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01.04.2015 | Original Article

Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers

verfasst von: Christine Miaskowski, Janine K. Cataldo, Christina R. Baggott, Claudia West, Laura B. Dunn, Anand Dhruva, John D. Merriman, Dale J. Langford, Kord M. Kober, Steven M. Paul, Bruce A. Cooper, Bradley E. Aouizerat

Erschienen in: Supportive Care in Cancer | Ausgabe 4/2015

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Abstract

Purpose

Anxiety is common among cancer patients and their family caregivers (FCs) and is associated with poorer outcomes. Recently, associations between inflammation and anxiety were identified. However, the relationship between variations in cytokine genes and anxiety warrants investigation. Therefore, phenotypic and genotypic characteristics associated with trait and state anxiety were evaluated in a sample of 167 oncology patients with breast, prostate, lung, or brain cancer and 85 of their FCs.

Methods

Using multiple regression analyses, the associations between participants’ demographic and clinical characteristics as well as variations in cytokine genes and trait and state anxiety were evaluated.

Results

In the bivariate analyses, a number of phenotypic characteristics were associated with both trait and state anxiety (e.g., age, functional status). However, some associations were specific only to trait anxiety (e.g., number of comorbid conditions) or state anxiety (e.g., participation with a FC). Variations in three cytokine genes (i.e., interleukin (IL) 1 beta, IL1 receptor 2 (IL1R2), nuclear factor kappa beta 2 (NFKB2)) were associated with trait anxiety, and variations in two genes (i.e., IL1R2, tumor necrosis factor alpha (TNFA)) were associated with state anxiety.

Conclusions

These findings suggest that both trait and state anxiety need to be assessed in oncology patients and their FCs. Furthermore, variations in cytokine genes may contribute to higher levels of anxiety in oncology patients and their FCs.

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Titel: Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers
verfasst von: Christine Miaskowski
Janine K. Cataldo
Christina R. Baggott
Claudia West
Laura B. Dunn
Anand Dhruva
John D. Merriman
Dale J. Langford
Kord M. Kober
Steven M. Paul
Bruce A. Cooper
Bradley E. Aouizerat
Publikationsdatum: 01.04.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 4/2015
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-014-2443-5

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Cytokine gene variations associated with trait and state anxiety in oncology patients and their family caregivers

Abstract

Purpose

Methods

Results

Conclusions

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Abstract

Purpose

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Conclusions

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