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Erschienen in: Osteoporosis International 10/2009

01.10.2009 | Original Article

Cross-geographic region differences in quality of life in women with and without vertebral fracture

verfasst von: N. M. van Schoor, H. Yu, J. Bobula, P. Lips

Erschienen in: Osteoporosis International | Ausgabe 10/2009

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Abstract

Summary

Not much is known about cross-geographic region differences in quality of life (QoL) in women with and without prevalent vertebral fractures (VFX). QoL differed between continents, countries, and ethnicities. The observed differences in QoL mostly appeared larger than the difference in QoL between women with or without mild to moderate VFX.

Introduction

Quality of life (QoL) is an increasingly important outcome measure in randomized controlled trials and cost-utility studies. However, not much is known about cross-geographic region differences in QoL. The objective of this study was to describe the cross-geographic region differences in QoL in women with and without mild to moderate prevalent vertebral fractures (VFX).

Methods

The study was performed using baseline data of the bazedoxifene study. The study was carried out in 25 countries in six continents (n = 7117). QoL was assessed using the index and Visual Analogue Scale (VAS) scores of the EQ-5D, Qualeffo-41, and Women's Health Questionnaire (WHQ). VFX were assessed using semi-quantitative and quantitative morphometric methods.

Results

In general, all four instruments followed more or less the same pattern. In most analyses, the reported QoL was lowest in Asia and Europe and highest in North America and Oceania. To examine the influence of ethnicity, North and South America were stratified on race. In both continents, a lower QoL was observed in Hispanic people.

Conclusions

QoL differed between continents, countries, and ethnicities. The observed differences in QoL appeared larger between most continents and countries than the difference in QoL between women with or without mild to moderate VFX.
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Metadaten
Titel
Cross-geographic region differences in quality of life in women with and without vertebral fracture
verfasst von
N. M. van Schoor
H. Yu
J. Bobula
P. Lips
Publikationsdatum
01.10.2009
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 10/2009
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-009-0853-x

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