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Erschienen in: Medical Oncology 3/2009

01.09.2009 | Original Paper

Curative stereotactic body radiotherapy for liver malignancy

verfasst von: Peter Gunvén, Henric Blomgren, Ingmar Lax, Seymour H. Levitt

Erschienen in: Medical Oncology | Ausgabe 3/2009

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Abstract

Nine patients with 11 primary or secondary liver non-neuroendocrine malignancies with mean and maximum diameters of 4.0 and 7.7 cm became long-term survivors after precision irradiation in a stereotactic body frame. Doses varied from 20 to 45 Gy split at 2–4 occasions a few days apart, with higher doses in the target centers. Occasional chemotherapy was stopped well before irradiation. No hospitalizations were needed because side effects, regional pain and nausea, were mild. All patients have now survived 5–14 years without recurrences. Two verified and one suspected secondary cancers occurred in organs close to the irradiated targets, and two of them could be resected for cure. Precision irradiation can thus cure selected liver malignancies. It is the first non-invasive method to achieve this, and the present patients are its first long-term survivors. A prolonged follow-up period is, however, necessary, because we have in other patients seen local tumor regrowth as late as four years after irradiation. The approach may cure some tumors, which are technically unsuited for other treatment modalities, and can be used for patients at high surgical risk. The success rate for local control seems good, but has to be defined by formal studies after optimization of radiation doses.
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Metadaten
Titel
Curative stereotactic body radiotherapy for liver malignancy
verfasst von
Peter Gunvén
Henric Blomgren
Ingmar Lax
Seymour H. Levitt
Publikationsdatum
01.09.2009
Verlag
Humana Press Inc
Erschienen in
Medical Oncology / Ausgabe 3/2009
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-008-9125-4

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