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Lasers in Medical Science

Erschienen in:

06.09.2021 | Original Article

Antidepressant and antioxidant effects of transcranial irradiation with 830-nm low-power laser in an animal model of depression

verfasst von: Haitham S. Mohammed, Yasser A. Khadrawy

Erschienen in: Lasers in Medical Science | Ausgabe 3/2022

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Abstract

The present study aimed at investigating the antidepressant and antioxidant actions of near-infrared (NIR) laser at a wavelength of 830 nm and power of 100 mW which applied transcranially on an animal model of depression induced by repeated doses of reserpine (0.2 mg/kg). Thirty male Wistar adult rats were divided into three groups: rat model of depression; rat model of depression irradiated with laser for 14 days after induction of depression; and the control group that was given the drug vehicle and sham-exposed to the laser. Forced swimming test (FST) was used to verify the induction of animal model of depression and to screen the effect of antidepressant effect of low-level laser at the end of the experiment. Monoamine level, oxidative stress markers, and activities of acetylcholinesterase (AchE) and monoamine oxidase (MAO) were determined in the cortex and hippocampus of the rat brain. Reserpine resulted in depletion of monoamines and elevation in the oxidative stress markers and change in the enzymatic activities measured in both brain areas. Laser irradiation has an inhibitory action on the monoamine oxidase (MAO) in the cortex and hippocampus leading to elevation of the monoamine levels and attenuation of the oxidative stress in the studied areas. FST has emphasized the antidepressant effect of the utilized laser irradiation parameters on the behavioral level. The present findings provide evidence for the antidepressant and antioxidant actions of NIR low-power laser in the rat model of depression. Accordingly, low-laser irradiation may be presented as a potential candidate modality for depression treatment.

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Titel: Antidepressant and antioxidant effects of transcranial irradiation with 830-nm low-power laser in an animal model of depression
verfasst von: Haitham S. Mohammed
Yasser A. Khadrawy
Publikationsdatum: 06.09.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 3/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03410-1

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Antidepressant and antioxidant effects of transcranial irradiation with 830-nm low-power laser in an animal model of depression

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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