Skip to main content
Erschienen in: Journal of Neurology 9/2016

29.06.2016 | Original Communication

CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt–Jakob disease suspected cases with inconclusive 14-3-3 result

verfasst von: M. J. Leitão, I. Baldeiras, M. R. Almeida, M. H. Ribeiro, A. C. Santos, M. Ribeiro, J. Tomás, S. Rocha, I. Santana, C. R. Oliveira

Erschienen in: Journal of Neurology | Ausgabe 9/2016

Einloggen, um Zugang zu erhalten

Abstract

Cerebrospinal fluid (CSF) 14-3-3 protein supports sporadic Creutzfeldt–Jakob (sCJD) diagnosis, but often leads to weak-positive results and lacks standardization. In this study, we explored the added diagnostic value of Total Tau (t-Tau) and phosphorylated Tau (p-Tau) in sCJD diagnosis, particularly in the cases with inconclusive 14-3-3 result. 95 definite sCJD and 287 patients without prion disease (non-CJD) were included in this study. CSF samples were collected in routine clinical diagnosis and analysed for 14-3-3 detection by Western blot (WB). CSF t-Tau and p-Tau were quantified by commercial ELISA kits and PRNP and APOE genotyping assessed by PCR–RFLP. In a regression analysis of the whole cohort, 14-3-3 protein revealed an overall accuracy of 82 % (sensitivity = 96.7 %; specificity = 75.6 %) for sCJD. Regarding 14-3-3 clear positive results, we observed no added value either of t-Tau alone or p-Tau/t-Tau ratio in the model. On the other hand, considering 14-3-3 weak-positive cases, t-Tau protein increased the overall accuracy of 14-3-3 alone from 91 to 94 % and specificity from 74 to 93 % (p < 0.05), with no sensitivity improvement. However, inclusion of p-Tau/t-Tau ratio did not significantly improve the first model (p = 0.0595). Globally, t-Tau protein allowed a further discrimination of 65 % within 14-3-3 inconclusive results. Furthermore, PRNP MV genotype showed a trend to decrease 14-3-3 sensitivity (p = 0.051), but such effect was not seen on t-Tau protein. In light of these results, we suggest that t-Tau protein assay is of significant importance as a second marker in identifying 14-3-3 false-positive results among sCJD probable cases.
Literatur
1.
Zurück zum Zitat Pocchiari M, Poupolo M, Croes EA, Budka H, Gelpi E, Collins S, Lewis V, Sutcliffe T, Guilivi A, Delasnerie-Laupretre N, Brandel JP, Alperovitch A, Zerr I, Poser S, Kretzschmar HA, Ladogana A, Rietvald I, Mitrova E, Martinez-Martin P, de Pedro-Cuesta J, Glatzel M, Aguzzi A, Cooper S, Mackenzie J, van Duijn CM, Will RG (2004) Predictors of survival in sporadic Creutzfeldt–Jakob disease and other human transmissible spongiform encephalopathies. Brain 127:2348–2359CrossRefPubMed Pocchiari M, Poupolo M, Croes EA, Budka H, Gelpi E, Collins S, Lewis V, Sutcliffe T, Guilivi A, Delasnerie-Laupretre N, Brandel JP, Alperovitch A, Zerr I, Poser S, Kretzschmar HA, Ladogana A, Rietvald I, Mitrova E, Martinez-Martin P, de Pedro-Cuesta J, Glatzel M, Aguzzi A, Cooper S, Mackenzie J, van Duijn CM, Will RG (2004) Predictors of survival in sporadic Creutzfeldt–Jakob disease and other human transmissible spongiform encephalopathies. Brain 127:2348–2359CrossRefPubMed
2.
Zurück zum Zitat Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N (2011) Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med 17:175–178CrossRefPubMed Atarashi R, Satoh K, Sano K, Fuse T, Yamaguchi N, Ishibashi D, Matsubara T, Nakagaki T, Yamanaka H, Shirabe S, Yamada M, Mizusawa H, Kitamoto T, Klug G, McGlade A, Collins SJ, Nishida N (2011) Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med 17:175–178CrossRefPubMed
3.
Zurück zum Zitat McGuire LI, Peden AH, Orrú CD, Wilham JM, Appleford NE, Mallinson G, Andrews M, Head MW, Caughey B, Will RG, Knight RS, Green AJ (2012) Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt–Jakob disease. Ann Neurol 72:278–285CrossRefPubMedPubMedCentral McGuire LI, Peden AH, Orrú CD, Wilham JM, Appleford NE, Mallinson G, Andrews M, Head MW, Caughey B, Will RG, Knight RS, Green AJ (2012) Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt–Jakob disease. Ann Neurol 72:278–285CrossRefPubMedPubMedCentral
4.
Zurück zum Zitat Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Kl Jellinger (1995) Neuropathological diagnostic criteria for Creutzfeldt–Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol 5:459–466CrossRefPubMed Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Kl Jellinger (1995) Neuropathological diagnostic criteria for Creutzfeldt–Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol 5:459–466CrossRefPubMed
5.
Zurück zum Zitat Poser S, Mollenhauer B, Kraubeta A, Zerr I, Steinhoff BJ, Schroeter A, Finkenstaedt M, Schulz-Schaeffer WJ, Kretzschmar HA, Felgenhauer K (1999) How to improve the clinical diagnosis of Creutzfeldt–Jakob disease. Brain 12:2345–2351CrossRef Poser S, Mollenhauer B, Kraubeta A, Zerr I, Steinhoff BJ, Schroeter A, Finkenstaedt M, Schulz-Schaeffer WJ, Kretzschmar HA, Felgenhauer K (1999) How to improve the clinical diagnosis of Creutzfeldt–Jakob disease. Brain 12:2345–2351CrossRef
6.
Zurück zum Zitat World Health Organization (1998) Report of a WHO consultation on global surveillance, diagnosis and therapy of human transmissible spongiform encephalopathies. WHO, Geneva, pp 8–11 World Health Organization (1998) Report of a WHO consultation on global surveillance, diagnosis and therapy of human transmissible spongiform encephalopathies. WHO, Geneva, pp 8–11
7.
Zurück zum Zitat Heinemann U, Krasnianski A, Meissner B, Varges D, Kallenberg K, Schulz-Schaeffer WJ, Steinhoff BJ, Grasbon-Frodl EM, Kretzschmar HA, Zerr I (2007) Creutzfeldt–Jakob disease in Germany: a prospective 12-year surveillance. Brain 130:1350–1359CrossRefPubMed Heinemann U, Krasnianski A, Meissner B, Varges D, Kallenberg K, Schulz-Schaeffer WJ, Steinhoff BJ, Grasbon-Frodl EM, Kretzschmar HA, Zerr I (2007) Creutzfeldt–Jakob disease in Germany: a prospective 12-year surveillance. Brain 130:1350–1359CrossRefPubMed
8.
Zurück zum Zitat Zerr I, Bodemer M, Gefeller O, Otto M, Poser S, Wiltfang J, Windl O, Kretzschmar HA, Weber T (1998) Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt–Jakob disease. Ann Neurol 43:32–40CrossRefPubMed Zerr I, Bodemer M, Gefeller O, Otto M, Poser S, Wiltfang J, Windl O, Kretzschmar HA, Weber T (1998) Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt–Jakob disease. Ann Neurol 43:32–40CrossRefPubMed
9.
Zurück zum Zitat Lemstra AW, van Meegen MT, Vreyling JP, Meijering PH, Jansen GH, Bulk S, Baas F, van Gool WA (2000) 14-3-3 testing in diagnosing Creutzfeldt–Jakob disease: a prospective study in 112 patients. Neurology 55:514–516CrossRefPubMed Lemstra AW, van Meegen MT, Vreyling JP, Meijering PH, Jansen GH, Bulk S, Baas F, van Gool WA (2000) 14-3-3 testing in diagnosing Creutzfeldt–Jakob disease: a prospective study in 112 patients. Neurology 55:514–516CrossRefPubMed
10.
Zurück zum Zitat Collins SJ, Sanchez-Juan P, Masters CL, Klug GM, van Duijn C, Poleggi A, Pocchiari M, Almonti S, Cuadrado-Corrales N, de Pedro-Cuesta J, Budka H, Gelpi E, Glatzel M, Tolnay M, Hewer E, Zerr I, Heinemann U, Kretszchmar HA, Jansen GH, Olsen E, Mitrova E, Alpérovitch A, Brandel JP, Mackenzie J, Murray K, Will RG (2006) Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt–Jakob disease. Brain 129:2278–2287CrossRefPubMed Collins SJ, Sanchez-Juan P, Masters CL, Klug GM, van Duijn C, Poleggi A, Pocchiari M, Almonti S, Cuadrado-Corrales N, de Pedro-Cuesta J, Budka H, Gelpi E, Glatzel M, Tolnay M, Hewer E, Zerr I, Heinemann U, Kretszchmar HA, Jansen GH, Olsen E, Mitrova E, Alpérovitch A, Brandel JP, Mackenzie J, Murray K, Will RG (2006) Determinants of diagnostic investigation sensitivities across the clinical spectrum of sporadic Creutzfeldt–Jakob disease. Brain 129:2278–2287CrossRefPubMed
11.
Zurück zum Zitat Otto M, Wiltfang J, Cepek L, Neumann M, Mollenhauer B, Steinacker P, Ciesielczyk B, Schulz-Schaeffer W, Kretzschmar HA, Poser S (2002) Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt–Jakob disease. Neurology 58:192–197CrossRefPubMed Otto M, Wiltfang J, Cepek L, Neumann M, Mollenhauer B, Steinacker P, Ciesielczyk B, Schulz-Schaeffer W, Kretzschmar HA, Poser S (2002) Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt–Jakob disease. Neurology 58:192–197CrossRefPubMed
12.
Zurück zum Zitat Van Everbroeck B, Quoilin S, Boons J, Martin JJ, Cras P (2003) A prospective study of CSF markers in 250 patients with possible Creutzfeldt–Jakob disease. JNNP 74:1210–1214 Van Everbroeck B, Quoilin S, Boons J, Martin JJ, Cras P (2003) A prospective study of CSF markers in 250 patients with possible Creutzfeldt–Jakob disease. JNNP 74:1210–1214
13.
Zurück zum Zitat Sanchez-Juan P, Green A, Ladogana A, Cuadrado-Corrales N, Sáanchez-Valle R, Mitrováa E, Stoeck K, Sklaviadis T, Kulczycki J, Hess K, Bodemer M, Slivarichová D, Saiz A, Calero M, Ingrosso L, Knight R, Janssens AC, van Duijn CM, Zerr I (2006) CSF tests in the differential diagnosis of Creutzfeldt–Jakob disease. Neurology 67:637–643CrossRefPubMed Sanchez-Juan P, Green A, Ladogana A, Cuadrado-Corrales N, Sáanchez-Valle R, Mitrováa E, Stoeck K, Sklaviadis T, Kulczycki J, Hess K, Bodemer M, Slivarichová D, Saiz A, Calero M, Ingrosso L, Knight R, Janssens AC, van Duijn CM, Zerr I (2006) CSF tests in the differential diagnosis of Creutzfeldt–Jakob disease. Neurology 67:637–643CrossRefPubMed
14.
Zurück zum Zitat Baldeiras IE, Ribeiro MH, Pacheco P, Machado A, Santana I, Cunha L, Oliveira CR (2009) Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients. J Neurol 256:1540–1550CrossRefPubMed Baldeiras IE, Ribeiro MH, Pacheco P, Machado A, Santana I, Cunha L, Oliveira CR (2009) Diagnostic value of CSF protein profile in a Portuguese population of sCJD patients. J Neurol 256:1540–1550CrossRefPubMed
15.
Zurück zum Zitat Chapman T, McKeel DW Jr, Morris JC (2000) Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt–Jakob disease. Neurology 55:1396–1397CrossRefPubMed Chapman T, McKeel DW Jr, Morris JC (2000) Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt–Jakob disease. Neurology 55:1396–1397CrossRefPubMed
16.
Zurück zum Zitat Burkhard PR, Sanchez JC, Landis T, Hochstrasser DF (2001) CSF detection of the 14-3-3 protein in unselected patients with dementia. Neurology 56:1528–1533CrossRefPubMed Burkhard PR, Sanchez JC, Landis T, Hochstrasser DF (2001) CSF detection of the 14-3-3 protein in unselected patients with dementia. Neurology 56:1528–1533CrossRefPubMed
17.
Zurück zum Zitat Geschwind MD, Martindale J, Miller D, DeArmond SJ, Uyehara-Lock J, Gaskin D, Kramer JH, Barbaro NM, Miller BL (2003) Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt–Jakob disease. Arch Neurol 60:813–816CrossRefPubMed Geschwind MD, Martindale J, Miller D, DeArmond SJ, Uyehara-Lock J, Gaskin D, Kramer JH, Barbaro NM, Miller BL (2003) Challenging the clinical utility of the 14-3-3 protein for the diagnosis of sporadic Creutzfeldt–Jakob disease. Arch Neurol 60:813–816CrossRefPubMed
18.
Zurück zum Zitat Machado A, Ribeiro M, Rodrigues M, Ferreira C, Baldeiras I, Ribeiro MH, Santana I, Almeida R, Castro L, Carpenter S (2009) Sporadic Creutzfeldt–Jakob disease causing a 2-years slowly progressive isolated dementia. Behav Neurol 21:175–179CrossRefPubMed Machado A, Ribeiro M, Rodrigues M, Ferreira C, Baldeiras I, Ribeiro MH, Santana I, Almeida R, Castro L, Carpenter S (2009) Sporadic Creutzfeldt–Jakob disease causing a 2-years slowly progressive isolated dementia. Behav Neurol 21:175–179CrossRefPubMed
19.
Zurück zum Zitat Chohan G, Pennington C, Mackenzie JM, Andrews M, Everington D, Will RG, Knight RSG, Green AJE (2010) The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt–Jakob disease in the UK: a 10-year review. J Neurol Neurosurg Psychiatry 81:1243–1248CrossRefPubMed Chohan G, Pennington C, Mackenzie JM, Andrews M, Everington D, Will RG, Knight RSG, Green AJE (2010) The role of cerebrospinal fluid 14-3-3 and other proteins in the diagnosis of sporadic Creutzfeldt–Jakob disease in the UK: a 10-year review. J Neurol Neurosurg Psychiatry 81:1243–1248CrossRefPubMed
20.
Zurück zum Zitat Stoeck K, Sanchez-Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M, Sanchez-Valle R, Mitrova E, Sklaviadis T, Kulczycki J, Slivarichova D, Saiz A, Calero M, Knight R, Aguzzi A, Laplanche JL, Peoc’h K, Schelzke G, Karch A, van Duijn CM, Zerr I (2012) Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt–Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. Brain 135:3051–3061CrossRefPubMedPubMedCentral Stoeck K, Sanchez-Juan P, Gawinecka J, Green A, Ladogana A, Pocchiari M, Sanchez-Valle R, Mitrova E, Sklaviadis T, Kulczycki J, Slivarichova D, Saiz A, Calero M, Knight R, Aguzzi A, Laplanche JL, Peoc’h K, Schelzke G, Karch A, van Duijn CM, Zerr I (2012) Cerebrospinal fluid biomarker supported diagnosis of Creutzfeldt–Jakob disease and rapid dementias: a longitudinal multicentre study over 10 years. Brain 135:3051–3061CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Klug GMJA, Wand H, Simpson M, Boyd A, Law M, Masters CL, Matěj R, Howley R, Farrell M, Breithaupt M, Zerr I, van Duijn C, Ibrahim-Verbaas C, Mackenzie J, Will RG, Brandel JP, Alperovitch A, Budka H, Kovacs GG, Jansen GH, Coulthard M, Collins SJ (2013) Intensity of human prion disease surveillance predicts observed disease incidence. J Neurol Neurosurg Psychiatry 0:1–6 Klug GMJA, Wand H, Simpson M, Boyd A, Law M, Masters CL, Matěj R, Howley R, Farrell M, Breithaupt M, Zerr I, van Duijn C, Ibrahim-Verbaas C, Mackenzie J, Will RG, Brandel JP, Alperovitch A, Budka H, Kovacs GG, Jansen GH, Coulthard M, Collins SJ (2013) Intensity of human prion disease surveillance predicts observed disease incidence. J Neurol Neurosurg Psychiatry 0:1–6
22.
Zurück zum Zitat Kapaki E, Kilidireas K, Paraskevas GP, Michalopoulou M, Patsouris E (2001) Highly increased CSF tau protein and decreased β-amyloid (1–42) in sporadic CJD: a discrimination from Alzheimer’s disease? JNNP 71:401–403 Kapaki E, Kilidireas K, Paraskevas GP, Michalopoulou M, Patsouris E (2001) Highly increased CSF tau protein and decreased β-amyloid (1–42) in sporadic CJD: a discrimination from Alzheimer’s disease? JNNP 71:401–403
23.
Zurück zum Zitat Van Everbroeck B, Green AJE, Vanmechelen E, Vanderstichele H, Pals P, Sanchez-Valle R, Cuadrado Corrales N, Martin JJ, Cras P (2002) Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt–Jakob disease. JNNP 73:79–82 Van Everbroeck B, Green AJE, Vanmechelen E, Vanderstichele H, Pals P, Sanchez-Valle R, Cuadrado Corrales N, Martin JJ, Cras P (2002) Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt–Jakob disease. JNNP 73:79–82
24.
Zurück zum Zitat Bahl JM, Heegaard N, Falkenhorst G, Laursen H, Høgenhaven H, Mølbak K, Jespersgaard C, Hougs L, Waldemar G, Johannsen P, Christiansen M (2009) The diagnostic efficiency of biomarkers in sporadic Creutzfeldt Jakob disease compared to Alzheimer’s disease. Neurobiol Aging 30:1834–1841CrossRefPubMed Bahl JM, Heegaard N, Falkenhorst G, Laursen H, Høgenhaven H, Mølbak K, Jespersgaard C, Hougs L, Waldemar G, Johannsen P, Christiansen M (2009) The diagnostic efficiency of biomarkers in sporadic Creutzfeldt Jakob disease compared to Alzheimer’s disease. Neurobiol Aging 30:1834–1841CrossRefPubMed
25.
Zurück zum Zitat Hamlin C, Puoti G, Berri S, Sting E, Harris C, Cohen M, Spear C, Bizzi A, Debanne SM, Rowland DY (2012) A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt–Jakob disease. Neurology 79:547–552CrossRefPubMedPubMedCentral Hamlin C, Puoti G, Berri S, Sting E, Harris C, Cohen M, Spear C, Bizzi A, Debanne SM, Rowland DY (2012) A comparison of tau and 14-3-3 protein in the diagnosis of Creutzfeldt–Jakob disease. Neurology 79:547–552CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Satoh K, Shirabe S, Tsujino A, Eguchi H, Motomura M, Honda H, Tomita I, Satoh A, Tsujihata M, Matsuo H, Nakagawa M, Eguchi K (2007) Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt–Jakob disease. Dement Geriatr Cognit Disord 24:207–212CrossRef Satoh K, Shirabe S, Tsujino A, Eguchi H, Motomura M, Honda H, Tomita I, Satoh A, Tsujihata M, Matsuo H, Nakagawa M, Eguchi K (2007) Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt–Jakob disease. Dement Geriatr Cognit Disord 24:207–212CrossRef
27.
Zurück zum Zitat Pennington C, Chohan G, Mackenzie J, Andrews M, Will R, Knight R, Green A (2009) The role of cerebrospinal fluid proteins as early diagnostic markers for sporadic Creutzfeldt–Jakob disease. Neurosci Lett 455:56–59CrossRefPubMed Pennington C, Chohan G, Mackenzie J, Andrews M, Will R, Knight R, Green A (2009) The role of cerebrospinal fluid proteins as early diagnostic markers for sporadic Creutzfeldt–Jakob disease. Neurosci Lett 455:56–59CrossRefPubMed
28.
Zurück zum Zitat Dorey A, Tholance Y, Vighetto A, Perret-Liaudet A, Lachman I, Krolak-Salmon P, Wagner U, Struyfs H, De Deyn PP, El-Moualij B, Zorzi W, Meyronet D, Streichenberger N, Engelborghs S, Kovacs GG, Quadrio I (2015) Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and Creutzfeldt–Jakob disease. JAMA Neurol 72:267–275CrossRefPubMed Dorey A, Tholance Y, Vighetto A, Perret-Liaudet A, Lachman I, Krolak-Salmon P, Wagner U, Struyfs H, De Deyn PP, El-Moualij B, Zorzi W, Meyronet D, Streichenberger N, Engelborghs S, Kovacs GG, Quadrio I (2015) Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and Creutzfeldt–Jakob disease. JAMA Neurol 72:267–275CrossRefPubMed
29.
Zurück zum Zitat Riemenschneider M, Wagenpfeil S, Vanderstichele H, Otto M, Wiltfang J, Kretzschmar H, Vanmechelen E, Förstl H, Kurz A (2003) Phospho-tau/total tau ratio in cerebrospinal fluid discirminates Creutzfeldt–Jakob disease from other dementias. Mol Psychiatry 8:343–347CrossRefPubMed Riemenschneider M, Wagenpfeil S, Vanderstichele H, Otto M, Wiltfang J, Kretzschmar H, Vanmechelen E, Förstl H, Kurz A (2003) Phospho-tau/total tau ratio in cerebrospinal fluid discirminates Creutzfeldt–Jakob disease from other dementias. Mol Psychiatry 8:343–347CrossRefPubMed
30.
Zurück zum Zitat Buerger K, Otto M, Teiperl SJ, Zinkowski R, Blennow K, DeBernardis J, Kerkman D, Schröeder J, Schönknecht P, Cepek L, McCulloch C, Möller HJ, Wiltfang J, Kretzschmar H, Hampel H (2006) Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt–Jakob disease. Neurobiol Aging 27:10–15CrossRefPubMed Buerger K, Otto M, Teiperl SJ, Zinkowski R, Blennow K, DeBernardis J, Kerkman D, Schröeder J, Schönknecht P, Cepek L, McCulloch C, Möller HJ, Wiltfang J, Kretzschmar H, Hampel H (2006) Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt–Jakob disease. Neurobiol Aging 27:10–15CrossRefPubMed
31.
Zurück zum Zitat Hyeon JW, Kim SY, Lee J, Park JS, Hwang KJ, Lee SM, An SA, Lee MK, Ju YR (2015) Alternative application of Tau protein in Creutzfeldt–Jakob disease diagnosis: improvement for weakly positive 14-3-3 protein in the laboratory. Sci Rep 5:15283CrossRefPubMedPubMedCentral Hyeon JW, Kim SY, Lee J, Park JS, Hwang KJ, Lee SM, An SA, Lee MK, Ju YR (2015) Alternative application of Tau protein in Creutzfeldt–Jakob disease diagnosis: improvement for weakly positive 14-3-3 protein in the laboratory. Sci Rep 5:15283CrossRefPubMedPubMedCentral
32.
Zurück zum Zitat Machado A, Soares H, Antunes H, Magalhães Z, Ferreira C, Baldeiras I, Ribeiro MH, Santana I, Ramalheira J, Castro L, Carpenter S (2008) Variant Creutzfeldt–Jakob disease: the second case in Portugal and in the same geographical region. JNNP 79:180–182 Machado A, Soares H, Antunes H, Magalhães Z, Ferreira C, Baldeiras I, Ribeiro MH, Santana I, Ramalheira J, Castro L, Carpenter S (2008) Variant Creutzfeldt–Jakob disease: the second case in Portugal and in the same geographical region. JNNP 79:180–182
33.
Zurück zum Zitat Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O’Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K (2011) The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement 7:386–395CrossRefPubMedPubMedCentral Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O’Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K (2011) The Alzheimer’s Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement 7:386–395CrossRefPubMedPubMedCentral
34.
Zurück zum Zitat Crook R, Hardy J, Duff K (1994) Single-day apolipoprotein E genotyping. J Neurosci Methods 53:125–127CrossRefPubMed Crook R, Hardy J, Duff K (1994) Single-day apolipoprotein E genotyping. J Neurosci Methods 53:125–127CrossRefPubMed
36.
Zurück zum Zitat Coulthart MB, Jansen GH, Olsen E, Godal DL, Connolly T, Choi BC, Wang Z, Cashman NR (2011) Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt–Jakob disease in Canada: a 6-year prospective study. BMC Neurol 11:133CrossRefPubMedPubMedCentral Coulthart MB, Jansen GH, Olsen E, Godal DL, Connolly T, Choi BC, Wang Z, Cashman NR (2011) Diagnostic accuracy of cerebrospinal fluid protein markers for sporadic Creutzfeldt–Jakob disease in Canada: a 6-year prospective study. BMC Neurol 11:133CrossRefPubMedPubMedCentral
37.
Zurück zum Zitat Satoh K, Tobiume M, Matsui Y, Mutsukura K, Nishida N, Shiga Y, Eguhchi K, Shirabe S, Sata T (2010) Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt–Jakob disease. Lab Investig 90:1637–1644CrossRefPubMed Satoh K, Tobiume M, Matsui Y, Mutsukura K, Nishida N, Shiga Y, Eguhchi K, Shirabe S, Sata T (2010) Establishment of a standard 14-3-3 protein assay of cerebrospinal fluid as a diagnostic tool for Creutzfeldt–Jakob disease. Lab Investig 90:1637–1644CrossRefPubMed
38.
Zurück zum Zitat Kenney K, Brechtel C, Takahashi H, Kurohara K, Anderson P, Gibbs CJ Jr (2000) An enzyme-linked immunsorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt–Jakob disease. Ann Neurol 48:395–398CrossRefPubMed Kenney K, Brechtel C, Takahashi H, Kurohara K, Anderson P, Gibbs CJ Jr (2000) An enzyme-linked immunsorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt–Jakob disease. Ann Neurol 48:395–398CrossRefPubMed
39.
Zurück zum Zitat Green AJ, Ramljak S, Muller WE, Knoght RS, Schroeder HC (2002) 14-3-3 in the cerebrospinal fluid of patients with variant and sporadic Creutzfeldt–Jakob disease measured using a capture assay able to detect low levels of 14-3-3 protein. Neurosci Lett 324:57–60CrossRefPubMed Green AJ, Ramljak S, Muller WE, Knoght RS, Schroeder HC (2002) 14-3-3 in the cerebrospinal fluid of patients with variant and sporadic Creutzfeldt–Jakob disease measured using a capture assay able to detect low levels of 14-3-3 protein. Neurosci Lett 324:57–60CrossRefPubMed
40.
Zurück zum Zitat Matsui Y, Satoh K, Miyazaki T, Shirabe S, Atarashi R, Mutsukura K, Satoh A, Kataoka Y, Nishid N (2011) High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease. BMC Neurol 11:120–129CrossRefPubMedPubMedCentral Matsui Y, Satoh K, Miyazaki T, Shirabe S, Atarashi R, Mutsukura K, Satoh A, Kataoka Y, Nishid N (2011) High sensitivity of an ELISA kit for detection of the gamma-isoform of 14-3-3 proteins: usefulness in laboratory diagnosis of human prion disease. BMC Neurol 11:120–129CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Schmitz M, Ebert E, Stoeck K, Karch A, Collins S, Calero M, Sklaviadis T, Laplanche JL, Golanska E, Baldeiras I, Satoh K, Sanchez-Valle R, Ladogana A, Skinningsrud A, Hammarin AL, Mitrova E, Llorens F, Sun Kim Y, Green A, Zerr I (2015) Validation of 14-3-3 protein as a marker in sporadic Creutzfeldt–Jakob disease diagnostic. Mol Neurobiol 53(4):2189–2199CrossRefPubMed Schmitz M, Ebert E, Stoeck K, Karch A, Collins S, Calero M, Sklaviadis T, Laplanche JL, Golanska E, Baldeiras I, Satoh K, Sanchez-Valle R, Ladogana A, Skinningsrud A, Hammarin AL, Mitrova E, Llorens F, Sun Kim Y, Green A, Zerr I (2015) Validation of 14-3-3 protein as a marker in sporadic Creutzfeldt–Jakob disease diagnostic. Mol Neurobiol 53(4):2189–2199CrossRefPubMed
42.
Zurück zum Zitat Leitão MJ, Baldeiras I, Almeida MR, Ribeiro MH, Santos AC, Ribeiro M, Tomás J, Rocha S, Santana I, Oliveira CR (2016) Sporadic Creutzfeldt–Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3γ assay. Neuroscience 13(322):398–407CrossRef Leitão MJ, Baldeiras I, Almeida MR, Ribeiro MH, Santos AC, Ribeiro M, Tomás J, Rocha S, Santana I, Oliveira CR (2016) Sporadic Creutzfeldt–Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3γ assay. Neuroscience 13(322):398–407CrossRef
43.
Zurück zum Zitat Del Campo M, Jongbloed W, Twaalfhoven HAM, Veerhuis R, Blankenstein MA, Teunissen CE (2015) Facilitating the validation of novel protein biomarkers for dementia: an optimal workflow for the development of sandwich immunoassays. Front Neurol 6:1–10 Del Campo M, Jongbloed W, Twaalfhoven HAM, Veerhuis R, Blankenstein MA, Teunissen CE (2015) Facilitating the validation of novel protein biomarkers for dementia: an optimal workflow for the development of sandwich immunoassays. Front Neurol 6:1–10
44.
Zurück zum Zitat Andreasson U et al (2015) A practical guide to immunoassay method validation. Front Neurol 6:1–8CrossRef Andreasson U et al (2015) A practical guide to immunoassay method validation. Front Neurol 6:1–8CrossRef
45.
Zurück zum Zitat Leitão MJ, Baldeiras I, Herukka SK, Pikkarainen M, Simonsen A, Perret-Liaudet A, Fourier A, Quadrio I, Mota Veiga P, Oliveira CR (2015) Chasing the effects of pre-analytical confounders—a multicentre study on CSF biomarkers. Front Neurol 6:153CrossRefPubMedPubMedCentral Leitão MJ, Baldeiras I, Herukka SK, Pikkarainen M, Simonsen A, Perret-Liaudet A, Fourier A, Quadrio I, Mota Veiga P, Oliveira CR (2015) Chasing the effects of pre-analytical confounders—a multicentre study on CSF biomarkers. Front Neurol 6:153CrossRefPubMedPubMedCentral
46.
Zurück zum Zitat Green AJE, Harvey RJ, Thompson EJ, Rossor MN (1999) Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer’s disease. Neurosci Lett 259:133–135CrossRefPubMed Green AJE, Harvey RJ, Thompson EJ, Rossor MN (1999) Increased tau in the cerebrospinal fluid of patients with frontotemporal dementia and Alzheimer’s disease. Neurosci Lett 259:133–135CrossRefPubMed
47.
Zurück zum Zitat Baldeiras I, Santana I, Leitão MJ, Ribeiro MH, Pascoal R, Duro D, Lemos R, Santiago B, Almeida MR, Oliveira CR (2015) Cerebrospinal fluid Aβ40 is similarly reduced in patients with frontotemporal lobar degeneration and Alzheimer’s disease. J Neurol Sci 358(1–2):308–316CrossRefPubMed Baldeiras I, Santana I, Leitão MJ, Ribeiro MH, Pascoal R, Duro D, Lemos R, Santiago B, Almeida MR, Oliveira CR (2015) Cerebrospinal fluid Aβ40 is similarly reduced in patients with frontotemporal lobar degeneration and Alzheimer’s disease. J Neurol Sci 358(1–2):308–316CrossRefPubMed
48.
Zurück zum Zitat Noguchi-Shinohara M, Hamaguchi T, Nozaki I, Sakai K, Yamada M (2011) Serum tau protein as a marker for the diagnosis of Creutzfeldt–Jakob disease. J Neurol 258:1464–1468CrossRefPubMed Noguchi-Shinohara M, Hamaguchi T, Nozaki I, Sakai K, Yamada M (2011) Serum tau protein as a marker for the diagnosis of Creutzfeldt–Jakob disease. J Neurol 258:1464–1468CrossRefPubMed
49.
Zurück zum Zitat Skillbäck T, Rosén C, Asztely F, Mattsson N, Blennow K, Zetterberg H (2014) Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt–Jakob disease: results from the Swedish mortality registry. JAMA Neurol 71:114CrossRef Skillbäck T, Rosén C, Asztely F, Mattsson N, Blennow K, Zetterberg H (2014) Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt–Jakob disease: results from the Swedish mortality registry. JAMA Neurol 71:114CrossRef
50.
Zurück zum Zitat Llorens F, Schmitz M, Karch A, Cramm M, Lange P, Gherib K, Varges D, Schmidt C, Zerr I, Stoeck K (2015) Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia. Alzheimers Dement 12(5):577–589. doi:10.1016/j.jalz.2015.10.009 CrossRefPubMed Llorens F, Schmitz M, Karch A, Cramm M, Lange P, Gherib K, Varges D, Schmidt C, Zerr I, Stoeck K (2015) Comparative analysis of cerebrospinal fluid biomarkers in the differential diagnosis of neurodegenerative dementia. Alzheimers Dement 12(5):577–589. doi:10.​1016/​j.​jalz.​2015.​10.​009 CrossRefPubMed
51.
Zurück zum Zitat Calero O, Bullido MJ, Clarimón J, Frank-García A, Martínez-Martín P, Lleó A, Rey MJ, Rábano A, Blesa R, Gómez-Isla T, Valdivieso F, de Pedro-Cuesta J, Ferrer I, Calero M (2011) Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer’s and Creutzfeldt–Jakob diseases. PLoS One 6:e22090CrossRefPubMedPubMedCentral Calero O, Bullido MJ, Clarimón J, Frank-García A, Martínez-Martín P, Lleó A, Rey MJ, Rábano A, Blesa R, Gómez-Isla T, Valdivieso F, de Pedro-Cuesta J, Ferrer I, Calero M (2011) Genetic cross-interaction between APOE and PRNP in sporadic Alzheimer’s and Creutzfeldt–Jakob diseases. PLoS One 6:e22090CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Gmitterová K, Heinemann U, Bodemer M, Krasnianski A, Meissner B, Kretzschmar HA, Zerr I (2009) 14-3-3 CSF levels in sporadic Creutzfeldt–Jakob disease differ across molecular subtypes. Neurobiol Aging 30:1842–1850CrossRefPubMed Gmitterová K, Heinemann U, Bodemer M, Krasnianski A, Meissner B, Kretzschmar HA, Zerr I (2009) 14-3-3 CSF levels in sporadic Creutzfeldt–Jakob disease differ across molecular subtypes. Neurobiol Aging 30:1842–1850CrossRefPubMed
53.
Zurück zum Zitat Karch A, Hermann P, Ponto C, Schmitz M, Arora A, Zafar S, Llorens F, Müller-Heine A, Zerr I (2014) Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt–Jakob disease. Neurobiol Aging 36:1964–1968CrossRef Karch A, Hermann P, Ponto C, Schmitz M, Arora A, Zafar S, Llorens F, Müller-Heine A, Zerr I (2014) Cerebrospinal fluid tau levels are a marker for molecular subtype in sporadic Creutzfeldt–Jakob disease. Neurobiol Aging 36:1964–1968CrossRef
Metadaten
Titel
CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt–Jakob disease suspected cases with inconclusive 14-3-3 result
verfasst von
M. J. Leitão
I. Baldeiras
M. R. Almeida
M. H. Ribeiro
A. C. Santos
M. Ribeiro
J. Tomás
S. Rocha
I. Santana
C. R. Oliveira
Publikationsdatum
29.06.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Neurology / Ausgabe 9/2016
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI
https://doi.org/10.1007/s00415-016-8209-x

Weitere Artikel der Ausgabe 9/2016

Journal of Neurology 9/2016 Zur Ausgabe

Pioneers in Neurology

Vladimir K. Roth (1848–1916)

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.