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Inflammopharmacology
Erschienen in: Inflammopharmacology 4/2018

07.05.2018 | Original Article

Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer

verfasst von: Brian M. Kennedy, Randall E. Harris

Erschienen in: Inflammopharmacology | Ausgabe 4/2018

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Abstract

We examined the expression of major inflammatory genes, cyclooxygenase-1 and 2 (COX1, COX2) and arachidonate 5-lipoxygenase (ALOX5) in 1090 tumor samples of invasive breast cancer from The Cancer Genome Atlas (TCGA). Mean cyclooxygenase expression (COX1 + COX2) ranked in the upper 99th percentile of all 20,531 genes and surprisingly, the mean expression of COX1 was more than tenfold higher than COX2. Highly significant correlations were observed between COX2 with eight tumor-promoting genes (EGR2, IL6, RGS2, B3GNT5, SGK1, SLC2A3, SFRP1 and ETS2) and between ALOX5 and ten tumor promoter genes (CD33, MYOF1, NLRP1, GAB3, CD4, IFR8, CYTH4, BTK, FGR, CD37). Expression of CYP19A1 (aromatase) was significantly correlated with COX2, but only in tumors positive for ER, PR and HER2. Tumor-promoting genes correlated with the expression of COX1, COX2, and ALOX5 are known to effectively increase mitogenesis, mutagenesis, angiogenesis, cell survival, immunosuppression and metastasis in the pathogenesis of breast cancer.
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Metadaten
Titel
Cyclooxygenase and lipoxygenase gene expression in the inflammogenesis of breast cancer
verfasst von
Brian M. Kennedy
Randall E. Harris
Publikationsdatum
07.05.2018
Verlag
Springer International Publishing
Erschienen in
Inflammopharmacology / Ausgabe 4/2018
Print ISSN: 0925-4692
Elektronische ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-018-0489-6

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