Skip to main content
Erschienen in: Gynäkologische Endokrinologie 4/2011

01.11.2011 | Leitthema

Das Anti-Müller-Hormon

Ein Blick auf die biologische Uhr?

verfasst von: PD Dr. C. Gnoth

Erschienen in: Gynäkologische Endokrinologie | Ausgabe 4/2011

Einloggen, um Zugang zu erhalten

Zusammenfassung

Das Anti-Müller-Hormon (AMH) ist ein sensitiver Laborparameter zur Einschätzung der ovariellen Reserve und ein wichtiger Faktor zur Abschätzung des individuellen reproduktiven Potenzials. Die Höhe des AMH-Werts zeigt, ob die biologische Uhr bereits deutlich vor- oder möglicherweise nachgeht. Eine grobe Prognose des perimenopausalen Übergangs ist möglich. Alter, AMH-Konzentration und Dauer des bisher unerfüllten Kinderwunschs sind die wichtigsten Variablen, die beim Vorhaben Familiengründung über aktives oder abwartendes Vorgehen entscheiden. Deshalb sollte der AMH-Wert bei allen Frauen mit Kinderwunsch ab einem Alter von 30 Jahren und vor allem ab 35 Jahren im Screening bestimmt und in eine anschließende individuelle Beratung einbezogen werden.
Literatur
1.
Zurück zum Zitat Almog B, Shehata F, Shalom-Paz E et al (2011) Age-related normogram for antral follicle count: McGill reference guide. Fertil Steril 95:663–666PubMedCrossRef Almog B, Shehata F, Shalom-Paz E et al (2011) Age-related normogram for antral follicle count: McGill reference guide. Fertil Steril 95:663–666PubMedCrossRef
2.
Zurück zum Zitat Almog B, Shehata F, Suissa S et al (2011) Age-related normograms of serum antimullerian hormone levels in a population of infertile women: a multicenter study. Fertil Steril 95:2359–2363PubMedCrossRef Almog B, Shehata F, Suissa S et al (2011) Age-related normograms of serum antimullerian hormone levels in a population of infertile women: a multicenter study. Fertil Steril 95:2359–2363PubMedCrossRef
3.
Zurück zum Zitat Barad DH, Weghofer A, Gleicher N (2011) Utility of age-specific serum anti-Mullerian hormone concentrations. Reprod Biomed Online 22:284–291PubMedCrossRef Barad DH, Weghofer A, Gleicher N (2011) Utility of age-specific serum anti-Mullerian hormone concentrations. Reprod Biomed Online 22:284–291PubMedCrossRef
4.
Zurück zum Zitat Broekmans FJ, Kwee J, Hendriks DJ et al (2006) A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 12:685–718PubMedCrossRef Broekmans FJ, Kwee J, Hendriks DJ et al (2006) A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 12:685–718PubMedCrossRef
5.
Zurück zum Zitat Broekmans FJ, Soules MR, Fauser BC (2009) Ovarian aging: mechanisms and clinical consequences. Endocr Rev 30:465–493PubMedCrossRef Broekmans FJ, Soules MR, Fauser BC (2009) Ovarian aging: mechanisms and clinical consequences. Endocr Rev 30:465–493PubMedCrossRef
6.
Zurück zum Zitat Broer SL, Dolleman M, Opmeer BC et al (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17:46–54PubMedCrossRef Broer SL, Dolleman M, Opmeer BC et al (2011) AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis. Hum Reprod Update 17:46–54PubMedCrossRef
7.
Zurück zum Zitat Broer SL, Mol BW, Hendriks D et al (2009) The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 91:705–714PubMedCrossRef Broer SL, Mol BW, Hendriks D et al (2009) The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 91:705–714PubMedCrossRef
8.
Zurück zum Zitat Ebner T, Sommergruber M, Moser M et al (2006) Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod 21:2022–2026PubMedCrossRef Ebner T, Sommergruber M, Moser M et al (2006) Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod 21:2022–2026PubMedCrossRef
9.
Zurück zum Zitat Fraisse T, Ibecheole V, Streuli I et al (2008) Undetectable serum anti-Mullerian hormone levels and occurrence of ongoing pregnancy. Fertil Steril 89:723–711PubMedCrossRef Fraisse T, Ibecheole V, Streuli I et al (2008) Undetectable serum anti-Mullerian hormone levels and occurrence of ongoing pregnancy. Fertil Steril 89:723–711PubMedCrossRef
10.
Zurück zum Zitat Freeman EW, Gracia CR, Sammel MD et al (2007) Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril 87:101–106PubMedCrossRef Freeman EW, Gracia CR, Sammel MD et al (2007) Association of anti-mullerian hormone levels with obesity in late reproductive-age women. Fertil Steril 87:101–106PubMedCrossRef
11.
Zurück zum Zitat Gnoth C, Frank-Herrmann P, Freundl G et al (2003) Time to pregnancy: results of the German prospective study and impact on the management of infertility. Hum Reprod 18:1959–1966PubMedCrossRef Gnoth C, Frank-Herrmann P, Freundl G et al (2003) Time to pregnancy: results of the German prospective study and impact on the management of infertility. Hum Reprod 18:1959–1966PubMedCrossRef
12.
Zurück zum Zitat Gnoth C, Godehardt E, Frank-Herrmann P et al (2005) Definition and prevalence of subfertility and infertility. Hum Reprod 20:1144–1147PubMedCrossRef Gnoth C, Godehardt E, Frank-Herrmann P et al (2005) Definition and prevalence of subfertility and infertility. Hum Reprod 20:1144–1147PubMedCrossRef
13.
Zurück zum Zitat Gnoth C, Maxrath B, Skonieczny T et al (2011) Final ART success rates: a 10 yrs survey. Hum Reprod 26:2239–2246PubMedCrossRef Gnoth C, Maxrath B, Skonieczny T et al (2011) Final ART success rates: a 10 yrs survey. Hum Reprod 26:2239–2246PubMedCrossRef
14.
Zurück zum Zitat Gnoth C, Schuring AN, Friol K et al (2008) Relevance of anti-Mullerian hormone measurement in a routine IVF program. Hum Reprod 23:1359–1365PubMedCrossRef Gnoth C, Schuring AN, Friol K et al (2008) Relevance of anti-Mullerian hormone measurement in a routine IVF program. Hum Reprod 23:1359–1365PubMedCrossRef
15.
Zurück zum Zitat Greb RR, Grieshaber K, Gromoll J et al (2005) A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. J Clin Endocrinol Metab 90:4866–4872PubMedCrossRef Greb RR, Grieshaber K, Gromoll J et al (2005) A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle. J Clin Endocrinol Metab 90:4866–4872PubMedCrossRef
16.
Zurück zum Zitat Hansen KR, Hodnett GM, Knowlton N et al (2011) Correlation of ovarian reserve tests with histologically determined primordial follicle number. Fertil Steril 95:170–175PubMedCrossRef Hansen KR, Hodnett GM, Knowlton N et al (2011) Correlation of ovarian reserve tests with histologically determined primordial follicle number. Fertil Steril 95:170–175PubMedCrossRef
17.
Zurück zum Zitat Josso N, di Clemente N, Gouedard L (2001) Anti-Mullerian hormone and its receptors. Mol Cell Endocrinol 179:25–32PubMedCrossRef Josso N, di Clemente N, Gouedard L (2001) Anti-Mullerian hormone and its receptors. Mol Cell Endocrinol 179:25–32PubMedCrossRef
18.
Zurück zum Zitat Josso N, Belville C, di Clemente N et al (2005) AMH and AMH receptor defects in persistent Müllerian duct syndrome. Hum Reprod Update 11:351–356PubMedCrossRef Josso N, Belville C, di Clemente N et al (2005) AMH and AMH receptor defects in persistent Müllerian duct syndrome. Hum Reprod Update 11:351–356PubMedCrossRef
19.
Zurück zum Zitat Kevenaar ME, Themmen AP, Laven JS et al (2007) Anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women. Hum Reprod 22:1547–1554PubMedCrossRef Kevenaar ME, Themmen AP, Laven JS et al (2007) Anti-Mullerian hormone and anti-Mullerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women. Hum Reprod 22:1547–1554PubMedCrossRef
20.
Zurück zum Zitat Kevenaar ME, Themmen AP, Rivadeneira F et al (2007) A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity. Hum Reprod 22:2382–2388PubMedCrossRef Kevenaar ME, Themmen AP, Rivadeneira F et al (2007) A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity. Hum Reprod 22:2382–2388PubMedCrossRef
21.
Zurück zum Zitat La Marca A, Malmusi S, Giulini S et al (2004) Anti-mullerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation. Hum Reprod 19:2738–2741CrossRef La Marca A, Malmusi S, Giulini S et al (2004) Anti-mullerian hormone plasma levels in spontaneous menstrual cycle and during treatment with FSH to induce ovulation. Hum Reprod 19:2738–2741CrossRef
22.
Zurück zum Zitat La Marca A, Nelson SM, Sighinolfi G et al (2011) Anti-Mullerian hormone-based prediction model for a live birth in assisted reproduction. Reprod Biomed Online 22:341–349CrossRef La Marca A, Nelson SM, Sighinolfi G et al (2011) Anti-Mullerian hormone-based prediction model for a live birth in assisted reproduction. Reprod Biomed Online 22:341–349CrossRef
23.
Zurück zum Zitat La Marca A, Sighinolfi G, Giulini S et al (2010) Normal serum concentrations of anti-Mullerian hormone in women with regular menstrual cycles. Reprod Biomed Online 21:463–469CrossRef La Marca A, Sighinolfi G, Giulini S et al (2010) Normal serum concentrations of anti-Mullerian hormone in women with regular menstrual cycles. Reprod Biomed Online 21:463–469CrossRef
24.
Zurück zum Zitat La Marca A, Volpe A (2006) Anti-Mullerian serum levels during pregnancy. Clin Endocrinol (Oxf) 64:715–716 La Marca A, Volpe A (2006) Anti-Mullerian serum levels during pregnancy. Clin Endocrinol (Oxf) 64:715–716
25.
Zurück zum Zitat Lane AH, Lee MM, Fuller AF Jr et al (1999) Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. Gynecol Oncol 73:51–55PubMedCrossRef Lane AH, Lee MM, Fuller AF Jr et al (1999) Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. Gynecol Oncol 73:51–55PubMedCrossRef
26.
Zurück zum Zitat Ludwig M, Hugo U, Sonntag B (2011) Spontane Fertilität jenseits der Vierzig. Frauenarzt 52:369–372 Ludwig M, Hugo U, Sonntag B (2011) Spontane Fertilität jenseits der Vierzig. Frauenarzt 52:369–372
27.
Zurück zum Zitat Nawroth F, Gnoth C, Krüssel J-S et al (2011) Gemeinsame Stellungnahme der Deutschen Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF) und der Deutschen Gesellschaft für Reproduktionsmedizin (DGRM) zum Thema Anti-Müller-Hormon (AMH). J Reproduktionsmed Endokrinol 8:150–151 Nawroth F, Gnoth C, Krüssel J-S et al (2011) Gemeinsame Stellungnahme der Deutschen Gesellschaft für Gynäkologische Endokrinologie und Fortpflanzungsmedizin (DGGEF) und der Deutschen Gesellschaft für Reproduktionsmedizin (DGRM) zum Thema Anti-Müller-Hormon (AMH). J Reproduktionsmed Endokrinol 8:150–151
28.
Zurück zum Zitat Seifer DB, Baker VL, Leader B (2011) Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertil Steril 95:747–750PubMedCrossRef Seifer DB, Baker VL, Leader B (2011) Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States. Fertil Steril 95:747–750PubMedCrossRef
29.
Zurück zum Zitat Stanford JB, White GL, Hatasaka H (2002) Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol 100:1333–1341PubMedCrossRef Stanford JB, White GL, Hatasaka H (2002) Timing intercourse to achieve pregnancy: current evidence. Obstet Gynecol 100:1333–1341PubMedCrossRef
30.
Zurück zum Zitat Streuli I, Fraisse T, Chapron C et al (2009) Clinical uses of anti-Mullerian hormone assays: pitfalls and promises. Fertil Steril 91:226–230PubMedCrossRef Streuli I, Fraisse T, Chapron C et al (2009) Clinical uses of anti-Mullerian hormone assays: pitfalls and promises. Fertil Steril 91:226–230PubMedCrossRef
31.
Zurück zum Zitat Streuli I, Fraisse T, Pillet C et al (2008) Serum antimullerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids. Fertil Steril 90:395–400PubMedCrossRef Streuli I, Fraisse T, Pillet C et al (2008) Serum antimullerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids. Fertil Steril 90:395–400PubMedCrossRef
32.
Zurück zum Zitat te Velde ER, Pearson PL (2002) The variability of female reproductive ageing. Hum Reprod Update 8:141–154CrossRef te Velde ER, Pearson PL (2002) The variability of female reproductive ageing. Hum Reprod Update 8:141–154CrossRef
33.
Zurück zum Zitat Tremellen K, Kolo M (2010) Serum anti-Mullerian hormone is a useful measure of quantitative ovarian reserve but does not predict the chances of live-birth pregnancy. Aust N Z J Obstet Gynaecol 50:568–572PubMedCrossRef Tremellen K, Kolo M (2010) Serum anti-Mullerian hormone is a useful measure of quantitative ovarian reserve but does not predict the chances of live-birth pregnancy. Aust N Z J Obstet Gynaecol 50:568–572PubMedCrossRef
34.
Zurück zum Zitat Disseldorp J van, Faddy MJ, Themmen AP et al (2008) Relationship of serum antimüllerian hormone concentration to age at menopause. J Clin Endocrinol Metab 93:2129–2134PubMedCrossRef Disseldorp J van, Faddy MJ, Themmen AP et al (2008) Relationship of serum antimüllerian hormone concentration to age at menopause. J Clin Endocrinol Metab 93:2129–2134PubMedCrossRef
35.
Zurück zum Zitat Disseldorp J van, Lambalk CB, Kwee J et al (2010) Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts. Hum Reprod 25:221–227PubMedCrossRef Disseldorp J van, Lambalk CB, Kwee J et al (2010) Comparison of inter- and intra-cycle variability of anti-Mullerian hormone and antral follicle counts. Hum Reprod 25:221–227PubMedCrossRef
36.
Zurück zum Zitat Rooij IA van, Broekmans FJ, Scheffer GJ et al (2005) Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril 83:979–987PubMedCrossRef Rooij IA van, Broekmans FJ, Scheffer GJ et al (2005) Serum antimullerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study. Fertil Steril 83:979–987PubMedCrossRef
37.
Zurück zum Zitat Rooij IA van, Tonkelaar I, Broekmans FJ et al (2004) Anti-mullerian hormone is a promising predictor for the occurrence of the menopausal transition. Menopause 11:601–606PubMedCrossRef Rooij IA van, Tonkelaar I, Broekmans FJ et al (2004) Anti-mullerian hormone is a promising predictor for the occurrence of the menopausal transition. Menopause 11:601–606PubMedCrossRef
38.
Zurück zum Zitat Wallace AM, Faye SA, Fleming R et al (2011) A multicentre evaluation of the new Beckman Coulter anti-Mullerian hormone immunoassay (AMH Gen II). Ann Clin Biochem 48:370–373.PubMedCrossRef Wallace AM, Faye SA, Fleming R et al (2011) A multicentre evaluation of the new Beckman Coulter anti-Mullerian hormone immunoassay (AMH Gen II). Ann Clin Biochem 48:370–373.PubMedCrossRef
39.
Zurück zum Zitat Wang X, Chen C, Wang L et al (2003) Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril 79:577–584PubMedCrossRef Wang X, Chen C, Wang L et al (2003) Conception, early pregnancy loss, and time to clinical pregnancy: a population-based prospective study. Fertil Steril 79:577–584PubMedCrossRef
Metadaten
Titel
Das Anti-Müller-Hormon
Ein Blick auf die biologische Uhr?
verfasst von
PD Dr. C. Gnoth
Publikationsdatum
01.11.2011
Verlag
Springer-Verlag
Erschienen in
Gynäkologische Endokrinologie / Ausgabe 4/2011
Print ISSN: 1610-2894
Elektronische ISSN: 1610-2908
DOI
https://doi.org/10.1007/s10304-011-0435-9

Weitere Artikel der Ausgabe 4/2011

Gynäkologische Endokrinologie 4/2011 Zur Ausgabe

CME Weiterbildung · Zertifizierte Fortbildung

Medikamentöse Therapie der chronischen Endometriose

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.