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Erschienen in:

03.11.2016

Critical review of IgG4-related hypophysitis

verfasst von: Junpei Shikuma, Kenshi Kan, Rokuro Ito, Kazuo Hara, Hiroyuki Sakai, Takashi Miwa, Akira Kanazawa, Masato Odawara

Erschienen in: Pituitary | Ausgabe 2/2017

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Abstract

Purpose

IgG4-related hypophysitis is a rare disease, with only 34 cases published in English (2015). Available short reviews may not present complete details of IgG4-related hypophysitis. We aimed to survey case reports of IgG4-related hypophysitis, including abstracts of scientific meetings, in English and Japanese.

Methods

We searched for information about IgG4-related hypophysitis in PubMed and Igakuchuozasshi (Japan Medical Abstracts Society). Among 104 case reports found, we reviewed 84 fulfilling Leporati’s diagnostic criteria.

Results

The mean ± SD age of onset was 64.2 ± 13.9, 67.5 ± 9.8, and 56.4 ± 18.6 years for all subjects, men, and women, respectively. Men:women was 2.4:1. On magnetic resonance imaging, pituitary, stalk, and pituitary-stalk mass were observed at frequencies of 14.3, 21.4, and 64.3%, respectively. Manifestations were anterior hypopituitarism in 26.2% (22 cases), central diabetes insipidus in 17.9% (15 cases), and panhypopituitarism in 52.4% (44 cases). The median level of serum IgG4 was 264.5 mg/dL for all subjects, 405 mg/dL for men, and 226 mg/dL for women. The mean number of IgG4-related systemic diseases was 2.7 ± 1.5 in all subjects, 3.0 ± 1.5 in men, and 1.8 ± 1.1 in women. Among the IgG4-related diseases, retroperitoneal fibrosis was the most frequent (26.2%), followed by salivary gland diseases (25%). Glucocorticoid therapy was generally effective, except for two cases that received replacement doses. There were significant differences between sexes in terms of age, serum IgG4 levels, and number of IgG4-related diseases.

Conclusion

IgG4-related hypophysitis may have different clinical characteristics between genders. This survey may lack some information because the Japanese abstracts did not contain certain details.

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Titel: Critical review of IgG4-related hypophysitis
verfasst von: Junpei Shikuma
Kenshi Kan
Rokuro Ito
Kazuo Hara
Hiroyuki Sakai
Takashi Miwa
Akira Kanazawa
Masato Odawara
Publikationsdatum: 03.11.2016
Verlag: Springer US
Erschienen in: Pituitary / Ausgabe 2/2017
Print ISSN: 1386-341X
Elektronische ISSN: 1573-7403
DOI: https://doi.org/10.1007/s11102-016-0773-7

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Critical review of IgG4-related hypophysitis

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