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Erschienen in: Journal of Natural Medicines 1/2017

07.09.2016 | Note

Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina

verfasst von: Sutin Kaennakam, Pongpun Siripong, Santi Tip-pyang

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2017

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Abstract

Two new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (35) were isolated from the roots of Dalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound 5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC50 values in the range 3.47–9.76 µM. In addition, compound 3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC50 values of 8.29 and 9.54 µM, respectively, and compound 2 showed significant cytotoxicity against the MCF-7 cell line, with an IC50 value of 4.69 µM.
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Metadaten
Titel
Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina
verfasst von
Sutin Kaennakam
Pongpun Siripong
Santi Tip-pyang
Publikationsdatum
07.09.2016
Verlag
Springer Japan
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2017
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-016-1039-4

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