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12.04.2017 | Akute lymphatische Leukämie | Leitthema

Antiinfektiöse Therapieprinzipien bei akuten Leukämien

verfasst von: Prof. Dr. M. von Lilienfeld-Toal

Erschienen in: Die Onkologie | Ausgabe 7/2017

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Zusammenfassung

Hintergrund

Patienten mit akuten Leukämien sind insbesondere in der Neutropeniephase nach myelosuppressiver Chemotherapie durch Infektionen bedroht.

Ziel der Arbeit

Häufige Infektkomplikationen sowie diagnostische, prophylaktische und therapeutische Strategien werden dargestellt.

Material und Methoden

Aktuelle Leitlinien zum Infektmanagement bei Patienten mit akuten Leukämien wurden zusammengefasst.

Ergebnisse

Von den Leukämiepatienten mit lang anhaltender Neutropenie entwickeln 80 % eine Fieberepisode, deren vermutlich bakterielle Genese immer eine empirische Antibiotikatherapie erfordert. Invasive Pilzinfektionen stellen ebenfalls eine relevante Bedrohung dar, während Virusinfektionen relativ selten sind. Strategien zu Prophylaxe, Diagnostik und Therapie werden erläutert.

Schlussfolgerung

Infektkomplikationen sind bei Leukämiepatienten häufig, aber in der Regel gut behandelbar, wenn ein adäquates Management erfolgt.
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Metadaten
Titel
Antiinfektiöse Therapieprinzipien bei akuten Leukämien
verfasst von
Prof. Dr. M. von Lilienfeld-Toal
Publikationsdatum
12.04.2017
Verlag
Springer Medizin
Erschienen in
Die Onkologie / Ausgabe 7/2017
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI
https://doi.org/10.1007/s00761-017-0223-9

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