Skip to main content
Erschienen in: International Orthopaedics 4/2019

30.11.2018 | Review Article

Current concepts for lumbar disc herniation

verfasst von: Thami Benzakour, Vasilios Igoumenou, Andreas F. Mavrogenis, Ahmed Benzakour

Erschienen in: International Orthopaedics | Ausgabe 4/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To present the pathophysiology, biology, clinical presentation, diagnosis, and current treatment options for lumbar disc herniation.

Methods

A thorough literature search was undertaken in PubMed and Google Scholar to summarize the current knowledge and future perspectives on lumbar disc herniation.

Results

Several changes in the biology of the intervertebral disc are thought to contribute to disc herniation; nevertheless, the exact inciting event leading to disc herniation is yet to be discovered. Non-operative treatments have stood the test of time as the first-line treatment for most patients with lumbar disc herniation; however, operative treatment remains the current gold standard, with minimally invasive endoscopic microdiscectomy techniques showing best results with respect to postoperative pain and function.

Conclusions

The exact event leading to disc herniation remains unclear. Non-operative treatments should be the first-line treatment for most patients with lumbar disc herniation. Operative treatment remains the current gold standard, with minimally invasive endoscopic microdiscectomy techniques showing best results with respect to postoperative pain and function. Regenerative medicine is promising.
Literatur
5.
10.
Zurück zum Zitat Garfin SR, Eismont FJ, Bell GR, Bono CM, Fischgrund J (2017) Lumbar disk herniations. In: Rothman-Simeone and Herkowitz’s The Spine. 7th edn. Elsevier, Philadelphia, PA Garfin SR, Eismont FJ, Bell GR, Bono CM, Fischgrund J (2017) Lumbar disk herniations. In: Rothman-Simeone and Herkowitz’s The Spine. 7th edn. Elsevier, Philadelphia, PA
11.
Zurück zum Zitat Herkowitz HN, Garfin SR, Eismont FJ, Bell GR, Balderston RA (2011 Lumbar disk herniations. In: Rothman-Simeone The Spine. 6th edn. Saunders Herkowitz HN, Garfin SR, Eismont FJ, Bell GR, Balderston RA (2011 Lumbar disk herniations. In: Rothman-Simeone The Spine. 6th edn. Saunders
12.
Zurück zum Zitat Zhang Y, Sun Z, Liu J, Guo X (2008) Advances in susceptibility genetics of intervertebral degenerative disc disease. Int J Biol Sci 4(5):283–290CrossRefPubMedPubMedCentral Zhang Y, Sun Z, Liu J, Guo X (2008) Advances in susceptibility genetics of intervertebral degenerative disc disease. Int J Biol Sci 4(5):283–290CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Capoor MN, Ruzicka F, Machackova T, Jancalek R, Smrcka M, Schmitz JE, Hermanova M, Sana J, Michu E, Baird JC, Ahmed FS, Maca K, Lipina R, Alamin TF, Coscia MF, Stonemetz JL, Witham T, Ehrlich GD, Gokaslan ZL, Mavrommatis K, Birkenmaier C, Fischetti VA, Slaby O (2016) Prevalence of propionibacterium acnes in intervertebral discs of patients undergoing lumbar microdiscectomy: a prospective cross-sectional study. PLoS One 11(8):e0161676. https://doi.org/10.1371/journal.pone.0161676 CrossRefPubMedPubMedCentral Capoor MN, Ruzicka F, Machackova T, Jancalek R, Smrcka M, Schmitz JE, Hermanova M, Sana J, Michu E, Baird JC, Ahmed FS, Maca K, Lipina R, Alamin TF, Coscia MF, Stonemetz JL, Witham T, Ehrlich GD, Gokaslan ZL, Mavrommatis K, Birkenmaier C, Fischetti VA, Slaby O (2016) Prevalence of propionibacterium acnes in intervertebral discs of patients undergoing lumbar microdiscectomy: a prospective cross-sectional study. PLoS One 11(8):e0161676. https://​doi.​org/​10.​1371/​journal.​pone.​0161676 CrossRefPubMedPubMedCentral
31.
Zurück zum Zitat Yuan Y, Chen Y, Zhou Z, Jiao Y, Li C, Zheng Y, Lin Y, Xiao J, Chen Z, Cao P (2017) Association between chronic inflammation and latent infection of Propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study. Eur Spine J. https://doi.org/10.1007/s00586-017-5363-5 Yuan Y, Chen Y, Zhou Z, Jiao Y, Li C, Zheng Y, Lin Y, Xiao J, Chen Z, Cao P (2017) Association between chronic inflammation and latent infection of Propionibacterium acnes in non-pyogenic degenerated intervertebral discs: a pilot study. Eur Spine J. https://​doi.​org/​10.​1007/​s00586-017-5363-5
32.
Zurück zum Zitat Rajasekaran S, Tangavel C, Aiyer SN, Nayagam SM, Raveendran M, Demonte NL, Subbaiah P, Kanna R, Shetty AP, Dharmalingam K (2017) ISSLS PRIZE IN CLINICAL SCIENCE 2017: is infection the possible initiator of disc disease? An insight from proteomic analysis. Eur Spine J 26(5):1384–1400. https://doi.org/10.1007/s00586-017-4972-3 CrossRefPubMed Rajasekaran S, Tangavel C, Aiyer SN, Nayagam SM, Raveendran M, Demonte NL, Subbaiah P, Kanna R, Shetty AP, Dharmalingam K (2017) ISSLS PRIZE IN CLINICAL SCIENCE 2017: is infection the possible initiator of disc disease? An insight from proteomic analysis. Eur Spine J 26(5):1384–1400. https://​doi.​org/​10.​1007/​s00586-017-4972-3 CrossRefPubMed
35.
Zurück zum Zitat Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P II, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF, North American Spine S (2014) An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J 14(1):180–191. https://doi.org/10.1016/j.spinee.2013.08.003 CrossRefPubMed Kreiner DS, Hwang SW, Easa JE, Resnick DK, Baisden JL, Bess S, Cho CH, DePalma MJ, Dougherty P II, Fernand R, Ghiselli G, Hanna AS, Lamer T, Lisi AJ, Mazanec DJ, Meagher RJ, Nucci RC, Patel RD, Sembrano JN, Sharma AK, Summers JT, Taleghani CK, Tontz WL Jr, Toton JF, North American Spine S (2014) An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy. Spine J 14(1):180–191. https://​doi.​org/​10.​1016/​j.​spinee.​2013.​08.​003 CrossRefPubMed
39.
Zurück zum Zitat Splendiani A, Perri M, Grattacaso G, Di Tunno V, Marsecano C, Panebianco L, Gennarelli A, Felli V, Varrassi M, Barile A, Di Cesare E, Masciocchi C, Gallucci M (2016) Magnetic resonance imaging (MRI) of the lumbar spine with dedicated G-scan machine in the upright position: a retrospective study and our experience in 10 years with 4305 patients. Radiol Med 121(1):38–44. https://doi.org/10.1007/s11547-015-0570-9 CrossRefPubMed Splendiani A, Perri M, Grattacaso G, Di Tunno V, Marsecano C, Panebianco L, Gennarelli A, Felli V, Varrassi M, Barile A, Di Cesare E, Masciocchi C, Gallucci M (2016) Magnetic resonance imaging (MRI) of the lumbar spine with dedicated G-scan machine in the upright position: a retrospective study and our experience in 10 years with 4305 patients. Radiol Med 121(1):38–44. https://​doi.​org/​10.​1007/​s11547-015-0570-9 CrossRefPubMed
40.
Zurück zum Zitat Eguchi Y, Ohtori S, Orita S, Kamoda H, Arai G, Ishikawa T, Miyagi M, Inoue G, Suzuki M, Masuda Y, Andou H, Takaso M, Aoki Y, Toyone T, Watanabe A, Takahashi K (2011) Quantitative evaluation and visualization of lumbar foraminal nerve root entrapment by using diffusion tensor imaging: preliminary results. AJNR Am J Neuroradiol 32(10):1824–1829. https://doi.org/10.3174/ajnr.A2681 CrossRefPubMedPubMedCentral Eguchi Y, Ohtori S, Orita S, Kamoda H, Arai G, Ishikawa T, Miyagi M, Inoue G, Suzuki M, Masuda Y, Andou H, Takaso M, Aoki Y, Toyone T, Watanabe A, Takahashi K (2011) Quantitative evaluation and visualization of lumbar foraminal nerve root entrapment by using diffusion tensor imaging: preliminary results. AJNR Am J Neuroradiol 32(10):1824–1829. https://​doi.​org/​10.​3174/​ajnr.​A2681 CrossRefPubMedPubMedCentral
47.
Zurück zum Zitat Kasimcan O, Kaptan H (2010) Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia. Neurol Med Chir 50(12):1070–1073CrossRef Kasimcan O, Kaptan H (2010) Efficacy of gabapentin for radiculopathy caused by lumbar spinal stenosis and lumbar disk hernia. Neurol Med Chir 50(12):1070–1073CrossRef
49.
Zurück zum Zitat Korhonen T, Karppinen J, Paimela L, Malmivaara A, Lindgren KA, Bowman C, Hammond A, Kirkham B, Jarvinen S, Niinimaki J, Veeger N, Haapea M, Torkki M, Tervonen O, Seitsalo S, Hurri H (2006) The treatment of disc-herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial. Spine 31(24):2759–2766. https://doi.org/10.1097/01.brs.0000245873.23876.1e CrossRefPubMed Korhonen T, Karppinen J, Paimela L, Malmivaara A, Lindgren KA, Bowman C, Hammond A, Kirkham B, Jarvinen S, Niinimaki J, Veeger N, Haapea M, Torkki M, Tervonen O, Seitsalo S, Hurri H (2006) The treatment of disc-herniation-induced sciatica with infliximab: one-year follow-up results of FIRST II, a randomized controlled trial. Spine 31(24):2759–2766. https://​doi.​org/​10.​1097/​01.​brs.​0000245873.​23876.​1e CrossRefPubMed
52.
Zurück zum Zitat Thackeray A, Fritz JM, Brennan GP, Zaman FM, Willick SE (2010) A pilot study examining the effectiveness of physical therapy as an adjunct to selective nerve root block in the treatment of lumbar radicular pain from disk herniation: a randomized controlled trial. Phys Ther 90(12):1717–1729. https://doi.org/10.2522/ptj.20090260 CrossRefPubMed Thackeray A, Fritz JM, Brennan GP, Zaman FM, Willick SE (2010) A pilot study examining the effectiveness of physical therapy as an adjunct to selective nerve root block in the treatment of lumbar radicular pain from disk herniation: a randomized controlled trial. Phys Ther 90(12):1717–1729. https://​doi.​org/​10.​2522/​ptj.​20090260 CrossRefPubMed
55.
Zurück zum Zitat Manchikanti L, Singh V, Falco FJ, Cash KA, Pampati V (2010) Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind, controlled trial. Pain Phys 13(4):343–355 Manchikanti L, Singh V, Falco FJ, Cash KA, Pampati V (2010) Evaluation of the effectiveness of lumbar interlaminar epidural injections in managing chronic pain of lumbar disc herniation or radiculitis: a randomized, double-blind, controlled trial. Pain Phys 13(4):343–355
56.
Zurück zum Zitat Manchikanti L, Pampati V, Benyamin RM, Hirsch JA (2017) Cost utility analysis of lumbar interlaminar epidural injections in the treatment of lumbar disc herniation, central spinal stenosis, and axial or discogenic low back pain. Pain Phys 20(4):219–228 Manchikanti L, Pampati V, Benyamin RM, Hirsch JA (2017) Cost utility analysis of lumbar interlaminar epidural injections in the treatment of lumbar disc herniation, central spinal stenosis, and axial or discogenic low back pain. Pain Phys 20(4):219–228
62.
Zurück zum Zitat Paul R, Haydon RC, Cheng H, Ishikawa A, Nenadovich N, Jiang W, Zhou L, Breyer B, Feng T, Gupta P, He TC, Phillips FM (2003) Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. Spine 28(8):755–763PubMedPubMedCentral Paul R, Haydon RC, Cheng H, Ishikawa A, Nenadovich N, Jiang W, Zhou L, Breyer B, Feng T, Gupta P, He TC, Phillips FM (2003) Potential use of Sox9 gene therapy for intervertebral degenerative disc disease. Spine 28(8):755–763PubMedPubMedCentral
63.
Zurück zum Zitat Mercuri J, Addington C, Pascal R 3rd, Gill S, Simionescu D (2014) Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration. J Biomed Mater Res A 102(12):4380–4393. https://doi.org/10.1002/jbm.a.35104 CrossRefPubMed Mercuri J, Addington C, Pascal R 3rd, Gill S, Simionescu D (2014) Development and initial characterization of a chemically stabilized elastin-glycosaminoglycan-collagen composite shape-memory hydrogel for nucleus pulposus regeneration. J Biomed Mater Res A 102(12):4380–4393. https://​doi.​org/​10.​1002/​jbm.​a.​35104 CrossRefPubMed
64.
65.
Zurück zum Zitat Mochida J, Sakai D, Nakamura Y, Watanabe T, Yamamoto Y, Kato S (2015) Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety. Eur Cells Mater 29:202–212 discussion 212CrossRef Mochida J, Sakai D, Nakamura Y, Watanabe T, Yamamoto Y, Kato S (2015) Intervertebral disc repair with activated nucleus pulposus cell transplantation: a three-year, prospective clinical study of its safety. Eur Cells Mater 29:202–212 discussion 212CrossRef
73.
Zurück zum Zitat Perri M, Marsecano C, Varrassi M, Giordano AV, Splendiani A, di Cesare E, Masciocchi C, Gallucci M (2016) Indications and efficacy of O2-O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients. Radiol Med 121(6):463–471. https://doi.org/10.1007/s11547-015-0598-x CrossRefPubMed Perri M, Marsecano C, Varrassi M, Giordano AV, Splendiani A, di Cesare E, Masciocchi C, Gallucci M (2016) Indications and efficacy of O2-O3 intradiscal versus steroid intraforaminal injection in different types of disco vertebral pathologies: a prospective randomized double-blind trial with 517 patients. Radiol Med 121(6):463–471. https://​doi.​org/​10.​1007/​s11547-015-0598-x CrossRefPubMed
77.
Zurück zum Zitat Cohen SP, Williams S, Kurihara C, Griffith S, Larkin TM (2005) Nucleoplasty with or without intradiscal electrothermal therapy (IDET) as a treatment for lumbar herniated disc. J Spinal Disord Tech 18(Suppl):S119–S124CrossRefPubMed Cohen SP, Williams S, Kurihara C, Griffith S, Larkin TM (2005) Nucleoplasty with or without intradiscal electrothermal therapy (IDET) as a treatment for lumbar herniated disc. J Spinal Disord Tech 18(Suppl):S119–S124CrossRefPubMed
78.
Zurück zum Zitat Gerszten PC, Smuck M, Rathmell JP, Simopoulos TT, Bhagia SM, Mocek CK, Crabtree T, Bloch DA, Group SS (2010) Plasma disc decompression compared with fluoroscopy-guided transforaminal epidural steroid injections for symptomatic contained lumbar disc herniation: a prospective, randomized, controlled trial. J Neurosurg Spine 12(4):357–371. https://doi.org/10.3171/2009.10.SPINE09208 CrossRefPubMed Gerszten PC, Smuck M, Rathmell JP, Simopoulos TT, Bhagia SM, Mocek CK, Crabtree T, Bloch DA, Group SS (2010) Plasma disc decompression compared with fluoroscopy-guided transforaminal epidural steroid injections for symptomatic contained lumbar disc herniation: a prospective, randomized, controlled trial. J Neurosurg Spine 12(4):357–371. https://​doi.​org/​10.​3171/​2009.​10.​SPINE09208 CrossRefPubMed
85.
Zurück zum Zitat Benzakour T, Hefti A, Lemseffer M, Benzakour A (2010) Long-term outcome of discectomy in the discal lumboradiculalgia (376 cases). E-mémoires de l'Académie Nationale de. Chirurgie 9(1):61–66 Benzakour T, Hefti A, Lemseffer M, Benzakour A (2010) Long-term outcome of discectomy in the discal lumboradiculalgia (376 cases). E-mémoires de l'Académie Nationale de. Chirurgie 9(1):61–66
90.
Zurück zum Zitat Ruetten S, Komp M, Godolias G (2005) An extreme lateral access for the surgery of lumbar disc herniations inside the spinal canal using the full-endoscopic uniportal transforaminal approach-technique and prospective results of 463 patients. Spine 30(22):2570–2578CrossRefPubMed Ruetten S, Komp M, Godolias G (2005) An extreme lateral access for the surgery of lumbar disc herniations inside the spinal canal using the full-endoscopic uniportal transforaminal approach-technique and prospective results of 463 patients. Spine 30(22):2570–2578CrossRefPubMed
93.
Zurück zum Zitat Feng F, Xu Q, Yan F, Xie Y, Deng Z, Hu C, Zhu X, Cai L (2017) Comparison of 7 surgical interventions for lumbar disc herniation: a network meta-analysis. Pain Physician 20(6):E863–E871PubMed Feng F, Xu Q, Yan F, Xie Y, Deng Z, Hu C, Zhu X, Cai L (2017) Comparison of 7 surgical interventions for lumbar disc herniation: a network meta-analysis. Pain Physician 20(6):E863–E871PubMed
Metadaten
Titel
Current concepts for lumbar disc herniation
verfasst von
Thami Benzakour
Vasilios Igoumenou
Andreas F. Mavrogenis
Ahmed Benzakour
Publikationsdatum
30.11.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
International Orthopaedics / Ausgabe 4/2019
Print ISSN: 0341-2695
Elektronische ISSN: 1432-5195
DOI
https://doi.org/10.1007/s00264-018-4247-6

Weitere Artikel der Ausgabe 4/2019

International Orthopaedics 4/2019 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.