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01.12.2012 | Research | Ausgabe 1/2012 Open Access

World Journal of Surgical Oncology 1/2012

CT-guided percutaneous microwave ablation of pulmonary malignancies: Results in 69 cases

Zeitschrift:
World Journal of Surgical Oncology > Ausgabe 1/2012
Autoren:
Qiang Lu, Wei Cao, Lijun Huang, Yi Wan, Tonggang Liu, Qingshu Cheng, Yong Han, Xiaofei Li
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1477-7819-10-80) contains supplementary material, which is available to authorized users.
Qiang Lu, Wei Cao, Lijun Huang, Yi Wan contributed equally to this work.

Competing interests

All of the authors in this manuscript declared that no financial or non-financial interests were related to this study or future application after publication.

Authors’ contributions

QL was responsible for manuscript writing (First Author); WC and LH supervised QL to write this manuscript and gave comments to revise it (co-author); YH and XL were responsible for whole project design (Corresponding Author); YW is in charge of data analysis; TL and QC is in charge of correction of manuscript. All authors read and approved the final manuscript.

Abstract

Background

Microwave ablation (MWA) has attracted a worldwide attention gradually in treating inoperable pulmonary malignancies. However, in the lung tissues treated with MWA recurrence of tumor may still occur and few data in large patient groups till now were reported about the safety or effectiveness of microwave ablation in treating primary lung cancer and metastatic pulmonary malignancies. The purpose of this study is to evaluate the clinical curative effect (local control, survival data) MWA and its safety as well.

Methods

From 1 January 2005 to 1 January 2008, retrospective analyses, 69 patients underwent computed tomography (CT)-guided percutaneous MWA of pulmonary malignancies. All patients were deemed medically inoperable. The correlation of tumor sizes and local progression after ablation was analyzed and the survival rates within 3 years post surgery were compared between non-small-cell lung cancer and pulmonary metastases groups also.

Results

Pneumothorax was the most frequent complication and occurred in 24.64% patients after ablation. Neither needle track implantation was found nor did patient death occur in these patients within 30 days. The 1-, 2-, and 3-year overall survival rates were 66.7%, 44.9% and 24.6%, respectively. The overall survival rates for NSCLC patients in 1 year, 2 years, and 3 years were 75.0%, 54.2%, and 29.2%, respectively. The overall survival rates for pulmonary metastatic tumor patients in 1 year, 2 years, and 3 years were 47.6%, 23.8%, and 14.3%, respectively. The recurrence-free survival rates for NSCLC patients in 1 year, 2 years, and 3 years were 72.9%, 50.0%, and 27.1%, respectively. The mortality rates for pulmonary metastatic tumor patients in 1 year, 2 years, and 3 years were 47.6%, 19.0%, and 14.3%, respectively.

Conclusions

Percutaneous microwave coagulation therapy was one safe and effective method and could be beneficial for the improvement of inoperable pulmonary malignancies treatment effect.
Zusatzmaterial
Authors’ original file for figure 1
12957_2012_996_MOESM1_ESM.tiff
Authors’ original file for figure 2
12957_2012_996_MOESM2_ESM.tiff
Literatur
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