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Erschienen in: Angiogenesis 1/2024

27.04.2023 | Review Paper

Damage to endothelial barriers and its contribution to long COVID

verfasst von: Xiaoming Wu, Mengqi Xiang, Haijiao Jing, Chengyue Wang, Valerie A. Novakovic, Jialan Shi

Erschienen in: Angiogenesis | Ausgabe 1/2024

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Abstract

The world continues to contend with COVID-19, fueled by the emergence of viral variants. At the same time, a subset of convalescent individuals continues to experience persistent and prolonged sequelae, known as long COVID. Clinical, autopsy, animal and in vitro studies all reveal endothelial injury in acute COVID-19 and convalescent patients. Endothelial dysfunction is now recognized as a central factor in COVID-19 progression and long COVID development. Different organs contain different types of endothelia, each with specific features, forming different endothelial barriers and executing different physiological functions. Endothelial injury results in contraction of cell margins (increased permeability), shedding of glycocalyx, extension of phosphatidylserine-rich filopods, and barrier damage. During acute SARS-CoV-2 infection, damaged endothelial cells promote diffuse microthrombi and destroy the endothelial (including blood–air, blood–brain, glomerular filtration and intestinal–blood) barriers, leading to multiple organ dysfunction. During the convalescence period, a subset of patients is unable to fully recover due to persistent endothelial dysfunction, contributing to long COVID. There is still an important knowledge gap between endothelial barrier damage in different organs and COVID-19 sequelae. In this article, we mainly focus on these endothelial barriers and their contribution to long COVID.
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Metadaten
Titel
Damage to endothelial barriers and its contribution to long COVID
verfasst von
Xiaoming Wu
Mengqi Xiang
Haijiao Jing
Chengyue Wang
Valerie A. Novakovic
Jialan Shi
Publikationsdatum
27.04.2023
Verlag
Springer Netherlands
Erschienen in
Angiogenesis / Ausgabe 1/2024
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-023-09878-5

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