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10.06.2016 | Computed Tomography

CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours

verfasst von: Peijie Lv, Jie Liu, Xiaopeng Yan, Yaru Chai, Yan Chen, Jianbo Gao, Yuanwei Pan, Shuai Li, Hua Guo, Yue Zhou

Erschienen in: European Radiology | Ausgabe 3/2017

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Abstract

Purpose

The aim of this study was to evaluate the value of computed tomography (CT) spectral imaging in assessing the therapeutic efficacy of a vascular endothelial growth factor (VEGF) receptor inhibitor AG-013736 in rabbit VX2 liver tumours.

Methods

Twenty-three VX2 liver tumour–bearing rabbits were scanned with CT in spectral imaging mode during the arterial phase (AP) and portal phase (PP). The iodine concentrations(ICs)of tumours normalized to aorta (nICs) at different time points (baseline, 2, 4, 7, 10, and 14 days after treatment) were compared within the treated group (n = 17) as well as between the control (n = 6) and treated groups. Correlations between the tumour size, necrotic fraction (NF), microvessel density (MVD), and nICs were analysed.

Results

The change of nICs relative to baseline in the treated group was lower compared to the control group. A greater decrease in the nIC of a tumour at 2 days was positively correlated with a smaller increase in tumour size at 14 days (P < 0.05 for both). The tumour nIC values in AP and PP had correlations with MVD (r = 0.71 and 0.52) and NF (r = -0.54 and -0.51) (P < 0.05 for all).

Conclusions

CT spectral imaging allows for the evaluation and early prediction of tumour response to AG-013736.

Key Points

• AG-013736 treatment response was evaluated by CT in a rabbit tumour model.

• CT spectral imaging allows for the early treatment monitoring of targeted anti-tumour therapies.

• Spectral CT findings correlated with vascular changes after anti-tumour therapies.

• Spectral CT is a promising method for assessing clinical treatment response.

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Titel: CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours
verfasst von: Peijie Lv
Jie Liu
Xiaopeng Yan
Yaru Chai
Yan Chen
Jianbo Gao
Yuanwei Pan
Shuai Li
Hua Guo
Yue Zhou
Publikationsdatum: 10.06.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 3/2017
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4458-4

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CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours

Abstract

Purpose

Methods

Results

Conclusions

Key Points

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