Background
Methods
Patient recruitment
Blood collection and ex vivo parasite development
Static protein binding assays
Results
Patient details | |||||
---|---|---|---|---|---|
Study reference
|
P0002
|
P0006
|
P0009
|
P0010
|
P0011
|
Age
| 16 | 47 | 28 | 27 | 37 |
Sex
| M | F | M | M | M |
% Parasitaemia
| 0.4 | 0.8 | 7 | 0.8 | 1.3 |
Fever duration (days)
| 7 | 5 | 6 | 5 | 4 |
Axillary Temp°C
| 37.5 | 38.5 | 39.2 | 38.7 | 38 |
Mean Art BP mmHg
| 79 | 96 | 70 | 86 | 77 |
Pulse per min
| 62 | 96 | 96 | 103 | 94 |
Haemoglobin g/dL
| 13.4 | 13.2 | 12.3 | 14.1 | 12.8 |
Platelets/uL
| 93,000 | 106,000 | 19,000 | 39,000 | 65,000 |
White cells/uL
| 6600 | 6700 | 6900 | 7500 | 4600 |
Sodium mmol/L
| 133 | 131 | 120 | 132 | 131 |
Potassium mmol/L
| 3.7 | 4.9 | 3.6 | 3.3 | 3.9 |
Chloride mmol/L
| 100 | 99 | 92 | 101 | 100 |
Total bilirubin umol/L
| 20.6 | 15.7 | 38.4 | 9.7 | 48.9 |
Conjugated bilirubin umol/L
| 5 | 12.8 | 23 | 4 | 32.6 |
Alkaline phosphatase U/L
| 100 | 62 | 87 | 131 | 233 |
Alanine aminotransferase U/L
| 28 | 21 | 43 | 35 | 68 |
Asparagine aminotransferase UL
| 17 | 30 | 118 | 23 | 22 |
Blood urea mmol/L
| 4.4 | 5.7 | 44.7 | 6 | 8.8 |
Serum creatinine umol/L
| - | 78 | 600 | 59 | 133 |
Static binding assay details
| |||||
% Mature Troph/Schizonts before
ex vivo
culture
| 25 | 40 | 17 | 10 | 10 |
Hours
ex-vivo
culture
| 10 | 14.5 | 10 | 10 | 12 |
% Mature Troph/Schizonts at start of assay
| 75 | 50 | 91 | 63 | 50 |