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Erschienen in: General Thoracic and Cardiovascular Surgery 1/2023

07.08.2022 | Original Article

Assessment of listing criteria for lung transplant candidates with interstitial lung disease

verfasst von: Shunichi Nagata, Akihiro Ohsumi, Tomohiro Handa, Yoshito Yamada, Satona Tanaka, Yojiro Yutaka, Daisuke Nakajima, Kiminobu Tanizawa, Toyohiro Hirai, Hiroshi Date

Erschienen in: General Thoracic and Cardiovascular Surgery | Ausgabe 1/2023

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Abstract

Objectives

Lung transplantation (LT) is an effective treatment for patients with interstitial lung disease (ILD) refractory to medical treatment. Although the cases of cadaveric LT (CLT) have increased, the donor shortage in Japan has remained severe. This study aimed to evaluate the International Society of Heart and Lung Transplantation (ISHLT) listing criteria for LT in patients with ILD by predicting outcomes during the waiting time for CLT.

Methods

We retrospectively identified 166 patients with fibrotic ILDs who were evaluated and registered for CLT at Kyoto Universal Hospital from April 1, 2008, to December 31, 2017. We examined the correlation between individual parameters of the ISHLT listing criteria and patient outcomes.

Results

Among 166 patients, 57 (34.3%) underwent CLT, whereas 83 (50.0%) died before CLT. The median survival time from the date of registration was 22.5 months. The 2-year survival rate was 47.8%. On multivariate Cox proportional hazards analysis, relative decline of percent predicted forced vital capacity (%FVC) in 6 months ≥ 10% (hazard ratio [HR]: 1.72; 95% confidence interval [95%CI]: 1.03–2.87, p = 0.04) and 6-min walking distance (6MWD) < 250 m (HR: 2.77; 95%CI: 1.64–4.69, p < 0.001) were independently associated with worse outcome (i.e., death or living-donor lobar LT).

Conclusions

The 2014 ISHLT criteria could appropriately identify patients with ILD who have a potentially poor prognosis. In particular, 6-month decline in %FVC and shorter 6 min walk distance may be useful for selecting patients with higher risks of mortality.
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Metadaten
Titel
Assessment of listing criteria for lung transplant candidates with interstitial lung disease
verfasst von
Shunichi Nagata
Akihiro Ohsumi
Tomohiro Handa
Yoshito Yamada
Satona Tanaka
Yojiro Yutaka
Daisuke Nakajima
Kiminobu Tanizawa
Toyohiro Hirai
Hiroshi Date
Publikationsdatum
07.08.2022
Verlag
Springer Nature Singapore
Erschienen in
General Thoracic and Cardiovascular Surgery / Ausgabe 1/2023
Print ISSN: 1863-6705
Elektronische ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-022-01861-z

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