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01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Trials 1/2018

Data sharing in clinical trials – practical guidance on anonymising trial datasets

Zeitschrift:
Trials > Ausgabe 1/2018
Autoren:
Catriona Keerie, Christopher Tuck, Garry Milne, Sandra Eldridge, Neil Wright, Steff C. Lewis
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:https://​doi.​org/​10.​1186/​s13063-017-2382-9) contains supplementary material, which is available to authorized users.

Abstract

Background

There is an increasing demand by non-commercial funders that trialists should provide access to trial data once the primary analysis is completed. This has to take into account concerns about identifying individual trial participants, and the legal and regulatory requirements.

Methods

Using the good practice guideline laid out by the work funded by the Medical Research Council Hubs for Trials Methodology Research (MRC HTMR), we anonymised a dataset from a recently completed trial. Using this example, we present practical guidance on how to anonymise a dataset, and describe rules that could be used on other trial datasets. We describe how these might differ if the trial was to be made freely available to all, or if the data could only be accessed with specific permission and data usage agreements in place.

Results

Following the good practice guidelines, we successfully created a controlled access model for trial data sharing. The data were assessed on a case-by-case basis classifying variables as direct, indirect and superfluous identifiers with differing methods of anonymisation assigned depending on the type of identifier. A final dataset was created and checks of the anonymised dataset were applied. Lastly, a procedure for release of the data was implemented to complete the process.

Conclusions

We have implemented a practical solution to the data anonymisation process resulting in a bespoke anonymised dataset for a recently completed trial. We have gained useful learnings in terms of efficiency of the process going forward, the need to balance anonymity with data utilisation and future work that should be undertaken.
Zusatzmaterial
Additional file 1: Methods employed for recoding of unique patient identifiers. (DOCX 12 kb)
13063_2017_2382_MOESM1_ESM.docx
Additional file 2: Data Request Form v1.0 06Jan2017. (DOCX 18 kb)
13063_2017_2382_MOESM2_ESM.docx
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