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07.11.2019 | Dental Restorative Materials (M Özcan and P Cesar, Section Editor) | Ausgabe 4/2019

Current Oral Health Reports 4/2019

Current Developments on Enamel and Dentin Remineralization

Zeitschrift:
Current Oral Health Reports > Ausgabe 4/2019
Autoren:
Roberto Ruggiero Braga, Stefan Habelitz
Wichtige Hinweise
This article is part of the Topical Collection on Dental Restorative Materials.

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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Abstract

Purpose of Review

To present an overview of the ongoing research on enamel and dentin remineralization and to describe particle-mediated and biomimetic approaches. The importance of restoring tissue functionality as the ultimate goal of remineralization is emphasized.

Recent Findings

Calcium-releasing particles and adjuvants to increase fluoride uptake by enamel are described in the literature. In order to recover the prismatic structure in mineral-depleted enamel, amelogenin-derived peptides and amelogenin analogues have been proposed as templates for apatite deposition. In dentin, mineral deposition per se is not enough to recover the mechanical properties, and the use of biomimetic analogs is necessary to guide apatite formation into the collagen intrafibrillar spaces.

Summary

The use of biomimetic analogues associated with ion-releasing materials seems a promising approach for both enamel and dentin remineralization. Clinical translational protocols are still premature and have, so far, only been explored experimentally in vitro, with good outcomes particularly on structural and functional repair of artificial dentin carious lesions.

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