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Erschienen in: Neurocritical Care 1/2020

29.05.2020 | A Day in the Life of a Neurocritical Care Trainee

CT Perfusion for the Detection of Delayed Cerebral Ischemia in the Presence of Neurologic Confounders

verfasst von: Shaurya Taran, Daniel M. Mandell, Victoria A. McCredie

Erschienen in: Neurocritical Care | Ausgabe 1/2020

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Excerpt

Delayed cerebral ischemia (DCI) is a common complication of aneurysmal subarachnoid hemorrhage (SAH), affecting up to 30% of patients and manifesting as new neurologic deficits or a declining level of consciousness, or both [1]. Timely identification and management of DCI are crucial to improving outcomes in patients with SAH [2]. However, diagnosing DCI remains challenging. Multiple confounders may present as worsening of the neurologic examination, potentially delaying recognition of underlying DCI. Moreover, confounders may hinder efforts to monitor the clinical response to a chosen therapy. Here, we present the case of a patient with SAH in whom the use of CT perfusion (CTP) scans was used to diagnose and subsequently manage DCI in the setting of multiple confounders. …
Literatur
1.
Zurück zum Zitat Francoeur CL, Mayer SA. Management of delayed cerebral ischemia after subarachnoid hemorrhage. Crit Care. 2016;20(1):277.CrossRef Francoeur CL, Mayer SA. Management of delayed cerebral ischemia after subarachnoid hemorrhage. Crit Care. 2016;20(1):277.CrossRef
2.
Zurück zum Zitat Vergouwen MD, et al. Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011;31(7):1545–53.CrossRef Vergouwen MD, et al. Lower incidence of cerebral infarction correlates with improved functional outcome after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2011;31(7):1545–53.CrossRef
3.
Zurück zum Zitat Ma H, et al. A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). Int J Stroke. 2012;7(1):74–80.CrossRef Ma H, et al. A multicentre, randomized, double-blinded, placebo-controlled Phase III study to investigate EXtending the time for Thrombolysis in Emergency Neurological Deficits (EXTEND). Int J Stroke. 2012;7(1):74–80.CrossRef
4.
Zurück zum Zitat Kidwell CS, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013;368(10):914–23.CrossRef Kidwell CS, et al. A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med. 2013;368(10):914–23.CrossRef
5.
Zurück zum Zitat Lannes M, et al. Milrinone and homeostasis to treat cerebral vasospasm associated with subarachnoid hemorrhage: the Montreal Neurological Hospital protocol. Neurocrit Care. 2012;16(3):354–62.CrossRef Lannes M, et al. Milrinone and homeostasis to treat cerebral vasospasm associated with subarachnoid hemorrhage: the Montreal Neurological Hospital protocol. Neurocrit Care. 2012;16(3):354–62.CrossRef
6.
Zurück zum Zitat Rowland MJ, et al. Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm. Br J Anaesth. 2012;109(3):315–29.CrossRef Rowland MJ, et al. Delayed cerebral ischaemia after subarachnoid haemorrhage: looking beyond vasospasm. Br J Anaesth. 2012;109(3):315–29.CrossRef
7.
Zurück zum Zitat Vergouwen MD, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391–5.CrossRef Vergouwen MD, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: proposal of a multidisciplinary research group. Stroke. 2010;41(10):2391–5.CrossRef
8.
Zurück zum Zitat Budohoski KP, et al. The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2014;85(12):1343–53.CrossRef Budohoski KP, et al. The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry. 2014;85(12):1343–53.CrossRef
9.
Zurück zum Zitat Dreier JP, et al. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain. 2006;129(Pt 12):3224–37.CrossRef Dreier JP, et al. Delayed ischaemic neurological deficits after subarachnoid haemorrhage are associated with clusters of spreading depolarizations. Brain. 2006;129(Pt 12):3224–37.CrossRef
10.
Zurück zum Zitat Millikan CH. Cerebral vasospasm and ruptured intracranial aneurysm. Arch Neurol. 1975;32(7):433–49.CrossRef Millikan CH. Cerebral vasospasm and ruptured intracranial aneurysm. Arch Neurol. 1975;32(7):433–49.CrossRef
11.
Zurück zum Zitat Sanelli PC, et al. Using quantitative CT perfusion for evaluation of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2011;32(11):2047–53.CrossRef Sanelli PC, et al. Using quantitative CT perfusion for evaluation of delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2011;32(11):2047–53.CrossRef
12.
Zurück zum Zitat Dankbaar JW, et al. Diagnostic threshold values of cerebral perfusion measured with computed tomography for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke. 2010;41(9):1927–32.CrossRef Dankbaar JW, et al. Diagnostic threshold values of cerebral perfusion measured with computed tomography for delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke. 2010;41(9):1927–32.CrossRef
13.
Zurück zum Zitat Greenberg ED, et al. Role of CT perfusion imaging in the diagnosis and treatment of vasospasm. Imaging Med. 2011;3(3):287–97.CrossRef Greenberg ED, et al. Role of CT perfusion imaging in the diagnosis and treatment of vasospasm. Imaging Med. 2011;3(3):287–97.CrossRef
14.
Zurück zum Zitat Washington CW, Zipfel GJ. Detection and monitoring of vasospasm and delayed cerebral ischemia: a review and assessment of the literature. Neurocrit Care. 2011;15(2):312–7.CrossRef Washington CW, Zipfel GJ. Detection and monitoring of vasospasm and delayed cerebral ischemia: a review and assessment of the literature. Neurocrit Care. 2011;15(2):312–7.CrossRef
15.
Zurück zum Zitat Carrera E, et al. Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage. Neurosurgery. 2009;65(2):316–23 (Discussion 323–4).CrossRef Carrera E, et al. Transcranial Doppler for predicting delayed cerebral ischemia after subarachnoid hemorrhage. Neurosurgery. 2009;65(2):316–23 (Discussion 323–4).CrossRef
16.
Zurück zum Zitat Konstas AA, et al. Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations. AJNR Am J Neuroradiol. 2009;30(5):885–92.CrossRef Konstas AA, et al. Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations. AJNR Am J Neuroradiol. 2009;30(5):885–92.CrossRef
17.
Zurück zum Zitat Mnyusiwalla A, Aviv RI, Symons SP. Radiation dose from multidetector row CT imaging for acute stroke. Neuroradiology. 2009;51(10):635–40.CrossRef Mnyusiwalla A, Aviv RI, Symons SP. Radiation dose from multidetector row CT imaging for acute stroke. Neuroradiology. 2009;51(10):635–40.CrossRef
Metadaten
Titel
CT Perfusion for the Detection of Delayed Cerebral Ischemia in the Presence of Neurologic Confounders
verfasst von
Shaurya Taran
Daniel M. Mandell
Victoria A. McCredie
Publikationsdatum
29.05.2020
Verlag
Springer US
Erschienen in
Neurocritical Care / Ausgabe 1/2020
Print ISSN: 1541-6933
Elektronische ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-020-01005-2

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