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Erschienen in: International Journal of Hematology 3/2024

04.02.2024 | Progress in Hematology

Aplastic anemia: history and recent developments in diagnosis and treatment

verfasst von: Yasushi Onishi

Erschienen in: International Journal of Hematology | Ausgabe 3/2024

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Abstract

Acquired aplastic anemia is an immune-mediated disease that targets hematopoietic stem cells, which is diagnosed by findings of peripheral blood pancytopenia and hypocellular bone marrow. Although the diagnostic definition is simple, differential diagnosis from other overlapping hematopoietic disorders such as hypoplastic myelodysplastic syndrome and inherited bone marrow failure syndrome is not easy. Immune suppressive therapy and allogeneic hematopoietic stem cell transplantation are important treatment approaches for aplastic anemia, and both have advanced in recent years. This issue of Progress in Hematology covers four topics related to aplastic anemia: (1) laboratory markers to identify immune pathophysiology and their role on differential diagnosis and prognosis, (2) the path to combination therapy with horse anti-thymocyte globulin, cyclosporine A, and eltrombopag, (3) more than 60 years of history and recent trends in allogeneic HSCT, and (4) genetic testing for differential diagnosis from IBMFS and novel approaches to transplantation for children including fludarabine/melphalan-based conditioning.
Literatur
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Zurück zum Zitat Onishi Y, Mori T, Yamazaki H, Hiramoto N, Zaimoku Y, Kanaya M, et al. Comparison of haploidentical stem cell transplantation with post-transplantation cyclophosphamide versus umbilical cord blood transplantation in adult patients with aplastic anemia. Transplant Cell Ther. 2023;29(12):766 e1 e8. https://doi.org/10.1016/j.jtct.2023.09.009.CrossRef Onishi Y, Mori T, Yamazaki H, Hiramoto N, Zaimoku Y, Kanaya M, et al. Comparison of haploidentical stem cell transplantation with post-transplantation cyclophosphamide versus umbilical cord blood transplantation in adult patients with aplastic anemia. Transplant Cell Ther. 2023;29(12):766 e1 e8. https://​doi.​org/​10.​1016/​j.​jtct.​2023.​09.​009.CrossRef
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Metadaten
Titel
Aplastic anemia: history and recent developments in diagnosis and treatment
verfasst von
Yasushi Onishi
Publikationsdatum
04.02.2024
Verlag
Springer Nature Singapore
Erschienen in
International Journal of Hematology / Ausgabe 3/2024
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI
https://doi.org/10.1007/s12185-024-03715-1

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