Skip to main content
Erschienen in: World Journal of Surgery 10/2018

19.03.2018 | Original Scientific Report

Critical Care Management of Peritonitis in a Low-Resource Setting

verfasst von: Jennifer Rickard, Christian Ngarambe, Leonard Ndayizeye, Blair Smart, Robert Riviello, Jean Paul Majyambere

Erschienen in: World Journal of Surgery | Ausgabe 10/2018

Einloggen, um Zugang zu erhalten

Abstract

Background

Management of critically ill patients is challenging in a low-resource setting. In Rwanda, peritonitis is a common surgical condition where patients often present late, with advanced disease. We aim to describe critical care management of patients with peritonitis in Rwanda.

Methods

Data were collected at a tertiary referral hospital in Rwanda on patients undergoing operation for peritonitis over a 6-month period. Data included epidemiology, hospital course and outcomes. Patients requiring admission to the intensive care unit (ICU) were compared with those not requiring ICU admission using Chi-square and Wilcoxon rank-sum test.

Results

Over a 6-month period, 280 patients were operated for peritonitis. Of these, 46 (16.4%) were admitted to the ICU. The most common diagnoses were intestinal obstruction (N = 17, 37.0%) and typhoid intestinal perforation (N = 6, 13.0%). Thirty-nine (89%) patients had sepsis. The median American Society of Anesthesiologist score was 3 (range 2–4), and the median Surgical Apgar Score was 4 (range 0–6). Twenty-four (52.2%) patients required vasopressors, with dopamine and adrenaline being the only vasopressors available. Patients admitted to the ICU, compared with non-critically ill patients, were more likely to have major complications (80.4 vs. 14%, p < 0.001), unplanned reoperation (28 vs. 10%, p < 0.001) and death (72 vs. 8%, p < 0.001).

Conclusion

Patients with peritonitis admitted to the ICU commonly presented with features of sepsis. Due to limited resources in this setting, interventions are primarily supportive with intravenous fluids, intravenous antibiotics, ventilator support and vasopressors. Morbidity and mortality remain high in this patient population.
Literatur
1.
Zurück zum Zitat Meara JG, Leather AJ, Hagander L et al (2015) Global Surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Lancet 386:569–624CrossRefPubMed Meara JG, Leather AJ, Hagander L et al (2015) Global Surgery 2030: evidence and solutions for achieving health, welfare, and economic development. Lancet 386:569–624CrossRefPubMed
2.
Zurück zum Zitat Vukoja M, Riviello E, Gavrilovic S et al (2014) A survey on critical care resources and practices in low- and middle-income countries. Glob Heart 9(337–342):e331–e335 Vukoja M, Riviello E, Gavrilovic S et al (2014) A survey on critical care resources and practices in low- and middle-income countries. Glob Heart 9(337–342):e331–e335
3.
Zurück zum Zitat Firth P, Ttendo S (2012) Intensive care in low-income countries–a critical need. N Engl J Med 367:1974–1976CrossRefPubMed Firth P, Ttendo S (2012) Intensive care in low-income countries–a critical need. N Engl J Med 367:1974–1976CrossRefPubMed
4.
Zurück zum Zitat Stafford RE, Morrison CA, Godfrey G et al (2014) Challenges to the provision of emergency services and critical care in resource-constrained settings. Glob Heart 9:319–323CrossRefPubMed Stafford RE, Morrison CA, Godfrey G et al (2014) Challenges to the provision of emergency services and critical care in resource-constrained settings. Glob Heart 9:319–323CrossRefPubMed
5.
Zurück zum Zitat Ilori IU, Kalu QN (2012) Intensive care admissions and outcome at the University of Calabar Teaching Hospital, Nigeria. J Crit Care 27(105):e101–e104 Ilori IU, Kalu QN (2012) Intensive care admissions and outcome at the University of Calabar Teaching Hospital, Nigeria. J Crit Care 27(105):e101–e104
6.
Zurück zum Zitat Sawe HR, Mfinanga JA, Lidenge SJ et al (2014) Disease patterns and clinical outcomes of patients admitted in intensive care units of tertiary referral hospitals of Tanzania. BMC Int Health Hum Rights 14:26CrossRefPubMedPubMedCentral Sawe HR, Mfinanga JA, Lidenge SJ et al (2014) Disease patterns and clinical outcomes of patients admitted in intensive care units of tertiary referral hospitals of Tanzania. BMC Int Health Hum Rights 14:26CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Schultz MJ, Dunser MW, Dondorp AM et al (2017) Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med 43:612–624CrossRefPubMed Schultz MJ, Dunser MW, Dondorp AM et al (2017) Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med 43:612–624CrossRefPubMed
8.
Zurück zum Zitat Shrestha GS, Kwizera A, Lundeg G et al (2017) International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries. Lancet Infect Dis 17:893–895CrossRefPubMed Shrestha GS, Kwizera A, Lundeg G et al (2017) International Surviving Sepsis Campaign guidelines 2016: the perspective from low-income and middle-income countries. Lancet Infect Dis 17:893–895CrossRefPubMed
9.
Zurück zum Zitat Tomlinson J, Haac B, Kadyaudzu C et al (2013) The burden of surgical diseases on critical care services at a tertiary hospital in sub-Saharan Africa. Trop Dr 43:27–29 Tomlinson J, Haac B, Kadyaudzu C et al (2013) The burden of surgical diseases on critical care services at a tertiary hospital in sub-Saharan Africa. Trop Dr 43:27–29
10.
Zurück zum Zitat Riviello ED, Kiviri W, Fowler RA et al (2016) Predicting mortality in low-income country ICUs: the Rwanda Mortality Probability Model (R-MPM). PLoS ONE 11:e0155858CrossRefPubMedPubMedCentral Riviello ED, Kiviri W, Fowler RA et al (2016) Predicting mortality in low-income country ICUs: the Rwanda Mortality Probability Model (R-MPM). PLoS ONE 11:e0155858CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat Smith ZA, Ayele Y, McDonald P (2013) Outcomes in critical care delivery at Jimma University Specialised Hospital, Ethiopia. Anaesth Intensive Care 41:363–368PubMed Smith ZA, Ayele Y, McDonald P (2013) Outcomes in critical care delivery at Jimma University Specialised Hospital, Ethiopia. Anaesth Intensive Care 41:363–368PubMed
12.
Zurück zum Zitat Andrews B, Muchemwa L, Kelly P et al (2014) Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia. Crit Care Med 42:2315–2324CrossRefPubMedPubMedCentral Andrews B, Muchemwa L, Kelly P et al (2014) Simplified severe sepsis protocol: a randomized controlled trial of modified early goal-directed therapy in Zambia. Crit Care Med 42:2315–2324CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Baelani I, Jochberger S, Laimer T et al (2011) Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers. Crit Care 15:R10CrossRefPubMedPubMedCentral Baelani I, Jochberger S, Laimer T et al (2011) Availability of critical care resources to treat patients with severe sepsis or septic shock in Africa: a self-reported, continent-wide survey of anaesthesia providers. Crit Care 15:R10CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Maitland K, Kiguli S, Opoka RO et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495CrossRefPubMed Maitland K, Kiguli S, Opoka RO et al (2011) Mortality after fluid bolus in African children with severe infection. N Engl J Med 364:2483–2495CrossRefPubMed
15.
Zurück zum Zitat Andrews B, Semler MW, Muchemwa L et al (2017) Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension: a randomized clinical trial. JAMA 318:1233–1240CrossRefPubMedPubMedCentral Andrews B, Semler MW, Muchemwa L et al (2017) Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension: a randomized clinical trial. JAMA 318:1233–1240CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Ndayizeye L, Ngarambe C, Smart B et al (2016) Peritonitis in Rwanda: epidemiology and risk factors for morbidity and mortality. Surgery 160:1645–1656CrossRefPubMed Ndayizeye L, Ngarambe C, Smart B et al (2016) Peritonitis in Rwanda: epidemiology and risk factors for morbidity and mortality. Surgery 160:1645–1656CrossRefPubMed
18.
Zurück zum Zitat WHO (2017) WHO model list of essential medicines. WHO, Geneva WHO (2017) WHO model list of essential medicines. WHO, Geneva
19.
Zurück zum Zitat WHO (2017) The selection and use of essential medicine, executive summary. WHO, Geneva WHO (2017) The selection and use of essential medicine, executive summary. WHO, Geneva
20.
Zurück zum Zitat Petroze RT, Nzayisenga A, Rusanganwa V et al (2012) Comprehensive national analysis of emergency and essential surgical capacity in Rwanda. Br J Surg 99:436–443CrossRefPubMed Petroze RT, Nzayisenga A, Rusanganwa V et al (2012) Comprehensive national analysis of emergency and essential surgical capacity in Rwanda. Br J Surg 99:436–443CrossRefPubMed
21.
Zurück zum Zitat Barr J, Fraser GL, Puntillo K et al (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the Intensive Care Unit: executive summary. Am J Health Syst Pharm 70:53–58PubMed Barr J, Fraser GL, Puntillo K et al (2013) Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the Intensive Care Unit: executive summary. Am J Health Syst Pharm 70:53–58PubMed
22.
Zurück zum Zitat Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377CrossRefPubMed Rhodes A, Evans LE, Alhazzani W et al (2017) Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med 43:304–377CrossRefPubMed
23.
Zurück zum Zitat Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228CrossRefPubMed Dellinger RP, Levy MM, Rhodes A et al (2013) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39:165–228CrossRefPubMed
Metadaten
Titel
Critical Care Management of Peritonitis in a Low-Resource Setting
verfasst von
Jennifer Rickard
Christian Ngarambe
Leonard Ndayizeye
Blair Smart
Robert Riviello
Jean Paul Majyambere
Publikationsdatum
19.03.2018
Verlag
Springer International Publishing
Erschienen in
World Journal of Surgery / Ausgabe 10/2018
Print ISSN: 0364-2313
Elektronische ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-018-4598-6

Weitere Artikel der Ausgabe 10/2018

World Journal of Surgery 10/2018 Zur Ausgabe

Update Chirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

S3-Leitlinie „Diagnostik und Therapie des Karpaltunnelsyndroms“

Karpaltunnelsyndrom BDC Leitlinien Webinare
CME: 2 Punkte

Das Karpaltunnelsyndrom ist die häufigste Kompressionsneuropathie peripherer Nerven. Obwohl die Anamnese mit dem nächtlichen Einschlafen der Hand (Brachialgia parästhetica nocturna) sehr typisch ist, ist eine klinisch-neurologische Untersuchung und Elektroneurografie in manchen Fällen auch eine Neurosonografie erforderlich. Im Anfangsstadium sind konservative Maßnahmen (Handgelenksschiene, Ergotherapie) empfehlenswert. Bei nicht Ansprechen der konservativen Therapie oder Auftreten von neurologischen Ausfällen ist eine Dekompression des N. medianus am Karpaltunnel indiziert.

Prof. Dr. med. Gregor Antoniadis
Berufsverband der Deutschen Chirurgie e.V.

S2e-Leitlinie „Distale Radiusfraktur“

Radiusfraktur BDC Leitlinien Webinare
CME: 2 Punkte

Das Webinar beschäftigt sich mit Fragen und Antworten zu Diagnostik und Klassifikation sowie Möglichkeiten des Ausschlusses von Zusatzverletzungen. Die Referenten erläutern, welche Frakturen konservativ behandelt werden können und wie. Das Webinar beantwortet die Frage nach aktuellen operativen Therapiekonzepten: Welcher Zugang, welches Osteosynthesematerial? Auf was muss bei der Nachbehandlung der distalen Radiusfraktur geachtet werden?

PD Dr. med. Oliver Pieske
Dr. med. Benjamin Meyknecht
Berufsverband der Deutschen Chirurgie e.V.

S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“

Appendizitis BDC Leitlinien Webinare
CME: 2 Punkte

Inhalte des Webinars zur S1-Leitlinie „Empfehlungen zur Therapie der akuten Appendizitis bei Erwachsenen“ sind die Darstellung des Projektes und des Erstellungswegs zur S1-Leitlinie, die Erläuterung der klinischen Relevanz der Klassifikation EAES 2015, die wissenschaftliche Begründung der wichtigsten Empfehlungen und die Darstellung stadiengerechter Therapieoptionen.

Dr. med. Mihailo Andric
Berufsverband der Deutschen Chirurgie e.V.