with COVID-19

Ramandeep Kaur, Tyler T. Weiss, Andrew Perez, James B. Fink, Rongchang Chen, Fengming Luo, Zongan Liang, Sara Mirza, Jie Li

Open Access Research Letter

Sensitivity of point-of-care IgM and IgG test in critically ill patients with SARS-Cov-2

Lee S. Nguyen, Driss Laghlam, Emmanuelle De Gonfreville, Frédéric Pène, Flore Rozenberg, Jean-Paul Mira

Open Access COVID-19 Research Letter

Fibrin-derived peptide Bβ15-42 (FX06) as salvage treatment in critically ill patients with COVID-19-associated acute respiratory distress syndrome

Elisabeth H. Adam, Benedikt Schmid, Michael Sonntagbauer, Peter Kranke, Kai Zacharowski, Patrick Meybohm

Open Access Review

Mechanical ventilation in aneurysmal subarachnoid hemorrhage: systematic review and recommendations

James E. Towner, Redi Rahmani, Christopher G. Zammit, Imad R. Khan, David A. Paul, Tarun Bhalla, Debra E. Roberts

Open Access Research Letter

SuPAR levels in BAL fluid from patients with acute respiratory distress syndrome—a pilot study

Alexander C. Reisinger, Gerald Hackl, Tobias Niedrist, Martin Hoenigl, Philipp Eller, Juergen Prattes

Open Access Research

Implications for post critical illness trial design: sub-phenotyping trajectories of functional recovery among sepsis survivors

Zudin A. Puthucheary, Jochen S. Gensichen, Aylin S. Cakiroglu, Richard Cashmore, Lara Edbrooke, Christoph Heintze, Konrad Neumann, Tobias Wollersheim, Linda Denehy, Konrad F. R. Schmidt

Open Access COVID-19 Research Letter

Oral favipiravir for patients with delayed SARS-CoV-2 viral RNA clearance: a case series

Dian Fu, Ruiyuan Cao, Lei Zhao, Wei Li, Wu Zhong, Jiqiu Wen

Open Access Research

Cost-effectiveness of adrenaline for out-of-hospital cardiac arrest

Felix Achana, Stavros Petrou, Jason Madan, Kamran Khan, Chen Ji, Anower Hossain, Ranjit Lall, Anne-Marie Slowther, Charles D. Deakin, Tom Quinn, Jerry P. Nolan, Helen Pocock, Nigel Rees, Michael Smyth, Simon Gates, Dale Gardiner, Gavin D. Perkins, Stavros Petrou, Jason Madan, Kamran Khan, Chen Ji, Anower Hossain, Ranjit Lall, Anne-Marie Slowther, Charles D. Deakin, Tom Quinn, Jerry P. Nolan, Helen Pocock, Nigel Rees, Michael Smyth, Simon Gates, Dale Gardiner, Gavin D. Perkins, Matthew Cooke, Sarah Lamb, Andrew Carson, Ian Jacobs, Ed England, John Black, Nicola Brock, Claire Godfrey, Sarah Taylor, Michelle Thomson, Isabel Rodriguez-Bachiller, Claire King, Marie Stevens, Johanna Lazarus, Helen Werts, Joshua Golding, Rachel Fothergill, Fionna Moore, Alex Boda, Richard Whitfield, Laura Galligan, Rob Lovett, Jennifer Bradley, Lyndsay O’Shea, Mark Docherty, Imogen Gunsen, Gill Price, Andy Rosser, Garry Parcell, Mindy Jhamat, Josh Miller, Jenny Sears Brown, Alice Pretty, Madison Larden, Emma Harris, Jenny Lumley-Holmes, Rhiannon Boldy, Prudence Horwood, Kyee Han, Karl Charlton, Sonia Byers, Gary Shaw, Matt Limmer, Craig Wynne, Michelle Jackson, Emma Bell, Oliver Gupta, Rima Gupta, Charlotte Scomparin, Susie Hennings, Jessica Horton, James Buck, Sarah Rumble, Hayley Johnson, Eva Kritzer, Chockalingham Muthiah, Adrian Willis, Claire Daffern, Louise Clarkson, Felix Achana, Nicola Cashin, Emma Skilton, Malvenia Richmond, Martin Underwood, Natalie Strickland, Sarah Duggan, Scott Regan, Jill Wood, Jon Nicholl, Neil Bayliss, Helen Snooks, Jonathan Benger, Robert Andrews, David Pitcher, William Lee, Matt Wise, Marion Campbell, Jasmeet Soar, Kathy Rowan, Sue Mason

Open Access COVID-19 Research Letter

Lessons from an ICU recovery clinic: two cases of meralgia paresthetica after prone positioning to treat COVID-19-associated ARDS and modification of unit practices

Amy L. Bellinghausen, Jamie N. LaBuzetta, Frank Chu, Francesca Novelli, Anthony R. Rodelo, Robert L. Owens

Open Access COVID-19 Research Letter

Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19

John Whittle, Jeroen Molinger, David MacLeod, Krista Haines, Paul E. Wischmeyer, John Whittle, Jeroen Molinger, David MacLeod, Krista Haines, Paul E. Wischmeyer, Anthony Sung, Marat Fudim, Lindsie Boerger, Kathryn Lessig, Jessica Lumbard, Leslie C. Murray, Sue Steves, Jhana Parikh, Jacob Ribet, Melanie Hollidge

Open Access Research

Effect of antiviral therapy on the outcomes of mechanically ventilated patients with herpes simplex virus detected in the respiratory tract: a systematic review and meta-analysis

Stefan Hagel, André Scherag, Lukas Schuierer, Reinhard Hoffmann, Charles-Edouard Luyt, Mathias W. Pletz, Miriam Kesselmeier, Sebastian Weis

Open Access COVID-19 Review

COVID-19: instruments for the allocation of mechanical ventilators—a narrative review

Marcelo José dos Santos, Maristela Santini Martins, Fabiana Lopes Pereira Santana, Maria Carolina Silvano Pacheco Corrêa Furtado, Fabiana Cristina Bazana Remédio Miname, Rafael Rodrigo da Silva Pimentel, Ágata Nunes Brito, Patrick Schneider, Edson Silva dos Santos, Luciane Hupalo da Silva

Open Access Research

Epinephrine’s effects on cerebrovascular and systemic hemodynamics during cardiopulmonary resuscitation

Constantine D. Mavroudis, Tiffany S. Ko, Ryan W. Morgan, Lindsay E. Volk, William P. Landis, Benjamin Smood, Rui Xiao, Marco Hefti, Timothy W. Boorady, Alexandra Marquez, Michael Karlsson, Daniel J. Licht, Vinay M. Nadkarni, Robert A. Berg, Robert M. Sutton, Todd J. Kilbaugh

Open Access Research Letter

Metformin use and early lactate levels in critically ill patients according to chronic and acute renal impairment

Rene A. Posma, Adam Hulman, Reimar W. Thomsen, Bente Jespersen, Maarten W. Nijsten, Christian F. Christiansen

Open Access COVID-19 Research Letter

Presence of SARS-CoV-2 in urine is rare and not associated with acute kidney injury in critically ill COVID-19 patients

Robert Frithiof, Anders Bergqvist, Josef D. Järhult, Miklos Lipcsey, Michael Hultström

Open Access COVID-19 Research

Efficacy of tocilizumab in patients with COVID-19 ARDS undergoing noninvasive ventilation

Francesco Menzella, Matteo Fontana, Carlo Salvarani, Marco Massari, Patrizia Ruggiero, Chiara Scelfo, Chiara Barbieri, Claudia Castagnetti, Chiara Catellani, Giorgia Gibellini, Francesco Falco, Giulia Ghidoni, Francesco Livrieri, Gloria Montanari, Eleonora Casalini, Roberto Piro, Pamela Mancuso, Luca Ghidorsi, Nicola Facciolongo

Open Access COVID-19 Letter

No time for pending confirmation of invasive fungal disease in critically ill COVID-19 patients—think empirical treatment

Anne-Lise Bienvenu, Nathalie Bleyzac, Jean-Christophe Richard, Gilles Leboucher

Open Access COVID-19 Letter

Procedural justice and egalitarian principles for rationing decisions in the COVID-19 crisis

Alexander Supady, Christoph Bode, Daniel Duerschmied

Open Access COVID-19 Letter

Response to “Co-infections in COVID-19 critically ill and antibiotic management: a prospective cohort analysis”

Marieke B. Nieuwenhuis, Stefaan Van Biesen, Nicole P. Juffermans

Open Access Review

Ultrasound-guided peripheral vascular catheterization in pediatric patients: a narrative review

Yoshinobu Nakayama, Jun Takeshita, Yasufumi Nakajima, Nobuaki Shime

Open Access COVID-19 Research

Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review

Salleh N. Ehaideb, Mashan L. Abdullah, Bisher Abuyassin, Abderrezak Bouchama

Open Access Research

Chlorhexidine bathing of the exposed circuits in extracorporeal membrane oxygenation: an uncontrolled before-and-after study

Hye Ju Yeo, Dohyung Kim, Mihyang Ha, Hyung Gon Je, Jeong Soo Kim, Woo Hyun Cho

Open Access COVID-19 Research

Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study

Carlos Ferrando, Ricard Mellado-Artigas, Alfredo Gea, Egoitz Arruti, César Aldecoa, Ramón Adalia, Fernando Ramasco, Pablo Monedero, Emilio Maseda, Gonzalo Tamayo, María L. Hernández-Sanz, Jordi Mercadal, Ascensión Martín-Grande, Robert M. Kacmarek, Jesús Villar, Fernando Suárez-Sipmann, Marina Vendrell, Gerard Sánchez-Etayo, Amalia Alcón, Isabel Belda, Mercé Agustí, Albert Carramiñana, Isabel Gracia, Miriam Panzeri, Irene León, Jaume Balust, Ricard Navarro, María José Arguís, María José Carretero, Cristina Ibáñez, Juan Perdomo, Antonio López, Manuel López-Baamonde, Tomás Cuñat, Marta Ubré, Antonio Ojeda, Andrea Calvo, Eva Rivas, Paola Hurtado, Roger Pujol, Nuria Martín, Javier Tercero, Pepe Sanahuja, Marta Magaldi, Miquel Coca, Elena del Rio, Julia Martínez-Ocon, Paula Masgoret, Angel Caballero, Raquel Risco, Lidia Gómez, Nicolás de Riva, Ana Ruiz, Beatriz Tena, Monserrat Tio, Sebastián Jaramillo, José María Balibrea, Francisco Borja de Lacy, Ana Otero, Ainitze Ibarzabal, Raquel Bravo, Anna Carreras, Daniel Martín-Barreda, Alfonso Jesús Alias, Mariano Balaguer, Jorge Aliaga, Alex Almuedo, Joan Ramón Alonso, Rut Andrea, Gerard Sergi Angelès, Marilyn Arias, Fátima Aziz, Joan Ramon Badía, Enric Barbeta, Toni Torres, Guillem Batiste, Pau Benet, Xavi Borrat, María Borrell, Ernest Bragulat, Inmaculada Carmona, Manuel Castellà, Pedro Castro, Joan Ceravalls, Oscar Comino, Claudia Cucciniello, Clàudia De Deray, Oriol De Diego, Paula De la Matta, Marta Farrero, Javier Fernández, Sara Fernández, Anna Fernández, Miquel Ferrer, Ana Fervienza, María Tallo Forga, Daniel Forné, Clàudia Galán, Andrea Gómez, Eduard Guasch, María Hernández- Tejero, Adriana Jacas, Beltrán Jiménez, Pere Leyes, Teresa López, José Antonio Martínez, Graciela Martínez-Pallí, Jordi Mercadal, Guido Muñoz, José Muñoz, Josep María Nicolás, José Tomás Ortiz, Anna Peiró, Manuel Pérez, Esteban Poch, Margarida Pujol, Eduard Quintana, Bartomeu Ramis, Enric Reverter, Irene Rovira, Pablo Ruiz, Elena Sandoval, Stefan Schneider, Oriol Sibila, Carla Solé, Alex Soriano, Dolors Soy, M. Suárez, Adrián Téllez, Néstor David Toapanta, Antoni Torres, Xavier Urra, César Aldecoa, Alicia Bordell, Silvia Martín, Judith Andrés, Alberto Martínez Ruiz, Gonzalo Tamayo Medel, Iñaki Bilbao Villasante, Fernando Iturri Clavero, Covadonga Peralta Álvarez, Julia T. Herrera Díez, Andrea García Trancho, Iñaki Sainz Mandiola, Carmen Ruano Suarez, Angela Ruiz Bocos, Eneritz Urrutia Izagirre, Pablo Ortiz de Urbina Fernández, Naiara Apodaka López, Leire Prieto Molano, Eunate Ganuza Martínez, Iratxe Vallinas Hidalgo, Karmele de Orte Sancho, Celia González Paniagua, Gemma Ortiz Labrador, Mireia Pérez Larrañaga, Marta López Miguelez, Estíbaliz Bárcena Andrés, Erik Urutxurtu Laureano, Maria Jesús Maroño Boedo, Blanca Escontrela Rodríguez, Aitziber Ereñozaga Camiruaga, Deiene Lasuen Aguirre, Ainhoa Zabal Maeztu, Ane Guereca Gala, Iker Castelo Korro, Andrés Álvarez Campo, Alejandro Carcelen Viana, Alejandro Alberdi Enríquez, Xabier Ormazábal Rementeria, Alberto Sánchez Campos, Rosa Gutiérrez Rico, Pablo Barbier Damborenea, Marta Guerenabarrena Momeñe, Borja Cuesta Ruiz, Alejandro López Rico, Ana Rojo Polo, Covadonga García Grijelmo, Mikel Celorrio Reta, Eneko Martín Arroyo, Leire Artaza Aparicio, Iñaki Ituarte Aspiazu, Ane Igeregi Basabe, Itxaso Merino Julian, Isabel Diaz Rico, Maria Paz Martínez, Ramón Adalia, Luigi Zattera, Irina Adalid Hernández, Leire Larrañaga Altuna, Aina Serrallonga Castells, Adriana Vilchez Garcia, María Núñez, Lorena Román, Francisco Javier Redondo Calvo, Rubén Villazala González, Victor Baladron González, Patricia Faba, Omar Montenegro, Natalia Bejarano Ramírez, Sergio Marcos Contreras, Alejandro Garcia Rodríguez, Saleta Rey Vázquez, Cristina Garcia Pérez, Eva Higuera Miguelez, Irene Pérez Blanco, David García Rivera, Ane Martín de la Fuente, Marta Pardo, Vanessa Rodriguez, Unai Bengoetxea, Fernando Ramasco, Sheila Olga Santidrián Bernal, Alvar Santa Cruz Hernando, Antonio Planas Roca, Carlos Figueroa Yusta, Esther García Villabona, Carmen Vallejo Lantero, Eva Patiño Rodriguez, Alvaro Esquivel Toledo, David Arribas Méndez, Mar Orts Rodriguez, Rosa Méndez Hernández, Jesús Nieves Alonso, Inés Imaz Artazcoz, Sonia Expósito Carazo, Carlos Román Guerrero, Elena Rojo Rodríguez, Ricardo Moreno González, Julia Hernando Santos, Jara Torrente Pérez, Esperanza Mata Mena, Manuel José Muñoz Martínez, Enrique Alday Muñoz, Patricia Martin Serrano, Laura Cotter Muñoz, Amadea Mjertan, Diego Gutierrez Martínez, Carmen Rodríguez García, Olaya Alonso Viejo, Juan Alvarez Pereira, Ana Carmona Bonet, Diana Parrado López, Eva de Dios Tomas, Rafael Martín Celemin, María Luisa Meilan Paz, Luis Quecedo Gutiérrez, Noemí Diaz Velasco, Gabriel Martin Hernández, Francisco Garcia del Corral, Gloria Hernandez Arias, David Rodriguez Cuesta, Ana Gómez Rice, Encarna Mateos Sevillano, Natalia Olmos Molpeceres, Beatriz Domínguez, Ana Vázquez Lima, Ángel Candela, Ismael A. Acevedo Bambaren, Maria Isabel Albala Blanco, Paloma Alonso Montoiro, Fernando Álvarez Utrera, Juan Avellanosa Esteruelas, Amal Azzam López, Alberto José Balvis Balvis, Tommaso Bardi, María Beltrán Martín, Jacobo Benatar Haserfaty, Alberto Berruezo Camacho, Laura Betolaza Weimer, María del Mar Carbonell Soto, Cristina Carrasco Seral, Cristina Cerro Zaballos, Elizabeth Claros Llamas, Pilar Coleta Orduna, Ingrid P. Cortes Forero, Pascual Agustín Crespo Aliseda, María Angélica de Pablo Pajares, Yolanda Díez Remesal, Trinidad Dorado Díaz, Noemí Echevarría Blasco, María Elena Elías Martín, Javier Felices Triviño, Natalia Fernández López, Cristina Fernández Martín, Natalia Ferreiro Pozuelo, Luis Gajate Martín, Clara Gallego Santos, Diego Gil Mayo, María Gómez Rojo, Claudia González Cibrián, Elena Herrera López, Borja Hinojal Olmedillo, Berta Iglesias Gallego, Sassan Khonsari, María Nuria Mane Ruiz, María Manzanero Arroyo, Ana María Mariscal Ortega, Sara Martín Burcio, María del Carmen Martín González, Ascensión Martín Grande, Jose Juan Martín López, Cecilia Martín Rabes, Marcos Martínez Borja, Nilda Martínez Castro, Adolfo Martínez Pérez, Snejana Matcan, Cristina Medrano Viñas, Lisset Miguel Herrera, Adrián Mira Betancur, María Montiel Carbajo, Javier Moya Moradas, Lorena Muñoz Pérez, Mónica Nuñez Murias, Eva Ordiales González, Óscar Ordoñez Recio, Miguel Ángel Palomero Rodriguez, Diego Parise Roux, Lucia Pereira Torres, David Pestaña Lagunas, Juana María Pinto Corraliza, Marian Prieto Rodrigo, Inmaculada Rodriguez Diaz-Regaño, David Rodriguez Esteban, Víctor Rojas Pernia, Álvaro Ruigómez Saiz, Bárbara Saavedra Villarino, Noemí Samaranch Palero, Gloria Santos Pérez, Jaume Serna Pérez, Ana Belén Serrano Romero, Jesús Tercero López, Carlos Tiscar García, Marta de la Torre Concostrina, Eva María Ureta Mesa, Eva Velasco Olarte, Judith Villahoz Martínez, Raúl Villalaba Palacios, Gema Villanueva García, Cristina Vogel de Medeiros, Soraya Gholamian Ovejero, Marta Vicente Orgaz, Patricia Lloreda Herradon, Cristina Crespo Gómez, Tatiana Sarmiento-Trujillo, Noemí García Medina, María Martínez García, Carles Espinós Ramírez, Nabil Mouhaffel Rivero, Jose Antonio Bernia Gil, Sonsoles Martín, María Victoria Moral, Josefina Galán, Pilar Paniagua, Sergio Pérez, Albert Bainac, Ana Arias, Elsa Ramil, Jorge Escudero, Pablo Monedero, Carmen Cara, Andrea Lara, Elena Mendez Martínez, Jorge Mendoza, Íñigo Rubio Baines, Carmen Sala Trull, Pablo Montero López, Alfredo Gea, Alejandro Montero, Rocío Armero Ibañez, Juan Vicente Llau Pitarch, Fernando Rauer Alcóver, Cristina Álvarez Herreros, Cyntia Sánchez Martín, Lucía López Ocáriz Olmos, Marta Navas Moruno, Fernando García Montoto, Mirón Rodriguez, Laura Fuentes Coco, Cristina Hernández Gamito, Antonio Barba Orejudo, Luis Gerardo Smith Vielma, Yasmina González Marín, Francisco de Borja Amador Penco, Marta Donoso Domínguez, Silvia Esquivel Ramírez, José Antonio Carbonell, Berta Monleón López, Sara Martínez-Castro, Gerardo Aguilar, María Gestal, Pablo Casas, Angel Outeiro Rosato, Andrea Naveiro Pan, María Alonso Portela, Adrián García Romar, Eva Mosquera Rodríguez, Diego Ruanova Seijo, Pablo Rama Maceiras, Francisco Castro-Ceoane, Esther Moreno López, Sergio Gil, Julia Guillén Antón, Patricia García-Consuegra Tirado, Aurora Callau Calvo, Laura Forés Lisbona, María Carbonell Romero, Belén Albericio Gil, Laura Pradal Jarne, María Soria Lozano, Diego Loscos López, Andrea Patiño Abarca, Jordi Serrano, Javier Pérez-Asenjo, Ángel Díez-Domínguez, Ion Zubizarreta, Jon Ramos, Iosu Fernández, Emilio Maseda, Alejandro Suárez de la Rica, Javier Veganzones, Itziar Insausti, Javier Sagra, Sofía Díaz Carrasco, Ana Montero Feijoo, Julio Yagüe, Ignacio Garutti, Eva Bassas Parga, Carmen Deiros Garcia, Elisenda Pujol Rosa, Ana Tejedor Navarro, Roser Font Gabernet, Maria José Bernat, Meritxell Serra Valls, Cristina Cobaleda Garcia-Bernalt, Jesus Fernanz Anton, Adriana Aponte Sierra, Lucia Gil Gomez, Olaia Guenaga Vaqueiro, Susana Hernandez Marin, Laura Pardo Pinzon, Sira Garcia Aranda, Carlos Briones Orejuela, Edgar Cortes Sanchez, Alejandro Romero Fernandez, Esther Fernández Sanjosé, Patricia Iglesias Garsabal, Guillermo Isidro Lopez, Ana Vicol, Sara Espejo Malagon, María Sanabra Loewe, Laura Grau Torradeflo, Lourdes Blanco Alcaide, Gloria Buenaventura Sanclemente, Pere Serra Pujol, Gustavo Cuadros Mendoza, Miroslawa Konarska, Fedra Bachs Almenara, Agnieszka Golska, Aleix Carmona Blesa, Arantxa Mas Serra, Javier Ripolles Melchor, Ana Nieto Moreno, Káteri Chao Novo, Sandra Gadín López, Elena Nieto Moreno, Bérénice Gutiérrez Tonal, Elena Lucena de Pablo, Barbara Algar Yañez, Beatriz Vázquez Rivero, Beatriz Nozal Mateo, Marina de Retes, Norma Aracil Escoda, Cristina Gallardo Mayo, Rosa Sanz González, Alicia Ruiz Escobar, Maria Laura Pelegrina López, Marina Valenzuela Peña, David Stolle Dueñas, Ane Abad Motos, Alfredo Abad-Gurumeta, Ana Tirado Errazquin, Elena Sáez Ruiz, Nerea Gómez Pérez, Francisco de Borja Bau González, Cesar Morcillo Serra, Jessica Souto Higueras, Rosario Vicente, Raquel Ferrandis, Silvia Polo Martín, Azucena Pajares Moncho, Ignacio Moreno Puigdollers, Juan Pérez Artacho Cortés, Ana Moret Calvo, Ana Pi Peña, María Catalán Fernández, Marina Varela, Pilar Díaz Parada, Raquel Rey Carlín, Sarra Barreiro Aragunde, María Isabel Forés Chiva, A. Javier Agulló, Antonio Pérez Ferrer, María Galiana, Antoni Margarit, Válerie Mourre del Rio, Eva Heras Muxella, Anna Vidal

Open Access COVID-19 Letter

Anakinra: a silver lining in COVID-19?

Rahul Gupta

Open Access Letter

TPE seems to be a treatment that may improve outcomes by effectively removing fibrin degradation products and restoring coagulation status: fact or fiction?

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?

Miranda van Berkel, Matthijs Kox, Tim Frenzel, Peter Pickkers, Jeroen Schouten, Miranda van Berkel, Matthijs Kox, Tim Frenzel, Peter Pickkers, Jeroen Schouten, Denise Waanders, Niklas Bruse, Emma Kooistra, Hugo Touw, Pleun Hemelaar, Remi Beunders, Johannes van der Hoeven, Sjef van der Velde, Hetty van der Eng, Noortje Rovers, Margreet Klop-Riehl, Jelle Gerretsen, Nicole Waalders, Wout Claassen, Hidde Heesakkers, Tirsa van Schaik, Mihai Netea, Leo Joosten, Nico Janssen, Inge Grondman, Aline de Nooijer, Quirijn de Mast, Martin Jaeger, Ilse Kouijzer, Helga Dijkstra, Heidi Lemmers, Reinout van Crevel, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esther Taks, Priya Debisarun, Heiman Wertheim, Joost Hopman, Janette Rahamat-Langendoen, Chantal Bleeker-Rovers, Esther Fasse, Esther van Rijssen, Manon Kolkman, Bram van Cranenbroek, Ruben Smeets, Irma Joosten

Open Access Research

Energy transmission in mechanically ventilated children: a translational study

Martin C. J. Kneyber, Stavroula Ilia, Alette A. Koopman, Patrick van Schelven, Jefta van Dijk, Johannes G. M. Burgerhof, Dick G. Markhorst, Robert G. T. Blokpoel

Open Access COVID-19 Letter

Infliximab can reduce mortality from 35 to 14% in critically ill patients with COVID-19: perhaps some potential confounders to consider

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Research

Early hyperoxemia is associated with lower adjusted mortality after severe trauma: results from a French registry

Josefine S. Baekgaard, Paer-Selim Abback, Marouane Boubaya, Jean-Denis Moyer, Delphine Garrigue, Mathieu Raux, Benoit Champigneulle, Guillaume Dubreuil, Julien Pottecher, Philippe Laitselart, Fleur Laloum, Coralie Bloch-Queyrat, Frédéric Adnet, Catherine Paugam-Burtz, Romain Pirracchio, Anne Godier, Anatole Harrois, Thomas Geeraerts, Eric Meaudre, Sylvain Ausset, Tobias Gauss, Alain Meyer, Sophie Hamada, Arthur Neuschwander, Fabrice Cook, Helene Vinour, Jean Luc Hanouz, Arnaud Foucrier, Mathieu Boutonnet, Pascal Raclot, James Arthur, Nathalie Bruneau, Jean Cotte, Marc Leone, Gerard Audibert

Open Access COVID-19 Research

Blood purification therapy with a hemodiafilter featuring enhanced adsorptive properties for cytokine removal in patients presenting COVID-19: a pilot study

Gianluca Villa, Stefano Romagnoli, Silvia De Rosa, Massimiliano Greco, Marco Resta, Diego Pomarè Montin, Federico Prato, Francesco Patera, Fiorenza Ferrari, Giuseppe Rotondo, Claudio Ronco

Open Access Letter

Mortality in non-elderly septic patients was increased with hypothermia and decreased with fever while mortality in elderly patients was not associated with body temperature: beware of some confounders!

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access COVID-19 Research Letter

Dynamic trajectory of platelet-related indicators and survival of severe COVID-19 patients

Jieyu He, Yongyue Wei, Jiao Chen, Feng Chen, Wei Gao, Xiang Lu

Open Access Editorial

Establishing a critical care network in Asia to improve care for critically ill patients in low- and middle-income countries

Abi Beane, Arjen M. Dondorp, Arshad Taqi, A. S. M. Areef Ahsan, Bharath Kumar Tirupakuzhi Vijayaraghavan, Chairrat Permpikul, Christopher Pell, David Gandy, Dilanthi Priyadarshani, Diptesh Aryal, Dong Phu Khiem, Duong Bich Thuy, Guy Thwaites, Gyan Kayastha, Ishara Udayanga, Jorge Salluh, Khamsay Detleuxay, Lakshmi Ranganathan, Lam Minh Yen, Lim Chew Har, Louise Thwaites, Madiha Hashmi, Marcus J. Schultz, Mavuto Mukaka, Meghan Leaver, Mohd Basri Mat Nor, Muhammad Hayat, Nick Day, Ramani Moonesinghe, Rashan Haniffa, Ratapum Champunot, Rebecca Inglis, Rozina Sultana, Sophie Yacoub, Steve Harris, Subhash Prasad Acharya, Swagata Tripathy, Syed Muneeb Ali, Tamilarasu Kadhiravan, Yoel Lubell

Open Access Research

Frailty, delirium and hospital mortality of older adults admitted to intensive care: the Delirium (Deli) in ICU study

David Sanchez, Kathleen Brennan, Masar Al Sayfe, Sharon-Ann Shunker, Tony Bogdanoski, Sonja Hedges, Yu Chin Hou, Joan Lynch, Leanne Hunt, Evan Alexandrou, Manoj Saxena, Simon Abel, Ramanathan Lakshmanan, Deepak Bhonagiri, Michael J. Parr, Anders Aneman, Danielle Ni Chroinin, Kenneth M. Hillman, Steven A. Frost

Open Access COVID-19 Research

SARS-CoV-2 detection in the lower respiratory tract of invasively ventilated ARDS patients

Niccolò Buetti, Paul-Henri Wicky, Quentin Le Hingrat, Stéphane Ruckly, Timothy Mazzuchelli, Ambre Loiodice, Pierpaolo Trimboli, Valentina Forni Ogna, Etienne de Montmollin, Enos Bernasconi, Benoit Visseaux, Jean-François Timsit

Open Access Research

Antibiotic-related gut dysbiosis induces lung immunodepression and worsens lung infection in mice

Rodrigue Dessein, Marvin Bauduin, Teddy Grandjean, Rémi Le Guern, Martin Figeac, Delphine Beury, Karine Faure, Christelle Faveeuw, Benoit Guery, Philippe Gosset, Eric Kipnis

Open Access Editorial

Rethinking brain injury after subarachnoid hemorrhage

Sara Amodio, Pierre Bouzat, Chiara Robba, Fabio Silvio Taccone

Open Access Research

Sex differences in survival after out-of-hospital cardiac arrest: a meta-analysis

Hao Lei, Jiahui Hu, Leiling Liu, Danyan Xu

Open Access Review

Gut-liver crosstalk in sepsis-induced liver injury

Jian Sun, Jingxiao Zhang, Xiangfeng Wang, Fuxi Ji, Claudio Ronco, Jiakun Tian, Yongjie Yin

Open Access Research

The use of venous Doppler to predict adverse kidney events in a general ICU cohort

Rory Spiegel, William Teeter, Scott Sullivan, Keegan Tupchong, Nabeel Mohammed, Mark Sutherland, Evan Leibner, Philippe Rola, Samuel M. Galvagno Jr., Sarah B. Murthi

Open Access Research Letter

Clearance of micronutrients during continuous renal replacement therapy

Nuttha Lumlertgul, Danielle E. Bear, Marlies Ostermann

Open Access Research

Increased percentage of PD-L1+ natural killer cells predicts poor prognosis in sepsis patients: a prospective observational cohort study

Wenqiang Jiang, Xusheng Li, Miaoyun Wen, Xiaoyu Liu, Kangrong Wang, Qiaosheng Wang, Ya Li, Maohua Zhou, Mengting Liu, Bei Hu, Hongke Zeng

Open Access Research

Cognitive phenotypes 1 month after ICU discharge in mechanically ventilated patients: a prospective observational cohort study

Sol Fernández-Gonzalo, Guillem Navarra-Ventura, Neus Bacardit, Gemma Gomà Fernández, Candelaria de Haro, Carles Subirà, Josefina López-Aguilar, Rudys Magrans, Leonardo Sarlabous, Jose Aquino Esperanza, Mercè Jodar, Montse Rué, Ana Ochagavía, Diego J. Palao, Rafael Fernández, Lluís Blanch

Open Access COVID-19 Research

COVID-19: What Iodine Maps From Perfusion CT can reveal—A Prospective Cohort Study

Mario G. Santamarina, Dominique Boisier Riscal, Ignacio Beddings, Roberto Contreras, Martiniano Baque, Mariano Volpacchio, Felipe Martinez Lomakin

Open Access Research

Recommendations for hemodynamic monitoring for critically ill children—expert consensus statement issued by the cardiovascular dynamics section of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)

Yogen Singh, Javier Urbano Villaescusa, Eduardo M. da Cruz, Shane M. Tibby, Gabriella Bottari, Rohit Saxena, Marga Guillén, Jesus Lopez Herce, Matteo Di Nardo, Corrado Cecchetti, Joe Brierley, Willem de Boode, Joris Lemson

Open Access Viewpoint

A call for collaboration and consensus on training for endotracheal intubation in the medical intensive care unit

Wade Brown, Lekshmi Santhosh, Anna K. Brady, Joshua L. Denson, Abesh Niroula, Meredith E. Pugh, Wesley H. Self, Aaron M. Joffe, P. O’Neal Maynord, W. Graham Carlos

Open Access Research

Gravitational distribution of regional opening and closing pressures, hysteresis and atelectrauma in ARDS evaluated by electrical impedance tomography

Gaetano Scaramuzzo, Elena Spinelli, Savino Spadaro, Alessandro Santini, Donatella Tortolani, Francesca Dalla Corte, Antonio Pesenti, Carlo Alberto Volta, Giacomo Grasselli, Tommaso Mauri

Open Access Letter

SARS-CoV-2 infection as a risk factor for herpesviridae reactivation: consider the potential influence of corticosteroid therapy

Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani, David De Bels

Open Access Letter

Central venous pressure monitoring and mortality: What was neglected?

Shaowei Gao, Zhanxin Du, Lu Yang, Zhongxing Wang

Open Access Research Letter

Is there still a place for transcranial Doppler in patients with IABP?

Juliana R. Caldas, Ronney B. Panerai, Rogério Passos, Ludhmila A. Hajjar

Open Access Research

Inpatient hospital performance is associated with post-discharge sepsis mortality

Nicholas M. Mohr, Alexis M. Zebrowski, David F. Gaieski, David G. Buckler, Brendan G. Carr

Open Access COVID-19 Editorial

Corticosteroids in severe COVID-19: a critical view of the evidence

Daniel De Backer, Elie Azoulay, Jean-Louis Vincent

Open Access Research

Breath-synchronized electrical stimulation of the expiratory muscles in mechanically ventilated patients: a randomized controlled feasibility study and pooled analysis

Annemijn H. Jonkman, Tim Frenzel, Euan J. McCaughey, Angus J. McLachlan, Claire L. Boswell-Ruys, David W. Collins, Simon C. Gandevia, Armand R. J. Girbes, Oscar Hoiting, Matthijs Kox, Eline Oppersma, Marco Peters, Peter Pickkers, Lisanne H. Roesthuis, Jeroen Schouten, Zhong-Hua Shi, Peter H. Veltink, Heder J. de Vries, Cyndi Shannon Weickert, Carsten Wiedenbach, Yingrui Zhang, Pieter R. Tuinman, Angélique M. E. de Man, Jane E. Butler, Leo M. A. Heunks

Open Access Research

Electroencephalographic features in patients undergoing extracorporeal membrane oxygenation

Lorenzo Peluso, Serena Rechichi, Federico Franchi, Selene Pozzebon, Sabino Scolletta, Alexandre Brasseur, Benjamin Legros, Jean-Louis Vincent, Jacques Creteur, Nicolas Gaspard, Fabio Silvio Taccone

Open Access Research

Right ventricular failure in septic shock: characterization, incidence and impact on fluid responsiveness

Antoine Vieillard-Baron, Amélie Prigent, Xavier Repessé, Marine Goudelin, Gwenaël Prat, Bruno Evrard, Cyril Charron, Philippe Vignon, Guillaume Geri

Open Access COVID-19 Research

CXCL10 could drive longer duration of mechanical ventilation during COVID-19 ARDS

Mathieu Blot, Marine Jacquier, Ludwig-Serge Aho Glele, Guillaume Beltramo, Maxime Nguyen, Philippe Bonniaud, Sebastien Prin, Pascal Andreu, Belaid Bouhemad, Jean-Baptiste Bour, Christine Binquet, Lionel Piroth, Jean-Paul Pais de Barros, David Masson, Jean-Pierre Quenot, Pierre-Emmanuel Charles, François Aptel, Auguste Dargent, Marjolaine Georges, Marie Labruyère, Laurent Lagrost, Audrey Large, Serge Monier, Jean-Baptiste Roudaut, Charles Thomas

Open Access Research

Anxiety, depression and post-traumatic stress disorder management after critical illness: a UK multi-centre prospective cohort study

Robert Hatch, Duncan Young, Vicki S. Barber, John Griffiths, David A. Harrison, Peter J. Watkinson

Open Access Research

Omega-3 fatty acid-containing parenteral nutrition in ICU patients: systematic review with meta-analysis and cost-effectiveness analysis

Lorenzo Pradelli, Stanislaw Klek, Konstantin Mayer, Abdul Jabbar Omar Alsaleh, Martin D. Rosenthal, Axel R. Heller, Maurizio Muscaritoli

Open Access COVID-19 Research Letter

Eosinophilia in critically ill COVID-19 patients: a French monocenter retrospective study

Megan Fraissé, Elsa Logre, Hervé Mentec, Radj Cally, Gaëtan Plantefève, Damien Contou

Open Access Research

Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness

Oscar H. M. Lundberg, Maria Lengquist, Martin Spångfors, Martin Annborn, Deborah Bergmann, Janin Schulte, Helena Levin, Olle Melander, Attila Frigyesi, Hans Friberg

Open Access Research

Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness

Kirby P. Mayer, Melissa L. Thompson Bastin, Ashley A. Montgomery-Yates, Amy M. Pastva, Esther E. Dupont-Versteegden, Selina M. Parry, Peter E. Morris

Open Access COVID-19 Research Letter

Spontaneous hemothorax in 4 COVID-19 ARDS patients on VV-ECMO revealing pulmonary artery aneurysms

Cyrielle Desnos, Samia Boussouar, Guillaume Hekimian, Alban Redheuil, Alain Combes

Open Access COVID-19 Research Letter

Weak anti-SARS-CoV-2 antibody response is associated with mortality in a Swedish cohort of COVID-19 patients in critical care

Sana Asif, Robert Frithiof, Miklos Lipcsey, Bjarne Kristensen, Kjell Alving, Michael Hultström

Open Access Review

Iodinated contrast medium: Is there a re(n)al problem? A clinical vignette-based review

Karim Lakhal, Stephan Ehrmann, Vincent Robert-Edan

Open Access Research

Point of care aspergillus testing in intensive care patients

Toine Mercier, Albert Dunbar, Vincent Veldhuizen, Michelle Holtappels, Alexander Schauwvlieghe, Johan Maertens, Bart Rijnders, Joost Wauters

Open Access Research

Corticosteroid therapy for coronavirus disease 2019-related acute respiratory distress syndrome: a cohort study with propensity score analysis

Chaomin Wu, Dongni Hou, Chunling Du, Yanping Cai, Junhua Zheng, Jie Xu, Xiaoyan Chen, Cuicui Chen, Xianglin Hu, Yuye Zhang, Juan Song, Lu Wang, Yen-cheng Chao, Yun Feng, Weining Xiong, Dechang Chen, Ming Zhong, Jie Hu, Jinjun Jiang, Chunxue Bai, Xin Zhou, Jinfu Xu, Yuanlin Song, Fengyun Gong

Open Access COVID-19 Research Letter

Inhaled nitric oxide for critically ill Covid-19 patients: a prospective study

Osama Abou-Arab, Pierre Huette, Fanny Debouvries, Hervé Dupont, Vincent Jounieaux, Yazine Mahjoub

Open Access Research

Mode of bacterial killing affects the inflammatory response and associated organ dysfunctions in a porcine E. coli intensive care sepsis model

Paul Skorup, Lisa Maudsdotter, Miklós Lipcsey, Anders Larsson, Jan Sjölin

Open Access Editorial

How I do a brain death examination: the tools of the trade

Eelco F. M. Wijdicks

Open Access COVID-19 Commentary

ECMO during the COVID-19 pandemic: When is it justified?

Silver Heinsar, Giles J. Peek, John F. Fraser

Open Access COVID-19 Research Letter

Feasibility study of a portable transparent vinyl chloride shield for use in an ambulance during the COVID-19 pandemic

Kohei Tsukahara, Hiromichi Naito, Tsuyoshi Nojima, Takashi Yorifuji, Atsunori Nakao

Open Access Research

Continuous assessment of neuro-ventilatory drive during 12 h of pressure support ventilation in critically ill patients

Rosa Di mussi, Savino Spadaro, Carlo Alberto Volta, Nicola Bartolomeo, Paolo Trerotoli, Francesco Staffieri, Luigi Pisani, Rachele Iannuzziello, Lidia Dalfino, Francesco Murgolo, Salvatore Grasso

Open Access COVID-19 Research

Dosing of thromboprophylaxis and mortality in critically ill COVID-19 patients

Sandra Jonmarker, Jacob Hollenberg, Martin Dahlberg, Otto Stackelberg, Jacob Litorell, Åsa H. Everhov, Hans Järnbert-Pettersson, Mårten Söderberg, Jonathan Grip, Anna Schandl, Mattias Günther, Maria Cronhjort

Open Access Research

Nasal high flow higher than 60 L/min in patients with acute hypoxemic respiratory failure: a physiological study

Maria Cristina Basile, Tommaso Mauri, Elena Spinelli, Francesca Dalla Corte, Giacomo Montanari, Ines Marongiu, Savino Spadaro, Alessandro Galazzi, Giacomo Grasselli, Antonio Pesenti

Open Access Research

Impact of a computerized decision support tool deployed in two intensive care units on acute kidney injury progression and guideline compliance: a prospective observational study

Christopher Bourdeaux, Erina Ghosh, Louis Atallah, Krishnamoorthy Palanisamy, Payaal Patel, Matthew Thomas, Timothy Gould, John Warburton, Jon Rivers, John Hadfield

Open Access Research Letter

SARS-CoV-2-associated encephalitis: arguments for a post-infectious mechanism

Adrien Picod, Vera Dinkelacker, Julien Savatovsky, Pierre Trouiller, Antoine Guéguen, Nicolas Engrand

Open Access COVID-19 Research Letter

Correlation of interleukin-6 with Epstein–Barr virus levels in COVID-19

Georg Franz Lehner, Sebastian Johann Klein, Heinz Zoller, Andreas Peer, Romuald Bellmann, Michael Joannidis

Open Access Research

Prediction of hypotension events with physiologic vital sign signatures in the intensive care unit

Joo Heung Yoon, Vincent Jeanselme, Artur Dubrawski, Marilyn Hravnak, Michael R. Pinsky, Gilles Clermont

Open Access Research

Individualized flow-controlled ventilation compared to best clinical practice pressure-controlled ventilation: a prospective randomized porcine study

Patrick Spraider, Judith Martini, Julia Abram, Gabriel Putzer, Bernhard Glodny, Tobias Hell, Tom Barnes, Dietmar Enk

Open Access Research Letter

Influence of the acuity of patients’ illness on effectiveness of early, goal-directed mobilization in the intensive care unit: a post hoc analysis

Ludwig Scheffenbichler, Bijan Teja, Flora Scheffenbichler, Manfred Blobner, Timothy Houle, Matthias Eikermann, Timothy Houle, Stefan Schaller, Karen Waak, Nicole Mazwi, Maximilian Hammer, Stephanie Grabitz, Karuna Wongtangman, Omid Azimaraghi

Open Access Research

Antibiotic therapeutic drug monitoring in intensive care patients treated with different modalities of extracorporeal membrane oxygenation (ECMO) and renal replacement therapy: a prospective, observational single-center study

Dennis Kühn, Carlos Metz, Frederik Seiler, Holger Wehrfritz, Sophie Roth, Mohammad Alqudrah, André Becker, Hendrik Bracht, Stefan Wagenpfeil, Mathias Hoffmann, Robert Bals, Ulrich Hübner, Jürgen Geisel, Philipp M. Lepper, Sören L. Becker

Open Access COVID-19 Correction

Correction to: Inhaled nitric oxide in patients admitted to intensive care unit with COVID-19 pneumonia

Guido Tavazzi, Marco Pozzi, Silvia Mongodi, Valentino Dammassa, Giovanni Romito, Francesco Mojoli

Open Access COVID-19 Research

Severe manifestations of SARS-CoV-2 in children and adolescents: from COVID-19 pneumonia to multisystem inflammatory syndrome: a multicentre study in pediatric intensive care units in Spain

Alberto García-Salido, Juan Carlos de Carlos Vicente, Sylvia Belda Hofheinz, Joan Balcells Ramírez, María Slöcker Barrio, Inés Leóz Gordillo, Alexandra Hernández Yuste, Carmina Guitart Pardellans, Maite Cuervas-Mons Tejedor, Beatriz Huidobro Labarga, José Luís Vázquez Martínez, Míriam Gutiérrez Jimeno, Ignacio Oulego-Erróz, Javier Trastoy Quintela, Carmen Medina Monzón, Laura Medina Ramos, María Soledad Holanda Peña, Javier Gil-Antón, Clara Sorribes Ortí, José Carlos Flores González, Rosa María Hernández Palomo, Inma Sánchez Ganfornina, Emilia Fernández Romero, María García-Besteiro, Jesús López-Herce Cid, Rafael González Cortés, María Slöcker Barrio, Amaya Bustinza Arriortua, Jesús López-Herce Cid, Rafael González Cortés, Juan Carlos de Carlos Vicente, Maite Cuervas-Mons Tejedor, Pedro Pablo Oyágüez Ugidos, Iolanda Jordan, Carmina Guitart Pardellans, Sonia Sanchíz Cárdenas, Javier Gil-Antón, Belén Joyanes, Ainhoa Jiménez Olmos, Antonio Rodríguez Núñez, Javier Trastoy Quintela, Alexandra Hernández Yuste, Laura Díaz Munilla, Carlos Solís Reyes, Laura Medina Ramos, David Roca Pascual, Joan Ballcels Ramírez, Mario Sánchez Fernández, Alberto García-Salido, Inés Leóz Gordillo, Montserrat Nieto Moro, Amelia Martínez de Azagra Garde, María Ángeles García Teresa, Corsino Rey Galán, Alfredo Molina Cambra, Manuel González-Ripoll Garzón, Pepe Fernández-Cantalejo Padial, Ignacio Oulego-Erroz, Laia Vega Puyal, Daniel Moreno, Emilia Fernández Romero, María García Besteiro, José Carlos Flores González, Carmen Medina Monzón, Beatriz Huidobro Labarga, Rosa María Hernández Palomo, Cristina Calvo Monge, Francisco Fernández, Nieves González, Lorena Bermúdez Barrezueta, Cesar Villa Francisco, Ana Abril Molina, Mónica Valeron, Ramón Hernández Rastrollo, Sylvia Belda Hofheinz, Manuel Gijón Mediavilla, José Luis Vázquez Martínez, Manuel Frias, Raúl Montero Yéboles, Juan Ignacio Muñóz Bonet, María Velázquez, Inma Sánchez Ganfornina, Antonio Pérez Iranzo, David Lozano, Clara Sorribes Ortí, María Soledad Holanda Peña, Miriam Gutiérrez Jimeno

Open Access Research

Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Rita Campos-Pires, Haldis Onggradito, Eszter Ujvari, Shughoofa Karimi, Flavia Valeo, Jitka Aldhoun, Christopher J. Edge, Nicholas P. Franks, Robert Dickinson

Open Access COVID-19 Research Letter

VICINO@TE, distant but together, new app to communicate with families living in complete isolation during COVID-19 pandemic

Giovanni Pedrotti, Angelo Attilio Colombo, Fabrizio Corradini, Rosella Martini, Massimiliano Raggi, Mariavittoria Modena

Open Access Research

Ultrasound shear wave elastography for assessing diaphragm function in mechanically ventilated patients: a breath-by-breath analysis

Quentin Fossé, Thomas Poulard, Marie-Cécile Niérat, Sara Virolle, Elise Morawiec, Jean-Yves Hogrel, Thomas Similowski, Alexandre Demoule, Jean-Luc Gennisson, Damien Bachasson, Martin Dres

Open Access COVID-19 Research

Right ventricular-arterial uncoupling independently predicts survival in COVID-19 ARDS

Michele D’Alto, Alberto M. Marra, Sergio Severino, Andrea Salzano, Emanuele Romeo, Rosanna De Rosa, Francesca Maria Stagnaro, Gianpiero Pagnano, Raffaele Verde, Patrizia Murino, Andrea Farro, Giovanni Ciccarelli, Maria Vargas, Giuseppe Fiorentino, Giuseppe Servillo, Ivan Gentile, Antonio Corcione, Antonio Cittadini, Robert Naeije, Paolo Golino

Open Access Editorial

How I approach membrane lung dysfunction in patients receiving ECMO

Bishoy Zakhary, Leen Vercaemst, Phillip Mason, Marta V. Antonini, Roberto Lorusso, Daniel Brodie

Open Access Research

Impact of advance directives on the variability between intensivists in the decisions to forgo life-sustaining treatment

Margot Smirdec, Mercé Jourdain, Virginie Guastella, Céline Lambert, Jean-Christophe Richard, Laurent Argaud, Samir Jaber, Kada Klouche, Anne Medard, Jean Reignier, Jean-Philippe Rigaud, Jean-Marc Doise, Russell Chabanne, Bertrand Souweine, Jeremy Bourenne, Julie Delmas, Pierre-Marie Bertrand, Philippe Verdier, Jean-Pierre Quenot, Cecile Aubron, Nathanael Eisenmann, Pierre Asfar, Alexandre Fratani, Jean Dellamonica, Nicolas Terzi, Jean-Michel Constantin, Axelle Van Lander, Renaud Guerin, Bruno Pereira, Alexandre Lautrette

Open Access COVID-19 Research

Thromboembolic complications in critically ill COVID-19 patients are associated with impaired fibrinolysis

Jan Matthias Kruse, Abakar Magomedov, Annika Kurreck, Frédéric H. Münch, Roland Koerner, Julian Kamhieh-Milz, Andreas Kahl, Inka Gotthardt, Sophie K. Piper, Kai-Uwe Eckardt, Thomas Dörner, Daniel Zickler

Open Access COVID-19 Research Letter

The Adaptive COVID-19 Treatment Trial-1 (ACTT-1) in a real-world population: a comparative observational study

Matilde Tejlbo Frost, Espen Jimenez-Solem, Mikkel Zöllner Ankarfeldt, Martin Erik Nyeland, Anne Helms Andreasen, Tonny Studsgaard Petersen

Open Access COVID-19 Research

Electrical impedance tomography to titrate positive end-expiratory pressure in COVID-19 acute respiratory distress syndrome

François Perier, Samuel Tuffet, Tommaso Maraffi, Glasiele Alcala, Marcus Victor, Anne-Fleur Haudebourg, Keyvan Razazi, Nicolas De Prost, Marcelo Amato, Guillaume Carteaux, Armand Mekontso Dessap

Open Access Research

Transesophageal echocardiography-associated tracheal microaspiration and ventilator-associated pneumonia in intubated critically ill patients: a multicenter prospective observational study

François Bagate, Anahita Rouzé, Farid Zerimech, Florence Boissier, Vincent Labbe, Keyvan Razazi, Guillaume Carteaux, Nicolas de Prost, Malika Balduyck, Patrice Maboudou, Saad Nseir, Armand Mekontso Dessap

Open Access Research

Standardized visual EEG features predict outcome in patients with acute consciousness impairment of various etiologies

Michael Müller, Andrea O. Rossetti, Rebekka Zimmermann, Vincent Alvarez, Stephan Rüegg, Matthias Haenggi, Werner J. Z’Graggen, Kaspar Schindler, Frédéric Zubler

Open Access Research

Peripheral blood transcriptomic sub-phenotypes of pediatric acute respiratory distress syndrome

Nadir Yehya, Brian M. Varisco, Neal J. Thomas, Hector R. Wong, Jason D. Christie, Rui Feng

Open Access Research

Postoperative hypotension in patients discharged to the intensive care unit after non-cardiac surgery is associated with adverse clinical outcomes

Nathan J. Smischney, Andrew D. Shaw, Wolf H. Stapelfeldt, Isabel J. Boero, Qinyu Chen, Mitali Stevens, Ashish K. Khanna

Open Access Research

Role of extracorporeal membrane oxygenation in children with sepsis: a systematic review and meta-analysis

Kollengode Ramanathan, Nicholas Yeo, Peta Alexander, Lakshmi Raman, Ryan Barbaro, Chuen Seng Tan, Luregn J. Schlapbach, Graeme MacLaren

Open Access Research

Risk factors and events in the adult intensive care unit associated with pain as self-reported at the end of the intensive care unit stay

Pierre Kalfon, Mohamed Boucekine, Philippe Estagnasie, Marie-Agnès Geantot, Audrey Berric, Georges Simon, Bernard Floccard, Thomas Signouret, Mélanie Fromentin, Martine Nyunga, Juliette Audibert, Adel Ben Salah, Bénédicte Mauchien, Achille Sossou, Marion Venot, René Robert, Arnaud Follin, Anne Renault, Maïté Garrouste-Orgeas, Olivier Collange, Quentin Levrat, Isabelle Villard, Didier Thevenin, Julien Pottecher, René-Gilles Patrigeon, Nathalie Revel, Coralie Vigne, Elie Azoulay, Olivier Mimoz, Pascal Auquier, Karine Baumstarck, Karine Vie, Gwenaëlle Lannuzel, Hélène Bout, Jean-Philippe Parthiot, Isabelle Chazal, Philippe Charve, Caroline Prum, Jean-Pierre Quenot, Nora Perrot, Francis Augier, Niloufar Behechti, Claudine Cocusse, Céline Foulon, Laurence Goncalves, Abdesselem Hanchi, Etienne Legros, Ana Isabel Mercier, Nicolas Meunier-Beillard, Nathalie Nuzillat, Alicia Richard, Claire Boulle, Benjamin Kowalski, Elisa Klusek, Tarek Sharshar, Andrea Polito, Caroline Duvallet, Sonia Krim, Nicolas Girard, Cécile Jourdain, Stéphane Techer, Corinne Chauvel, Corinne Bruchet, Johanna Temime, Stéphanie Beaussart, Fabienne Jarosz, Jullien Crozon-Clauzel, Serge Olousouzian, Sylvie Pereira, Loïc Argentin, Valérie Cerro, Déborah Levy, Sébastien Andre, Christophe Guervilly, Laurent Papazian, Myriam Moussa, Stéphanie Renoult, Delphine Biet, Steve Novak, Jean-Christophe Orban, Aminata Diop, Carole Ichai, Antoine Tesniere, Jean-Pascal Goupil, Frédérique Laville, Nadège Rutter, Sandie Brochon, Kelly Tiercelet, Julien Amour, Nora Ait-Hamou, Marjorie Leger, Virginie Souppart, Emilie Griffault, Marie-Line Debarre, Céline Deletage, Anne-Laure Guerin, Carole Guignon, Sabrina Seguin, Christophe Hart, Kathy Dernivoix, Caroline Wuiot, Karine Sanches, Stéphane Hecketsweiler, Catherine Sylvestre-Marconville, Vincent Gardan, Stéphanie Deparis-Dusautois, Yana Chaban

Open Access Editorial

A manifesto for the future of ICU trials

Ewan C. Goligher, Fernando Zampieri, Carolyn S. Calfee, Christopher W. Seymour

Open Access Letter

Chlorhexidine-dress related contact dermatitis—the precautionary principle is no more relevant!

Philippe Eggimann, Jean-Luc Pagani, Jean-Pierre Revelly, Yok-Ai Que

Open Access COVID-19 Research

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers, Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers, Pleun Hemelaar, Remi Beunders, Niklas Bruse, Tim Frenzel, Jeroen Schouten, Hugo Touw, Sjef van der Velde, Hetty van der Eng, Noortje Roovers, Margreet Klop-Riehl, Jelle Gerretsen, Wout Claassen, Hidde Heesakkers, Tirsa van Schaik, Leonie Buijsse, Leo Joosten, Quirijn de Mast, Martin Jaeger, Ilse Kouijzer, Helga Dijkstra, Heidi Lemmers, Reinout van Crevel, Josephine van de Maat, Gerine Nijman, Simone Moorlag, Esther Taks, Priya Debisarun, Heiman Wertheim, Joost Hopman, Janette Rahamat-Langendoen, Chantal Bleeker-Rovers, Hans Koenen, Esther Fasse, Esther van Rijssen, Manon Kolkman, Bram van Cranenbroek, Ruben Smeets, Irma Joosten

Open Access Research Letter

Machine learning to predict hemorrhage and thrombosis during extracorporeal membrane oxygenation

Adeel Abbasi, Yasmin Karasu, Cindy Li, Neel R. Sodha, Carsten Eickhoff, Corey E. Ventetuolo

Open Access COVID-19 Research Letter

Incidence rate and clinical impacts of arrhythmia following COVID-19: a systematic review and meta-analysis of 17,435 patients

Shu-Chen Liao, Shih-Chieh Shao, Chi-Wen Cheng, Yung-Chang Chen, Ming-Jui Hung

Open Access COVID-19 Research

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

Jesús F. Bermejo-Martin, Milagros González-Rivera, Raquel Almansa, Dariela Micheloud, Ana P. Tedim, Marta Domínguez-Gil, Salvador Resino, Marta Martín-Fernández, Pablo Ryan Murua, Felipe Pérez-García, Luis Tamayo, Raúl Lopez-Izquierdo, Elena Bustamante, César Aldecoa, José Manuel Gómez, Jesús Rico-Feijoo, Antonio Orduña, Raúl Méndez, Isabel Fernández Natal, Gregoria Megías, Montserrat González-Estecha, Demetrio Carriedo, Cristina Doncel, Noelia Jorge, Alicia Ortega, Amanda de la Fuente, Félix del Campo, José Antonio Fernández-Ratero, Wysali Trapiello, Paula González-Jiménez, Guadalupe Ruiz, Alyson A. Kelvin, Ali Toloue Ostadgavahi, Ruth Oneizat, Luz María Ruiz, Iria Miguéns, Esther Gargallo, Ioana Muñoz, Sara Pelegrin, Silvia Martín, Pablo García Olivares, Jamil Antonio Cedeño, Tomás Ruiz Albi, Carolina Puertas, Jose Ángel Berezo, Gloria Renedo, Rubén Herrán, Juan Bustamante-Munguira, Pedro Enríquez, Ramón Cicuendez, Jesús Blanco, Jesica Abadia, Julia Gómez Barquero, Nuria Mamolar, Natalia Blanca-López, Luis Jorge Valdivia, Belén Fernández Caso, María Ángeles Mantecón, Anna Motos, Laia Fernandez-Barat, Ricard Ferrer, Ferrán Barbé, Antoni Torres, Rosario Menéndez, José María Eiros, David J. Kelvin

Open Access Research

High flow nasal therapy versus noninvasive ventilation as initial ventilatory strategy in COPD exacerbation: a multicenter non-inferiority randomized trial

Andrea Cortegiani, Federico Longhini, Fabiana Madotto, Paolo Groff, Raffaele Scala, Claudia Crimi, Annalisa Carlucci, Andrea Bruni, Eugenio Garofalo, Santi Maurizio Raineri, Roberto Tonelli, Vittoria Comellini, Enrico Lupia, Luigi Vetrugno, Enrico Clini, Antonino Giarratano, Stefano Nava, Paolo Navalesi, Cesare Gregoretti, Lorenzo Ball, Tiziana Bove, Raffaele Campisi, Paola Chirco, Maria Stella Dionisi, Mariachiara Ippolito, Riccardo Fantini, Luca Guidelli, Uberto Maccari, Luca Tabbì, Maria Rita Taliani

Open Access Research

Resuscitation fluid types in sepsis, surgical, and trauma patients: a systematic review and sequential network meta-analyses

Chien-Hua Tseng, Tzu-Tao Chen, Mei-Yi Wu, Ming-Cheng Chan, Ming-Chieh Shih, Yu-Kang Tu

Open Access Research

Local signs at insertion site and catheter-related bloodstream infections: an observational post hoc analysis using individual data of four RCTs

Niccolò Buetti, Stéphane Ruckly, Jean-Christophe Lucet, Lila Bouadma, Maité Garrouste-Orgeas, Carole Schwebel, Olivier Mimoz, Bertrand Souweine, Jean-François Timsit

Open Access COVID-19 Research

Corticosteroid use in COVID-19 patients: a systematic review and meta-analysis on clinical outcomes

Judith van Paassen, Jeroen S. Vos, Eva M. Hoekstra, Katinka M. I. Neumann, Pauline C. Boot, Sesmu M. Arbous

Open Access Research

Lower versus higher hemoglobin threshold for transfusion in ARDS patients with and without ECMO

O. Hunsicker, L. Materne, V. Bünger, A. Krannich, F. Balzer, C. Spies, R. C. Francis, S. Weber-Carstens, M. Menk, J. A. Graw

Open Access COVID-19 Research

Corticosteroid therapy in critically ill patients with COVID-19: a multicenter, retrospective study

Yiming Li, Qinghe Meng, Xin Rao, Binbin Wang, Xingguo Zhang, Fang Dong, Tao Yu, Zhongyi Li, Huibin Feng, Jinpeng Zhang, Xiangyang Chen, Hunian Li, Yi Cheng, Xiaoyang Hong, Xiang Wang, Yimei Yin, Zhongheng Zhang, Dawei Wang

Open Access COVID-19 Research

Risks of ventilator-associated pneumonia and invasive pulmonary aspergillosis in patients with viral acute respiratory distress syndrome related or not to Coronavirus 19 disease

Keyvan Razazi, Romain Arrestier, Anne Fleur Haudebourg, Brice Benelli, Guillaume Carteaux, Jean‑Winoc Decousser, Slim Fourati, Paul Louis Woerther, Frederic Schlemmer, Anais Charles-Nelson, Francoise Botterel, Nicolas de Prost, Armand Mekontso Dessap

Open Access COVID-19 Research

Prognostic value of bedside lung ultrasound score in patients with COVID-19

Li Ji, Chunyan Cao, Ying Gao, Wen Zhang, Yuji Xie, Yilian Duan, Shuangshuang Kong, Manjie You, Rong Ma, Lili Jiang, Jie Liu, Zhenxing Sun, Ziming Zhang, Jing Wang, Yali Yang, Qing Lv, Li Zhang, Yuman Li, Jinxiang Zhang, Mingxing Xie

Open Access Research

Comparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure

Benjamin Seeliger, Michael Döbler, Robert Friedrich, Klaus Stahl, Christian Kühn, Johann Bauersachs, Folkert Steinhagen, Stefan F. Ehrentraut, Jens-Christian Schewe, Christian Putensen, Tobias Welte, Marius M. Hoeper, Andreas Tiede, Sascha David, Christian Bode

Open Access COVID-19 Review

Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

Arif Hussain, Gabriele Via, Lawrence Melniker, Alberto Goffi, Guido Tavazzi, Luca Neri, Tomas Villen, Richard Hoppmann, Francesco Mojoli, Vicki Noble, Laurent Zieleskiewicz, Pablo Blanco, Irene W. Y. Ma, Mahathar Abd. Wahab, Abdulmohsen Alsaawi, Majid Al Salamah, Martin Balik, Diego Barca, Karim Bendjelid, Belaid Bouhemad, Pablo Bravo-Figueroa, Raoul Breitkreutz, Juan Calderon, Jim Connolly, Roberto Copetti, Francesco Corradi, Anthony J. Dean, André Denault, Deepak Govil, Carmela Graci, Young-Rock Ha, Laura Hurtado, Toru Kameda, Michael Lanspa, Christian B. Laursen, Francis Lee, Rachel Liu, Massimiliano Meineri, Miguel Montorfano, Peiman Nazerian, Bret P. Nelson, Aleksandar N. Neskovic, Ramon Nogue, Adi Osman, José Pazeli, Elmo Pereira-Junior, Tomislav Petrovic, Emanuele Pivetta, Jan Poelaert, Susanna Price, Gregor Prosen, Shalim Rodriguez, Philippe Rola, Colin Royse, Yale Tung Chen, Mike Wells, Adrian Wong, Wang Xiaoting, Wang Zhen, Yaseen Arabi

Open Access Editorial

The fluid challenge

Jean-Louis Vincent, Maurizio Cecconi, Daniel De Backer

Open Access COVID-19 Letter

Plasma levels of the active form of suPAR are associated with COVID-19 severity

Mingxiang Huang, Linlin Li, Jianshan Shen, Yao Wang, Rui Wang, Cai Yuan, Mingdong Huang, Longguang Jiang

Neu im Fachgebiet AINS

Schläge auf den Rücken sind die beste Erste Hilfe

11.07.2024 Techniken in der Notfallmedizin Nachrichten

Bei der Aspiration eines Fremdkörpers mit Verschluss der Atemwege ist rasche Hilfe erforderlich. Doch welche Methode verspricht den meisten Erfolg? Eine Studie aus Kanada hat drei Techniken miteinander verglichen.

Bewusstsein während Reanimation – gibt es "typische" Fälle?

10.07.2024 Kardiopulmonale Reanimation Nachrichten

Australische Rettungsdienstdaten deuten darauf hin, dass sich Fälle, in denen eine laufende Reanimation Anzeichen von Bewusstsein induziert, von anderen Wiederbelebungsfällen unterscheiden könnten. Etwa mit Blick auf die Überlebenschancen.

Cholestatische Hepatitis durch Syphilis

09.07.2024 Treponema pallidum Nachrichten

Ein Mann kommt mit Gelbsucht in die Notaufnahme. In der Klinik wird eine cholestatische Hepatitis festgestellt, die Ursache bleibt zunächst jedoch im Dunklen. Erst ein Sehschärfenverlust durch ein Retinaödem weist auf den Auslöser: Treponema pallidum.

Engpass-Syndrom als Rückenschmerz-Ursache oft übersehen?

04.07.2024 Nacken- und Rückenschmerz Nachrichten

Hinter anhaltenden Rückenschmerzen im Bereich der Lendenwirbel könnte ein Engpass-Syndrom der oberen Gesäßnerven stecken. Wie eine Studie aus Istanbul nahelegt, wird dieses in der Praxis möglicherweise häufig übersehen.

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