The online version of this article (doi:10.1186/1475-2840-11-16) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
All authors contributed equally in the patient evaluation and article draft composition. AEM and OSL performed statistical analysis of the data. EMM edited the manuscript for content and AEM revised it and translated into English. All authors read and approved the final manuscript.
People of different racial and ethnic backgrounds have a distinct pattern of central fat deposition, thus making it necessary to devise a race based approach for the diagnosis and evaluation of abdominal obesity (AO). This is the first study to determine the optimal waist circumference (WC) cutoff values for definition of AO in an ethnic Kyrgyz population.
323 persons of Kyrgyz ethnicity (183 women and 140 men), with a mean age of 51.8 ± 9.5 years old were included in the study. Measurement of blood pressure (BP), anthropometric data (including body mass index calculation and WC measurement), fasting blood sugar, serum lipid parameters and insulin were performed in all examined individuals. Insulin resistance (IR) was considered as HOMA index (insulin × fasting glucose/22.5) ≥ 2.77. Sensitivity and specificity for the presence of IR or two other criteria of MS (according to the international classification, 2009) were calculated by using receiver operating characteristic (ROC) curves for men and women separately.
The optimal sensitivity and specificity obtained from the ROC curves for IR were 88 cm in women (sensitivity of 0.85, 95%CI (0.72-0.93), specificity of 0.58, 95%CI (0.49-0.66)) and 94 cm for men (sensitivity of 0.8, 95% CI (0.65-0.91), specificity of 0.61, 95% CI (0.51-0.71)). The data from the ROC curve for any two other MS criteria confirmed the results and the WC 88 cm in women (sensitivity of 0.82, 95% CI (0.72-0.9), specificity of 0.72, 95% CI (0.62-0.8)) and 94 cm in men (sensitivity of 0.74, 95% CI (0.62-0.84), specificity of 0.73, 95% CI (0.61-0.83)) were corresponded to the optimal sensitivity and specificity.
WC ≥ 88 cm and ≥ 94 cm should be used as a criterion for the diagnosis of AO for Kyrgyz women and men respectively based on these results.
Wakabayashi I, Daimon T: Receiver-operated characteristics (ROCs) of the relationships between obesity indices and multiple risk factors (MRFs) for atherosclerosis at different ages in men and women. Arch Gerontol Geriatr. 2011.
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and reatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002, 106: 3143-3421.
Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung and Blood Institute scientific statement. Curr Opin Cardiol. 2006, 21: 1-6. 10.1097/01.hco.0000200416.65370.a0. CrossRefPubMed
Park JS, Ahn SG, Hwang JW, Lim HS, Choi BJ, Choi SY, Yoon MH, Hwang GS, Tahk SJ, Shin JH: Impact of body mass index on the relationship of epicardial adipose tissue to metabolic syndrome and coronary artery disease in an Asian population. Cardiovasc Diabetol. 2010, 9: 29-10.1186/1475-2840-9-29. PubMedCentralCrossRefPubMed
Scott R, Donoghoe M, Watts GF, O'Brien R, Pardy C, Taskinen MR, Davis TM, Colman PG, Manning P, Fulcher G, Keech AC: Impact of metabolic syndrome and its components on cardiovascular disease event rates in 4900 patients with type 2 diabetes assigned to placebo in the FIELD randomised trial. Cardiovasc Diabetol. 2011, 10 (1): 102-10.1186/1475-2840-10-102. PubMedCentralCrossRefPubMed
Yokoyama H, Hirose H, Kanda T, Kawabe H, Saito I: Relationship between waist circumferences measured at the umbilical level and midway between the ribs and iliac crest - a solution to the debate on optimal waist circumference standards in the diagnostic criteria of metabolic syndrome in Japan. J Atheroscler Thromb. 2011, 18: 735-743. 10.5551/jat.7369. CrossRefPubMed
Alberti MM, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KI: Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the Association for the Study of Obesity Heart Federation; International Atherosclerosis Society; and International National Heart, Lung, and Blood Institute; American Heart Association; World International Diabetes Federation Task Force on Epidemiology and Prevention. Circulation. 2009, 120: 1640-1645. 10.1161/CIRCULATIONAHA.109.192644. CrossRefPubMed
Fridewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972, 18: 499-502.
Zhu S, Heymsfield SB, Toyoshima H, Wang Z, Pietrobelli A, Heshka S: Race-ethnicity-specific waist circumference cutoffs for identifying cardiovascular disease risk factors. Am J Clin Nutr. 2005, 81: 409-415. PubMed
World Health Organization: Obesity: Preventing and Managing the Global Epidemic: Report on a WHO Consultation (WHO Technical Report Series 894. 2000, Geneva, Switzerland: World Health Organization
Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovitz HE: Body composition, visceral fat, leptin and insulin resistance in Asian Indian men. J Clin Endocrinol Metab. 1999, 84: 137-144. 10.1210/jc.84.1.137. PubMed
Chandalia M, Abate N, Garg A, Stray-Gundersen J, Grundy SM: Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men. J Clin Endocrinol Metab. 1999, 84: 2329-2335. 10.1210/jc.84.7.2329. PubMed
Zhou BF: Cooperative Meta-Analysis Group of the Working Group on Obesity in China. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults: study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002, 15: 83-96. PubMed
Examination Committee of Criteria for "Obesity Disease" in Japan; Japan Society for the Study of Obesity. New criteria for "obesity disease" in Japan. Circ J. 2002, 66 (11): 987-992. 10.1253/circj.66.987.
Park YM, Kwon HS, Lim SY, Lee JH, Yoon KH, Son HY: Optimal waist circumference cutoff value reflecting insulin resistance as a diagnostic criterion of metabolic syndrome in a nondiabetic Korean population aged 40 years and over: the Chungju Metabolic Disease Cohort (CMC) study. Yonsei Med J. 2010, 51 (4): 511-518. 10.3349/ymj.2010.51.4.511. PubMedCentralCrossRefPubMed
Heshmat R, Khashayar P, Meybodi HR, Homami MR, Larijani B: The appropriate waist circumference cut-off for Iranian population. Acta Med Indones. 2010, 42 (4): 209-215. PubMed
- Cut off values for abdominal obesity as a criterion of metabolic syndrome in an ethnic Kyrgyz population (Central Asian region)
Aibek E Mirrakhimov
Olga S Lunegova
Alina S Kerimkulova
Cholpon B Moldokeeva
Malik P Nabiev
Erkin M Mirrakhimov
- BioMed Central
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