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Erschienen in: Der Onkologe 2/2013

01.02.2013 | CME Zertifizierte Fortbildung

Das Peniskarzinom

verfasst von: PD Dr. C. Protzel, C. Kakies, S. Schwarzenboeck, T. Kuhnt, A. Erbersdobler, B. Krause, O.W. Hakenberg

Erschienen in: Die Onkologie | Ausgabe 2/2013

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Zusammenfassung

Aufgrund der geringen Inzidenz des Peniskarzinoms ist die Evidenzlage zu seiner Therapie sehr schwach. Durch die zunehmend an onkologischen Zentren erfolgende Versorgung betroffener Patienten konnten jedoch in den letzten Jahren deutliche Fortschritte in der Behandlungsqualität erzielt und neue therapeutische Ansätze entwickelt werden. Bei der operativen Therapie des frühen Primärkarzinoms steht zunehmend die Organerhaltung im Vordergrund, vorausgesetzt, die tumorfreien Schnittränder können per Schnellschnittuntersuchung gesichert werden. Entscheidend für die Prognose des Peniskarzinoms ist ein stadiengerechtes Management der inguinalen Lymphknoten. Voraussetzung für einen kurativen Therapieansatz ist die Entfernung aller metastatisch befallenen Lymphknoten. Aufgrund aktueller Studienergebnisse ist der taxan- und cisplatinhaltigen Chemotherapie der Vorzug zu geben, da mit dieser Kombination im neoadjuvanten und adjuvanten Setting die besten Ergebnisse erzielt werden konnten.
Literatur
1.
Zurück zum Zitat Protzel C, Ruppin S, Milerski S et al (2009) The current state of the art of chemotherapy of penile cancer: results of a nationwide survey of German clinics. Urologe A 48(12):1495–1498PubMedCrossRef Protzel C, Ruppin S, Milerski S et al (2009) The current state of the art of chemotherapy of penile cancer: results of a nationwide survey of German clinics. Urologe A 48(12):1495–1498PubMedCrossRef
2.
Zurück zum Zitat Hughes BE, Leijte JA, Kroon BK et al (2010) Lymph node metastasis in intermediate-risk penile squamous cell cancer: a two-centre experience. Eur Urol 57(4):688–692PubMedCrossRef Hughes BE, Leijte JA, Kroon BK et al (2010) Lymph node metastasis in intermediate-risk penile squamous cell cancer: a two-centre experience. Eur Urol 57(4):688–692PubMedCrossRef
3.
Zurück zum Zitat Parkin DM, Whelan SL, Ferlay J et al (Hrsg) (2002) Cancer incidence in five continents. IARC Scientific Publications No155. IARC, Lyon Parkin DM, Whelan SL, Ferlay J et al (Hrsg) (2002) Cancer incidence in five continents. IARC Scientific Publications No155. IARC, Lyon
4.
Zurück zum Zitat Dillner J, Krogh G von, Horenblas S, Meijer CJ (2000) Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl 205:189–193PubMedCrossRef Dillner J, Krogh G von, Horenblas S, Meijer CJ (2000) Etiology of squamous cell carcinoma of the penis. Scand J Urol Nephrol Suppl 205:189–193PubMedCrossRef
5.
Zurück zum Zitat Madsen BS, Brule AJ van den, Jensen HL et al (2008) Risk factors for squamous cell carcinoma of the penis – population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 17:2683–2691PubMedCrossRef Madsen BS, Brule AJ van den, Jensen HL et al (2008) Risk factors for squamous cell carcinoma of the penis – population-based case-control study in Denmark. Cancer Epidemiol Biomarkers Prev 17:2683–2691PubMedCrossRef
6.
Zurück zum Zitat Favorito LA, Nardi AC, Ronalsa M et al (2008) Epidemiologic study on penile cancer in Brazil. Int Braz J Urol 34:587–591 PubMedCrossRef Favorito LA, Nardi AC, Ronalsa M et al (2008) Epidemiologic study on penile cancer in Brazil. Int Braz J Urol 34:587–591 PubMedCrossRef
7.
8.
Zurück zum Zitat Rubin MA, Kleter B, Zhou M et al (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159:1211–1218PubMedCrossRef Rubin MA, Kleter B, Zhou M et al (2001) Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol 159:1211–1218PubMedCrossRef
9.
Zurück zum Zitat Cubilla AL, Dillner J, Schellhammer PF et al (2004) Tumours of the penis. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (Hrsg) World Health Organization classification of tumours. Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, Lyon, S 280–290 Cubilla AL, Dillner J, Schellhammer PF et al (2004) Tumours of the penis. In: Eble JN, Sauter G, Epstein JI, Sesterhenn IA (Hrsg) World Health Organization classification of tumours. Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, Lyon, S 280–290
10.
Zurück zum Zitat Ficarra V, Zattoni F, Artibani W et al (2006) Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis. J Urol 175(5):1700–1704PubMedCrossRef Ficarra V, Zattoni F, Artibani W et al (2006) Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis. J Urol 175(5):1700–1704PubMedCrossRef
11.
Zurück zum Zitat Sobin LH, Gospodariwicz M, Wittekind C (Hrsg) (2009) TNM classification of malignant tumours. UICC International Union against Cancer, 7. Aufl. Wiley-Blackwell, New York Sobin LH, Gospodariwicz M, Wittekind C (Hrsg) (2009) TNM classification of malignant tumours. UICC International Union against Cancer, 7. Aufl. Wiley-Blackwell, New York
12.
Zurück zum Zitat Poetsch M, Schuart BJ, Schwesinger G et al (2007) Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol 20:1069–1077PubMedCrossRef Poetsch M, Schuart BJ, Schwesinger G et al (2007) Screening of microsatellite markers in penile cancer reveals differences between metastatic and nonmetastatic carcinomas. Mod Pathol 20:1069–1077PubMedCrossRef
13.
Zurück zum Zitat Poetsch M, Hemmerich M, Kakies C et al (2011) Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas. Virchows Arch 458:221–229PubMedCrossRef Poetsch M, Hemmerich M, Kakies C et al (2011) Alterations in the tumor suppressor gene p16(INK4A) are associated with aggressive behavior of penile carcinomas. Virchows Arch 458:221–229PubMedCrossRef
14.
Zurück zum Zitat Martins AC, Faria SM, Cologna AJ et al (2002) Immunoexpression of p53 protein and proliferating cell nuclear antigen in penile carcinoma. J Urol 167:83–92CrossRef Martins AC, Faria SM, Cologna AJ et al (2002) Immunoexpression of p53 protein and proliferating cell nuclear antigen in penile carcinoma. J Urol 167:83–92CrossRef
15.
Zurück zum Zitat Pizzocaro G, Algaba F, Horenblas S et al (2010) EAU penile cancer guidelines 2009. Eur Urol 57(6):1002–1012 PubMedCrossRef Pizzocaro G, Algaba F, Horenblas S et al (2010) EAU penile cancer guidelines 2009. Eur Urol 57(6):1002–1012 PubMedCrossRef
16.
Zurück zum Zitat Kayes O, Minhas S, Allen C et al (2007) The role of magnetic resonance imaging in the local staging of penile cancer. Eur Urol 51:1313–1319)PubMedCrossRef Kayes O, Minhas S, Allen C et al (2007) The role of magnetic resonance imaging in the local staging of penile cancer. Eur Urol 51:1313–1319)PubMedCrossRef
17.
Zurück zum Zitat Velazquez EF, Barreto JE, Rodriguez I et al (2004) Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol 12:139–146PubMedCrossRef Velazquez EF, Barreto JE, Rodriguez I et al (2004) Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma. Int J Surg Pathol 12:139–146PubMedCrossRef
18.
Zurück zum Zitat Protzel C, Alcaraz A, Horenblas S et al (2009) Lymphadenectomy in the surgical management of penile cancer. Eur Urol 55:1075–1088PubMedCrossRef Protzel C, Alcaraz A, Horenblas S et al (2009) Lymphadenectomy in the surgical management of penile cancer. Eur Urol 55:1075–1088PubMedCrossRef
19.
Zurück zum Zitat Kroon BK, Horenblas S, Lont AP et al (2005) Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol 173:816–819PubMedCrossRef Kroon BK, Horenblas S, Lont AP et al (2005) Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol 173:816–819PubMedCrossRef
20.
Zurück zum Zitat Saisorn I, Lawrentschuk N, Leewansangtong S, Bolton DM (2006) Fine-needle aspiration cytology predicts inguinal lymph node metastasis without antibiotic pretreatment in penile carcinoma. BJU Int 97:1225–1228PubMedCrossRef Saisorn I, Lawrentschuk N, Leewansangtong S, Bolton DM (2006) Fine-needle aspiration cytology predicts inguinal lymph node metastasis without antibiotic pretreatment in penile carcinoma. BJU Int 97:1225–1228PubMedCrossRef
21.
Zurück zum Zitat Scher B, Seitz M, Reiser M et al (2005) 18F-FDG PET/CT for staging of penile cancer. J Nucl Med 46:1460–1465PubMed Scher B, Seitz M, Reiser M et al (2005) 18F-FDG PET/CT for staging of penile cancer. J Nucl Med 46:1460–1465PubMed
22.
Zurück zum Zitat Leijte JA, Kirrander P, Antonini N et al (2008) Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol 54:161–168PubMedCrossRef Leijte JA, Kirrander P, Antonini N et al (2008) Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol 54:161–168PubMedCrossRef
23.
Zurück zum Zitat Philippou P, Shabbir M, Malone P et al (2012) Conservative surgery for squamous cell carcinoma of the penis: resection margins and long-term oncological control. J Urol 188(3):803–808PubMedCrossRef Philippou P, Shabbir M, Malone P et al (2012) Conservative surgery for squamous cell carcinoma of the penis: resection margins and long-term oncological control. J Urol 188(3):803–808PubMedCrossRef
24.
Zurück zum Zitat Minhas S, Kayes O, Hegarty P et al (2005) What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int 96:1040–1043PubMedCrossRef Minhas S, Kayes O, Hegarty P et al (2005) What surgical resection margins are required to achieve oncological control in men with primary penile cancer? BJU Int 96:1040–1043PubMedCrossRef
25.
Zurück zum Zitat Schlenker B, Gratzke C, Seitz M et al (2009) Fluorescence-guided laser therapy for penile carcinoma and precancerous lesions: long-term follow-up. Urol Oncol 29(6):788–793PubMed Schlenker B, Gratzke C, Seitz M et al (2009) Fluorescence-guided laser therapy for penile carcinoma and precancerous lesions: long-term follow-up. Urol Oncol 29(6):788–793PubMed
26.
Zurück zum Zitat Hegarty PK, Shabbir M, Hughes B et al (2009) Penile preserving surgery and surgical strategies to maximize penile form and function in penile cancer: recommendations from the United Kingdom experience. World J Urol 27:179–187PubMedCrossRef Hegarty PK, Shabbir M, Hughes B et al (2009) Penile preserving surgery and surgical strategies to maximize penile form and function in penile cancer: recommendations from the United Kingdom experience. World J Urol 27:179–187PubMedCrossRef
27.
Zurück zum Zitat Alnajjar HM, Lam W, Bolgeri M et al (2012) Treatment of carcinoma in situ of the glans penis with topical chemotherapy agents. Eur Urol 62(5):923–928PubMedCrossRef Alnajjar HM, Lam W, Bolgeri M et al (2012) Treatment of carcinoma in situ of the glans penis with topical chemotherapy agents. Eur Urol 62(5):923–928PubMedCrossRef
28.
Zurück zum Zitat Ficarra V, Galfano A (2007) Should the dynamic sentinel node biopsy (DSNB) be considered the gold standard in the evaluation of lymph node status in patients with penile carcinoma? Eur Urol 52:17–21PubMedCrossRef Ficarra V, Galfano A (2007) Should the dynamic sentinel node biopsy (DSNB) be considered the gold standard in the evaluation of lymph node status in patients with penile carcinoma? Eur Urol 52:17–21PubMedCrossRef
29.
Zurück zum Zitat Pizzocaro G, Piva L, Bandieramonte G, Tana S (1997) Up-to-date management of carcinoma of the penis. Eur Urol 32:5–15PubMed Pizzocaro G, Piva L, Bandieramonte G, Tana S (1997) Up-to-date management of carcinoma of the penis. Eur Urol 32:5–15PubMed
30.
Zurück zum Zitat Hakenberg OW, Nippgen JB, Froehner M et al (2006) Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int 98:1225–1227PubMedCrossRef Hakenberg OW, Nippgen JB, Froehner M et al (2006) Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma. BJU Int 98:1225–1227PubMedCrossRef
31.
Zurück zum Zitat Dexeus FH, Logothetis CJ, Sella A et al (1991) Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract. J Urol 146:1284–1287PubMed Dexeus FH, Logothetis CJ, Sella A et al (1991) Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract. J Urol 146:1284–1287PubMed
32.
Zurück zum Zitat Haas GP, Blumenstein BA, Gagliano RG et al (1999) Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol 161:1823–1825PubMedCrossRef Haas GP, Blumenstein BA, Gagliano RG et al (1999) Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol 161:1823–1825PubMedCrossRef
33.
Zurück zum Zitat Pizzocaro G, Piva L (1988) Adjuvant and neoadjuvant vincristine, bleomycin, and methotrexate for inguinal metastases from squamous cell carcinoma of the penis. Acta Oncol 27:823–824PubMedCrossRef Pizzocaro G, Piva L (1988) Adjuvant and neoadjuvant vincristine, bleomycin, and methotrexate for inguinal metastases from squamous cell carcinoma of the penis. Acta Oncol 27:823–824PubMedCrossRef
34.
Zurück zum Zitat Pizzocaro G, Nicolai N, Milani A (2008) Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results. Eur Urol 55(3):546–551PubMedCrossRef Pizzocaro G, Nicolai N, Milani A (2008) Taxanes in combination with cisplatin and fluorouracil for advanced penile cancer: preliminary results. Eur Urol 55(3):546–551PubMedCrossRef
35.
Zurück zum Zitat Pagliaro LC, Williams DL, Daliani D et al (2010) Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol 28:3851–3857PubMedCrossRef Pagliaro LC, Williams DL, Daliani D et al (2010) Neoadjuvant paclitaxel, ifosfamide, and cisplatin chemotherapy for metastatic penile cancer: a phase II study. J Clin Oncol 28:3851–3857PubMedCrossRef
36.
Zurück zum Zitat Protzel C, Hakenberg OW (2009) Chemotherapy in patients with penile carcinoma. Urol Int 82(1):1–7PubMedCrossRef Protzel C, Hakenberg OW (2009) Chemotherapy in patients with penile carcinoma. Urol Int 82(1):1–7PubMedCrossRef
37.
Zurück zum Zitat Necchi A, Nicolai N, Colecchia M et al (2011) Proof of activity of anti-epidermal growth factor receptor-targeted therapy for relapsed squamous cell carcinoma of the penis. J Clin Oncol 29:e650–e652PubMedCrossRef Necchi A, Nicolai N, Colecchia M et al (2011) Proof of activity of anti-epidermal growth factor receptor-targeted therapy for relapsed squamous cell carcinoma of the penis. J Clin Oncol 29:e650–e652PubMedCrossRef
38.
Zurück zum Zitat Mahlmann B, Doehn C, Feyerabend T (2001) Radiotherapy of penis carcinoma. Urologe A 40:308–312PubMedCrossRef Mahlmann B, Doehn C, Feyerabend T (2001) Radiotherapy of penis carcinoma. Urologe A 40:308–312PubMedCrossRef
39.
Zurück zum Zitat Crook J, Jezioranski J, Cygler JE (2010) Penile brachytherapy: technical aspects and postimplant issues. Brachytherapy 9:151–158PubMedCrossRef Crook J, Jezioranski J, Cygler JE (2010) Penile brachytherapy: technical aspects and postimplant issues. Brachytherapy 9:151–158PubMedCrossRef
40.
Zurück zum Zitat Crook J, Ma C, Grimard L (2009) Radiation therapy in the management of the primary penile tumor: an update. World J Urol 27:189–196PubMedCrossRef Crook J, Ma C, Grimard L (2009) Radiation therapy in the management of the primary penile tumor: an update. World J Urol 27:189–196PubMedCrossRef
41.
Zurück zum Zitat Crevoisier R de, Slimane K, Sanfilippo N et al (2009) Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys 74:1150–1156PubMedCrossRef Crevoisier R de, Slimane K, Sanfilippo N et al (2009) Long-term results of brachytherapy for carcinoma of the penis confined to the glans (N- or NX). Int J Radiat Oncol Biol Phys 74:1150–1156PubMedCrossRef
42.
Zurück zum Zitat Gotsadze D, Matveev B, Zak B, Mamaladze V (2000) Is conservative organ-sparing treatment of penile carcinoma justified? Eur Urol 38:306–312PubMedCrossRef Gotsadze D, Matveev B, Zak B, Mamaladze V (2000) Is conservative organ-sparing treatment of penile carcinoma justified? Eur Urol 38:306–312PubMedCrossRef
43.
Zurück zum Zitat Ozsahin M, Jichlinski P, Weber DC et al (2006) Treatment of penile carcinoma: to cut or not to cut? Int J Radiat Oncol Biol Phys 66:674–679PubMedCrossRef Ozsahin M, Jichlinski P, Weber DC et al (2006) Treatment of penile carcinoma: to cut or not to cut? Int J Radiat Oncol Biol Phys 66:674–679PubMedCrossRef
44.
Zurück zum Zitat Franks KN, Kancherla K, Sethugavalar B et al (2011) Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals. J Urol 186:524–5299PubMedCrossRef Franks KN, Kancherla K, Sethugavalar B et al (2011) Radiotherapy for node positive penile cancer: experience of the Leeds teaching hospitals. J Urol 186:524–5299PubMedCrossRef
Metadaten
Titel
Das Peniskarzinom
verfasst von
PD Dr. C. Protzel
C. Kakies
S. Schwarzenboeck
T. Kuhnt
A. Erbersdobler
B. Krause
O.W. Hakenberg
Publikationsdatum
01.02.2013
Verlag
Springer-Verlag
Erschienen in
Die Onkologie / Ausgabe 2/2013
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-012-2421-9

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