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Erschienen in: Current Allergy and Asthma Reports 7/2022

01.04.2022 | Allergic Skin Diseases (L Fonacier, Section Editor)

Aeroallergens in Atopic Dermatitis and Chronic Urticaria

verfasst von: Albert C. Chong, Won Jong Chwa, Peck Y. Ong

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 7/2022

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Abstract

Purpose of Review

While aeroallergens are a well-established trigger of asthma and allergic rhinitis, their role in allergic skin diseases such as atopic dermatitis and chronic urticaria remains controversial. This paper reviews the pathophysiology and clinical evidence for aeroallergens in these allergic skin diseases and summarizes current strategies for evaluation and management.

Recent Findings

Current evidence implicates aeroallergens as triggers of cutaneous reactions in atopic dermatitis. Direct skin contact is the likely route of trigger. Aeroallergens may also trigger chronic urticaria, though mechanistic studies are limited. These allergens may cross the skin barrier and directly trigger neurons to release substance P, resulting in mast cell degranulation and dumping of histamine and prostaglandin D2. Many studies link aeroallergen sensitization to chronic urticaria, and case reports suggest the utility of avoidance strategies.

Summary

The role of aeroallergens as a trigger is clear in atopic dermatitis and becoming emergent in chronic urticaria. Skin prick testing or serum-specific immunoglobulin E testing may be used to determine sensitivities. Management at this time centers on avoidance, and further studies are necessary to evaluate the efficacy of aeroallergen immunotherapy for both conditions.
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Metadaten
Titel
Aeroallergens in Atopic Dermatitis and Chronic Urticaria
verfasst von
Albert C. Chong
Won Jong Chwa
Peck Y. Ong
Publikationsdatum
01.04.2022
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 7/2022
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-022-01033-2

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