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24.09.2018 | Review Article

Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis

verfasst von: Jonathan Vigne, James Thackeray, Jeroen Essers, Marcus Makowski, Zoreh Varasteh, Adelina Curaj, Angelos Karlas, Emmanuel Canet-Soulas, Willem Mulder, Fabian Kiessling, Michael Schäfers, René Botnar, Moritz Wildgruber, Fabien Hyafil, on behalf of the Cardiovascular study group of the European Society of Molecular Imaging

Erschienen in: Molecular Imaging and Biology | Ausgabe 6/2018

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Abstract

Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composition. Rupture-prone plaques usually consist of a thin fibrous cap with few smooth muscle cells, a large lipid core, a dense infiltrate of inflammatory cells, and neovessels. Such lesions, termed high-risk plaques, can remain asymptomatic until the thrombotic event. Various imaging technologies currently allow visualization of morphological and biological characteristics of high-risk atherosclerotic plaques. Conventional protocols are often complex and lack specificity for high-risk plaque. Conversely, new imaging approaches are emerging which may overcome these limitations. Validation of these novel imaging techniques in preclinical models of atherosclerosis is essential for effective translational to clinical practice. Imaging the vessel wall, as well as its biological milieu in small animal models, is challenging because the vessel wall is a small structure that undergoes continuous movements imposed by the cardiac cycle as it is adjacent to circulating blood. The focus of this paper is to provide a state-of-the-art review on techniques currently available for preclinical imaging of atherosclerosis in small animal models and to discuss the advantages and limitations of each approach.

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Titel: Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis
verfasst von: Jonathan Vigne
James Thackeray
Jeroen Essers
Marcus Makowski
Zoreh Varasteh
Adelina Curaj
Angelos Karlas
Emmanuel Canet-Soulas
Willem Mulder
Fabian Kiessling
Michael Schäfers
René Botnar
Moritz Wildgruber
Fabien Hyafil
on behalf of the Cardiovascular study group of the European Society of Molecular Imaging
Publikationsdatum: 24.09.2018
Verlag: Springer International Publishing
Erschienen in: Molecular Imaging and Biology / Ausgabe 6/2018
Print ISSN: 1536-1632
Elektronische ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-018-1264-1

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Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis

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