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Erschienen in: Japanese Journal of Radiology 2/2019

20.09.2018 | Invited Review

CT-based mediastinal compartment classifications and differential diagnosis of mediastinal tumors

verfasst von: Takahiko Nakazono, Ken Yamaguchi, Ryoko Egashira, Yukari Takase, Junichi Nojiri, Masanobu Mizuguchi, Hiroyuki Irie

Erschienen in: Japanese Journal of Radiology | Ausgabe 2/2019

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Abstract

Division of the mediastinum into compartments is used to help narrow down the differential diagnosis of mediastinal tumors, assess tumor growth, and plan biopsies and surgical procedures. There are several traditional mediastinal compartment classification systems based upon anatomical landmarks and lateral chest radiograph. Recently, the Japanese Association of Research of the Thymus (JART) and the International Thymic Malignancy Interest Group (ITMIG) proposed new mediastinal compartment classification systems based on transverse CT images. These CT-based classification systems are useful for more consistent and exact diagnosis of mediastinal tumors. In this article, we review these CT-based mediastinal compartment classifications in relation to the differential diagnosis of mediastinal tumors.
Literatur
1.
Zurück zum Zitat Davies DV, Coupland RE. Gray's anatomy: descriptive and applied. London: Longmans, Green, & Company; 1958. Davies DV, Coupland RE. Gray's anatomy: descriptive and applied. London: Longmans, Green, & Company; 1958.
2.
Zurück zum Zitat Felson B. Chest roentgenology. Philadelphia: WB Saunders; 1973. Felson B. Chest roentgenology. Philadelphia: WB Saunders; 1973.
3.
Zurück zum Zitat Fraser RG, Para JA. Diagnosis of diseases of the chest. Philadelphia: WB Saunders; 1973. Fraser RG, Para JA. Diagnosis of diseases of the chest. Philadelphia: WB Saunders; 1973.
4.
Zurück zum Zitat Heitzman ER. The mediastinum, radiologic correlation with anatomy and pathology. St. Louis: CV Mosby; 1977. Heitzman ER. The mediastinum, radiologic correlation with anatomy and pathology. St. Louis: CV Mosby; 1977.
5.
Zurück zum Zitat Whitten CR, Khan S, Munneke GJ, Grubnic S. A diagnostic approach to mediastinal abnormalities. Radiographics. 2007;27:657–71.CrossRefPubMed Whitten CR, Khan S, Munneke GJ, Grubnic S. A diagnostic approach to mediastinal abnormalities. Radiographics. 2007;27:657–71.CrossRefPubMed
6.
Zurück zum Zitat Zylak CJ, Pallie W, Jackson R. Correlative anatomy and computed tomography. A module on the mediastinum. Radiographics. 1982;2:555–92.CrossRef Zylak CJ, Pallie W, Jackson R. Correlative anatomy and computed tomography. A module on the mediastinum. Radiographics. 1982;2:555–92.CrossRef
7.
Zurück zum Zitat Fujimoto K, Hara M, Tomiyama N, Kusumoto M, Sakai F, Fujii Y. Proposal for a new mediastinal compartment classification of transverse plane images according to the Japanese Association for Research on the Thymus (JART) general rules for the study of mediastinal tumors. Oncol Rep. 2014;31:565–72.CrossRefPubMed Fujimoto K, Hara M, Tomiyama N, Kusumoto M, Sakai F, Fujii Y. Proposal for a new mediastinal compartment classification of transverse plane images according to the Japanese Association for Research on the Thymus (JART) general rules for the study of mediastinal tumors. Oncol Rep. 2014;31:565–72.CrossRefPubMed
8.
Zurück zum Zitat Carter BW, Tomiyama N, Bhora FY, et al. A modern definition of mediastinal compartments. J Thorac Oncol. 2014;9:S97–101.CrossRefPubMed Carter BW, Tomiyama N, Bhora FY, et al. A modern definition of mediastinal compartments. J Thorac Oncol. 2014;9:S97–101.CrossRefPubMed
9.
Zurück zum Zitat Sone S, Higashihara T, Morimoto S, et al. Potential spaces of the mediastinum: CT pneumomediastinography. AJR Am J Roentgenol. 1982;138:1051–7.CrossRefPubMed Sone S, Higashihara T, Morimoto S, et al. Potential spaces of the mediastinum: CT pneumomediastinography. AJR Am J Roentgenol. 1982;138:1051–7.CrossRefPubMed
10.
Zurück zum Zitat Strollo DC, Rosado de Christenson ML, Jett JR. Primary mediastinal tumors. Part 1: tumors of the anterior mediastinum. Chest. 1997;112:511–22.CrossRefPubMed Strollo DC, Rosado de Christenson ML, Jett JR. Primary mediastinal tumors. Part 1: tumors of the anterior mediastinum. Chest. 1997;112:511–22.CrossRefPubMed
12.
Zurück zum Zitat Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO classification of tumours of the lung, pleura, thymus and heart. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2015. Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO classification of tumours of the lung, pleura, thymus and heart. 4th ed. Lyon: International Agency for Research on Cancer (IARC); 2015.
13.
Zurück zum Zitat Sadohara J, Fujimoto K, Müller NL, et al. Thymic epithelial tumors: comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas. Eur J Radiol. 2006;60:70–9.CrossRefPubMed Sadohara J, Fujimoto K, Müller NL, et al. Thymic epithelial tumors: comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas. Eur J Radiol. 2006;60:70–9.CrossRefPubMed
14.
Zurück zum Zitat Tomiyama N, Johkoh T, Mihara N, et al. Using the World Health Organization classification of thymic epithelial neoplasms to describe CT findings. AJR Am J Roentgenol. 2002;179:881–6.CrossRefPubMed Tomiyama N, Johkoh T, Mihara N, et al. Using the World Health Organization classification of thymic epithelial neoplasms to describe CT findings. AJR Am J Roentgenol. 2002;179:881–6.CrossRefPubMed
15.
Zurück zum Zitat Kan X, Wang P, Gong Z, Gao F, Zhang Y, Ge Y. Investigation on computed tomography features of primary thymic atypical carcinoid tumors. J Comput Assist Tomogr. 2017;41:990–4.CrossRefPubMed Kan X, Wang P, Gong Z, Gao F, Zhang Y, Ge Y. Investigation on computed tomography features of primary thymic atypical carcinoid tumors. J Comput Assist Tomogr. 2017;41:990–4.CrossRefPubMed
17.
Zurück zum Zitat Takahashi K, Al-Janabi NJ. Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging. 2010;32:1325–39.CrossRefPubMed Takahashi K, Al-Janabi NJ. Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging. 2010;32:1325–39.CrossRefPubMed
18.
Zurück zum Zitat Inaoka T, Takahashi K, Mineta M, et al. Thymic hyperplasia and thymus gland tumors: differentiation with chemical shift MR imaging. Radiology. 2007;243:869–76.CrossRefPubMed Inaoka T, Takahashi K, Mineta M, et al. Thymic hyperplasia and thymus gland tumors: differentiation with chemical shift MR imaging. Radiology. 2007;243:869–76.CrossRefPubMed
19.
Zurück zum Zitat Rosado-de-Christenson ML, Pugatch RD, Moran CA, Galobardes J. Thymolipoma: analysis of 27 cases. Radiology. 1994;193:121–6.CrossRefPubMed Rosado-de-Christenson ML, Pugatch RD, Moran CA, Galobardes J. Thymolipoma: analysis of 27 cases. Radiology. 1994;193:121–6.CrossRefPubMed
20.
Zurück zum Zitat Strollo DC, Rosado-de-Christenson ML, Jett JR. Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 1997;112:1344–57.CrossRefPubMed Strollo DC, Rosado-de-Christenson ML, Jett JR. Primary mediastinal tumors: part II. Tumors of the middle and posterior mediastinum. Chest. 1997;112:1344–57.CrossRefPubMed
21.
Zurück zum Zitat Tateishi U, Müller NL, Johkoh T, et al. Primary mediastinal lymphoma: characteristic features of the various histological subtypes on CT. J Comput Assist Tomogr. 2004;28:782–9.CrossRefPubMed Tateishi U, Müller NL, Johkoh T, et al. Primary mediastinal lymphoma: characteristic features of the various histological subtypes on CT. J Comput Assist Tomogr. 2004;28:782–9.CrossRefPubMed
22.
Zurück zum Zitat Kuroki S, Nasu K, Murakami K, et al. Thymic MALT lymphoma: MR imaging findings and their correlation with histopathological findings on four cases. Clin Imaging. 2004;28:274–7.CrossRefPubMed Kuroki S, Nasu K, Murakami K, et al. Thymic MALT lymphoma: MR imaging findings and their correlation with histopathological findings on four cases. Clin Imaging. 2004;28:274–7.CrossRefPubMed
23.
Zurück zum Zitat Moeller KH, Rosado-de-Christenson ML, Templeton PA. Mediastinal mature teratoma: imaging features. AJR Am J Roentgenol. 1997;169:985–90.CrossRefPubMed Moeller KH, Rosado-de-Christenson ML, Templeton PA. Mediastinal mature teratoma: imaging features. AJR Am J Roentgenol. 1997;169:985–90.CrossRefPubMed
24.
Zurück zum Zitat Sasaka K, Kurihara Y, Nakajima Y, et al. Spontaneous rupture: a complication of benign mature teratomas of the mediastinum. AJR Am J Roentgenol. 1998;170:323–8.CrossRefPubMed Sasaka K, Kurihara Y, Nakajima Y, et al. Spontaneous rupture: a complication of benign mature teratomas of the mediastinum. AJR Am J Roentgenol. 1998;170:323–8.CrossRefPubMed
25.
Zurück zum Zitat Tian L, Liu LZ, Cui CY, Zhang WD, Kuang YL. CT findings of primary non-teratomatous germ cell tumors of the mediastinum—a report of 15 cases. Eur J Radiol. 2012;81:1057–61.CrossRefPubMed Tian L, Liu LZ, Cui CY, Zhang WD, Kuang YL. CT findings of primary non-teratomatous germ cell tumors of the mediastinum—a report of 15 cases. Eur J Radiol. 2012;81:1057–61.CrossRefPubMed
26.
Zurück zum Zitat Jeung MY, Gasser B, Gangi A, et al. Imaging of cystic masses of the mediastinum. Radiographics. 2002;22:S79–93.CrossRefPubMed Jeung MY, Gasser B, Gangi A, et al. Imaging of cystic masses of the mediastinum. Radiographics. 2002;22:S79–93.CrossRefPubMed
27.
Zurück zum Zitat Shaffer K, Rosado-de-Christenson ML, Patz EF Jr, Young S, Farver CF. Thoracic lymphangioma in adults: CT and MR imaging features. AJR Am J Roentgenol. 1994;162:283–9.CrossRefPubMed Shaffer K, Rosado-de-Christenson ML, Patz EF Jr, Young S, Farver CF. Thoracic lymphangioma in adults: CT and MR imaging features. AJR Am J Roentgenol. 1994;162:283–9.CrossRefPubMed
28.
Zurück zum Zitat Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972;29:670–83.CrossRef Keller AR, Hochholzer L, Castleman B. Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations. Cancer. 1972;29:670–83.CrossRef
29.
Zurück zum Zitat McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA. Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation. Radiology. 1998;209:221–8.CrossRefPubMed McAdams HP, Rosado-de-Christenson M, Fishback NF, Templeton PA. Castleman disease of the thorax: radiologic features with clinical and histopathologic correlation. Radiology. 1998;209:221–8.CrossRefPubMed
30.
Zurück zum Zitat Murayama S, Murakami J, Watanabe H, et al. Signal intensity characteristics of mediastinal cystic masses on T1-weighted MRI. J Comput Assist Tomogr. 1995;19:188–91.CrossRefPubMed Murayama S, Murakami J, Watanabe H, et al. Signal intensity characteristics of mediastinal cystic masses on T1-weighted MRI. J Comput Assist Tomogr. 1995;19:188–91.CrossRefPubMed
31.
Zurück zum Zitat Nakata H, Sato Y, Nakayama T, Yoshimatsu H, Kobayashi T. Bronchogenic cyst with high CT number: analysis of contents. J Comput Assist Tomogr. 1986;10:360.CrossRefPubMed Nakata H, Sato Y, Nakayama T, Yoshimatsu H, Kobayashi T. Bronchogenic cyst with high CT number: analysis of contents. J Comput Assist Tomogr. 1986;10:360.CrossRefPubMed
32.
33.
Zurück zum Zitat Abe T, Yachi A, Ishii Y, et al. Thoracic extramedullary hematopoiesis associated with hereditary spherocytosis. Intern Med. 1992;31:1151–4.CrossRefPubMed Abe T, Yachi A, Ishii Y, et al. Thoracic extramedullary hematopoiesis associated with hereditary spherocytosis. Intern Med. 1992;31:1151–4.CrossRefPubMed
34.
35.
Zurück zum Zitat Balcombe J, Torigian DA, Kim W, Miller WT Jr. Cross-sectional imaging of paragangliomas of the aortic body and other thoracic branchiomeric paraganglia. AJR Am J Roentgenol. 2007;188:1054–8.CrossRefPubMed Balcombe J, Torigian DA, Kim W, Miller WT Jr. Cross-sectional imaging of paragangliomas of the aortic body and other thoracic branchiomeric paraganglia. AJR Am J Roentgenol. 2007;188:1054–8.CrossRefPubMed
36.
Zurück zum Zitat Murphey MD, Smith WS, Smith SE, Kransdorf MJ, Temple HT. From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 1999;19:1253–80.CrossRefPubMed Murphey MD, Smith WS, Smith SE, Kransdorf MJ, Temple HT. From the archives of the AFIP. Imaging of musculoskeletal neurogenic tumors: radiologic-pathologic correlation. Radiographics. 1999;19:1253–80.CrossRefPubMed
37.
Zurück zum Zitat Bhargava R, Parham DM, Lasater OE, Chari RS, Chen G, Fletcher BD. MR imaging differentiation of benign and malignant peripheral nerve sheath tumors: use of the target sign. Pediatr Radiol. 1997;27:124–9.CrossRefPubMed Bhargava R, Parham DM, Lasater OE, Chari RS, Chen G, Fletcher BD. MR imaging differentiation of benign and malignant peripheral nerve sheath tumors: use of the target sign. Pediatr Radiol. 1997;27:124–9.CrossRefPubMed
38.
Zurück zum Zitat Jee WH, Oh SN, McCauley T, et al. Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 2004;183:629–33.CrossRefPubMed Jee WH, Oh SN, McCauley T, et al. Extraaxial neurofibromas versus neurilemmomas: discrimination with MRI. AJR Am J Roentgenol. 2004;183:629–33.CrossRefPubMed
39.
Zurück zum Zitat Varma DG, Moulopoulos A, Sara AS, et al. MR imaging of extracranial nerve sheath tumors. J Comput Assist Tomogr. 1992;16:448–53.CrossRefPubMed Varma DG, Moulopoulos A, Sara AS, et al. MR imaging of extracranial nerve sheath tumors. J Comput Assist Tomogr. 1992;16:448–53.CrossRefPubMed
40.
Zurück zum Zitat Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002;22:911–34.CrossRefPubMed Lonergan GJ, Schwab CM, Suarez ES, Carlson CL. Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: radiologic-pathologic correlation. Radiographics. 2002;22:911–34.CrossRefPubMed
41.
Zurück zum Zitat Sakai F, Sone S, Kiyono K, et al. Intrathoracic neurogenic tumors: MR-pathologic correlation. AJR Am J Roentgenol. 1992;159:279–83.CrossRefPubMed Sakai F, Sone S, Kiyono K, et al. Intrathoracic neurogenic tumors: MR-pathologic correlation. AJR Am J Roentgenol. 1992;159:279–83.CrossRefPubMed
42.
Zurück zum Zitat Kato M, Hara M, Ozawa Y, Shimizu S, Shibamoto Y. Computed tomography and magnetic resonance imaging features of posterior mediastinal ganglioneuroma. J Thorac Imaging. 2012;27:100–6.CrossRefPubMed Kato M, Hara M, Ozawa Y, Shimizu S, Shibamoto Y. Computed tomography and magnetic resonance imaging features of posterior mediastinal ganglioneuroma. J Thorac Imaging. 2012;27:100–6.CrossRefPubMed
44.
Zurück zum Zitat Erickson D, Kudva YC, Ebersold MJ, et al. Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 2001;86:5210–6.CrossRefPubMed Erickson D, Kudva YC, Ebersold MJ, et al. Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients. J Clin Endocrinol Metab. 2001;86:5210–6.CrossRefPubMed
45.
Zurück zum Zitat Lee KY, Oh YW, Noh HJ, et al. Extraadrenal paragangliomas of the body: imaging features. AJR Am J Roentgenol. 2006;187:492–504.CrossRefPubMed Lee KY, Oh YW, Noh HJ, et al. Extraadrenal paragangliomas of the body: imaging features. AJR Am J Roentgenol. 2006;187:492–504.CrossRefPubMed
46.
Zurück zum Zitat Takashima Y, Kamitani T, Kawanami S, et al. Mediastinal paraganglioma. Jpn J Radiol. 2015;33:433–6.CrossRefPubMed Takashima Y, Kamitani T, Kawanami S, et al. Mediastinal paraganglioma. Jpn J Radiol. 2015;33:433–6.CrossRefPubMed
47.
Zurück zum Zitat Olsen WL, Dillon WP, Kelly WM, Norman D, Brant-Zawadzki M, Newton TH. MR imaging of paragangliomas. AJR Am J Roentgenol. 1987;148:201–4.CrossRefPubMed Olsen WL, Dillon WP, Kelly WM, Norman D, Brant-Zawadzki M, Newton TH. MR imaging of paragangliomas. AJR Am J Roentgenol. 1987;148:201–4.CrossRefPubMed
Metadaten
Titel
CT-based mediastinal compartment classifications and differential diagnosis of mediastinal tumors
verfasst von
Takahiko Nakazono
Ken Yamaguchi
Ryoko Egashira
Yukari Takase
Junichi Nojiri
Masanobu Mizuguchi
Hiroyuki Irie
Publikationsdatum
20.09.2018
Verlag
Springer Japan
Erschienen in
Japanese Journal of Radiology / Ausgabe 2/2019
Print ISSN: 1867-1071
Elektronische ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-018-0777-5

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