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01.08.2008

Administration of the Rho-Kinase Inhibitor Fasudil Before Ischemia or just After Reperfusion, but not 30 min After Reperfusion, Protects the Stunned Myocardium in Swine

verfasst von: Itsuko Shibata, Osamu Yoshitomi, Tadasuke Use, Hiroyuki Ureshino, Sungsam Cho, Takuji Maekawa, Tetsuya Hara, Koji Sumikawa

Erschienen in: Cardiovascular Drugs and Therapy | Ausgabe 4/2008

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Abstract

Objectives

We assessed the effect of administration time for fasudil treatment of the stunned myocardium in 40 anesthetized open chest swine.

Materials and methods

All swine were subjected to 12 min ischemia followed by reperfusion to generate stunned myocardium. Group A (n = 11) received saline in place of fasudil both before ischemia and after reperfusion. Group B (n = 10) received 30 min intravenous fasudil at a rate of 13 μg/kg/min starting 45 min before ischemia and received saline after reperfusion. Groups C (n = 10) and D (n = 9) received saline before ischemia, and received fasudil at a rate of 13 μg kg−1 min−1 starting just before reperfusion in group C and 30 min after reperfusion in group D. In both groups, treatment lasted 30 min. Myocardial contractility was assessed by percent segment shortening (%SS).

Results and discussion

Three swine in group A, 2 swine in each of groups B and C, and one swine in group D had ventricular fibrillation or tachycardia after reperfusion and were excluded from further analysis. The changes of %SS from baseline at 90 min after reperfusion in groups B and C were 68 ± 8% and 75 ± 8%, respectively, which were significantly higher than in group A or D (47 ± 10% or 43 ± 8%).

Conclusion

We conclude that fasudil administered before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium.
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Metadaten
Titel
Administration of the Rho-Kinase Inhibitor Fasudil Before Ischemia or just After Reperfusion, but not 30 min After Reperfusion, Protects the Stunned Myocardium in Swine
verfasst von
Itsuko Shibata
Osamu Yoshitomi
Tadasuke Use
Hiroyuki Ureshino
Sungsam Cho
Takuji Maekawa
Tetsuya Hara
Koji Sumikawa
Publikationsdatum
01.08.2008
Verlag
Springer US
Erschienen in
Cardiovascular Drugs and Therapy / Ausgabe 4/2008
Print ISSN: 0920-3206
Elektronische ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-008-6106-y

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