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Indian Journal of Pediatrics

01.06.2014 | Original Article

Cryptococcal Meningitis: Description of 3 Cases and Estimation of T-cell Subsets

verfasst von: Lei Zhu, Rui Huang, Huimin Guo, Jinli Zhang, Chen Dong, Hong Han

Erschienen in: Indian Journal of Pediatrics | Ausgabe 6/2014

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Abstract

Objectives

To describe three cases of cryptococcus neoformans meningitis and evaluate their cellular immunity.

Methods

This study involved three cases of cryptococcus neoformans meningitis admitted to Children’s Hospital of Shanxi Province between July 2010 and July 2011. Clinical presentations, laboratory findings, treatment and outcome in these cases has been discussed.

Results

Staining cerebrospinal fluid (CSF) with India ink showed Cryptococcus neoformans. Flow cytometric analysis of T-cell subsets revealed that their cellular immunity were depressed, which mainly embodies decline in CD4+ levels.

Conclusions

The authors speculate that decreased CD4+ T lymphocyte counts are attributed to cryptococcal infection, emphasizing the significance and importance of evaluating cellular immunity in patients who present with unusual infections. Early diagnosis of cryptococcal meningitis and appropriate antifungal therapy are essential to achieve a better outcome.

Meyer W, Castañeda A, Jackson S, Huynh M, Castañeda E; IberoAmerican Cryptococcal Study Group. Molecular typing of IberoAmerican cryptococcus neoformans isolates. Emerg Infec Dis. 2003;9:189–95.CrossRef

Mitchell TG, Perfect JR. Cryptococcosis in the era of AIDS–100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev. 1995;8:515–48.PubMedCentralPubMed

Chaudhary MW, Sardana K, Kumar P, Dewan V, Anand VK. Disseminated infection with Cryptococcus neoformans var neoformans in an 8 years immunocompetent girl. Indian J Pediatr. 2005;72:85.PubMedCrossRef

Speed BR, Kaldor J. Rarity of cryptococcal infection in children. Pediatr Infect Dis J. 1997;16:536–7.PubMedCrossRef

Yuanjie Z, Jianghan C, Nan X, Xiaojun W, Hai W, Wanqing L, et al. Cryptococcal meningitis in immunocompetent children. Mycoses. 2012;55:168–71.PubMed

Yuanjie Z, Jianghan C, Julin G, Hai W. Cryptococcal meningitis in an immunocompetent 8-year-old girl. Mycoses. 2009;52:377–8.PubMedCrossRef

Swe Han KS, Bekker A, Greeff S, Perkins DR. Cryptococcus meningitis and skin lesions in an HIV negative child. J Clin Pathol. 2008;61:1138–9.PubMedCrossRef

Shinjoh M, Miyairi I, Sakurai M, Takahashi M, Ariyasu D, Nakayama T, et al. Cryptococcal meningitis in an immunocompetent child. Eur J Pediatr. 2005;164:596–7.PubMedCrossRef

Othman N, Abdullah NA, Wahab ZA. Cryptococcal meningitis in an immunocompetent child: A case report and literature review. Southeast Asian J Trop Med Public Health. 2004;35:930–4.PubMed

10.

Kaur R, Mittal N, Rawat D, Mathur MD. Cryptococcal meningitis in a neonate. Scand J Infect Dis. 2002;34:542–3.PubMedCrossRef

11.

Chen S, Sorrell T, Nimmo G, Speed B, Currie B, Ellis D, et al. Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Australasian Cryptococcal Study Group. Clin Infect Dis. 2000;31:499–508.PubMedCrossRef

12.

Rozenbaum R, Gonçalves AJ. Clinical epidemiological study of 171 cases of cryptococcosis. Clin Infect Dis. 1994;18:369–80.PubMedCrossRef

13.

Lopes JO, Costa JM, Streher LA, Clock C, Pinto MS, Alves SH. Cryptococcosis not related to AIDS in Rio Grande do Sul: A report of 8 cases and a review of the literature. Rev Soc Bras Med Trop. 1997;30:369–72.PubMedCrossRef

14.

Huang KY, Huang YC, Hung IJ, Lin TY. Cryptococcosis in nonhuman immunodeficiency virus-infected children. Pediatr Neurol. 2010;42:267–70.PubMedCrossRef

15.

Severo CB, Xavier MO, Gazzoni AF, Severo LC. Cryptococcosis in children. Paediatr Respir Rev. 2009;10:166–71.PubMedCrossRef

16.

Bicanic T, Harrison TS. Cryptococcal meningitis. Brit Med Bull. 2004;72:99–118.PubMedCrossRef

17.

Salit RB, Hankey KG, Yi R, Rapoport AP, Mann DL. Detection of CD4(+) T-cell antibodies in a patient with idiopathic CD4 T lymphocytopenia and cryptococcal meningitis. Br J Haematol. 2007;139:133–7.PubMedCrossRef

18.

Cheung MC, Rachlis AR, Shumak SL. A cryptic cause of cryptococcal meningitis. CMAJ. 2003;168:451–2.PubMedCentralPubMed

19.

Muller J. Immunological aspects of cryptococcosis in AIDS patients. In: van den Bossche H, MacKenzie DWR, Cauwenbergh G, van Cutsem J, Drouhet E, Dupont B, eds. Mycoses in AIDS Patients. New York: Plenum; 1990. pp. 123–32.CrossRef

20.

Murphy JW. Clearance of cryptococcus neoformans from immunologically suppressed mice. Infect Immun. 1989;57:1946–52.PubMedCentralPubMed

21.

Levitz SM. The ecology of cryptococcus neoformans and the epidemiology of cryptococcosis. Rev Infect Dis. 1991;13:1163–9.PubMedCrossRef

22.

Saag MS, Graybill RJ, Larsen RA, Pappas PG, Perfect JR, Powderly WG, et al. Practice guidelines for the management of cryptococcal disease. Infectious Diseases Society of America. Clin Infect Dis. 2000;30:710–8.PubMedCrossRef

23.

Perfect JR, Dismukes WE, Dromer F, Goldman DL, Graybill JR, Hamill RJ, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis. 2010;50:291–322.PubMedCrossRef

Titel: Cryptococcal Meningitis: Description of 3 Cases and Estimation of T-cell Subsets
verfasst von: Lei Zhu
Rui Huang
Huimin Guo
Jinli Zhang
Chen Dong
Hong Han
Publikationsdatum: 01.06.2014
Verlag: Springer India
Erschienen in: Indian Journal of Pediatrics / Ausgabe 6/2014
Print ISSN: 0019-5456
Elektronische ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-013-1087-7

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Cryptococcal Meningitis: Description of 3 Cases and Estimation of T-cell Subsets

Abstract

Objectives

Methods

Results

Conclusions

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Conclusions

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