Background
Varicella is a common infectious disease that is caused by varicella zoster virus (VZV), which is transmitted from humans to humans by droplets [
1,
2]. Varicella is typically a mild disease but can cause serious complications; the rate for complications in children and adolescents in Switzerland has been estimated at 1 hospitalization per 1000 varicella cases [
3]. In adults the hospitalization rate is up to 10-fold higher [
2].
In Switzerland, vaccinations are voluntary; the decision to vaccinate oneself and one’s children is each individual’s responsibility. An annual vaccination schedule serves as a national guideline and classifies recommended vaccinations as either “basic”, “supplementary”, or “risk-based” vaccinations. Vaccinations are defined as “basic” if considered essential for individual and public health. These must be recommended by physicians to their patients. Vaccinations that provide optimal individual protection and are intended for people who want to protect themselves against clearly defined risks, but are not considered essential for public health, are categorized as “supplementary”. Physicians in Switzerland must inform their patients of the existence of supplementary vaccinations. Universal vaccination against varicella during childhood is not recommended. The Swiss Federal Office of Public Health currently recommends varicella vaccination in individuals 11 to 40 years of age who have not contracted varicella naturally in the past (i.e. who do not have a reliable varicella history or are seronegative for VZV-IgG serum antibodies) as a “basic” vaccination. Immunization against varicella is also recommended as a “risk-based” vaccination for individuals from the age of 1 year onwards with an increased risk for complications or transmission [
4]. As in most other European countries at a time before implementation of universal varicella vaccination, over 90% of the Swiss population has had varicella by the age of 15 years [
5].
The United States of America was the first country to introduce a UVV program, starting with a 1-dose recommendation in 1995 and switching to a 2-dose recommendation in 2005. UVV has also been introduced in Germany as a 1-dose program in 2004 with a switch to a 2-dose program in 2009. In both countries, implementation of UVV resulted in a strong decline of the incidence of varicella and varicella-related hospitalizations and deaths [
6,
7]. Italy started to progressively introduce UVV in different regions from 2003 on and switched to a national recommendation in 2017. Similarly, Spain progressed from UVV in a few regions to a national program in 2016 [
8]. In both Italy and Spain, a progressive reduction in the incidence of cases and hospitalizations was found in regions that introduced varicella vaccination programs [
9,
10]. While several countries have universal varicella vaccination programs in place, many postponed their introduction due to concerns about a shift in the disease to older groups, an increase in herpes zoster in the elderly, and cost-effectiveness [
11]. The concern about an age shift is based on modelling studies that suggested a high vaccination coverage (> 80%) is needed to prevent an increasing incidence rate of complications due to the potentially resulting shift in the incidence to older ages groups [
12,
13].
In Switzerland, there is no legal basis for mandatory vaccinations except for situations of major epidemics. Thus, mandatory vaccination is not a means to ensure a high level of varicella vaccination. To achieve a high varicella vaccination coverage rate, it is however important that practicing physicians comply with a potential recommendation for UVV. In this study, we therefore aimed at determining the perception of varicella and the current vaccination behavior among Swiss pediatricians and GPs who treat children. We also wanted to assess their intention to advise parents to vaccinate their children against varicella in the event the Swiss NITAG will recommend UVV.
Methods
Study population and design
Participants were recruited by QualiPro (
https://qualipro.ch/index.html), an agency specialized in Swiss healthcare professional recruitment for surveys, from their existing database. Based on screening questions, only office-based physicians from the German- and the French-speaking parts of Switzerland were selected. To qualify for participation, physicians had to be practicing in their specialty between 2 and 35 years and currently vaccinating children.
Based on previous experiences with unpublished surveys among physicians in Switzerland, a sample size of 130–150 is achievable in terms of recruitment and has proven to provide robust results. Therefore, the following set of sample quotas was defined: 35–50 GPs in the German-speaking part, 15–20 GPs in the French-speaking part, 60–75 pediatricians in the German-speaking part, and 20–25 pediatricians in the French-speaking part. Once 150 participants responded, the recruitment was stopped.
In November 2019, 1′208 GPs and 1′054 pediatricians received an invite to participate in an online-based survey study. Reminders were sent one week later. The first 150 physicians who completed the screening questions and passed the screening criteria continued with the questionnaire. Once 150 eligible physicians completed the questionnaire, the link showed a quota full screen indicating that the survey has been closed and the link to the questionnaire was no longer active. Physicians who participated gave their informed consent by filling out the questionnaire.
The questionnaire (additional file
1) was similar to that used by other investigators on the same topic [
14] and was adapted by the authors of this publication. It contained questions on background characteristics, knowledge about varicella, attitude towards universal varicella vaccination, and beliefs about the disease varicella and varicella vaccination. Most questions were phrased as statements on which the level of agreement was measured using a 5-point Likert scale.
Data analysis
Attitude towards universal varicella vaccination
The primary outcome of the study was to understand physicians’ intention to advise parents to vaccinate their children against varicella in case the Swiss NITAG would recommend UVV. The respondents were asked to indicate on a 5-point Likert-scale whether they agreed with the following statement (1 = strongly disagree, 5 = strongly agree): “If the NITAG recommends varicella vaccination for all infants starting at the age of 9 (-12) months as a basic vaccination, I will advise parents to vaccinate their children against varicella”. The respondents were classified to have a positive attitude towards a recommendation if they selected 4 or 5 on the 5-point Likert-scale.
Determinants of attitude towards universal varicella vaccination
Knowledge about varicella:
We calculated a knowledge score that was based on six knowledge questions. The maximum of this score was 6 points (1 point per correct answer, see also additional file
1). Respondents were classified as having ‘limited knowledge’ (0–2 points), ‘moderate knowledge’ (3–4 points) or ‘good knowledge’ (5–6 points) about varicella. We tested differences in knowledge between physicians using Pearson’s χ2 or Fisher’s exact test. We applied the Benjamini-Hochberg method with a false discovery rate of 0.05 to correct for multiple testing [
14,
15].
Beliefs about varicella and varicella vaccination:
To get insight into the perceived severity of varicella, participating physicians were asked to assess the importance of vaccination for children (from the approved age onwards) for different vaccine-preventable diseases including varicella. General beliefs and perceptions about varicella and varicella vaccination were measured by 7 statements: “Varicella can cause serious complications”, “Varicella generally has a mild disease course in healthy children”, “I believe that varicella is a burden to working parents and causes productivity loss”, “I think that varicella is a disease serious enough to vaccinate against”, “Varicella is a disease one should have experienced as a child (in order to develop specific immunity)”, “One should not keep children with varicella away from school or child care”, and “I am worried about potential side effects of the varicella vaccination”.
To study differences in beliefs between GPs and pediatricians mean scores and associated simultaneous Bonferroni confidence intervals with overall coverage of at least 95% were calculated.
Logistic regression analyses:
Logistic regression models were used to identify determinants for Swiss physicians’ intention to advise parents to vaccinate their children against varicella in case of recommendation for UVV through the Swiss NITAG.
The following potential determinants were included in the univariable and multivariable logistic regression analyses: gender, years of practice, specialty, varicella knowledge score and beliefs about varicella and varicella vaccination (see additional file
1 for more details on included questionnaire items). Only significant variables were kept in the model.
For these regression analyses, the agreement on statements regarding beliefs about varicella and varicella vaccination was divided into three categories: a) no agreement (‘strongly disagree’ or ‘disagree’), b) neutral (‘neutral’), and c) agreement (‘agree’ or ‘strongly agree’). A determinant was considered statistically significantly associated with the outcome if the P value was < 0.05. The logistic regression analyses were conducted using SPSS 24.0.
Discussion
Health care professionals are one of the strongest influencers in vaccination decisions [
16,
17] and therefore critically influence whether a recommended vaccination reaches high coverage in the population.
In the event the Swiss NITAG would recommend UVV, most participating physicians state that they would advise parents to have their children vaccinated. This expression of compliance was 92% among pediatricians and 77% among GPs. As pediatricians in Switzerland are the first-line providers of primary care in the early years of life [
18], the finding that more than 90% of pediatricians in our study showed a high intention to recommend UVV in case of a NITAG recommendation indicates that it should be feasible to achieve high vaccination coverage rates.
The high acceptance of an UVV recommendation in our study is supported by the finding that already more than a third of respondents – predominantly pediatricians – currently recommend varicella vaccination for all infants. It can be speculated that this recommendation behavior is influenced by the experience of nearby countries with universal varicella vaccination programs in place, such as Germany, Italy and Spain [
7,
9,
10].
It is also reassuring that most participating physicians indicated that they have strong arguments to educate parents on the importance of vaccination against varicella.
In line with this finding, about three quarters of the participating physicians perceived parents’ attitude towards having their children vaccinated as rather positive.
Nevertheless, further information and education of physicians on varicella should be considered to accompany the potential introduction of UVV, especially among the GP population who, according to the results of this study, seem to have a lower awareness of the burden of varicella.
Other recent studies investigated the attitudes to vaccinate against varicella among health care professionals and/or the public at a time when universal varicella vaccination was not recommended. A study previously conducted in the Netherlands showed that health care professionals and parents had a negative attitude or low intention to vaccinate universally against varicella, as a result of the perceived low severity of the disease. Accordingly, there was also very low demand for varicella vaccines in the private market with only ~ 165 varicella vaccines for children below 5 years delivered by Dutch community pharmacies in 2014 [
14]. In contrast, a small qualitative survey study among 20 caregivers and providers in New Zealand revealed positive support towards universal varicella vaccination and a high intention to vaccinate if available as a routine vaccine [
19]. The results of our survey study are thus more comparable to those observed in New Zealand than in the Netherlands.
Other survey studies have focused on parents, rather than on providers. One year after the introduction of a UVV program in Naples, Italy, a survey among 675 parents showed that less than 27% of parents knew that varicella vaccination was available and that the perceived utility of varicella vaccination was low. Importantly, the positive attitude towards the utility was however higher in those parents who had received information from a health care provider [
20]. A survey among visitors of a German internet vaccine forum for lay persons conducted a few months before UVV was introduced in Germany revealed modest acceptance of varicella immunization [
16]. Despite this early indication of low initial acceptance among parents, it is noteworthy that varicella vaccination coverage with 1 dose at the age of 24 months reached > 80% within 4 years after introduction of universal varicella vaccination in Germany [
21].
This study has some limitations. The study sample was not fully representative of the Swiss population of pediatricians and the GPs who treat pediatric patients. Physicians from the Italian-speaking part of Switzerland, who make up 4.35% of all GPs practicing and 4.25% of all pediatricians practicing in Switzerland [
22] were not included. Also, there is potential for selection bias as physicians who were willing to participate in the study might have had more favorable attitudes towards vaccination than the average Swiss pediatrician or GP. Furthermore, the outcome of this study is based on physicians’ perceptions and feedback (i.e. stated preferences) and not on a systematic analysis of patient record forms or chart review. Sampling errors could have affected the precision and interpretation of the results. The study is only a cross-sectional analysis at a specific point in time and does not allow an interpretation of developments or trends over time. The regression model analysis did not take into account all relevant confounders leading to unmeasured confounding bias. Finally, the questionnaire used for the survey study is not a standardized, validated questionnaire. Therefore, outcomes of this study are not comparable with those from other countries or studied samples.
Still, this is the first survey study among pediatricians and GPs in Switzerland specifically addressing varicella vaccination. Many aspects need to be taken into consideration in a national decision-making process about UVV, as has been outlined by a report of the European Centre for Disease Prevention and Control [
23]. The findings of this survey study may assist the Swiss NITAG in its evaluations of the feasibility of UVV introduction in the national immunization schedule.
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