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Erschienen in: Digestive Diseases and Sciences 9/2022

11.07.2022 | PROFILES AND PERSPECTIVES

DDS Perspective: Crohn’s Disease and Increased Intestinal Permeability—Initial Demonstration and Birth Pains

verfasst von: Daniel Hollander

Erschienen in: Digestive Diseases and Sciences | Ausgabe 9/2022

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Excerpt

I started to take care of patients with inflammatory bowel diseases (IBD) in the late 1960s. At that time knowledge about the etiology of IBD and its therapy was quite limited. The commonly held belief at that time was that IBD is caused by an abnormal immunological reaction to luminal antigen(s). Most research funding went to attempts to investigate the possibility of immune dysfunction in Crohn’s disease. Many excellent immunologists concentrated on mucosal immune abnormalities but failed to recognize that such a tunnel vision might impede progress towards understanding the pathogenesis of IBD. …
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Metadaten
Titel
DDS Perspective: Crohn’s Disease and Increased Intestinal Permeability—Initial Demonstration and Birth Pains
verfasst von
Daniel Hollander
Publikationsdatum
11.07.2022
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 9/2022
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-022-07614-5

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